Extrusion process enhances the anti-inflammatory effect of Acanthopanax senticosus leaves
The anti-inflammatory effects of Acanthopanax senticosus leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited in vitro and in vivo antiinflammatory activities in experimental systems. Extrusion increased the effect of ASL. ASL reduced C48/80-induced histamine release from HMC-1 ce...
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| Published in | Food science and biotechnology Vol. 23; no. 3; pp. 911 - 916 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
The Korean Society of Food Science and Technology
01.06.2014
한국식품과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-7708 2092-6456 |
| DOI | 10.1007/s10068-014-0122-4 |
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| Abstract | The anti-inflammatory effects of
Acanthopanax senticosus
leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited
in vitro
and
in vivo
antiinflammatory activities in experimental systems. Extrusion increased the effect of ASL. ASL reduced C48/80-induced histamine release from HMC-1 cells as well as
in vivo
model, suggesting that ASL induces mast cell stabilization and has an anti-histamine activity. The effects of ASL and extruded ASL (ASLE) on pro-inflammatory cytokine production were evaluated. ASL treatment reduced MCP- 1, TNF-α, and IL-1β mRNA expressions and decreased their protein levels in HMC-1 cells. Decreases in serum NO, MDA, and TNF-α levels were observed in acute inflammatory rats, and extrusion increased the effects of ASL in a dose-dependent manner. These data support pharmacological basis of ASL and the effect of extrusion for future treatment of inflammation. |
|---|---|
| AbstractList | The anti-inflammatory effects of Acanthopanaxsenticosus leaves (ASL) and the effects of extrusion wereevaluated. ASL exhibited in vitro and in vivo antiinflammatoryactivities in experimental systems. Extrusionincreased the effect of ASL. ASL reduced C48/80-inducedhistamine release from HMC-1 cells as well as in vivomodel, suggesting that ASL induces mast cell stabilizationand has an anti-histamine activity. The effects of ASL andextruded ASL (ASLE) on pro-inflammatory cytokineproduction were evaluated. ASL treatment reduced MCP-1, TNF-α, and IL-1β mRNA expressions and decreasedtheir protein levels in HMC-1 cells. Decreases in serumNO, MDA, and TNF-α levels were observed in acuteinflammatory rats, and extrusion increased the effects ofASL in a dose-dependent manner. These data supportpharmacological basis of ASL and the effect of extrusionfor future treatment of inflammation. KCI Citation Count: 10 The anti-inflammatory effects of Acanthopanax senticosus leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited in vitro and in vivo antiinflammatory activities in experimental systems. Extrusion increased the effect of ASL. ASL reduced C48/80-induced histamine release from HMC-1 cells as well as in vivo model, suggesting that ASL induces mast cell stabilization and has an anti-histamine activity. The effects of ASL and extruded ASL (ASLE) on pro-inflammatory cytokine production were evaluated. ASL treatment reduced MCP- 1, TNF-α, and IL-1β mRNA expressions and decreased their protein levels in HMC-1 cells. Decreases in serum NO, MDA, and TNF-α levels were observed in acute inflammatory rats, and extrusion increased the effects of ASL in a dose-dependent manner. These data support pharmacological basis of ASL and the effect of extrusion for future treatment of inflammation. The anti-inflammatory effects of Acanthopanax senticosus leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited in vitro and in vivo antiinflammatory activities in experimental systems. Extrusion increased the effect of ASL. ASL reduced C48/80-induced histamine release from HMC-1 cells as well as in vivo model, suggesting that ASL induces mast cell stabilization and has an anti-histamine activity. The effects of ASL and extruded ASL (ASLE) on pro-inflammatory cytokine production were evaluated. ASL treatment reduced MCP- 1, TNF- alpha , and IL-1 beta mRNA expressions and decreased their protein levels in HMC-1 cells. Decreases in serum NO, MDA, and TNF- alpha levels were observed in acute inflammatory rats, and extrusion increased the effects of ASL in a dose-dependent manner. These data support pharmacological basis of ASL and the effect of extrusion for future treatment of inflammation. |
| Author | Lee, Sena Leem, Kang-Hyun Kim, Hye Kyung |
| Author_xml | – sequence: 1 givenname: Kang-Hyun surname: Leem fullname: Leem, Kang-Hyun organization: College of Korean Medicine, Semyung University – sequence: 2 givenname: Sena surname: Lee fullname: Lee, Sena organization: College of Korean Medicine, Semyung University – sequence: 3 givenname: Hye Kyung surname: Kim fullname: Kim, Hye Kyung email: hkkim111@dreamwiz.com organization: Department of Food & Biotechnology, Hanseo University |
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| CitedBy_id | crossref_primary_10_1016_j_fitote_2017_06_025 crossref_primary_10_1016_j_phytol_2015_07_006 crossref_primary_10_1016_j_phytol_2016_01_008 crossref_primary_10_1016_j_fbio_2020_100841 crossref_primary_10_3390_molecules29194749 crossref_primary_10_1007_s11101_021_09775_z crossref_primary_10_1016_j_aquaculture_2024_742028 crossref_primary_10_1021_acs_jafc_0c02476 crossref_primary_10_1039_C9FO02475A crossref_primary_10_3390_molecules25225231 crossref_primary_10_1016_j_ctim_2015_11_005 crossref_primary_10_3390_molecules24010132 |
| Cites_doi | 10.1021/jf072742i 10.1016/0005-2760(87)90108-1 10.1165/rcmb.2004-0089OC 10.1111/j.1750-3841.2009.01221.x 10.1002/rcm.574 10.1002/9780470110409.ch3 10.1074/jbc.M106393200 10.1089/jir.2008.0076 10.1515/bchm2.1972.353.1.911 10.1016/j.foodchem.2009.03.084 10.1023/A:1018854107623 10.1016/j.ejphar.2006.11.014 10.1016/j.bbadis.2010.12.014 10.1002/ptr.2171 10.1021/jf902838b 10.1093/nar/29.9.e45 10.1016/j.jep.2004.11.026 10.1007/s12272-001-2110-5 |
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| Snippet | The anti-inflammatory effects of
Acanthopanax senticosus
leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited
in vitro
and
in vivo... The anti-inflammatory effects of Acanthopanax senticosus leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited in vitro and in vivo... The anti-inflammatory effects of Acanthopanaxsenticosus leaves (ASL) and the effects of extrusion wereevaluated. ASL exhibited in vitro and in vivo... |
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| Title | Extrusion process enhances the anti-inflammatory effect of Acanthopanax senticosus leaves |
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