Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization

The critical requirements in developing clinical-grade human-induced pluripotent stem cells–derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in vivo post-grafting differentiation, and acceptable safety profile. Here, we report on the use of manual-...

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Published inCell transplantation Vol. 32; p. 9636897231163232
Main Authors Shigyo, Michiko, Kobayashi, Yoshiomi, Platoshyn, Oleksandr, Marsala, Silvia, Kato Jr, Tomohisa, Takamura, Naoki, Yoshida, Kenji, Kishino, Akiyoshi, Bravo-Hernandez, Mariana, Juhas, Stefan, Juhasova, Jana, Studenovska, Hana, Proks, Vladimir, Ciacci, Joseph D., Marsala, Martin
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2023
Sage Publications Ltd
Subjects
Animals
Brain tumors
Cell Differentiation
Glutamatergic transmission
Good Manufacturing Practice
Humans
Immunodeficiency
Induced Pluripotent Stem Cells
Inhibitory postsynaptic potentials
Karyotypes
Leukocytes, Mononuclear
Neostriatum
Neural Stem Cells
Neurogenesis
Neuronal-glial interactions
Neurons - metabolism
Original
Peripheral blood mononuclear cells
Pluripotency
Rats
Sendai virus - genetics
Spinal cord
Stem cells
γ-Aminobutyric acid
brain grafting
human-induced pluripotent stem cells (hiPSCs)
neural precursor cells (NPCs)
immunodeficient rat
manual selection
spinal cord grafting
Online AccessGet full text
ISSN0963-6897
1555-3892
1555-3892
DOI10.1177/09636897231163232

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Abstract The critical requirements in developing clinical-grade human-induced pluripotent stem cells–derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in vivo post-grafting differentiation, and acceptable safety profile. Here, we report on the use of manual-selection protocol for generating expandable and stable human NPCs from induced pluripotent stem cells. The hiPSCs were generated by the reprogramming of peripheral blood mononuclear cells with Sendai-virus (SeV) vector encoding Yamanaka factors. After induction of neural rosettes, morphologically defined NPC colonies were manually harvested, re-plated, and expanded for up to 20 passages. Established NPCs showed normal karyotype, expression of typical NPCs markers at the proliferative stage, and ability to generate functional, calcium oscillating GABAergic or glutamatergic neurons after in vitro differentiation. Grafted NPCs into the striatum or spinal cord of immunodeficient rats showed progressive maturation and expression of early and late human-specific neuronal and glial markers at 2 or 6 months post-grafting. No tumor formation was seen in NPCs-grafted brain or spinal cord samples. These data demonstrate the effective use of in vitro manual-selection protocol to generate safe and expandable NPCs from hiPSCs cells. This protocol has the potential to be used to generate GMP (Good Manufacturing Practice)-grade NPCs from hiPSCs for future clinical use.
AbstractList The critical requirements in developing clinical-grade human-induced pluripotent stem cells-derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable post-grafting differentiation, and acceptable safety profile. Here, we report on the use of manual-selection protocol for generating expandable and stable human NPCs from induced pluripotent stem cells. The hiPSCs were generated by the reprogramming of peripheral blood mononuclear cells with Sendai-virus (SeV) vector encoding Yamanaka factors. After induction of neural rosettes, morphologically defined NPC colonies were manually harvested, re-plated, and expanded for up to 20 passages. Established NPCs showed normal karyotype, expression of typical NPCs markers at the proliferative stage, and ability to generate functional, calcium oscillating GABAergic or glutamatergic neurons after differentiation. Grafted NPCs into the striatum or spinal cord of immunodeficient rats showed progressive maturation and expression of early and late human-specific neuronal and glial markers at 2 or 6 months post-grafting. No tumor formation was seen in NPCs-grafted brain or spinal cord samples. These data demonstrate the effective use of manual-selection protocol to generate safe and expandable NPCs from hiPSCs cells. This protocol has the potential to be used to generate GMP (Good Manufacturing Practice)-grade NPCs from hiPSCs for future clinical use.
