Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin - Berge, Elisabet O.; Huun, Johanna; Lillehaug, Johan R.; Lønning, Per E.; Knappskog, Stian (Biochimica et biophysica acta, 2013)
Keywords: anthracyclines; Anthracyclines - pharmacology; Antibiotics, Antineoplastic - pharmacology; apoptosis; Apoptosis - drug effects; beta-galactosidase; binding capacity; Biopsy; Breast; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Female; fluorescent antibody technique; Gene Expression Regulation, Neoplastic - drug effects; genes; Humans; metastasis; mitomycin; Mitomycin - pharmacology; mutants; Mutation; p53; patients; Plasmids; precipitin tests; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; proteins; quantitative polymerase chain reaction; Resistance; Structure-Activity Relationship; Transcription, Genetic - drug effects; Transfection; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; variants; PR; HRP; DEPC; WST-1; p53; Resistance; BSA; SD; PD; NLS; FBS; Breast; Mutation; SDS-PAG; Cancer