Anti-inflammatory cytokines in autism spectrum disorders: A systematic review and meta-analysis
•In the search for the causes of autism, inflammatory markers have emerged as potential candidates.•Studies have provided inconsistent results on altered levels of cytokine in patients with autism.•Meta-analyses show lower levels of IL-10 and IL-1Ra in autistic patients compared with controls.•Meta-...
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| Published in | Cytokine (Philadelphia, Pa.) Vol. 123; p. 154740 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.11.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1043-4666 1096-0023 1096-0023 |
| DOI | 10.1016/j.cyto.2019.154740 |
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| Abstract | •In the search for the causes of autism, inflammatory markers have emerged as potential candidates.•Studies have provided inconsistent results on altered levels of cytokine in patients with autism.•Meta-analyses show lower levels of IL-10 and IL-1Ra in autistic patients compared with controls.•Meta-analysis shows slightly higher levels of serum IL-5 in patients with autism.•Meta-regression shows that latitude, age, and gender influence alteration of IL-5, -10, and -1Ra in autism.
In the search for the causes of autism spectrum disorders (ASD), inflammatory markers have emerged as potential candidates. The present meta-analysis was performed on studies examining circulating concentrations of anti-inflammatory cytokines in people with ASD compared with control subjects without ASD.
We identified potentially eligible studies by systematically searching electronic databases from inception to February 2018.
Twenty-five studies with a total of 1754 participants (1022 patients with ASD and 732 control subjects) were included in the mate-analysis; 4 for interferon (IFN)-α, 9 for interleukin (IL)-1 receptor antagonist (Ra), 9 for IL-4, 6 for IL-5, 3 for IL-9, 14 for IL-10, 7 for IL-13, and 6 for transforming growth factor (TGF)-β. We found a moderate decrease in plasma levels of IL-10 (SMD = −0.59) and a small decrease in serum levels of IL-1Ra (SMD = −0.25) in patients with ASD. On the contrary, serum IL-5 levels were slightly increased (SMD = 0.26) in these patients. We conducted meta-regression analyses to investigate the possible effect of moderatos on the effect size (ES) of difference in mean levels of IL-10. Difference in the mean age between patients and controls showed a negative influence on the ES and was able to explain about 0.4 of total between-study variance. In contrast, latitude exerted a positive effect on the ES and explained a lower proportion (0.1) of total between-study variance.
This meta-analysis provides evidence for the lower concentration of anti-inflammatory cytokines IL-10 and IL-1Ra in autistic patients compared with control subjects. Also, meta-regression analyses point to the interaction of latitude, age, and gender with peripheral alterations of associated anti-inflammatory cytokines. |
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| AbstractList | In the search for the causes of autism spectrum disorders (ASD), inflammatory markers have emerged as potential candidates. The present meta-analysis was performed on studies examining circulating concentrations of anti-inflammatory cytokines in people with ASD compared with control subjects without ASD.BACKGROUNDIn the search for the causes of autism spectrum disorders (ASD), inflammatory markers have emerged as potential candidates. The present meta-analysis was performed on studies examining circulating concentrations of anti-inflammatory cytokines in people with ASD compared with control subjects without ASD.We identified potentially eligible studies by systematically searching electronic databases from inception to February 2018.METHODSWe identified potentially eligible studies by systematically searching electronic databases from inception to February 2018.Twenty-five studies with a total of 1754 participants (1022 patients with ASD and 732 control subjects) were included in the mate-analysis; 4 for interferon (IFN)-α, 9 for interleukin (IL)-1 receptor antagonist (Ra), 9 for IL-4, 6 for IL-5, 3 for IL-9, 14 for IL-10, 7 for IL-13, and 6 for transforming growth factor (TGF)-β. We found a moderate decrease in plasma levels of IL-10 (SMD = -0.59) and a small decrease in serum levels of IL-1Ra (SMD = -0.25) in patients with ASD. On the contrary, serum IL-5 levels were slightly increased (SMD = 0.26) in these patients. We conducted meta-regression analyses to investigate the possible effect of moderatos on the effect size (ES) of difference in mean levels of IL-10. Difference in the mean age between patients and controls showed a negative influence on the ES and was able to explain about 0.4 of total between-study variance. In contrast, latitude exerted a positive effect on the ES and explained a lower proportion (0.1) of total between-study variance.RESULTSTwenty-five studies with a total of 1754 participants (1022 patients with ASD and 732 control subjects) were included in the mate-analysis; 4 for interferon (IFN)-α, 9 for interleukin (IL)-1 receptor antagonist (Ra), 9 for IL-4, 6 for IL-5, 3 for IL-9, 14 for IL-10, 7 for IL-13, and 6 for transforming growth factor (TGF)-β. We found a moderate decrease in plasma levels of IL-10 (SMD = -0.59) and a small decrease in serum levels of IL-1Ra (SMD = -0.25) in patients with ASD. On the contrary, serum IL-5 levels were slightly increased (SMD = 0.26) in these patients. We conducted meta-regression analyses to investigate the possible effect of moderatos on the effect size (ES) of difference in mean levels of IL-10. Difference in the mean age between patients and controls showed a negative influence on the ES and was able to explain about 0.4 of total between-study variance. In contrast, latitude exerted a positive effect on the ES and explained a lower proportion (0.1) of total between-study variance.This meta-analysis provides evidence for the lower concentration of