The critical requirements in developing clinical-grade human-induced pluripotent stem cells–derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in vivo post-grafting differentiation, and acceptable safety profile. Here, we report on the use of manual-selection protocol for generating expandable and stable human NPCs from induced pluripotent stem cells. The hiPSCs were generated by the reprogramming of peripheral blood mononuclear cells with Sendai-virus (SeV) vector encoding Yamanaka factors. After induction of neural rosettes, morphologically defined NPC colonies were manually harvested, re-plated, and expanded for up to 20 passages. Established NPCs showed normal karyotype, expression of typical NPCs markers at the proliferative stage, and ability to generate functional, calcium oscillating GABAergic or glutamatergic neurons after in vitro differentiation. Grafted NPCs into the striatum or spinal cord of immunodeficient rats showed progressive maturation and expression of early and late human-specific neuronal and glial markers at 2 or 6 months post-grafting. No tumor formation was seen in NPCs-grafted brain or spinal cord samples. These data demonstrate the effective use of in vitro manual-selection protocol to generate safe and expandable NPCs from hiPSCs cells. This protocol has the potential to be used to generate GMP (Good Manufacturing Practice)-grade NPCs from hiPSCs for future clinical use.
The critical requirements in developing clinical-grade human-induced pluripotent stem cells-derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in vivo post-grafting differentiation, and acceptable safety profile. Here, we report on the use of manual-selection protocol for generating expandable and stable human NPCs from induced pluripotent stem cells. The hiPSCs were generated by the reprogramming of peripheral blood mononuclear cells with Sendai-virus (SeV) vector encoding Yamanaka factors. After induction of neural rosettes, morphologically defined NPC colonies were manually harvested, re-plated, and expanded for up to 20 passages. Established NPCs showed normal karyotype, expression of typical NPCs markers at the proliferative stage, and ability to generate functional, calcium oscillating GABAergic or glutamatergic neurons after in vitro differentiation. Grafted NPCs into the striatum or spinal cord of immunodeficient rats showed progressive maturation and expression of early and late human-specific neuronal and glial markers at 2 or 6 months post-grafting. No tumor formation was seen in NPCs-grafted brain or spinal cord samples. These data demonstrate the effective use of in vitro manual-selection protocol to generate safe and expandable NPCs from hiPSCs cells. This protocol has the potential to be used to generate GMP (Good Manufacturing Practice)-grade NPCs from hiPSCs for future clinical use.The critical requirements in developing clinical-grade human-induced pluripotent stem cells-derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in vivo post-grafting differentiation, and acceptable safety profile. Here, we report on the use of manual-selection protocol for generating expandable and stable human NPCs from induced pluripotent stem cells. The hiPSCs were generated by the reprogramming of peripheral blood mononuclear cells with Sendai-virus (SeV) vector encoding Yamanaka factors. After induction of neural rosettes, morphologically defined NPC colonies were manually harvested, re-plated, and expanded for up to 20 passages. Established NPCs showed normal karyotype, expression of typical NPCs markers at the proliferative stage, and ability to generate functional, calcium oscillating GABAergic or glutamatergic neurons after in vitro differentiation. Grafted NPCs into the striatum or spinal cord of immunodeficient rats showed progressive maturation and expression of early and late human-specific neuronal and glial markers at 2 or 6 months post-grafting. No tumor formation was seen in NPCs-grafted brain or spinal cord samples. These data demonstrate the effective use of in vitro manual-selection protocol to generate safe and expandable NPCs from hiPSCs cells. This protocol has the potential to be used to generate GMP (Good Manufacturing Practice)-grade NPCs from hiPSCs for future clinical use.
Author Proks, Vladimir
Platoshyn, Oleksandr
Bravo-Hernandez, Mariana
Juhas, Stefan
Yoshida, Kenji
Shigyo, Michiko
Takamura, Naoki
Juhasova, Jana
Kato Jr, Tomohisa
Kobayashi, Yoshiomi
Kishino, Akiyoshi
Ciacci, Joseph D.
