Chromosome 1p loss: A favorable prognostic factor in low-grade gliomas

• Published in: Annals of neurology Vol. 58; no. 2; pp. 322 - 326
• Main Authors: Kujas, Michèle, Lejeune, Julie, Benouaich-Amiel, Alexandra, Crinière, Emmanuelle, Laigle-Donadey, Florence, Marie, Yannick, Mokhtari, Karima, Polivka, Marc, Bernier, Michèle, Chretien, Fabrice, Couvelard, Anne, Capelle, Laurent, Duffau, Hugues, Cornu, Philippe, Broët, Philippe, Thillet, Joëlle, Carpentier, Antoine F., Sanson, Marc, Hoang-Xuan, Khê, Delattre, Jean-Yves
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2005; Willey-Liss
• Subjects: Adolescent; Adult; Aged; Antineoplastic agents; Biological and medical sciences; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Chemotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Female; Glioma - genetics; Glioma - pathology; Humans; Immunohistochemistry - methods; Loss of Heterozygosity; Male; Medical sciences; Middle Aged; Molecular Biology - methods; Neurology; Pharmacology. Drug treatments; Tumors of the nervous system. Phacomatoses; Tumor; Chromosome; Nervous system diseases; Prognosis; Glioma; Central nervous system disease
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.20543

Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor (EGFR) gene amplification, and p53 expression was performed in a series of 131 low‐grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression‐free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression‐free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low‐grade gliomas. Ann Neurol 2005;58:322–326