anti-inflammatory cytokines IL-10 and IL-1Ra in autistic patients compared with control subjects. Also, meta-regression analyses point to the interaction of latitude, age, and gender with peripheral alterations of associated anti-inflammatory cytokines.CONCLUSIONSThis meta-analysis provides evidence for the lower concentration of anti-inflammatory cytokines IL-10 and IL-1Ra in autistic patients compared with control subjects. Also, meta-regression analyses point to the interaction of latitude, age, and gender with peripheral alterations of associated anti-inflammatory cytokines. In the search for the causes of autism spectrum disorders (ASD), inflammatory markers have emerged as potential candidates. The present meta-analysis was performed on studies examining circulating concentrations of anti-inflammatory cytokines in people with ASD compared with control subjects without ASD. We identified potentially eligible studies by systematically searching electronic databases from inception to February 2018. Twenty-five studies with a total of 1754 participants (1022 patients with ASD and 732 control subjects) were included in the mate-analysis; 4 for interferon (IFN)-α, 9 for interleukin (IL)-1 receptor antagonist (Ra), 9 for IL-4, 6 for IL-5, 3 for IL-9, 14 for IL-10, 7 for IL-13, and 6 for transforming growth factor (TGF)-β. We found a moderate decrease in plasma levels of IL-10 (SMD = -0.59) and a small decrease in serum levels of IL-1Ra (SMD = -0.25) in patients with ASD. On the contrary, serum IL-5 levels were slightly increased (SMD = 0.26) in these patients. We conducted meta-regression analyses to investigate the possible effect of moderatos on the effect size (ES) of difference in mean levels of IL-10. Difference in the mean age between patients and controls showed a negative influence on the ES and was able to explain about 0.4 of total between-study variance. In contrast, latitude exerted a positive effect on the ES and explained a lower proportion (0.1) of total between-study variance. This meta-analysis provides evidence for the lower concentration of anti-inflammatory cytokines IL-10 and IL-1Ra in autistic patients compared with control subjects. Also, meta-regression analyses point to the interaction of latitude, age, and gender with peripheral alterations of associated anti-inflammatory cytokines. •In the search for the causes of autism, inflammatory markers have emerged as potential candidates.•Studies have provided inconsistent results on altered levels of cytokine in patients with autism.•Meta-analyses show lower levels of IL-10 and IL-1Ra in autistic patients compared with controls.•Meta-analysis shows slightly higher levels of serum IL-5 in patients with autism.•Meta-regression shows that latitude, age, and gender influence alteration of IL-5, -10, and -1Ra in autism. In the search for the causes of autism spectrum disorders (ASD), inflammatory markers have emerged as potential candidates. The present meta-analysis was performed on studies examining circulating concentrations of anti-inflammatory cytokines in people with ASD compared with control subjects without ASD. We identified potentially eligible studies by systematically searching electronic databases from inception to February 2018. Twenty-five studies with a total of 1754 participants (1022 patients with ASD and 732 control subjects) were included in the mate-analysis; 4 for interferon (IFN)-α, 9 for interleukin (IL)-1 receptor antagonist (Ra), 9 for IL-4, 6 for IL-5, 3 for IL-9, 14 for IL-10, 7 for IL-13, and 6 for transforming growth factor (TGF)-β. We found a moderate decrease in plasma levels of IL-10 (SMD = −0.59) and a small decrease in serum levels of IL-1Ra (SMD = −0.25) in patients with ASD. On the contrary, serum IL-5 levels were slightly increased (SMD = 0.26) in these patients. We conducted meta-regression analyses to investigate the possible effect of moderatos on the effect size (ES) of difference in mean levels of IL-10. Difference in the mean age between patients and controls showed a negative influence on the ES and was able to explain about 0.4 of total between-study variance. In contrast, latitude exerted a positive effect on the ES and explained a lower proportion (0.1) of total between-study variance. This meta-analysis provides evidence for the lower concentration of anti-inflammatory cytokines IL-10 and IL-1Ra in autistic patients compared with control subjects. Also, meta-regression analyses point to the interaction of latitude, age, and gender with peripheral alterations of associated anti-inflammatory cytokines. |
| ArticleNumber | 154740 |
| Author | Saghazadeh, Amene Rezaei, Nima Abdolalizadeh, Amirhussein Hirbod-Mobarakeh, Armin Keynejad, Kimia Ataeinia, Bahar |
| Author_xml | – sequence: 1 givenname: Amene surname: Saghazadeh fullname: Saghazadeh, Amene organization: Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran – sequence: 2 givenname: Bahar surname: Ataeinia fullname: Ataeinia, Bahar organization: Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran – sequence: 3 givenname: Kimia surname: Keynejad fullname: Keynejad, Kimia organization: Border of Immune Tolerance Education and Research Network (BITERN), Universal Scientific Education and Research Network (USERN), Tehran, Iran – sequence: 4 givenname: Amirhussein surname: Abdolalizadeh fullname: Abdolalizadeh, Amirhussein organization: Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran – sequence: 5 givenname: Armin surname: Hirbod-Mobarakeh fullname: Hirbod-Mobarakeh, Armin organization: Department of Psychiatry, Iran University of Medical Sciences, Tehran, Iran – sequence: 6 givenname: Nima orcidid: 0000-0002-6739-6877 surname: Rezaei fullname: Rezaei, Nima email: Rezaei_nima@tums.ac.ir organization: Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31228728$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/sj.npp.1301029 10.1016/j.ejenta.2014.12.002 10.1186/s13229-016-0115-7 10.1016/j.cyto.2015.10.002 10.1016/j.jneuroim.2005.12.007 10.1016/j.jneuroim.2008.12.002 10.1007/BF02276236 