RODENT SPECIES AND STRAIN DIFFERENCE IN KIDNEY AND LUNG PATHOLOGY INDUCED BY N-ETHYL-N-HYDROXYETHYLNITROSAMINE
Lung and kidney tumor induction was evaluated in hamsters and in 2 strains each of rats and mice given N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks in either the drinking water or mixed in the diet. Both male and female Wistar rats developed renal cell tumors, while hyperplastic tubules were...
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| Published in | Journal of Toxicologic Pathology Vol. 7; no. 1; pp. 67 - 71 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
01.01.1994
The Japanese Society of Toxicologic Pathology Japan Science and Technology Agency |
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| Online Access | Get full text |
| ISSN | 0914-9198 1881-915X 1881-915X 1347-7404 |
| DOI | 10.1293/tox.7.67 |
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| Abstract | Lung and kidney tumor induction was evaluated in hamsters and in 2 strains each of rats and mice given N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks in either the drinking water or mixed in the diet. Both male and female Wistar rats developed renal cell tumors, while hyperplastic tubules were the characteristic lesions observed in the kidneys of male F344 rats, male BALB/c, and A/J mice, and male Syrian golden hamsters. In contrast, lung adenomas and carcinomas were induced in both strains of mice but not in rats or hamsters. It thus appears that there are differences in susceptibilities between strains as well as between species in EHEN carcinogenicity. |
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| AbstractList | Lung and kidney tumor induction was evaluated in hamsters and in 2 strains each of rats and mice given N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks in either the drinking water or mixed in the diet. Both male and female Wistar rats developed renal cell tumors, while hyperplastic tubules were the characteristic lesions observed in the kidneys of male F344 rats, male BALB/c, and A/J mice, and male Syrian golden hamsters. In contrast, lung adenomas and carcinomas were induced in both strains of mice but not in rats or hamsters. It thus appears that there are differences in susceptibilities between strains as well as between species in EHEN carcinogenicity. |
| Author | Matsuda, Hirofumi Kitamura, Motokazu Ohshima, Masato Konishi, Noboru Hiasa, Yoshio Hayashi, Isao Kitahori, Yoshiteru Nakaoka, Shingo Tsuzuki, Toshihide |
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| References | 3. Degawa, M, Kobayashi, K, Miura, S, Arai, H, Esumi, H, Sugimura, T, and Hashimoto, Y: Species difference among experimental rodents in induction of P450IA family enzymes by 2-amino-l-methyl-6-phenylimidazo [4, 5-6] pyridine. Jpn J Cancer Res 83: 1047-1051, 1992. 8. Ward, JM and Reznik, G: Refinements of rodents pathology and pathologist's contribution to evalution of carcinogenesis bioassays. Prog Exp Tumor Res 26: 266-291, 1983. 2. Huff, J, Cirvello, J, Haseman, J, and Bucher, J: Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents. Environ Health Perspect 93: 247-270, 1991. 9. Ward, JM: Pathology of Toxic, preneoplastic, and neoplastic lesions. In Carcinogenesis and mutagenesis testing, Ed. JF Douglas, Humana Press, Clifton, NI, pp. 97-130, 1984. 15. Witschi, H, Malkinsos, AM, Peraino, C, Russell, JJ, and Staffeldt, EF: Effects of glycerol on lung and liver tumor development. Fund Appl Toxicol 13: 174-180, 1989. 12. Li, JJ and Li, SA: Estrogen-induced tumorigenesis in hamsters: roles for hormonal and carcinogenic activities. Arch Toxicol 55: 110-118, 1984. 1. Diwan, BA and Rice, JM: Organ and species specificity in chemical carcinogenesis and tumor promotion. In: The pathology of neoplasia Ed. A Sirica, Plenum Publishing Co, pp. 149-171, 1989. 14. Shimkin, MB and Stoner, GD. Lung tumors in mice: application to carcinogenesis bioassay. Adv Cancer Res 21: 1-58, 1975. 5. Hiasa, Y and Ito, N: Experimental induction of renal tumors. CRC Crt Rev Toxicol 17: 279-343, 1987. 10. Pitot, HC: Progression: the terminal stage in carcinogenesis. Jpn J Cancer Res 80: 599-607, 1989. 