Histological characterization of liver involvement in systemic mastocytosis

• Published in: Liver international Vol. 44; no. 7; pp. 1680 - 1688
• Main Authors: Rossignol, Julien, Canioni, Danielle, Aouba, Achille, Bulai‐Livideanu, Cristina, Barete, Stéphane, Lancesseur, Charles, Polivka, Laura, Madrange, Marine, Ballul, Thomas, Neuraz, Antoine, Greco, Celine, Agopian, Julie, Brenet, Fabienne, Dubreuil, Patrice, Lemal, Richard, Tournilhac, Olivier, Terriou, Louis, Launay, David, Bouillet, Laurence, Gourguechon, Clément, Frenzel, Laurent, Meni, Cécile, Gaudy‐Marqueste, Caroline, Gousseff, Marie, Le Mouel, Edwige, Hamidou, Mohamed, Neel, Antoine, Ranta, Dana, Jaussaud, Roland, Guilpain, Philippe, Molina, Thierry J, Bruneau, Julie, Lhermitte, Ludovic, Garcelon, Nicolas, Javier, Rose‐Marie, Pelletier, Fabien, Castelain, Florence, Retornaz, Frederique, Cabrera, Quentin, Zunic, Patricia, Gourin, Marie Pierre, Wierzbicka‐Hainaut, Ewa, Viallard, Jean François, Lavigne, Christian, Hoarau, Cyrille, Durieu, Isabelle, Heiblig, Maël, Dimicoli‐Salazar, Sophie, Torregrosa‐Diaz, Jose M, Soria, Angèle, Arock, Michel, Lortholary, Olivier, Bodemer, Christine, Pol, Stanislas, Mallet, Vincent, Hermine, Olivier, Damaj, Ghandi
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2024; Wiley-Blackwell
• Series: Liver International
• Subjects: advanced systemic mastocytosis; Alkaline phosphatase; Biopsy; Cirrhosis; Diagnosis; Fibrosis; Histology; Hyperplasia; Hypertension; Life Sciences; Liver; Mast cells; Mastocytosis; Medical prognosis; nodular regenerative hyperplasia; Patients; portal hypertension; Subgroups; nodular regenerative hyperplasia; fibrosis; portal hypertension; mast cells; liver; advanced systemic mastocytosis
• ISSN: 1478-3223; 1478-3231; 1478-3231
• DOI: 10.1111/liv.15913

Background and Aims Systemic mastocytosis (SM) is characterized by the accumulation of atypical mast cells (MCs) in organs. Liver histology of SM has been marginally described and accurate histological classification is critical, given the consequences of aggressive SM diagnosis. We aimed to describe the histological features associated with liver SM using updated tools. Methods Using the database of the French Reference Centre for Mastocytosis, we retrospectively identified patients with a liver biopsy (LB) and a diagnosis of SM. All LB procedures were performed according to the local physician in charge and centrally reviewed by an expert pathologist. Results A total of 28 patients were included: 6 had indolent SM, 9 had aggressive SM, and 13 had SM with an associated hematologic neoplasm. Twenty‐five (89%) patients presented hepatomegaly, and 19 (68%) had portal hypertension. The LB frequently showed slight sinusoid dilatation (82%). Fibrosis was observed in 3/6 indolent SM and in almost all advanced SM cases (21/22), but none of them showed cirrhosis. A high MC burden (>50 MCs/high‐power field) was correlated with elevated blood alkaline phosphatase levels (p = .030). The presence of portal hypertension was associated with a higher mean fibrosis grade (1.6 vs. 0.8 in its absence; p = .026). In advanced SM, the presence of nodular regenerative hyperplasia (NRH) was associated with decreased overall survival (9.5 vs. 46.3 months, p = .002). Conclusions MC infiltration induced polymorphic hepatic lesions and the degree of fibrosis is associated with portal hypertension. NRH identifies a poor prognosis subgroup of patients with advanced SM. Assessing liver histology can aid in SM prognostic evaluation.