Evolution of Transcatheter Aortic Valve Replacement

Transcatheter aortic valve replacement emerged ≈20 years ago and changed the landscape of structural interventional cardiology. The first experiments in animal models provided proofs of the concept and the substrate for the first percutaneous valve implantation in patients. The initial promising res...

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Published inCirculation research Vol. 114; no. 6; pp. 1037 - 1051
Main Authors Bourantas, Christos V., Serruys, Patrick W.
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 14.03.2014
Subjects
Aortic Valve - surgery
Arrhythmias, Cardiac - etiology
Cardiac Catheterization
Clinical Trials as Topic
Endovascular Procedures - instrumentation
Endovascular Procedures - methods
Endovascular Procedures - trends
Equipment Design
Equipment Failure
Heart Diseases - etiology
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation - instrumentation
Heart Valve Prosthesis Implantation - methods
Heart Valve Prosthesis Implantation - trends
Humans
Minimally Invasive Surgical Procedures
Multicenter Studies as Topic
Pacemaker, Artificial
Patient Selection
Platelet Aggregation Inhibitors - therapeutic use
Postoperative Complications
Premedication
Prognosis
Randomized Controlled Trials as Topic
Stroke - etiology
Stroke - prevention & control
aortic valve stenosis
prognosis
Online AccessGet full text
ISSN0009-7330
1524-4571
1524-4571
DOI10.1161/CIRCRESAHA.114.302292

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Abstract Transcatheter aortic valve replacement emerged ≈20 years ago and changed the landscape of structural interventional cardiology. The first experiments in animal models provided proofs of the concept and the substrate for the first percutaneous valve implantation in patients. The initial promising results in a clinical setting drew the attention of the industry and of the scientific community, and an effort was made for the past 12 years to address the limitations of the technology, facilitate the procedure, minimize the risk of complications, and broaden the applications of transcatheter aortic valve replacement. This article reviews the evolution of transcatheter aortic valve replacement, presents the first steps in this field, cites the evidence from registries and clinical trials, highlights the limitations of this treatment, and discusses the future perspectives and the developments proposed to address the current pitfalls.
AbstractList Transcatheter aortic valve replacement emerged ≈20 years ago and changed the landscape of structural interventional cardiology. The first experiments in animal models provided proofs of the concept and the substrate for the first percutaneous valve implantation in patients. The initial promising results in a clinical setting drew the attention of the industry and of the scientific community, and an effort was made for the past 12 years to address the limitations of the technology, facilitate the procedure, minimize the risk of complications, and broaden the applications of transcatheter aortic valve replacement. This article reviews the evolution of transcatheter aortic valve replacement, presents the first steps in this field, cites the evidence from registries and clinical trials, highlights the limitations of this treatment, and discusses the future perspectives and the developments proposed to address the current pitfalls.Transcatheter aortic valve replacement emerged ≈20 years ago and changed the landscape of structural interventional cardiology. The first experiments in animal models provided proofs of the concept and the substrate for the first percutaneous valve implantation in patients. The initial promising results in a clinical setting drew the attention of the industry and of the scientific community, and an effort was made for the past 12 years to address the limitations of the technology, facilitate the procedure, minimize the risk of complications, and broaden the applications of transcatheter aortic valve replacement. This article reviews the evolution of transcatheter aortic valve replacement, presents the first steps in this field, cites the evidence from registries and clinical trials, highlights the limitations of this treatment, and discusses the future perspectives and the developments proposed to address the current pitfalls.
Transcatheter aortic valve replacement emerged ≈20 years ago and changed the landscape of structural interventional cardiology. The first experiments in animal models provided proofs of the concept and the substrate for the first percutaneous valve implantation in patients. The initial promising results in a clinical setting drew the attention of the industry and of the scientific community, and an effort was made for the past 12 years to address the limitations of the technology, facilitate the procedure, minimize the risk of complications, and broaden the applications of transcatheter aortic valve replacement. This article reviews the evolution of transcatheter aortic valve replacement, presents the first steps in this field, cites the evidence from registries and clinical trials, highlights the limitations of this treatment, and discusses the future perspectives and the developments proposed to address the current pitfalls.
Author Bourantas, Christos V.
Serruys, Patrick W.
AuthorAffiliation From the Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, The Netherlands (C.V.B., P.W.S.); and International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom (P.W.S.)
AuthorAffiliation_xml – name: From the Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, The Netherlands (C.V.B., P.W.S.); and International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom (P.W.S.)
Author_xml – sequence: 1
  givenname: Christos
  surname: Bourantas
  middlename: V.
  fullname: Bourantas, Christos V.
  organization: From the Department of Interventional Cardiology, ThoraxCenter, Erasmus Medical Center, Rotterdam, The Netherlands (C.V.B., P.W.S.); and International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom (P.W.S.)
– sequence: 2
  givenname: Patrick
  surname: Serruys
  middlename: W.
  fullname: Serruys, Patrick W.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24625728$$D View this record in MEDLINE/PubMed
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Snippet Transcatheter aortic valve replacement emerged ≈20 years ago and changed the landscape of structural interventional cardiology. The first experiments in animal...
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SubjectTerms Aortic Valve - surgery
Arrhythmias, Cardiac - etiology
Cardiac Catheterization
Clinical Trials as Topic
Endovascular Procedures - instrumentation
Endovascular Procedures - methods
Endovascular Procedures - trends
Equipment Design
Equipment Failure
Heart Diseases - etiology
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation - instrumentation
Heart Valve Prosthesis Implantation - methods
Heart Valve Prosthesis Implantation - trends
Humans
Minimally Invasive Surgical Procedures
Multicenter Studies as Topic
Pacemaker, Artificial
Patient Selection
Platelet Aggregation Inhibitors - therapeutic use
Postoperative Complications
Premedication
Prognosis
Randomized Controlled Trials as Topic
Stroke - etiology
Stroke - prevention & control
Title Evolution of Transcatheter Aortic Valve Replacement
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