The antileukemic activity of modified fibrinogen–methotrexate conjugate - Goszczyński, Tomasz; Nevozhay, Dmitry; Wietrzyk, Joanna; Omar, Mohamed Salah; Boratyński, Janusz (Biochimica et biophysica acta, 2013)
Keywords: Animals; Antileukemic activity; Antimetabolites, Antineoplastic - pharmacology; antineoplastic agents; aqueous solutions; bioactive properties; Cattle; Cell Survival - drug effects; drug carriers; Drug Carriers - pharmacology; educational institutions; Fibrinogen; Fibrinogen - analogs & derivatives; Fibrinogen - chemistry; Fibrinogen - pharmacology; hydrolysis; in vivo studies; leukemia; Leukemia P388 - drug therapy; Leukemia P388 - mortality; Leukemia P388 - pathology; Male; Methotrexate; Methotrexate - analogs & derivatives; Methotrexate - pharmacology; Mice; pharmaceutical industry; physicochemical properties; Protein–drug conjugate; Survival Analysis; Tumor Cells, Cultured; Protein–drug conjugate; Antileukemic activity; Methotrexate; Fibrinogen