Role of p53-mediated apoptotic pathway in oral lichen planus: Relationship among pro-apoptotic, anti-apoptotic, and keratinocytic markers
The aim of the study is to investigate the relationship between oral lichen planus (OLP) pathogenesis, apoptosis and keratinocyte markers. The study employed 98 subjects. In the epithelial portion of OLP biopsies expression of pro-apoptotic molecules, i.e. caspase-3, Bax, p53 and p63, or anti-apopto...
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| Published in | Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Vol. 26; no. 2; pp. 221 - 227 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Elsevier Ltd
01.04.2014
Elsevier BV |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2212-5558 2212-5566 |
| DOI | 10.1016/j.ajoms.2013.06.009 |
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| Abstract | The aim of the study is to investigate the relationship between oral lichen planus (OLP) pathogenesis, apoptosis and keratinocyte markers.
The study employed 98 subjects. In the epithelial portion of OLP biopsies expression of pro-apoptotic molecules, i.e. caspase-3, Bax, p53 and p63, or anti-apoptotic factor such as Bcl-2, involucrin as a keratinocyte-maturation marker and p63 as a keratinocyte stem cell marker were determined immunohistochemically.
Anti-apoptotic Bcl-2 expression showed no change. p53 expression rate among examined cells was significantly higher in the OLP group than in control group. p53 expression was significantly correlated with expression of p63 in total OLP group: the both were increased considerably after onset of more than a year. Bax expression was significantly higher in total OLP group. On the other hand, caspoase-3 expression was significantly lower in the total OLP group than in the control group, especially in subjects who were evaluated less than a year after onset.
Although pro-apoptotic factors are active, and anti-apoptotic factor is also active, the above results indicate that OLP might be resistant to p53-mediated caspase-3 dependent apoptosis, specially at less than a year following onset. |
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| AbstractList | The aim of the study is to investigate the relationship between oral lichen planus (OLP) pathogenesis, apoptosis and keratinocyte markers.
The study employed 98 subjects. In the epithelial portion of OLP biopsies expression of pro-apoptotic molecules, i.e. caspase-3, Bax, p53 and p63, or anti-apoptotic factor such as Bcl-2, involucrin as a keratinocyte-maturation marker and p63 as a keratinocyte stem cell marker were determined immunohistochemically.
Anti-apoptotic Bcl-2 expression showed no change. p53 expression rate among examined cells was significantly higher in the OLP group than in control group. p53 expression was significantly correlated with expression of p63 in total OLP group: the both were increased considerably after onset of more than a year. Bax expression was significantly higher in total OLP group. On the other hand, caspoase-3 expression was significantly lower in the total OLP group than in the control group, especially in subjects who were evaluated less than a year after onset.
Although pro-apoptotic factors are active, and anti-apoptotic factor is also active, the above results indicate that OLP might be resistant to p53-mediated caspase-3 dependent apoptosis, specially at less than a year following onset. |
| Author | Tovaru, Serban Tanaka, Tomoko Calenic, Bogdan Yaegaki, Ken Okamura, Kazuhiko Imai, Toshio |
| Author_xml | – sequence: 1 givenname: Bogdan surname: Calenic fullname: Calenic, Bogdan organization: Department of Oral Health, Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan – sequence: 2 givenname: Kazuhiko surname: Okamura fullname: Okamura, Kazuhiko organization: Section of Pathology, Department of Morphological Biology, Faculty of Dentistry, Fukuoka Dental College, Fukuoka 814-0193, Japan – sequence: 3 givenname: Ken surname: Yaegaki fullname: Yaegaki, Ken email: yaegaki-k@tky.ndu.ac.jp organization: Department of Oral Health, Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan – sequence: 4 givenname: Serban surname: Tovaru fullname: Tovaru, Serban organization: Department of Oral Pathology, Faculty of Dentistry, University of Medicine and Pharmacy, “Rarol Davila”, Bucharest, 1202, Romania – sequence: 5 givenname: Tomoko surname: Tanaka fullname: Tanaka, Tomoko organization: Department of Oral Health, Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan – sequence: 6 givenname: Toshio surname: Imai fullname: Imai, Toshio organization: Department of Oral Health, Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan |
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| Keywords | Bcl-2 Bax Lichen planus Apoptosis p53 |
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| Title | Role of p53-mediated apoptotic pathway in oral lichen planus: Relationship among pro-apoptotic, anti-apoptotic, and keratinocytic markers |
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