10.1371/journal.pone.0175437 10.1016/j.bbi.2018.03.025 10.1016/j.biopsych.2011.04.013 10.1371/journal.pone.0164153 10.1007/s10654-010-9491-z 10.1007/s10875-004-6241-6 10.1038/mp.2014.59 10.1371/journal.pmed.1000097 10.1111/j.0006-341X.2000.00455.x 10.1016/j.pnpbp.2017.07.011 10.1590/1516-4446-2015-1843 10.1016/j.pediatrneurol.2012.05.007 10.1159/000084164 10.1159/000048665 10.1089/cap.2010.0134 10.1684/ecn.2018.0404 10.1176/appi.ajp.157.5.683 10.1016/j.jneuroim.2005.11.007 10.1089/cap.2013.0108 10.1007/s12640-013-9393-4 10.1007/s12031-016-0847-z 10.1038/mp.2008.58 10.1016/j.rasd.2014.05.006 10.2307/2533446 10.1016/j.bbi.2010.09.011 10.1016/j.neulet.2010.01.033 10.1038/sj.mp.4002042 10.1515/revneuro-2017-0015 10.1093/nutrit/nuv026 10.1186/1742-2094-9-265 10.1016/j.molmed.2011.03.001 10.1186/2040-2392-2-13 10.1016/j.pediatrneurol.2005.03.014 10.1186/2040-2392-4-12 10.1186/1742-2094-10-38 10.3109/15622975.2011.639803 10.1055/s-0032-1301914 10.1371/journal.pone.0020470 10.1016/S0090-1229(05)80015-7 10.1007/s10803-016-3024-x 10.1016/j.ijdevneu.2011.12.003 10.1371/journal.pone.0190252 10.1016/j.biopsych.2009.09.033 10.1038/tp.2011.48 10.18632/oncotarget.19326 10.1016/j.bbi.2010.08.003 10.1016/j.rasd.2012.08.007 10.1016/0165-5728(96)00014-8 10.1515/revneuro-2013-0045 10.1016/j.jneuroim.2008.07.006 10.1111/j.1469-7610.1996.tb01459.x 10.1016/j.jneuroim.2012.07.013 10.1007/s10803-006-0123-0 10.1016/j.biopsych.2013.01.007 10.1016/j.pnpbp.2006.08.020 |
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| Keywords | Autism Systematic review Inflammation Latitude Cytokine Meta-analysis |
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| References | Dowlati, Herrmann, Swardfager (b0020) 2010; 67 Pardo, Farmer, Thurm (b0190) 2017; 8 Kronfol, Remick (b0005) 2000; 157 Saghazadeh, Mahmoudi, Meysamie, Gharedaghi, Zamponi, Rezaei (b0070) 2015; 73 El-Ansary, Al-Ayadhi (b0240) 2012; 9 Ricci, Businaro, Ippoliti (b0180) 2013; 24 Miller, Buckley, Seabolt, Mellor, Kirkpatrick (b0025) 2011; 70 Harsini, Saghazadeh, Nedjat, Rezaei (b0105) 2018; 29 Tostes, Teixeira, Gattaz, Brandão, Raposo (b0155) 2012; 45 Zhu, Blakely, Hewlett (b0010) 2006; 31 Choi, Widjaja, Careaga, Bent, Ashwood, Hendren (b0340) 2014; 24 Patterson (b0320) 2011; 17 El Gohary, El Aziz, Darweesh, Sadaa (b0245) 2015; 16 Kotagal, Broomall (b0045) 2012; 47 Saghazadeh, Rezaei (b0065) 2017; 79 Raison, Borisov, Woolwine, Massung, Vogt, Miller (b0015) 2010; 15 Agah, Zardoui, Saghazadeh, Ahmadi, Tafakhori, Rezaei (b0080) 2018; 13 Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J (b0260) 2011; 25 Okada, Hashimoto, Iwata (b0195) 2007; 31 . Tobiasova, van der Lingen, Scahill (b0160) 2011; 21 Saghazadeh, Mahmoudi, Ashkezari, Rezaie, Rezaei (b0100) 2017; 12 Napolioni, Ober-Reynolds, Szelinger (b0200) 2013; 10 Mandal, Marzouk, Donnelly, Ponzio (b0315) 2011; 25 Molloy, Morrow, Meinzen-Derr (b0325) 2006; 172 Grzadzinski, Huerta, Lord (b0035) 2013; 4 Han, Cheung, Wong (b0220) 2017; 8 Saghazadeh, Gharedaghi, Meysamie, Bauer, Rezaei (b0075) 2014; 25 Meyer, Murray, Urwyler, Yee, Schedlowski, Feldon (b0310) 2008; 13 Xie, Huang, Li (b0150) 2017; 8 Saghazadeh, Rezaei (b0095) 2017; 47 Duval, Tweedie (b0135) 2000; 56 Croonenberghs, Bosmans, Deboutte, Kenis, Maes (b0250) 2002; 45 Rose, Yang, Serena (b0330) 2018 Hill, Zuckerman, Hagen (b0050) 2014; 8 Stang (b0120) 2010; 25 Singh (b0175) 1996; 66 Manzardo, Henkhaus, Dhillon, Butler (b0205) 2012; 30 Suzuki, Matsuzaki, Iwata (b0165) 2011; 6 Bryn, Aass, Skjeldal, Isaksen, Saugstad, Ormstad (b0255) 2017; 61 Denney, Frei, Gaffney (b0270) 1996; 26 Higgins JPT GSe. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. . The Cochrane Collaboration, 2011 Available from Modabbernia, Taslimi, Brietzke, Ashrafi (b0030) 2013; 74 El-Ansary, Hassan, Qasem, Das (b0235) 2016; 11 Guloksuz, Abali, Cetin (b0225) 2017; 39 Pecorelli, Cervellati, Belmonte (b0185) 2016; 77 Zimmerman, Jyonouchi, Comi (b0145) 2005; 33 Begg, Mazumdar (b0130) 1994 Masi, Quintana, Glozier, Lloyd, Hickie, Guastella (b0060) 2015; 20 Heuer, Braunschweig, Ashwood, Van de Water, Campbell (b0290) 2011; 1 Abdallah, Larsen, Mortensen (b0295) 2012; 252 Saghazadeh, Ahangari, Hendi, Saleh, Rezaei (b0085) 2017; 28 Moher, Liberati, Tetzlaff, Altman, Prisma (b0110) 2009; 6 Russell, Jarrold, Henry (b0040) 1996; 37 Ashwood, Enstrom, Krakowiak (b0265) 2008; 204 Ashwood, Anthony, Torrente, Wakefield (b0275) 2004; 24 Abdallah, Larsen, Grove (b0300) 2013; 14 Ashwood, Wakefield (b0280) 2006; 173 Jacome, Chacon, Cuesta (b0210) 2016; 6 Leyfer, Folstein, Bacalman (b0055) 2006; 36 Duval, Tweedie (b0140) 2000; 56 Hashim, Abdelrahman, Mohammed, Karam (b0215) 2013; 7 Singh, Warren, Odell, Cole (b0170) 1991; 61 Li, Chauhan, Sheikh (b0305) 2009; 207 Rezaei, Abdurahman, Saghazadeh, Badv, Mahmoudi (b0090) 2017 Goines, Croen, Braunschweig (b0335) 2011; 2 Higgins, Green (b0125) 2011 Jyonouchi, Geng, Ruby, Zimmerman-Bier (b0285) 2005; 51 Emanuele, Orsi, Boso (b0230) 2010; 471 Saghazadeh (10.1016/j.cyto.2019.154740_b0100) 2017; 12 Ashwood (10.1016/j.cyto.2019.154740_b0275) 2004; 24 Tostes (10.1016/j.cyto.2019.154740_b0155) 2012; 45 El-Ansary (10.1016/j.cyto.2019.154740_b0235) 2016; 11 Kotagal (10.1016/j.cyto.2019.154740_b0045) 2012; 47 Singh (10.1016/j.cyto.2019.154740_b0170) 1991; 61 Choi (10.1016/j.cyto.2019.154740_b0340) 2014; 24 Heuer (10.1016/j.cyto.2019.154740_b0290) 2011; 1 Patterson (10.1016/j.cyto.2019.154740_b0320) 2011; 17 Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J (10.1016/j.cyto.2019.154740_b0260) 2011; 25 Saghazadeh (10.1016/j.cyto.2019.154740_b0070) 2015; 73 Agah (10.1016/j.cyto.2019.154740_b0080) 2018; 13 Singh (10.1016/j.cyto.2019.154740_b0175) 1996; 66 Begg (10.1016/j.cyto.2019.154740_b0130) 1994 Abdallah (10.1016/j.cyto.2019.154740_b0300) 2013; 14 Stang (10.1016/j.cyto.2019.154740_b0120) 2010; 25 Okada (10.1016/j.cyto.2019.154740_b0195) 2007; 31 Meyer (10.1016/j.cyto.2019.154740_b0310) 2008; 13 Leyfer (10.1016/j.cyto.2019.154740_b0055) 2006; 36 Saghazadeh (10.1016/j.cyto.2019.154740_b0065) 2017; 79 Saghazadeh (10.1016/j.cyto.2019.154740_b0085) 2017; 28 Bryn (10.1016/j.cyto.2019.154740_b0255) 2017; 61 Emanuele (10.1016/j.cyto.2019.154740_b0230) 2010; 471 Miller (10.1016/j.cyto.2019.154740_b0025) 2011; 70 Tobiasova (10.1016/j.cyto.2019.154740_b0160) 2011; 21 Zimmerman (10.1016/j.cyto.2019.154740_b0145) 2005; 33 Ricci (10.1016/j.cyto.2019.154740_b0180) 2013; 24 Ashwood (10.1016/j.cyto.2019.154740_b0280) 2006; 173 Han (10.1016/j.cyto.2019.154740_b0220) 2017; 8 Russell (10.1016/j.cyto.2019.154740_b0040) 1996; 37 Rose (10.1016/j.cyto.2019.154740_b0330) 2018 El-Ansary (10.1016/j.cyto.2019.154740_b0240) 2012; 9 Saghazadeh (10.1016/j.cyto.2019.154740_b0095) 2017; 47 Mandal (10.1016/j.cyto.2019.154740_b0315) 2011; 25 Masi (10.1016/j.cyto.2019.154740_b0060) 2015; 20 Denney (10.1016/j.cyto.2019.154740_b0270) 1996; 26 Pecorelli (10.1016/j.cyto.2019.154740_b0185) 2016; 77 Zhu (10.1016/j.cyto.2019.154740_b0010) 2006; 31 Duval (10.1016/j.cyto.2019.154740_b0140) 2000; 56 Goines (10.1016/j.cyto.2019.154740_b0335) 2011; 2 Hashim (10.1016/j.cyto.2019.154740_b0215) 2013; 7 Li (10.1016/j.cyto.2019.154740_b0305) 2009; 207 Guloksuz (10.1016/j.cyto.2019.154740_b0225) 2017; 39 Modabbernia (10.1016/j.cyto.2019.154740_b0030) 2013; 74 Pardo (10.1016/j.cyto.2019.154740_b0190) 2017; 8 Suzuki (10.1016/j.cyto.2019.154740_b0165) 2011; 6 10.1016/j.cyto.2019.154740_b0115 Ashwood (10.1016/j.cyto.2019.154740_b0265) 2008; 204 Jacome (10.1016/j.cyto.2019.154740_b0210) 2016; 6 Grzadzinski (10.1016/j.cyto.2019.154740_b0035) 2013; 4 Rezaei (10.1016/j.cyto.2019.154740_b0090) 2017 Dowlati (10.1016/j.cyto.2019.154740_b0020) 2010; 67 Hill (10.1016/j.cyto.2019.154740_b0050) 2014; 8 Higgins (10.1016/j.cyto.2019.154740_b0125) 2011 El Gohary (10.1016/j.cyto.2019.154740_b0245) 2015; 16 Moher (10.1016/j.cyto.2019.154740_b0110) 2009; 6 Croonenberghs (10.1016/j.cyto.2019.154740_b0250) 2002; 45 Jyonouchi (10.1016/j.cyto.2019.154740_b0285) 2005; 51 Abdallah (10.1016/j.cyto.2019.154740_b0295) 2012; 252 Manzardo (10.1016/j.cyto.2019.154740_b0205) 2012; 30 Molloy (10.1016/j.cyto.2019.154740_b0325) 2006; 172 Napolioni (10.1016/j.cyto.2019.154740_b0200) 2013; 10 Duval (10.1016/j.cyto.2019.154740_b0135) 2000; 56 Kronfol (10.1016/j.cyto.2019.154740_b0005) 2000; 157 Saghazadeh (10.1016/j.cyto.2019.154740_b0075) 2014; 25 Xie (10.1016/j.cyto.2019.154740_b0150) 2017; 8 Harsini (10.1016/j.cyto.2019.154740_b0105) 2018; 29 Raison (10.1016/j.cyto.2019.154740_b0015) 2010; 15 |
| References_xml | – volume: 20 start-page: 440 year: 2015 end-page: 446 ident: b0060 article-title: Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis publication-title: Mol. Psychiatry – volume: 25 start-page: 863 year: 2011 end-page: 871 ident: b0315 article-title: Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells publication-title: Brain Behav. Immun. – start-page: 1088 year: 1994 end-page: 1101 ident: b0130 article-title: Operating characteristics of a rank correlation test for publication bias publication-title: Biometrics – volume: 8 start-page: 1 year: 2017 ident: b0190 article-title: Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study publication-title: Mol. Autism – volume: 8 start-page: 1121 year: 2014 end-page: 1133 ident: b0050 article-title: Aggressive behavior problems in children with autism spectrum disorders: prevalence and correlates in a large clinical sample publication-title: Res. Autism Spectrum Disord. – volume: 172 start-page: 198 year: 2006 end-page: 205 ident: b0325 article-title: Elevated cytokine levels in children with autism spectrum disorder publication-title: J. Neuroimmunol. – volume: 67 start-page: 446 year: 2010 end-page: 457 ident: b0020 article-title: A meta-analysis of cytokines in major depression publication-title: Biol. Psychiatry – volume: 61 year: 2017 ident: b0255 article-title: Cytokine profile in autism spectrum disorders in children publication-title: J. Mol. Neurosci. – volume: 9 start-page: 265 year: 2012 ident: b0240 article-title: Neuroinflammation in autism spectrum disorders publication-title: J. Neuroinflammat. – volume: 13 year: 2018 ident: b0080 article-title: Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis publication-title: PLoS One – volume: 77 start-page: 180 year: 2016 end-page: 188 ident: b0185 article-title: Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients publication-title: Cytokine – volume: 14 start-page: 528 year: 2013 end-page: 538 ident: b0300 article-title: Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders publication-title: World J. Biol. Psychiatry – year: 2011 ident: b0125 article-title: Handbook for systematic reviews of interventions version 5.1. 0 [updated March 2011] publication-title: Cochrane Collaborat. – volume: 56 start-page: 455 year: 2000 end-page: 463 ident: b0135 article-title: Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis publication-title: Biometrics – volume: 24 start-page: 491 year: 2013 end-page: 501 ident: b0180 article-title: Altered cytokine and BDNF levels in autism spectrum disorder publication-title: Neurotox. Res. – volume: 79 start-page: 340 year: 2017 end-page: 368 ident: b0065 article-title: Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: Higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry – volume: 8 start-page: 82390 year: 2017 end-page: 82398 ident: b0150 article-title: Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children publication-title: Oncotarget – volume: 204 start-page: 149 year: 2008 end-page: 153 ident: b0265 article-title: Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes publication-title: J. Neuroimmunol. – volume: 15 start-page: 535 year: 2010 ident: b0015 article-title: Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior publication-title: Mol. Psychiatry – volume: 74 start-page: 15 year: 2013 end-page: 25 ident: b0030 article-title: Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies publication-title: Biol. Psychiatry – volume: 6 year: 2009 ident: b0110 article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement publication-title: PLoS Med. – volume: 