Microgeographical Differences of Plasmodium vivax Relapse and Re-Infection in the Peruvian Amazon
To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α and tandem repeat (TR) markers were compared for their ability to distinguish...
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| Published in | The American journal of tropical medicine and hygiene Vol. 89; no. 2; pp. 326 - 338 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The American Society of Tropical Medicine and Hygiene
01.08.2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9637 1476-1645 1476-1645 |
| DOI | 10.4269/ajtmh.13-0060 |
Cover
| Abstract | To determine the magnitude of
Plasmodium vivax
relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of
PvMSP-3α
and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with
P. vivax
malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using
Pvmsp-3α
alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (
P
< 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15–44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission. |
|---|---|
| AbstractList | To determine the magnitude of
Plasmodium vivax
relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of
PvMSP-3α
and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with
P. vivax
malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using
Pvmsp-3α
alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (
P
< 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15–44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission. To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3 alpha and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with P. vivax malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using Pvmsp-3 alpha alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (P < 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15-44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission. To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with P. vivax malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using Pvmsp-3α alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (P < 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15-44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission.To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with P. vivax malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using Pvmsp-3α alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (P < 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15-44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission. To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with P. vivax malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using Pvmsp-3α alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (P < 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15-44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission. |
| Author | Chuquiyauri, Raul Vinetz, Joseph M. Calderon, Maritza Kosek, Margaret Torres, Sonia Brouwer, Kimberly C. Peñataro, Pablo Gilman, Robert H. Fasabi, Manuel |
| AuthorAffiliation | Division of Infectious Diseases, Department of Medicine, University of California San Diego, La Jolla, California; Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Perú; Department of Cellular and Molecular Sciences, Faculty of Sciences and the Laboratory of Research and Development, Universidad Peruana Cayetano Heredia, Lima, Perú; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Asociación Benéfica PRISMA, Lima, Perú; Department of Medicine, Division of Global Public Health, University of California San Diego, La Jolla, California |
| AuthorAffiliation_xml | – name: Division of Infectious Diseases, Department of Medicine, University of California San Diego, La Jolla, California; Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Perú; Department of Cellular and Molecular Sciences, Faculty of Sciences and the Laboratory of Research and Development, Universidad Peruana Cayetano Heredia, Lima, Perú; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Asociación Benéfica PRISMA, Lima, Perú; Department of Medicine, Division of Global Public Health, University of California San Diego, La Jolla, California |
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| References | Kosek (R23) 2012; 86 Imwong (R14) 2007; 195 Karunaweera (R21) 2008; 410 Hay (R5) 2004; 4 Bruce (R29) 2000; 121 Flores-Mendoza (R8) 2004; 41 Vittor (R13) 2006; 74 Feng (R19) 2003; 100 Srivastava (R15) 1996; 33 Bruce (R18) 1999; 61 Galappaththy (R33) 2007 Baird (R3) 2007; 23 Pan American Health Organization, Health Information and Analysis (R7) 2008 Chen (R31) 2007; 195 Schoeler (R9) 2003; 19 Gomez (R20) 2003; 69 Collins (R32) 2007; 195 Mendis (R2) 2001; 64 Cui (R17) 2003; 19 Roshanravan (R12) 2003; 69 Khusmith (R25) 1998; 29 Solari-Soto (R35) 2002; 15 Pukrittayakamee (R26) 2000; 44 Branch (R10) 2005; 4 Duarte (R6) 2004; 70 Zakeri (R28) 2006; 5 Guerra (R1) 2006; 22 Kirchgatter (R24) 1998; 177 Nyachieo (R22) 2005; 73 Branch (R11) 2001; 69 Pukrittayakamee (R27) 2004; 89 Craig (R16) 1996; 174 Leclerc (R30) 2004; 101 Price (R4) 2007; 77 Orjuela-Sanchez (R34) 2009; 81 |
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| Snippet | To determine the magnitude of
Plasmodium vivax
relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain... To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain... |
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| SubjectTerms | Adolescent Adult Child Child, Preschool DNA, Protozoan - blood Female Genetic Markers Genotype Humans Malaria, Vivax - epidemiology Malaria, Vivax - parasitology Male Middle Aged Molecular Epidemiology Peru - epidemiology Plasmodium vivax Plasmodium vivax - classification Plasmodium vivax - genetics Plasmodium vivax - isolation & purification Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Protozoan Proteins - genetics Recurrence Time Factors |
| Title | Microgeographical Differences of Plasmodium vivax Relapse and Re-Infection in the Peruvian Amazon |
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