Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy - Hata, Masayuki; Hata, Maki; Dejda, Agnieszka; Pilon, Frédérique; Diaz-Marin, Roberto; Fournier, Frédérik; Joyal, Jean-Sebastien; Cagnone, Gael; Ochi, Yotaro; Crespo-Garcia, Sergio; Wilson, Ariel M.; Sapieha, Przemyslaw (Proceedings of the National Academy of Sciences - PNAS, 2024)
Keywords: Adrenal Cortex Hormones - pharmacology; Adrenal Cortex Hormones - therapeutic use; Age; Age related diseases; Angiogenesis; Animals; Anti-inflammatory agents; Biological Sciences; Blood vessels; Central nervous system; Chemokine receptors; Corticoids; Corticosteroids; CX3C Chemokine Receptor 1 - genetics; CX3C Chemokine Receptor 1 - metabolism; Damage; Dexamethasone; Dexamethasone - pharmacology; Diabetes mellitus; Disease Models, Animal; Eye diseases; Homeostasis; Immune response; Immune system; Immunity, Innate - drug effects; Immunosuppressive agents; Inflammation; Inflammation - drug therapy; Inflammation - pathology; Innate immunity; Lysozyme; Macular degeneration; Mice; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Microglia - metabolism; Microglia - pathology; Muramidase - metabolism; Myeloid cells; Myeloid Cells - drug effects; Myeloid Cells - metabolism; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - metabolism; Oxygen - metabolism; Population genetics; Regression models; Retina - drug effects; Retina - metabolism; Retina - pathology; Retinal Neovascularization - drug therapy; Retinal Neovascularization - metabolism; Retinal Neovascularization - pathology; Retinal Vessels - drug effects; Retinal Vessels - metabolism; Retinal Vessels - pathology; Retinopathy; Steroids; Vascular diseases; Vascular Remodeling - drug effects; Vascularization; dexamethasone; inflammation; retina; retinopathy; angiogenesis