Optical volumetric brain imaging: speed, depth, and resolution enhancement

Understanding how the brain functions is one of the grand challenges in modern scientific research. Similar to a computer, a functional brain is composed of hardware and software. The major bottleneck lies in the difficulty to directly observe the brain ‘software’, i.e. the rule and operating inform...

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Published in	Journal of physics. D, Applied physics Vol. 54; no. 32; pp. 323002 - 323029
Main Authors	Huang, Shih-Huan, Irawati, Ninik, Chien, Yu-Feng, Lin, Jyun-Yi, Tsai, Yu-Hsuan, Wang, Po-Yuan, Chu, Li-An, Li, Meng-Lin, Chiang, Ann-Shyn, Tsia, Kevin K, Chu, Shi-Wei
Format	Journal Article
Language	English
Published	IOP Publishing 12.08.2021
Subjects	camera and photodetector imaging depth optical microscopy single-photon and multiphoton excitation super-resolution volumetric speed
Online Access	Get full text
ISSN	0022-3727 1361-6463 1361-6463
DOI	10.1088/1361-6463/abff7b

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Abstract	Understanding how the brain functions is one of the grand challenges in modern scientific research. Similar to a computer, a functional brain is composed of hardware and software. The major bottleneck lies in the difficulty to directly observe the brain ‘software’, i.e. the rule and operating information used by the brain that might emerge from pan-neuron/synapse connectome. A recognized strategy for probing the functional connectome is to perform volumetric imaging in brains with high spatiotemporal resolution and deep brain penetration. Among various imaging technologies, optical imaging offers appealing combinations including spatial resolution of sub-micrometer to nanometer, temporal resolution of second to millisecond, penetration depth of millimeter or deeper, and molecular contrast based on the abundant choices of fluorescent indicators. Thus, it is ideal for enabling three-dimensional functional brain mapping of small animal models. In this review, we focus on recent technological advances in optical volumetric imaging, with an emphasis on the tools and methods for enhancing imaging speed, depth, and resolution. The review could serve as a quantitative reference for physicists and biologists to choose the techniques better suited for specific applications, as well as to stimulate novel technical developments to advance brain research.
AbstractList	Understanding how the brain functions is one of the grand challenges in modern scientific research. Similar to a computer, a functional brain is composed of hardware and software. The major bottleneck lies in the difficulty to directly observe the brain ‘software’, i.e. the rule and operating information used by the brain that might emerge from pan-neuron/synapse connectome. A recognized strategy for probing the functional connectome is to perform volumetric imaging in brains with high spatiotemporal resolution and deep brain penetration. Among various imaging technologies, optical imaging offers appealing combinations including spatial resolution of sub-micrometer to nanometer, temporal resolution of second to millisecond, penetration depth of millimeter or deeper, and molecular contrast based on the abundant choices of fluorescent indicators. Thus, it is ideal for enabling three-dimensional functional brain mapping of small animal models. In this review, we focus on recent technological advances in optical volumetric imaging, with an emphasis on the tools and methods for enhancing imaging speed, depth, and resolution. The review could serve as a quantitative reference for physicists and biologists to choose the techniques better suited for specific applications, as well as to stimulate novel technical developments to advance brain research.
Author	Wang, Po-Yuan Chu, Li-An Tsia, Kevin K Chiang, Ann-Shyn Chu, Shi-Wei Huang, Shih-Huan Tsai, Yu-Hsuan Chien, Yu-Feng Irawati, Ninik Li, Meng-Lin Lin, Jyun-Yi
Author_xml	– sequence: 1 givenname: Shih-Huan surname: Huang fullname: Huang, Shih-Huan organization: National Taiwan University Department of Physics, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan – sequence: 2 givenname: Ninik surname: Irawati fullname: Irawati, Ninik organization: National Taiwan University Department of Physics, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan – sequence: 3 givenname: Yu-Feng surname: Chien fullname: Chien, Yu-Feng organization: National Taiwan University Department of Physics, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan – sequence: 4 givenname: Jyun-Yi surname: Lin fullname: Lin, Jyun-Yi organization: National Taiwan University Department of Physics, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan – sequence: 5 givenname: Yu-Hsuan surname: Tsai fullname: Tsai, Yu-Hsuan organization: National Taiwan University Department of Physics, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan – sequence: 6 givenname: Po-Yuan surname: Wang fullname: Wang, Po-Yuan organization: National Taiwan University Department of Physics, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan – sequence: 7 givenname: Li-An surname: Chu fullname: Chu, Li-An organization: National Tsing Hua University Department of Biomedical Engineering & Environmental Sciences, 101, Sec 2, Kuangfu Road, Hsinchu 30013, Taiwan – sequence: 8 givenname: Meng-Lin surname: Li fullname: Li, Meng-Lin organization: Institute of Photonics Technologies, National Tsing Hua University , 101, Sec. 2, Kuangfu Road, Hsinchu 30013, Taiwan – sequence: 9 givenname: Ann-Shyn surname: Chiang fullname: Chiang, Ann-Shyn organization: Institute of Molecular and Genomic Medicine, National Health Research Institutes , 35, Keyan Road, Zhunan, Miaoli County 35053, Taiwan – sequence: 10 givenname: Kevin K surname: Tsia fullname: Tsia, Kevin K organization: Hong Kong Science Park Advanced Biomedical Instrumentation Centre, Shatin, New Territories, Hong Kong, People’s Republic of China – sequence: 11 givenname: Shi-Wei orcidid: 0000-0001-7728-4329 surname: Chu fullname: Chu, Shi-Wei organization: National Taiwan University Molecular Imaging Center, 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan
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Snippet	Understanding how the brain functions is one of the grand challenges in modern scientific research. Similar to a computer, a functional brain is composed of...
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SubjectTerms	camera and photodetector imaging depth optical microscopy single-photon and multiphoton excitation super-resolution volumetric speed
Title	Optical volumetric brain imaging: speed, depth, and resolution enhancement
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