Motion specific responses from a blind hemifield

• Published in: Brain (London, England : 1878) Vol. 119; no. 6; pp. 1971 - 1982
• Main Authors: ffytche, D. H., Guy, C. N., Zeki, S.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.12.1996; Oxford Publishing Limited (England)
• Subjects: Adult; Biological and medical sciences; dynamic parallelism; Electroencephalography; Functional Laterality; Humans; Injuries of the nervous system and the skull. Diseases due to physical agents; Male; Medical sciences; motion evoked response; residual vision; Traumas. Diseases due to physical agents; Vision Disorders - physiopathology; Visual Cortex - pathology; Visual Cortex - physiopathology; Visual Perception; Human; Motion; Nervous system diseases; Pathophysiology; Craniocerebral; Diseases of the osteoarticular system; Visual evoked potential; Male; Trauma; Cerebral disorder; Case study; Electrodiagnosis; Eye disease; Visual field disease; Central nervous system disease; Skull disease
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/119.6.1971

In a previous study we showed that fast moving stimuli activate V5, an area specialized for motion, at very short latencies through a pathway that reaches it without passing through VI. Using the same technique of visual evoked responses, we have tested our conclusions by studying patient GY, whose VI is damaged but whose V5 is intact. In spite of the contralateral hemi-blindness due to his VI lesion, GY has a residual visual capacity that allows him to perceive, consciously, fast but not slow moving stimuli presented in his affected hemifield. By stimulating GY's ‘blind’ hemifield and comparing the responses with those obtained from normal subjects, we were able to study the relative contribution of VI and V5 to the visual evoked response to motion in normal subjects. We found that GY's early response to fast motion is preserved and correlates with activity elicited in control subjects over area V5, while slow motion, pattern offset, and pattern reversal stimuli failed to elicit responses in GY. The results confirm our previous conclusions: namely, that the early part of the motion evoked response is generated in area V5 and that signals reach this area through a dynamically parallel pathway that bypasses area V1. They go on to demonstrate that neurophysiological activity in the prestriate cortex correlates with the conscious visual perception of motion.