6. Hiasa, Y, Konishi, N, Nakaoka, S, Nakamura, T, Nishii, K, and Ohshima, M: Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res 83: 688-694, 1992. 11. Konishi, N, Kitahori, Y, Shimoyama, T, Lin, JC, and Hiasa, Y: Monoclonal antibody against rat renal cell tumor-associated antigen as a new tool for the analysis of renal tumorigenesis. Jpn J Cancer Res 80: 771-777, 1989. 13. Degawa, M, Tanimura, S, Agatsuma, T, and Hashimoto, Y: Hepatocarcinogenic heterocyclic aromatic amines that induce cytochrome P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in rat liver. Carcinogenesis 10: 1119-1122, 1989. 7. Konishi, N, Nishii, K, Hayashi, I, Nakaoka, S, Matsumoto, K, Yabuno, T, Kitahori, Y, and Hiasa, Y: Inhibitory effect of potassium citrate in rat renal tumors induced by N-ethyl-N-hydroxyethyl-nitrosamine followed by potassium dibasic phosphate. Jpn J Cancer Res 84: 128-134, 1993. 4. Hiasa, Y, Ohshima, M, Iwata, C, and Tanikake, T: Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethyl-nitrosamine. Gann 70: 817-820, 1979. |
| References_xml | – reference: 6. Hiasa, Y, Konishi, N, Nakaoka, S, Nakamura, T, Nishii, K, and Ohshima, M: Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res 83: 688-694, 1992. – reference: 12. Li, JJ and Li, SA: Estrogen-induced tumorigenesis in hamsters: roles for hormonal and carcinogenic activities. Arch Toxicol 55: 110-118, 1984. – reference: 7. Konishi, N, Nishii, K, Hayashi, I, Nakaoka, S, Matsumoto, K, Yabuno, T, Kitahori, Y, and Hiasa, Y: Inhibitory effect of potassium citrate in rat renal tumors induced by N-ethyl-N-hydroxyethyl-nitrosamine followed by potassium dibasic phosphate. Jpn J Cancer Res 84: 128-134, 1993. – reference: 2. Huff, J, Cirvello, J, Haseman, J, and Bucher, J: Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents. Environ Health Perspect 93: 247-270, 1991. – reference: 5. Hiasa, Y and Ito, N: Experimental induction of renal tumors. CRC Crt Rev Toxicol 17: 279-343, 1987. – reference: 14. Shimkin, MB and Stoner, GD. Lung tumors in mice: application to carcinogenesis bioassay. Adv Cancer Res 21: 1-58, 1975. – reference: 13. Degawa, M, Tanimura, S, Agatsuma, T, and Hashimoto, Y: Hepatocarcinogenic heterocyclic aromatic amines that induce cytochrome P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in rat liver. Carcinogenesis 10: 1119-1122, 1989. – reference: 11. Konishi, N, Kitahori, Y, Shimoyama, T, Lin, JC, and Hiasa, Y: Monoclonal antibody against rat renal cell tumor-associated antigen as a new tool for the analysis of renal tumorigenesis. Jpn J Cancer Res 80: 771-777, 1989. – reference: 3. Degawa, M, Kobayashi, K, Miura, S, Arai, H, Esumi, H, Sugimura, T, and Hashimoto, Y: Species difference among experimental rodents in induction of P450IA family enzymes by 2-amino-l-methyl-6-phenylimidazo [4, 5-6] pyridine. Jpn J Cancer Res 83: 1047-1051, 1992. – reference: 8. Ward, JM and Reznik, G: Refinements of rodents pathology and pathologist's contribution to evalution of carcinogenesis bioassays. Prog Exp Tumor Res 26: 266-291, 1983. – reference: 1. Diwan, BA and Rice, JM: Organ and species specificity in chemical carcinogenesis and tumor promotion. In: The pathology of neoplasia Ed. A Sirica, Plenum Publishing Co, pp. 149-171, 1989. – reference: 9. Ward, JM: Pathology of Toxic, preneoplastic, and neoplastic lesions. In Carcinogenesis and mutagenesis testing, Ed. JF Douglas, Humana Press, Clifton, NI, pp. 97-130, 1984. – reference: 10. Pitot, HC: Progression: the terminal stage in carcinogenesis. Jpn J Cancer Res 80: 599-607, 1989. – reference: 15. Witschi, H, Malkinsos, AM, Peraino, C, Russell, JJ, and Staffeldt, EF: Effects of glycerol on lung and liver tumor development. Fund Appl Toxicol 13: 174-180, 1989. – reference: 4. Hiasa, Y, Ohshima, M, Iwata, C, and Tanikake, T: Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethyl-nitrosamine. Gann 70: 817-820, 1979. |
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| SubjectTerms | Carcinogenicity Drinking water Kidneys Lung tumors Mice N-ethyl-N-hydroxyethylnitrosamine Renal tumors Species differences |
| Title | RODENT SPECIES AND STRAIN DIFFERENCE IN KIDNEY AND LUNG PATHOLOGY INDUCED BY N-ETHYL-N-HYDROXYETHYLNITROSAMINE |
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