51 start-page: 77 year: 2005 end-page: 85 ident: b0285 article-title: Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention publication-title: Neuropsychobiology – volume: 39 start-page: 195 year: 2017 end-page: 200 ident: b0225 article-title: Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders publication-title: Revista Brasileira de Psiquiatria – volume: 16 start-page: 69 year: 2015 end-page: 73 ident: b0245 article-title: Plasma level of transforming growth factor β 1 in children with autism spectrum disorder publication-title: Egypt. J. Ear Nose Throat Allied Sci. – volume: 29 start-page: 16 year: 2018 end-page: 26 ident: b0105 article-title: Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis publication-title: Eur. Cytokine Netw. – volume: 36 start-page: 849 year: 2006 end-page: 861 ident: b0055 article-title: Comorbid psychiatric disorders in children with autism: interview development and rates of disorders publication-title: J. Autism Dev. Disord. – volume: 45 start-page: 241 year: 2012 end-page: 243 ident: b0155 article-title: Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism publication-title: Pharmacopsychiatry – volume: 7 start-page: 199 year: 2013 end-page: 204 ident: b0215 article-title: Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children publication-title: Res. Autism Spectrum Disord. – volume: 13 start-page: 208 year: 2008 ident: b0310 article-title: Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling publication-title: Mol. Psychiatry – volume: 28 start-page: 783 year: 2017 end-page: 809 ident: b0085 article-title: Status of essential elements in autism spectrum disorder: systematic review and meta-analysis publication-title: Rev. Neurosci. – start-page: 1 year: 2017 end-page: 18 ident: b0090 article-title: Short-term and long-term efficacy of classical ketogenic diet and modified Atkins diet in children and adolescents with epilepsy: a systematic review and meta-analysis publication-title: Nutritional Neurosci. – volume: 26 start-page: 87 year: 1996 end-page: 97 ident: b0270 article-title: Lymphocyte subsets and interleukin-2 receptors in autistic children publication-title: J. Autism Dev. Disord. – volume: 252 start-page: 75 year: 2012 end-page: 82 ident: b0295 article-title: Neonatal levels of cytokines and risk of autism spectrum disorders: an exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank publication-title: J. Neuroimmunol. – volume: 2 year: 2011 ident: b0335 article-title: Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: a case-control study publication-title: Mol. Autism – volume: 33 start-page: 195 year: 2005 end-page: 201 ident: b0145 article-title: Cerebrospinal fluid and serum markers of inflammation in autism publication-title: Pediatr. Neurol. – year: 2018 ident: b0330 article-title: Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms publication-title: Brain Behav. Immun. – volume: 31 start-page: 187 year: 2007 end-page: 190 ident: b0195 article-title: Decreased serum levels of transforming growth factor-β1 in patients with autism publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry – volume: 8 year: 2017 ident: b0220 article-title: Distinct cytokine and chemokine profiles in autism spectrum disorders publication-title: Front. Immunol – volume: 10 start-page: 38 year: 2013 ident: b0200 article-title: Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder publication-title: J. Neuroinflammat. – volume: 157 start-page: 683 year: 2000 end-page: 694 ident: b0005 article-title: Cytokines and the brain: implications for clinical psychiatry publication-title: Am. J. Psychiatry – reference: Higgins JPT GSe. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. . The Cochrane Collaboration, 2011 Available from – volume: 61 start-page: 448 year: 1991 end-page: 455 ident: b0170 article-title: Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children publication-title: Clin. Immunol. Immunopathol. – volume: 471 start-page: 162 year: 2010 end-page: 165 ident: b0230 article-title: Low-grade endotoxemia in patients with severe autism publication-title: Neurosci. Lett. – volume: 56 start-page: 455 year: 2000 end-page: 463 ident: b0140 article-title: Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis publication-title: Biometrics – volume: 45 start-page: 1 year: 2002 end-page: 6 ident: b0250 article-title: Activation of the inflammatory response system in autism publication-title: Neuropsychobiology – volume: 30 start-page: 121 year: 2012 end-page: 127 ident: b0205 article-title: Plasma cytokine levels in children with autistic disorder and unrelated siblings publication-title: Int. J. Develop. Neurosci.: Off. J. Int. Soc. Develop. Neurosci. – volume: 25 start-page: 281 year: 2014 end-page: 305 ident: b0075 article-title: Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis publication-title: Rev. Neurosci. – volume: 17 start-page: 389 year: 2011 end-page: 394 ident: b0320 article-title: Maternal infection and immune involvement in autism publication-title: Trends Mol. Med. – volume: 47 start-page: 1018 year: 2017 end-page: 1029 ident: b0095 article-title: Brain-derived neurotrophic factor levels in autism: a systematic review and meta-analysis publication-title: J. Autism Dev. Disord. – volume: 6 year: 2016 ident: b0210 article-title: Peripheral inflammatory markers contributing to comorbidities in autism publication-title: Behavioral Sci. – volume: 24 start-page: 664 year: 2004 end-page: 673 ident: b0275 article-title: Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10 publication-title: J. Clin. Immunol. – volume: 12 year: 2017 ident: b0100 article-title: Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium publication-title: PLoS One – volume: 73 start-page: 760 year: 2015 end-page: 779 ident: b0070 article-title: Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis publication-title: Nutr. Rev. – volume: 173 start-page: 126 year: 2006 end-page: 134 ident: b0280 article-title: Immune activation of peripheral blood and mucosal