Marsala, Silvia
Studenovska, Hana
Marsala, Martin
AuthorAffiliation 2 Murayama Medical Center, Department of Orthopaedic Surgery, Tokyo, Japan
1 Department of Anesthesiology, School of Medicine, University of California, San Diego, La Jolla, CA, USA
7 Department of Neurosurgery, School of Medicine, University of California, San Diego, La Jolla, CA, USA
3 Regenerative & Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd., Kobe, Japan
4 Division of Stem Cell Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, Japan
5 Institute of Animal Physiology and Genetics AS CR, v.v.i., Liběchov, Czech Republic
6 Department of Biomaterials and Bioanalogous System, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic
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Cites_doi 10.2183/pjab.85.348
10.1371/journal.pone.0042614
10.3727/096368912X653200
10.1038/srep03594
10.1371/journal.pone.0017540
10.1073/pnas.1108077108
10.1186/scrt87
10.1002/stem.59
10.1634/stemcells.2006-0744
10.1016/j.bpobgyn.2015.11.020
10.1038/nature05934
10.1093/hmg/ddy186
10.3390/cells8050403
10.5966/sctm.2011-0001
10.1007/7651_2015_202
10.1016/j.celrep.2019.01.099
10.3727/096368909X470829
10.1097/WCO.0b013e328352ec45
10.1101/gad.10.24.3129
10.1016/j.stem.2018.05.014
10.1523/JNEUROSCI.0311-05.2005
10.3727/096368910X503406
10.1111/j.1460-9568.2008.06599.x
10.1016/j.cell.2006.07.024
10.1186/s12967-014-0371-2
10.1242/bio.016477
10.1007/7651_2015_225
10.1126/scitranslmed.aam6651
10.1186/scrt209
10.1126/science.1151526
10.1016/S0165-0270(98)00126-5
10.1016/j.scr.2008.08.001
10.1093/brain/awl261
10.1371/journal.pone.0052787
10.1016/j.gene.2018.11.069
10.1111/j.1460-9568.2004.03702.x
10.1016/j.stemcr.2015.08.012
10.1016/j.expneurol.2013.05.017
10.1089/scd.2008.0124
10.1038/s41576-019-0100-z
10.3389/fnins.2020.00538
10.1038/npp.2013.208
10.1016/j.neuroscience.2007.02.065
10.3389/fnagi.2016.00282
10.1073/pnas.0901402106
10.1016/j.neulet.2018.02.064
10.1182/blood-2009-04-217406
10.1186/s13287-019-1163-7
10.1016/j.stem.2019.08.002
10.1016/j.stemcr.2014.04.017
10.3389/fncir.2016.00064
10.1002/stem.211
10.1016/j.stemcr.2018.10.022
10.1007/s00441-012-1341-8
10.1016/j.stem.2009.09.008
10.1007/978-1-62703-511-8_7
10.1038/nature10821
10.1227/NEU.0b013e31825ca05f
10.1016/j.cell.2007.11.019
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Keywords brain grafting
human-induced pluripotent stem cells (hiPSCs)
neural precursor cells (NPCs)
immunodeficient rat
manual selection
spinal cord grafting
Language English
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References Pruszak, Ludwig, Blak, Alavian, Isacson 2009; 27
Sevc, Goldberg, van Gorp, Leerink, Juhas, Juhasova, Marsala, Hruska-Plochan, Hefferan, Motlik, Rypacek 2013; 248
Eura, Matsui, Luginbühl, Matsubayashi, Nanaura, Shiota, Kinugawa, Iguchi, Kiriyama, Zheng, Kouno 2020; 14
Daadi, Lee, Arac, Grueter, Bhatnagar, Maag, Schaar, Malenka, Palmer, Steinberg 2009; 18
De Feo, Merlini, Laterza, Martino 2012; 25
Bohaciakova, Hruska-Plochan, Tsunemoto, Gifford, Driscoll, Glenn, Wu, Marsala, Navarro, Tadokoro, Juhas 2019; 10
Chohan, Moore 2016; 10
Lin, He, Liang, Guo, Sunnassee, Chen, Cao, Chen, Pan, Pei, Tan 2018; 674
Cizkova, Kakinohana, Kucharova, Marsala, Johe, Hazel, Hefferan, Marsala 2007; 147
Golebiewska, Atkinson, Lako, Armstrong 2009; 27
Riedel, Jou, Lai, Lux, Moreno, Spitzer, Christians, Tristani-Firouzi, Benjamin 2014; 3
Marsala, Kakinohana, Yaksh, Tomori, Marsala, Cizkova 2004; 20
Okita, Ichisaka, Yamanaka 2007; 448
Bühnemann, Scholz, Bernreuther, Malik, Braun, Schachner, Reymann, Dihné 2006; 129
Takahashi, Yamanaka 2006; 126
Haridhasapavalan, Borgohain, Dey, Saha, Narayan, Kumar, Thummer 2019; 686
Churko, Burridge, Wu 2013; 1036
