Using Next-Generation Sequencing Technology to Explore Genetic Pathways in Endophytic Fungi in the Syntheses of Plant Bioactive Metabolites
Recent investigations carried out all over the world have disclosed the capacity of a multitude of endophytic fungal species/strains to produce bioactive compounds which are the same or structurally related to those synthesized by their host plants. This intriguing phenomenon has implemented huge re...
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| Published in | Agriculture (Basel) Vol. 12; no. 2; p. 187 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
MDPI AG
01.02.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2077-0472 2077-0472 |
| DOI | 10.3390/agriculture12020187 |
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| Abstract | Recent investigations carried out all over the world have disclosed the capacity of a multitude of endophytic fungal species/strains to produce bioactive compounds which are the same or structurally related to those synthesized by their host plants. This intriguing phenomenon has implemented huge research activity aimed at ascertaining the nature of the biological processes underlying this convergence, as well as to characterize the genetic bases of the biosynthetic schemes. Insights on these basic issues may support the biotechnological exploitation of wild strains, and their eventual improvement through genome editing. Aspects concerning the use of next generation sequencing technologies for the comparative elucidation of the biosynthetic pathways operating in endophytic fungi and their host plants are reviewed in this paper in view of applicative perspectives. Our literature search yielded 21 references dealing with at least 26 strains which have been the subject of experimental activities involving massively parallel genome and transcriptome sequencing methods in the last eight years. |
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| AbstractList | Recent investigations carried out all over the world have disclosed the capacity of a multitude of endophytic fungal species/strains to produce bioactive compounds which are the same or structurally related to those synthesized by their host plants. This intriguing phenomenon has implemented huge research activity aimed at ascertaining the nature of the biological processes underlying this convergence, as well as to characterize the genetic bases of the biosynthetic schemes. Insights on these basic issues may support the biotechnological exploitation of wild strains, and their eventual improvement through genome editing. Aspects concerning the use of next generation sequencing technologies for the comparative elucidation of the biosynthetic pathways operating in endophytic fungi and their host plants are reviewed in this paper in view of applicative perspectives. Our literature search yielded 21 references dealing with at least 26 strains which have been the subject of experimental activities involving massively parallel genome and transcriptome sequencing methods in the last eight years. |
| Author | Nicoletti, Rosario Bielecka, Monika Pencakowski, Bartosz |
| Author_xml | – sequence: 1 givenname: Monika orcidid: 0000-0002-0067-6073 surname: Bielecka fullname: Bielecka, Monika – sequence: 2 givenname: Bartosz surname: Pencakowski fullname: Pencakowski, Bartosz – sequence: 3 givenname: Rosario orcidid: 0000-0002-3049-4641 surname: Nicoletti fullname: Nicoletti, Rosario |
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| SubjectTerms | agriculture Bacteria Bioactive compounds bioactive secondary metabolites Bioinformatics Biological activity biosynthesis Endophytes endophytic fungi Enzymes Exploitation functional/structural genes Fungi Gene expression Gene sequencing Genetic engineering genome Genome editing Genomes Genomics Host plants Hypotheses Metabolites Methods Next-generation sequencing Plasmids transcriptome Transcriptomes |
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