CD3(+) lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms publication-title: J. Neuroimmunol. – volume: 21 start-page: 555 year: 2011 end-page: 564 ident: b0160 article-title: Risperidone-related improvement of irritability in children with autism is not associated with changes in serum of epidermal growth factor and interleukin-13 publication-title: J. Child Adolesc. Psychopharmacol. – volume: 47 start-page: 242 year: 2012 end-page: 251 ident: b0045 article-title: Sleep in children with autism spectrum disorder publication-title: Pediatr. Neurol. – volume: 66 start-page: 143 year: 1996 end-page: 145 ident: b0175 article-title: Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism publication-title: J. Neuroimmunol. – volume: 24 start-page: 586 year: 2014 end-page: 589 ident: b0340 article-title: Change in plasma cytokine levels during risperidone treatment in children with autism publication-title: J. Child Adolesc. Psychopharmacol. – volume: 1 year: 2011 ident: b0290 article-title: Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression publication-title: Transl. Psychiatry – volume: 37 start-page: 673 year: 1996 end-page: 686 ident: b0040 article-title: Working memory in children with autism and with moderate learning difficulties publication-title: J. Child Psychol. Psychiatry – volume: 6 year: 2011 ident: b0165 article-title: Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders publication-title: PLoS One – volume: 4 start-page: 12 year: 2013 ident: b0035 article-title: DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes publication-title: Mol. Autism – reference: . – volume: 11 year: 2016 ident: b0235 article-title: Identification of Biomarkers of Impaired Sensory Profiles among Autistic Patients publication-title: PLoS One – volume: 70 start-page: 663 year: 2011 end-page: 671 ident: b0025 article-title: Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects publication-title: Biol. Psychiatry – volume: 25 start-page: 603 year: 2010 end-page: 605 ident: b0120 article-title: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses publication-title: Eur. J. Epidemiol. – volume: 25 start-page: 40 year: 2011 end-page: 45 ident: b0260 article-title: Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome publication-title: Brain Behav. Immun. – volume: 31 start-page: 2121 year: 2006 ident: b0010 article-title: The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters publication-title: Neuropsychopharmacol.: Off. Publ. Am. College Neuropsychopharmacol. – volume: 207 start-page: 111 year: 2009 end-page: 116 ident: b0305 article-title: Elevated immune response in the brain of autistic patients publication-title: J. Neuroimmunol. – volume: 31 start-page: 2121 issue: 10 year: 2006 ident: 10.1016/j.cyto.2019.154740_b0010 article-title: The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters publication-title: Neuropsychopharmacol.: Off. Publ. Am. College Neuropsychopharmacol. doi: 10.1038/sj.npp.1301029 – volume: 16 start-page: 69 issue: 1 year: 2015 ident: 10.1016/j.cyto.2019.154740_b0245 article-title: Plasma level of transforming growth factor β 1 in children with autism spectrum disorder publication-title: Egypt. J. Ear Nose Throat Allied Sci. doi: 10.1016/j.ejenta.2014.12.002 – volume: 8 start-page: 1 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0190 article-title: Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study publication-title: Mol. Autism doi: 10.1186/s13229-016-0115-7 – volume: 77 start-page: 180 year: 2016 ident: 10.1016/j.cyto.2019.154740_b0185 article-title: Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients publication-title: Cytokine doi: 10.1016/j.cyto.2015.10.002 – volume: 173 start-page: 126 issue: 1–2 year: 2006 ident: 10.1016/j.cyto.2019.154740_b0280 article-title: Immune activation of peripheral blood and mucosal CD3(+) lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2005.12.007 – volume: 207 start-page: 111 issue: 1–2 year: 2009 ident: 10.1016/j.cyto.2019.154740_b0305 article-title: Elevated immune response in the brain of autistic patients publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2008.12.002 – volume: 26 start-page: 87 issue: 1 year: 1996 ident: 10.1016/j.cyto.2019.154740_b0270 article-title: Lymphocyte subsets and interleukin-2 receptors in autistic children publication-title: J. Autism Dev. Disord. doi: 10.1007/BF02276236 – volume: 12 issue: 4 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0100 article-title: Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium publication-title: PLoS One doi: 10.1371/journal.pone.0175437 – year: 2018 ident: 10.1016/j.cyto.2019.154740_b0330 article-title: Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2018.03.025 – volume: 70 start-page: 663 issue: 7 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0025 article-title: Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.04.013 – volume: 11 issue: 11 year: 2016 ident: 10.1016/j.cyto.2019.154740_b0235 article-title: Identification of Biomarkers of Impaired Sensory Profiles among Autistic Patients publication-title: PLoS One doi: 10.1371/journal.pone.0164153 – volume: 25 start-page: 603 issue: 9 year: 2010 ident: 10.1016/j.cyto.2019.154740_b0120 article-title: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses publication-title: Eur. J. Epidemiol. doi: 10.1007/s10654-010-9491-z – volume: 24 start-page: 664 issue: 6 year: 2004 ident: 10.1016/j.cyto.2019.154740_b0275 article-title: Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10 publication-title: J. Clin. Immunol. doi: 10.1007/s10875-004-6241-6 – volume: 20 start-page: 440 issue: 4 year: 2015 ident: 10.1016/j.cyto.2019.154740_b0060 article-title: Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis publication-title: Mol. Psychiatry doi: 10.1038/mp.2014.59 – volume: 6 issue: 7 year: 2009 ident: 10.1016/j.cyto.2019.154740_b0110 article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement publication-title: PLoS Med. doi: 10.1371/journal.pmed.1000097 – volume: 56 start-page: 455 issue: 2 year: 2000 ident: 