Soares, Pedersen, Vallier 2016; 1357
Rowe, Daley 2019; 20
Strnadel, Carromeu, Bardy, Navarro, Platoshyn, Glud, Marsala, Kafka, Miyanohara, Kato, Tadokoro 2018; 10
Li, Zhu, Sun, Zuo, Lei, Wang, Bao, Wang 2016; 8
Svendsen, ter Borg, Armstrong, Rosser, Chandran, Ostenfeld, Caldwell 1998; 85
Curtis, Martin, Gabel, Sidhu, Rzesiewicz, Mandeville, Van Gorp, Leerink, Tadokoro, Marsala, Jamieson 2018; 22
van Gorp, Leerink, Kakinohana, Platoshyn, Santucci, Galik, Joosten, Hruska-Plochan, Goldberg, Marsala, Johe 2013; 4
Mazzini, Gelati, Profico, Sgaravizzi, Projetti Pensi, Muzi, Ricciolini, Rota Nodari, Carletti, Giorgi, Spera 2015; 13
Riley, Federici, Polak, Kelly, Glass, Raore, Taub, Kesner, Feldman, Boulis 2012; 71
Elitt, Barbar, Tesar 2018; 27
Usvald, Vodicka, Hlucilova, Prochazka, Motlik, Kuchorova, Johe, Marsala, Scadeng, Kakinohana, Navarro 2010; 19
Nori, Okada, Yasuda, Tsuji, Takahashi, Kobayashi, Fujiyoshi, Koike, Uchiyama, Ikeda, Toyama 2011; 108
Yu, Vodyanik, Smuga-Otto, Antosiewicz-Bourget, Frane, Tian, Nie, Jonsdottir, Ruotti, Stewart, Slukvin 2007; 318
Johe, Hazel, Muller, Dugich-Djordjevic, McKay 1996; 10
Israel, Yuan, Bardy, Reyna, Mu, Herrera, Hefferan, Van Gorp, Nazor, Boscolo, Carson 2012; 482
Cossetti, Alfaro-Cervello, Donegà, Tyzack, Pluchino 2012; 349
Sundberg, Jansson, Ketolainen, Pihlajamäki, Suuronen, Skottman, Inzunza, Hovatta, Narkilahti 2009; 2
Kumamaru, Lu, Rosenzweig, Kadoya, Tuszynski 2019; 26
Keirstead, Nistor, Bernal, Totoiu, Cloutier, Sharp, Steward 2005; 25
Blurton-Jones, Kitazawa, Martinez-Coria, Castello, Muller, Loring, Yamasaki, Poon, Green, LaFerla 2009; 106
Hefferan, Galik, Kakinohana, Sekerkova, Santucci, Marsala, Navarro, Hruska-Plochan, Johe, Feldman, Cleveland 2012; 7
Ohmine, Dietz, Deeds, Hartjes, Miller, Thatava, Sakuma, Kudva, Ikeda 2011; 2
Agu, Soares, Alderton, Patel, Ansari, Patel, Forrest, Yang, Lineham, Vallier, Kirton 2015; 5
Ye, Zhan, Mali, Dowey, Williams, Jang, Dang, Spivak, Moliterno, Cheng 2009; 114
Karumbayaram, Lee, Azghadi, Cooper, Patterson, Kohn, Pyle, Clark, Byrne, Zack, Plath 2012; 1
Kobayashi, Okada, Itakura, Iwai, Nishimura, Yasuda, Nori, Hikishima, Konomi, Fujiyoshi, Tsuji 2012; 7
Li, Nguyen, Tsang 2016; 1353
Pruszak, Sonntag, Aung, Sanchez-Pernaute, Isacson 2007; 25
Doss, Sachinidis 2019; 8
Åkesson, Sundström 2016; 31
Yuan, Martin, Elia, Flippin, Paramban, Hefferan, Vidal, Mu, Killian, Israel, Emre 2011; 6
Okubo, Nagoshi, Kohyama, Tsuji, Shinozaki, Shibata, Kase, Matsumoto, Nakamura, Okano 2018; 11
Kakinohana, Juhasova, Juhas, Motlik, Platoshyn, Galik, Hefferan, Yuan, Vidal, Carson, van Gorp 2012; 21
Komuta, Ishii, Kaneda, Ueda, Miyamoto, Toyoda, Umezawa, Seko 2016; 5
Peh, Lang, Pera, Hawes 2009; 18
Fusaki, Ban, Nishiyama, Saeki, Hasegawa 2009; 85
Ben-Menachem-Zidon, Ben-Menahem, Ben-Hur, Yirmiya 2014; 39
Giorgetti, Montserrat, Aasen, Gonzalez, Rodriguez-Piza, Vassena, Raya, Boue, Barrero, Corbella, Torrabadella 2009; 5
Trujillo, Gao, Negraes, Gu, Buchanan, Preissl, Wang, Wu, Haddad, Chaim 2019; 25
Takahashi, Tanabe, Ohnuki, Narita, Ichisaka, Tomoda, Yamanaka 2007; 131
Trueman, Klein, Lindgren, Lelos, Dunnett 2013; 15
Nakagawa, Taniguchi, Senda, Takizawa, Ichisaka, Asano, Morizane, Doi, Takahashi, Nishizawa, Yoshida 2014; 4
Hicks, Lappalainen, Narkilahti, Suuronen, Corbett, Sivenius, Hovatta, Jolkkonen 2009; 29
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References_xml – volume: 10
  start-page: 64
  year: 2016
  article-title: Interneuron progenitor transplantation to treat CNS dysfunction
  publication-title: Front Neural Circuits
– volume: 85
  issue: 2
  year: 1998
  article-title: A new method for the rapid and long term growth of human neural precursor cells
