Generation and Application of Directly Reprogrammed Endothelial Cells
Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate e...
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| Published in | Korean circulation journal Vol. 52; no. 9; pp. 643 - 658 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Society of Cardiology
01.09.2022
대한심장학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-5520 1738-5555 1738-5555 |
| DOI | 10.4070/kcj.2022.0190 |
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| Abstract | Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate endothelial cells (ECs), which can promote neovascularization and vascular regeneration. This review provides recent updates on the direct endothelial reprogramming. In general, directly reprogrammed ECs can be generated by two approaches: one by transitioning through a plastic intermediate state and the other in a one-step transition without any intermediate states toward pluripotency. Moreover, the methods to deliver reprogramming factors and chemicals for the fate conversion are highlighted. Next, the therapeutic effects of the directly reprogrammed ECs on animal models are reviewed in detail. Other applications using directly reprogrammed ECs, such as tissue engineering and disease modeling, are also discussed. Lastly, the remaining questions and foremost challenges are addressed. |
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| AbstractList | Direct cell reprogramming refers to the conversion of cell identity, without transition through an induced pluripotent state. Owing to the ability to directly reprogram into numerous cell types, this reprogramming strategy has received enormous attention for regenerative therapy. Particularly, direct reprogramming into functional endothelial cells, which are crucial for neovascularization and vascular regeneration, holds promising therapeutic potential for treating patients with ischemic cardiovascular diseases. This review provides a summary of the-state-of-art in direct endothelial reprograming strategies and highlights their potential applications. It also discusses key questions and challenges that will help guiding future research and development of this emerging area. Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate endothelial cells (ECs), which can promote neovascularization and vascular regeneration. This review provides recent updates on the direct endothelial reprogramming. In general, directly reprogrammed ECs can be generated by two approaches: one by transitioning through a plastic intermediate state and the other in a one-step transition without any intermediate states toward pluripotency. Moreover, the methods to deliver reprogramming factors and chemicals for the fate conversion are highlighted. Next, the therapeutic effects of the directly reprogrammed ECs on animal models are reviewed in detail. Other applications using directly reprogrammed ECs, such as tissue engineering and disease modeling, are also discussed. Lastly, the remaining questions and foremost challenges are addressed. Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate endothelial cells (ECs), which can promote neovascularization and vascular regeneration. This review provides recent updates on the direct endothelial reprogramming. In general, directly reprogrammed ECs can be generated by two approaches: one by transitioning through a plastic intermediate state and the other in a one-step transition without any intermediate states toward pluripotency. Moreover, the methods to deliver reprogramming factors and chemicals for the fate conversion are highlighted. Next, the therapeutic effects of the directly reprogrammed ECs on animal models are reviewed in detail. Other applications using directly reprogrammed ECs, such as tissue engineering and disease modeling, are also discussed. Lastly, the remaining questions and foremost challenges are addressed. Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate endothelial cells (ECs), which can promote neovascularization and vascular regeneration. This review provides recent updates on the direct endothelial reprogramming. In general, directly reprogrammed ECs can be generated by two approaches: one by transitioning through a plastic intermediate state and the other in a one-step transition without any intermediate states toward pluripotency. Moreover, the methods to deliver reprogramming factors and chemicals for the fate conversion are highlighted. Next, the therapeutic effects of the directly reprogrammed ECs on animal models are reviewed in detail. Other applications using directly reprogrammed ECs, such as tissue engineering and disease modeling, are also discussed. Lastly, the remaining questions and foremost challenges are addressed. KCI Citation Count: 0 Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate endothelial cells (ECs), which can promote neovascularization and vascular regeneration. This review provides recent updates on the direct endothelial reprogramming. In general, directly reprogrammed ECs can be generated by two approaches: one by transitioning through a plastic intermediate state and the other in a one-step transition without any intermediate states toward pluripotency. Moreover, the methods to deliver reprogramming factors and chemicals for the fate conversion are highlighted. Next, the therapeutic effects of the directly reprogrammed ECs on animal models are reviewed in detail. Other applications using directly reprogrammed ECs, such as tissue engineering and disease modeling, are also discussed. Lastly, the remaining questions and foremost challenges are addressed.Cell-based therapy has emerged as a promising option for treating advanced ischemic cardiovascular disease by inducing vascular regeneration. However, clinical trials with adult cells turned out disappointing in general. As a newer approach, direct reprogramming has emerged to efficiently generate endothelial cells (ECs), which can promote neovascularization and vascular regeneration. This review provides recent updates on the direct endothelial reprogramming. In general, directly reprogrammed ECs can be generated by two approaches: one by transitioning through a plastic intermediate state and the other in a one-step transition without any intermediate states toward pluripotency. Moreover, the methods to deliver reprogramming factors and chemicals for the fate conversion are highlighted. Next, the therapeutic effects of the directly reprogrammed ECs on animal models are reviewed in detail. Other applications using directly reprogrammed ECs, such as tissue engineering and disease modeling, are also discussed. Lastly, the remaining questions and foremost challenges are addressed. |
| Author | Yoon, Young-sup Lee, Sangho Jung, Cholomi Oh, Jee Eun |
| AuthorAffiliation | 3 Research and Development Center, KarisBio Inc., Seoul, Korea 4 Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA 1 Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea 2 Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul , Korea |
| AuthorAffiliation_xml | – name: 4 Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA – name: 1 Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea – name: 2 Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul , Korea – name: 3 Research and Development Center, KarisBio Inc., Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Cholomi orcidid: 0000-0001-9067-3724 surname: Jung fullname: Jung, Cholomi organization: Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea., Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea – sequence: 2 givenname: Jee Eun orcidid: 0000-0002-3469-8545 surname: Oh fullname: Oh, Jee Eun organization: Research and Development Center, KarisBio Inc., Seoul, Korea – sequence: 3 givenname: Sangho orcidid: 0000-0003-3771-7761 surname: Lee fullname: Lee, Sangho organization: Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA – sequence: 4 givenname: Young-sup orcidid: 0000-0003-0051-0935 surname: Yoon fullname: Yoon, Young-sup organization: Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea., Research and Development Center, KarisBio Inc., Seoul, Korea., Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA |
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| Copyright | Copyright © 2022. The Korean Society of Cardiology. Copyright © 2022. The Korean Society of Cardiology 2022 The Korean Society of Cardiology |
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| Keywords | Cell differentiation and regenerative medicine Cardiovascular disease Neovascularization Direct cell reprogramming Endothelial cells |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Cholomi Jung and Jee Eun Oh contributed equally to this work. https://doi.org/10.4070/kcj.2022.0190 |
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| Title | Generation and Application of Directly Reprogrammed Endothelial Cells |
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