10.1016/j.cyto.2019.154740_b0135 article-title: Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis publication-title: Biometrics doi: 10.1111/j.0006-341X.2000.00455.x – volume: 79 start-page: 340 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0065 article-title: Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: Higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2017.07.011 – volume: 39 start-page: 195 issue: 3 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0225 article-title: Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders publication-title: Revista Brasileira de Psiquiatria doi: 10.1590/1516-4446-2015-1843 – volume: 47 start-page: 242 issue: 4 year: 2012 ident: 10.1016/j.cyto.2019.154740_b0045 article-title: Sleep in children with autism spectrum disorder publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2012.05.007 – volume: 51 start-page: 77 issue: 2 year: 2005 ident: 10.1016/j.cyto.2019.154740_b0285 article-title: Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention publication-title: Neuropsychobiology doi: 10.1159/000084164 – volume: 45 start-page: 1 issue: 1 year: 2002 ident: 10.1016/j.cyto.2019.154740_b0250 article-title: Activation of the inflammatory response system in autism publication-title: Neuropsychobiology doi: 10.1159/000048665 – volume: 21 start-page: 555 issue: 6 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0160 article-title: Risperidone-related improvement of irritability in children with autism is not associated with changes in serum of epidermal growth factor and interleukin-13 publication-title: J. Child Adolesc. Psychopharmacol. doi: 10.1089/cap.2010.0134 – volume: 29 start-page: 16 issue: 1 year: 2018 ident: 10.1016/j.cyto.2019.154740_b0105 article-title: Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis publication-title: Eur. Cytokine Netw. doi: 10.1684/ecn.2018.0404 – volume: 157 start-page: 683 issue: 5 year: 2000 ident: 10.1016/j.cyto.2019.154740_b0005 article-title: Cytokines and the brain: implications for clinical psychiatry publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.157.5.683 – volume: 172 start-page: 198 issue: 1–2 year: 2006 ident: 10.1016/j.cyto.2019.154740_b0325 article-title: Elevated cytokine levels in children with autism spectrum disorder publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2005.11.007 – volume: 24 start-page: 586 issue: 10 year: 2014 ident: 10.1016/j.cyto.2019.154740_b0340 article-title: Change in plasma cytokine levels during risperidone treatment in children with autism publication-title: J. Child Adolesc. Psychopharmacol. doi: 10.1089/cap.2013.0108 – volume: 24 start-page: 491 issue: 4 year: 2013 ident: 10.1016/j.cyto.2019.154740_b0180 article-title: Altered cytokine and BDNF levels in autism spectrum disorder publication-title: Neurotox. Res. doi: 10.1007/s12640-013-9393-4 – volume: 61 issue: 1 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0255 article-title: Cytokine profile in autism spectrum disorders in children publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-016-0847-z – volume: 15 start-page: 535 issue: 5 year: 2010 ident: 10.1016/j.cyto.2019.154740_b0015 article-title: Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior publication-title: Mol. Psychiatry doi: 10.1038/mp.2008.58 – volume: 8 start-page: 1121 issue: 9 year: 2014 ident: 10.1016/j.cyto.2019.154740_b0050 article-title: Aggressive behavior problems in children with autism spectrum disorders: prevalence and correlates in a large clinical sample publication-title: Res. Autism Spectrum Disord. doi: 10.1016/j.rasd.2014.05.006 – start-page: 1088 year: 1994 ident: 10.1016/j.cyto.2019.154740_b0130 article-title: Operating characteristics of a rank correlation test for publication bias publication-title: Biometrics doi: 10.2307/2533446 – volume: 25 start-page: 863 issue: 5 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0315 article-title: Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2010.09.011 – volume: 471 start-page: 162 issue: 3 year: 2010 ident: 10.1016/j.cyto.2019.154740_b0230 article-title: Low-grade endotoxemia in patients with severe autism publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2010.01.033 – volume: 13 start-page: 208 issue: 2 year: 2008 ident: 10.1016/j.cyto.2019.154740_b0310 article-title: Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4002042 – volume: 28 start-page: 783 issue: 7 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0085 article-title: Status of essential elements in autism spectrum disorder: systematic review and meta-analysis publication-title: Rev. Neurosci. doi: 10.1515/revneuro-2017-0015 – volume: 73 start-page: 760 issue: 11 year: 2015 ident: 10.1016/j.cyto.2019.154740_b0070 article-title: Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis publication-title: Nutr. Rev. doi: 10.1093/nutrit/nuv026 – volume: 9 start-page: 265 year: 2012 ident: 10.1016/j.cyto.2019.154740_b0240 article-title: Neuroinflammation in autism spectrum disorders publication-title: J. Neuroinflammat. doi: 10.1186/1742-2094-9-265 – volume: 17 start-page: 389 issue: 7 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0320 article-title: Maternal infection and immune involvement in autism publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2011.03.001 – year: 2011 ident: 10.1016/j.cyto.2019.154740_b0125 article-title: Handbook for systematic reviews of interventions version 5.1. 