  publication-title: J Neurosci Methods
– volume: 2
  issue: 2
  year: 2009
  article-title: CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells
  publication-title: Stem Cell Res
– volume: 22
  issue: 6
  year: 2018
  article-title: A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury
  publication-title: Cell Stem Cell
– volume: 85
  issue: 8
  year: 2009
  article-title: Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
  publication-title: Proc Jpn Acad Ser B Phys Biol Sci
– volume: 15
  year: 2013
  article-title: Repair of the CNS using endogenous and transplanted neural stem cells
  publication-title: Curr Top Behav Neurosci
– volume: 114
  issue: 27
  year: 2009
  article-title: Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
  publication-title: Blood
– volume: 20
  issue: 7
  year: 2019
  article-title: Induced pluripotent stem cells in disease modelling and drug discovery
  publication-title: Nat Rev Genet
– volume: 27
  issue: 12
  year: 2009
  article-title: CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells
  publication-title: Stem Cells
– volume: 25
  issue: 3
  year: 2012
  article-title: Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection
  publication-title: Curr Opin Neurol
– volume: 5
  issue: 4
  year: 2009
  article-title: Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2
  publication-title: Cell Stem Cell
– volume: 25
  issue: 9
  year: 2007
  article-title: Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations
  publication-title: Stem Cells
– volume: 39
  issue: 2
  year: 2014
  article-title: Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer’s disease model
  publication-title: Neuropsychopharmacology
– volume: 10
  issue: 440
  year: 2018
  article-title: Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs
  publication-title: Sci Transl Med
– volume: 26
  issue: 9
  year: 2019
  article-title: Regenerating corticospinal axons innervate phenotypically appropriate neurons within neural stem cell grafts
  publication-title: Cell Rep
– volume: 71
  issue: 2
  year: 2012
  article-title: Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I safety trial, technical note, and lumbar safety outcomes
  publication-title: Neurosurgery
– volume: 349
  issue: 1
  year: 2012
  article-title: New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies
  publication-title: Cell Tissue Res
– volume: 25
  start-page: 4694
  issue: 19
  year: 2005
  end-page: 4705
  article-title: Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
  publication-title: J Neurosci
– volume: 106
  issue: 32
  year: 2009
  article-title: Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
  publication-title: Proc Natl Acad Sci U S A
– volume: 147
  issue: 2
  year: 2007
  article-title: Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells
  publication-title: Neuroscience
– volume: 25
  issue: 4
  year: 2019
  article-title: Complex oscillatory waves emerging from cortical organoids model early human brain network development
  publication-title: Cell Stem Cell
– volume: 27
  year: 2018
  article-title: Drug screening for human genetic diseases using iPSC models
  publication-title: Hum Mol Genet
– volume: 482
  issue: 7384
  year: 2012
  article-title: Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
  publication-title: Nature
– volume: 10
  start-page: 83
  issue: 1
  year: 2019
  article-title: A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors
  publication-title: Stem Cell Res Ther
– volume: 8
  start-page: 403
  issue: 5
  year: 2019
  article-title: Current challenges of iPSC-based disease modeling and therapeutic implications
  publication-title: Cells
– volume: 4
  start-page: 3594
