Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function - Notarangelo, Giulia; Spinelli, Jessica B.; Perez, Elizabeth M.; Baker, Gregory J.; Kurmi, Kiran; Elia, Ilaria; Stopka, Sylwia A.; Baquer, Gerard; Lin, Jia-Ren; Golby, Alexandra J.; Joshi, Shakchhi; Baron, Heide F.; et al. (Science (American Association for the Advancement of Science), 2022)
Keywords: Animals; Cancer; Carcinogenesis - genetics; Carcinogenesis - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell proliferation; Cytokines; Dehydrogenase; Gain of Function Mutation; Glucose metabolism; Glutarates - metabolism; Humans; Immunosuppressive agents; Interferon-gamma - metabolism; Isocitrate dehydrogenase; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - metabolism; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - antagonists & inhibitors; L-Lactate Dehydrogenase - metabolism; Lactate dehydrogenase; Lactic acid; Lymphocytes; Lymphocytes T; Metabolites; Mice; Mutation; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - metabolism