0 [updated March 2011] publication-title: Cochrane Collaborat. – volume: 2 issue: 1 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0335 article-title: Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: a case-control study publication-title: Mol. Autism doi: 10.1186/2040-2392-2-13 – volume: 33 start-page: 195 issue: 3 year: 2005 ident: 10.1016/j.cyto.2019.154740_b0145 article-title: Cerebrospinal fluid and serum markers of inflammation in autism publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2005.03.014 – volume: 8 issue: JAN year: 2017 ident: 10.1016/j.cyto.2019.154740_b0220 article-title: Distinct cytokine and chemokine profiles in autism spectrum disorders publication-title: Front. Immunol – volume: 4 start-page: 12 issue: 1 year: 2013 ident: 10.1016/j.cyto.2019.154740_b0035 article-title: DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes publication-title: Mol. Autism doi: 10.1186/2040-2392-4-12 – start-page: 1 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0090 article-title: Short-term and long-term efficacy of classical ketogenic diet and modified Atkins diet in children and adolescents with epilepsy: a systematic review and meta-analysis publication-title: Nutritional Neurosci. – volume: 10 start-page: 38 year: 2013 ident: 10.1016/j.cyto.2019.154740_b0200 article-title: Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder publication-title: J. Neuroinflammat. doi: 10.1186/1742-2094-10-38 – volume: 14 start-page: 528 issue: 7 year: 2013 ident: 10.1016/j.cyto.2019.154740_b0300 article-title: Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders publication-title: World J. Biol. Psychiatry doi: 10.3109/15622975.2011.639803 – volume: 45 start-page: 241 issue: 6 year: 2012 ident: 10.1016/j.cyto.2019.154740_b0155 article-title: Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism publication-title: Pharmacopsychiatry doi: 10.1055/s-0032-1301914 – volume: 6 issue: 5 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0165 article-title: Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders publication-title: PLoS One doi: 10.1371/journal.pone.0020470 – volume: 61 start-page: 448 issue: 3 year: 1991 ident: 10.1016/j.cyto.2019.154740_b0170 article-title: Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children publication-title: Clin. Immunol. Immunopathol. doi: 10.1016/S0090-1229(05)80015-7 – volume: 47 start-page: 1018 issue: 4 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0095 article-title: Brain-derived neurotrophic factor levels in autism: a systematic review and meta-analysis publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-016-3024-x – volume: 56 start-page: 455 issue: 2 year: 2000 ident: 10.1016/j.cyto.2019.154740_b0140 article-title: Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis publication-title: Biometrics doi: 10.1111/j.0006-341X.2000.00455.x – volume: 30 start-page: 121 issue: 2 year: 2012 ident: 10.1016/j.cyto.2019.154740_b0205 article-title: Plasma cytokine levels in children with autistic disorder and unrelated siblings publication-title: Int. J. Develop. Neurosci.: Off. J. Int. Soc. Develop. Neurosci. doi: 10.1016/j.ijdevneu.2011.12.003 – volume: 13 issue: 1 year: 2018 ident: 10.1016/j.cyto.2019.154740_b0080 article-title: Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: A systematic review and meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0190252 – volume: 67 start-page: 446 issue: 5 year: 2010 ident: 10.1016/j.cyto.2019.154740_b0020 article-title: A meta-analysis of cytokines in major depression publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2009.09.033 – ident: 10.1016/j.cyto.2019.154740_b0115 – volume: 1 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0290 article-title: Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression publication-title: Transl. Psychiatry doi: 10.1038/tp.2011.48 – volume: 8 start-page: 82390 issue: 47 year: 2017 ident: 10.1016/j.cyto.2019.154740_b0150 article-title: Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children publication-title: Oncotarget doi: 10.18632/oncotarget.19326 – volume: 25 start-page: 40 issue: 1 year: 2011 ident: 10.1016/j.cyto.2019.154740_b0260 article-title: Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2010.08.003 – volume: 7 start-page: 199 issue: 1 year: 2013 ident: 10.1016/j.cyto.2019.154740_b0215 article-title: Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children publication-title: Res. Autism Spectrum Disord. doi: 10.1016/j.rasd.2012.08.007 – volume: 66 start-page: 143 issue: 1–2 year: 1996 ident: 10.1016/j.cyto.2019.154740_b0175 article-title: Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism publication-title: J. Neuroimmunol. doi: 10.1016/0165-5728(96)00014-8 – volume: 25 start-page: 281 issue: 2 year: 2014 ident: 10.1016/j.cyto.2019.154740_b0075 article-title: Proinflammatory and anti-inflammatory cytokines in febrile seizures and epilepsy: systematic review and meta-analysis publication-title: Rev. Neurosci. doi: 10.1515/revneuro-2013-0045 – volume: 204 start-page: 149 issue: 1–2 year: 2008 ident: 10.1016/j.cyto.2019.154740_b0265 article-title: Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2008.07.006 – volume: 6 issue: 4 year: 2016 ident: 10.1016/j.cyto.2019.154740_b0210 article-title: Peripheral inflammatory markers contributing to comorbidities in autism publication-title: Behavioral Sci. – volume: 37 start-page: 673 issue: 6 year: 1996 ident: 10.1016/j.cyto.2019.154740_b0040 article-title: Working memory in children with autism and with moderate learning difficulties publication-title: J. Child Psychol. Psychiatry doi: 10.1111/j.1469-7610.1996.tb01459.x – volume: 252 start-page: 75 issue: 1–2 year: 2012 ident: 10.1016/j.cyto.2019.154740_b0295 article-title: Neonatal levels of cytokines and risk of autism spectrum disorders: an exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2012.07.013 – volume: 36 start-page: 849 issue: 7 year: 2006 ident: 10.1016/j.cyto.2019.154740_b0055 article-title: Comorbid psychiatric disorders in children with autism: interview development and rates of disorders publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-006-0123-0 – volume: 74 start-page: 15 issue: 1 year: 2013 ident: 10.1016/j.cyto.2019.154740_b0030 article-title: Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2013.01.007 – volume: 31 start-page: 187 issue: 1 year: 2007 ident: 10.1016/j.cyto.2019.154740_b0195 article-title: Decreased serum levels of transforming growth factor-β1 in patients with autism publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2006.08.020 |
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