Exploring Plant Tissue Culture and Steviol Glycosides Production in Stevia rebaudiana (Bert.) Bertoni: A Review

Stevia rebaudiana (Bert.) Bertoni, commonly called “sweet leaf” is a medicinally and industrially important plant known to be rich in zero-calorie natural sweetening compound(s) known as “steviol glycosides”. However, due to its poor seed germination and slow vegetative propagation, it has become ra...

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Published inAgriculture (Basel) Vol. 13; no. 2; p. 475
Main Authors Sharma, Shilpa, Gupta, Swati, Kumari, Deepa, Kothari, Shanker Lal, Jain, Rohit, Kachhwaha, Sumita
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.02.2023
Subjects
Acids
agriculture
Antimicrobial agents
bibliometric analysis
Bibliometrics
biochemical pathways
Biotechnology
Blood pressure
callus formation
Cancer
Cell culture
Chemistry
Cytotoxicity
Diabetes
Food
Gene expression
Genetic transformation
Germination
Glucose
Glycosides
Hairy root
Human subjects
Hypertension
in vitro propagation
Insulin
Leaves
Medicinal plants
Metabolic engineering
Metabolic pathways
Organogenesis
pathway engineering
Plant propagation
Plant tissues
Propagation
Seed germination
Stevia rebaudiana
steviol
Steviol glycosides
stevioside
sweet leaf
Tissue culture
Toxicology
vegetative propagation
Paraguay
United States > US
China
India
Online AccessGet full text
ISSN2077-0472
2077-0472
DOI10.3390/agriculture13020475

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Abstract Stevia rebaudiana (Bert.) Bertoni, commonly called “sweet leaf” is a medicinally and industrially important plant known to be rich in zero-calorie natural sweetening compound(s) known as “steviol glycosides”. However, due to its poor seed germination and slow vegetative propagation, it has become rather difficult to meet the increasing global demand for Stevia-based products. Different biotechnological approaches have been developed over the past few decades to overcome these limitations and allow for mass propagation of the plant. Several protocols for in vitro organogenesis, callogenesis, and cell suspension cultures have been developed during the past few years. Apart from this, attempts have also been made to improve the production of steviol glycosides through nutrient manipulation, the use of elicitors, hairy root cultures, genetic transformation, and metabolic pathway engineering. Therefore, this review provides an up-to-date report on the applications of various biotechnological tools for mass propagation and enhanced steviol glycoside production, along with a detailed bibliometrics analysis. This review also highlights research gaps and future considerations that could be fruitful for the scientific community to delve deeper into the various unexplored aspects of the architecture and functionality of this natural sweetening plant.
AbstractList Stevia rebaudiana (Bert.) Bertoni, commonly called “sweet leaf” is a medicinally and industrially important plant known to be rich in zero-calorie natural sweetening compound(s) known as “steviol glycosides”. However, due to its poor seed germination and slow vegetative propagation, it has become rather difficult to meet the increasing global demand for Stevia-based products. Different biotechnological approaches have been developed over the past few decades to overcome these limitations and allow for mass propagation of the plant. Several protocols for in vitro organogenesis, callogenesis, and cell suspension cultures have been developed during the past few years. Apart from this, attempts have also been made to improve the production of steviol glycosides through nutrient manipulation, the use of elicitors, hairy root cultures, genetic transformation, and metabolic pathway engineering. Therefore, this review provides an up-to-date report on the applications of various biotechnological tools for mass propagation and enhanced steviol glycoside production, along with a detailed bibliometrics analysis. This review also highlights research gaps and future considerations that could be fruitful for the scientific community to delve deeper into the various unexplored aspects of the architecture and functionality of this natural sweetening plant.
Stevia rebaudiana (Bert.) Bertoni, commonly called “sweet leaf” is a medicinally and industrially important plant known to be rich in zero-calorie natural sweetening compound(s) known as “steviol glycosides”. However, due to its poor seed germination and slow vegetative propagation, it has become rather difficult to meet the increasing global demand for Stevia-based products. Different biotechnological approaches have been developed over the past few decades to overcome these limitations and allow for mass propagation of the plant. Several protocols for in vitro organogenesis, callogenesis, and cell suspension cultures have been developed during the past few years. Apart from this, attempts have also been made to improve the production of steviol glycosides through nutrient manipulation, the use of elicitors, hairy root cultures, genetic transformation, and metabolic pathway engineering. Therefore, this review provides an up-to-date report on the applications of various biotechnological tools for mass propagation and enhanced steviol glycoside production, along with a detailed bibliometrics analysis. This review also highlights research gaps and future considerations that could be fruitful for the scientific community to delve deeper into the various unexplored aspects of the architecture and functionality of this natural sweetening plant.
Author Kothari, Shanker Lal
Jain, Rohit
Gupta, Swati
Sharma, Shilpa
Kumari, Deepa
Kachhwaha, Sumita
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  surname: Jain
  fullname: Jain, Rohit
– sequence: 6
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  surname: Kachhwaha
  fullname: Kachhwaha, Sumita
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Snippet Stevia rebaudiana (Bert.) Bertoni, commonly called “sweet leaf” is a medicinally and industrially important plant known to be rich in zero-calorie natural...
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SubjectTerms Acids
agriculture
Antimicrobial agents
bibliometric analysis
Bibliometrics
biochemical pathways
Biotechnology
Blood pressure
callus formation
Cancer
Cell culture
Chemistry
Cytotoxicity
Diabetes
Food
Gene expression
Genetic transformation
Germination
Glucose
Glycosides
Hairy root
Human subjects
Hypertension
in vitro propagation
Insulin
Leaves
Medicinal plants
Metabolic engineering
Metabolic pathways
Organogenesis
pathway engineering
Plant propagation
Plant tissues
Propagation
Seed germination
Stevia rebaudiana
steviol
Steviol glycosides
stevioside
sweet leaf
Tissue culture
Toxicology
vegetative propagation
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Title Exploring Plant Tissue Culture and Steviol Glycosides Production in Stevia rebaudiana (Bert.) Bertoni: A Review
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