  year: 2014
  article-title: A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells
  publication-title: Sci Rep
– volume: 6
  issue: 3
  year: 2011
  article-title: Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells
  publication-title: PLoS One
– volume: 674
  start-page: 11
  year: 2018
  end-page: 17
  article-title: Transplanted human neural precursor cells integrate into the host neural circuit and ameliorate neurological deficits in a mouse model of traumatic brain injury
  publication-title: Neurosci Lett
– volume: 7
  issue: 12
  year: 2012
  article-title: Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity
  publication-title: PLoS One
– volume: 108
  issue: 40
  year: 2011
  article-title: Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
  publication-title: Proc Natl Acad Sci U S A
– volume: 5
  issue: 6
  year: 2016
  article-title: In vitro transdifferentiation of human peripheral blood mononuclear cells to photoreceptor-like cells
  publication-title: Biol Open
– volume: 248
  start-page: 85
  year: 2013
  end-page: 99
  article-title: Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival
  publication-title: Exp Neurol
– volume: 1
  start-page: 36
  issue: 1
  year: 2012
  end-page: 43
  article-title: From skin biopsy to neurons through a pluripotent intermediate under good manufacturing practice protocols
  publication-title: Stem Cells Transl Med
– volume: 129
  year: 2006
  article-title: Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats
  publication-title: Brain
– volume: 2
  start-page: 46
  issue: 6
  year: 2011
  article-title: Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells
  publication-title: Stem Cell Res Ther
– volume: 29
  issue: 3
  year: 2009
  article-title: Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery
  publication-title: Eur J Neurosci
– volume: 31
  start-page: 69
  year: 2016
  end-page: 81
  article-title: Human neural progenitor cells in central nervous system lesions
  publication-title: Best Pract Res Clin Obstet Gynaecol
– volume: 7
  issue: 8
  year: 2012
  article-title: Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation
  publication-title: PLoS One
– volume: 27
  issue: 6
  year: 2009
  article-title: Epigenetic landscaping during hESC differentiation to neural cells
  publication-title: Stem Cells
– volume: 10
  issue: 24
  year: 1996
  article-title: Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
  publication-title: Genes Dev
– volume: 11
  issue: 6
  year: 2018
  article-title: Treatment with a gamma-secretase inhibitor promotes functional recovery in human iPSC-derived transplants for chronic spinal cord injury
  publication-title: Stem Cell Reports
– volume: 1036
  start-page: 81
  year: 2013
  end-page: 88
  article-title: Generation of human iPSCs from human peripheral blood mononuclear cells using non-integrative Sendai virus in chemically defined conditions
  publication-title: Methods Mol Biol
– volume: 19
  issue: 9
  year: 2010
  article-title: Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs
  publication-title: Cell Transplant
– volume: 18
  issue: 7
  year: 2009
  article-title: Functional engraftment of the medial ganglionic eminence cells in experimental stroke model
  publication-title: Cell Transplant
– volume: 1357
  start-page: 23
  year: 2016
  end-page: 31
  article-title: Generation of human induced pluripotent stem cells from peripheral blood mononuclear cells using sendai virus
  publication-title: Methods Mol Biol
– volume: 3
  issue: 1
  year: 2014
  article-title: Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells
  publication-title: Stem Cell Reports
– volume: 13
  start-page: 17
  year: 2015
