New Antihypertensive Agents. II. Studies on New Analogs of 4-Piperidylbenzimidazolinones

As a part of our search for new antihypertensive agents, several 4-piperidylbenzimidazolinone derivatives (I-III) were synthesized. These compounds showed only moderate antihypertensive activity in three hypertensive rat models.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 30; no. 2; pp. 474 - 483
Main Authors TAKAI, HARUKI, SHUTO, KATSUICHI, TERANISHI, MASAYUKI, KUBO, KAZUHIRO, KASUYA, YUTAKA, OBASE, HIROYUKI, NAKAMIZO, NOBUHIRO, SHIGENOBU, KOKI
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 1982
Japan Science and Technology Agency
Subjects
Animals
Antihypertensive Agents - chemical synthesis
Benzimidazoles - chemical synthesis
Benzimidazoles - pharmacology
Male
Rats
structure-activity relationship
Online AccessGet full text
ISSN0009-2363
1347-5223
1347-5223
DOI10.1248/cpb.30.474

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Summary:As a part of our search for new antihypertensive agents, several 4-piperidylbenzimidazolinone derivatives (I-III) were synthesized. These compounds showed only moderate antihypertensive activity in three hypertensive rat models.
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ISSN:0009-2363
1347-5223
1347-5223
DOI:10.1248/cpb.30.474