  article-title: Human neural stem cell transplantation in ALS: initial results from a phase I trial
  publication-title: J Transl Med
– volume: 21
  issue: 12
  year: 2012
  article-title: Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed minipigs: a qualitative and quantitative study
  publication-title: Cell Transplant
– volume: 126
  issue: 4
  year: 2006
  article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
  publication-title: Cell
– volume: 4
  start-page: 57
  issue: 3
  year: 2013
  article-title: Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation
  publication-title: Stem Cell Res Ther
– volume: 14
  start-page: 538
  year: 2020
  article-title: Brainstem organoids from human pluripotent stem cells
  publication-title: Front Neurosci
– volume: 686
  year: 2019
  article-title: An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells
  publication-title: Gene
– volume: 318
  issue: 5858
  year: 2007
  article-title: Induced pluripotent stem cell lines derived from human somatic cells
  publication-title: Science
– volume: 5
  issue: 4
  year: 2015
  article-title: Successful generation of human induced pluripotent stem cell lines from blood samples held at room temperature for up to 48 hr
  publication-title: Stem Cell Reports
– volume: 448
  issue: 7151
  year: 2007
  article-title: Generation of germline-competent induced pluripotent stem cells
  publication-title: Nature
– volume: 131
  issue: 5
  year: 2007
  article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors
  publication-title: Cell
– volume: 1353
  start-page: 77
  year: 2016
  end-page: 88
  article-title: Skin biopsy and patient-specific stem cell lines
  publication-title: Methods Mol Biol
– volume: 8
  start-page: 282
  year: 2016
  article-title: Human neural stem cell transplantation rescues cognitive defects in APP/PS1 model of Alzheimer’s disease by enhancing neuronal connectivity and metabolic activity
  publication-title: Front Aging Neurosci
– volume: 20
  issue: 9
  year: 2004
  article-title: Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia
  publication-title: Eur J Neurosci
– volume: 18
  issue: 2
  year: 2009
  article-title: CD133 expression by neural progenitors derived from human embryonic stem cells and its use for their prospective isolation
  publication-title: Stem Cells Dev
– ident: bibr30-09636897231163232
  doi: 10.2183/pjab.85.348
– ident: bibr15-09636897231163232
  doi: 10.1371/journal.pone.0042614
– ident: bibr54-09636897231163232
  doi: 10.3727/096368912X653200
– ident: bibr35-09636897231163232
  doi: 10.1038/srep03594
– ident: bibr43-09636897231163232
  doi: 10.1371/journal.pone.0017540
– ident: bibr58-09636897231163232
  doi: 10.1073/pnas.1108077108
– ident: bibr24-09636897231163232
  doi: 10.1186/scrt87
– ident: bibr42-09636897231163232
  doi: 10.1002/stem.59
– ident: bibr38-09636897231163232
  doi: 10.1634/stemcells.2006-0744
– ident: bibr17-09636897231163232
  doi: 10.1016/j.bpobgyn.2015.11.020
– ident: bibr26-09636897231163232
  doi: 10.1038/nature05934
– ident: bibr5-09636897231163232
  doi: 10.1093/hmg/ddy186
– ident: bibr3-09636897231163232
  doi: 10.3390/cells8050403
– ident: bibr21-09636897231163232
  doi: 10.5966/sctm.2011-0001
– ident: bibr32-09636897231163232
  doi: 10.1007/7651_2015_202
– ident: bibr52-09636897231163232
  doi: 10.1016/j.celrep.2019.01.099
– ident: bibr11-09636897231163232
  doi: 10.3727/096368909X470829
– ident: bibr16-09636897231163232
  doi: 10.1097/WCO.0b013e328352ec45
– ident: bibr50-09636897231163232
  doi: 10.1101/gad.10.24.3129
– ident: bibr49-09636897231163232
  doi: 10.1016/j.stem.2018.05.014
– ident: bibr51-09636897231163232
  doi: 10.1523/JNEUROSCI.0311-05.2005
– ident: bibr53-09636897231163232
  doi: 10.3727/096368910X503406
– ident: bibr9-09636897231163232
  doi: 10.1111/j.1460-9568.2008.06599.x
– ident: bibr25-09636897231163232
  doi: 10.1016/j.cell.2006.07.024
– ident: bibr47-09636897231163232
  doi: 10.1186/s12967-014-0371-2
– ident: bibr33-09636897231163232
  doi: 10.1242/bio.016477
– ident: bibr22-09636897231163232
  doi: 10.1007/7651_2015_225
– ident: bibr36-09636897231163232
  doi: 10.1126/scitranslmed.aam6651
– ident: bibr55-09636897231163232
  doi: 10.1186/scrt209
– ident: bibr2-09636897231163232
  doi: 10.1126/science.1151526
– volume: 15
  year: 2013
  ident: bibr19-09636897231163232
  publication-title: Curr Top Behav Neurosci
– ident: bibr46-09636897231163232
  doi: 10.1016/S0165-0270(98)00126-5
– ident: bibr40-09636897231163232
  doi: 10.1016/j.scr.2008.08.001
– ident: bibr10-09636897231163232
  doi: 10.1093/brain/awl261
– ident: bibr57-09636897231163232
  doi: 10.1371/journal.pone.0052787
– ident: bibr29-09636897231163232
  doi: 10.1016/j.gene.2018.11.069
– ident: bibr59-09636897231163232
  doi: 10.1111/j.1460-9568.2004.03702.x
– ident: bibr23-09636897231163232
  doi: 10.1016/j.stemcr.2015.08.012
– ident: bibr56-09636897231163232
  doi: 10.1016/j.expneurol.2013.05.017
– ident: bibr41-09636897231163232
  doi: 10.1089/scd.2008.0124
– ident: bibr4-09636897231163232
  doi: 10.1038/s41576-019-0100-z
– ident: bibr45-09636897231163232
  doi: 10.3389/fnins.2020.00538
– ident: bibr12-09636897231163232
  doi: 10.1038/npp.2013.208
– ident: bibr60-09636897231163232
  doi: 10.1016/j.neuroscience.2007.02.065
– ident: bibr14-09636897231163232
  doi: 10.3389/fnagi.2016.00282
– ident: bibr13-09636897231163232
  doi: 10.1073/pnas.0901402106
– ident: bibr8-09636897231163232
  doi: 10.1016/j.neulet.2018.02.064
– ident: bibr28-09636897231163232
  doi: 10.1182/blood-2009-04-217406
– ident: bibr37-09636897231163232
  doi: 10.1186/s13287-019-1163-7
– ident: bibr44-09636897231163232
  doi: 10.1016/j.stem.2019.08.002
– ident: bibr34-09636897231163232
  doi: 10.1016/j.stemcr.2014.04.017
– ident: bibr20-09636897231163232
  doi: 10.3389/fncir.2016.00064
– ident: bibr39-09636897231163232
  doi: 10.1002/stem.211
– ident: bibr7-09636897231163232
  doi: 10.1016/j.stemcr.2018.10.022
– ident: bibr18-09636897231163232
  doi: 10.1007/s00441-012-1341-8
– ident: bibr27-09636897231163232
  doi: 10.1016/j.stem.2009.09.008
– ident: bibr31-09636897231163232
  doi: 10.1007/978-1-62703-511-8_7
– ident: bibr6-09636897231163232
  doi: 10.1038/nature10821
– ident: bibr48-09636897231163232
  doi: 10.1227/NEU.0b013e31825ca05f
– ident: bibr1-09636897231163232
  doi: 10.1016/j.cell.2007.11.019
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Snippet The critical requirements in developing clinical-grade human-induced pluripotent stem cells–derived neural precursors (hiPSCs-NPCs) are defined by...
The critical requirements in developing clinical-grade human-induced pluripotent stem cells-derived neural precursors (hiPSCs-NPCs) are defined by...
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StartPage 9636897231163232
SubjectTerms Animals
Brain tumors
Cell Differentiation
Glutamatergic transmission
Good Manufacturing Practice
Humans
Immunodeficiency
Induced Pluripotent Stem Cells
Inhibitory postsynaptic potentials
Karyotypes
Leukocytes, Mononuclear
Neostriatum
Neural Stem Cells
Neurogenesis
Neuronal-glial interactions
Neurons - metabolism
Original
Peripheral blood mononuclear cells
Pluripotency
Rats
Sendai virus - genetics
Spinal cord
Stem cells
γ-Aminobutyric acid
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Title Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization
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