Oxidative imbalance in bipolar disorder subtypes: A comparative study

The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of...

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Published in	Progress in neuro-psychopharmacology & biological psychiatry Vol. 33; no. 6; pp. 1070 - 1074
Main Authors	Yumru, Mehmet, Savas, Haluk A., Kalenderoglu, Aysun, Bulut, Mahmut, Celik, Hakim, Erel, Ozcan
Format	Journal Article
Language	English
Published	Amsterdam Elsevier Inc 31.08.2009 Elsevier
Subjects	Adult Adult and adolescent clinical studies Antioxidants - metabolism Biological and medical sciences Bipolar disorder Bipolar Disorder - classification Bipolar Disorder - etiology Bipolar Disorder - metabolism Bipolar disorders Female Free Radicals - metabolism Humans Male Medical sciences Mood disorders Neuropharmacology Oxidants - metabolism Oxidative stress Oxidative Stress - physiology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Total antioxidant status Total oxidant status Young Adult NO Oxidative stress Total oxidant status BD OSI CGI AIM TAS TOS Bipolar disorder Total antioxidant status Mood disorder Human Exploration Antioxidant Subtype Comparative study
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ISSN	0278-5846 1878-4216 1878-4216
DOI	10.1016/j.pnpbp.2009.06.005

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Abstract	The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of free radicals both in the subtypes of BD (Bipolar disorders I and II) and in antidepressant induced mania (AIM). In this study, we aimed to investigate the status of oxidative metabolism in BD and its subtypes. 94 bipolar patients (BD I–II and AIM) diagnosed according to DSM IV and as control group 41 healthy subjects were included to the study. The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were examined in the properly obtained plasma samples of subjects and healthy controls included in the study. The patients' TAS, TOS and OSI were significantly higher than the controls. TAS is negatively correlated with the number of previous total episodes in BD I. The BD I group appeared to have higher TOS compared to BD II group. Oxidative balance is impaired in bipolar disorder. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. Another important result of our study was that in the comparison of the three disease subtypes BD I group was found to have higher TOS compared to the BD II group. This finding is compatible with the literature on BD I and may be associated with the more severe course of BD I.
AbstractList	Objective - The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of free radicals both in the subtypes of BD (Bipolar disorders I and II) and in antidepressant induced mania (AIM). In this study, we aimed to investigate the status of oxidative metabolism in BD and its subtypes. Methods - 94 bipolar patients (BD I-II and AIM) diagnosed according to DSM IV and as control group 41 healthy subjects were included to the study. The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were examined in the properly obtained plasma samples of subjects and healthy controls included in the study. Results - The patients' TAS, TOS and OSI were significantly higher than the controls. TAS is negatively correlated with the number of previous total episodes in BD I. The BD I group appeared to have higher TOS compared to BD II group. Conclusions - Oxidative balance is impaired in bipolar disorder. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. Another important result of our study was that in the comparison of the three disease subtypes BD I group was found to have higher TOS compared to the BD II group. This finding is compatible with the literature on BD I and may be associated with the more severe course of BD I. The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of free radicals both in the subtypes of BD (Bipolar disorders I and II) and in antidepressant induced mania (AIM). In this study, we aimed to investigate the status of oxidative metabolism in BD and its subtypes. 94 bipolar patients (BD I-II and AIM) diagnosed according to DSM IV and as control group 41 healthy subjects were included to the study. The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were examined in the properly obtained plasma samples of subjects and healthy controls included in the study. The patients' TAS, TOS and OSI were significantly higher than the controls. TAS is negatively correlated with the number of previous total episodes in BD I. The BD I group appeared to have higher TOS compared to BD II group. Oxidative balance is impaired in bipolar disorder. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. Another important result of our study was that in the comparison of the three disease subtypes BD I group was found to have higher TOS compared to the BD II group. This finding is compatible with the literature on BD I and may be associated with the more severe course of BD I. The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of free radicals both in the subtypes of BD (Bipolar disorders I and II) and in antidepressant induced mania (AIM). In this study, we aimed to investigate the status of oxidative metabolism in BD and its subtypes.OBJECTIVEThe oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders. Several studies were performed on the effects of free radicals in bipolar disorder. However, there are no studies investigating the effects of free radicals both in the subtypes of BD (Bipolar disorders I and II) and in antidepressant induced mania (AIM). In this study, we aimed to investigate the status of oxidative metabolism in BD and its subtypes.94 bipolar patients (BD I-II and AIM) diagnosed according to DSM IV and as control group 41 healthy subjects were included to the study. The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were examined in the properly obtained plasma samples of subjects and healthy controls included in the study.METHODS94 bipolar patients (BD I-II and AIM) diagnosed according to DSM IV and as control group 41 healthy subjects were included to the study. The total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were examined in the properly obtained plasma samples of subjects and healthy controls included in the study.The patients' TAS, TOS and OSI were significantly higher than the controls. TAS is negatively correlated with the number of previous total episodes in BD I. The BD I group appeared to have higher TOS compared to BD II group.RESULTSThe patients' TAS, TOS and OSI were significantly higher than the controls. TAS is negatively correlated with the number of previous total episodes in BD I. The BD I group appeared to have higher TOS compared to BD II group.Oxidative balance is impaired in bipolar disorder. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. Another important result of our study was that in the comparison of the three disease subtypes BD I group was found to have higher TOS compared to the BD II group. This finding is compatible with the literature on BD I and may be associated with the more severe course of BD I.CONCLUSIONSOxidative balance is impaired in bipolar disorder. Antioxidant levels may be increased compensatorily in response to increased oxidant levels. Another important result of our study was that in the comparison of the three disease subtypes BD I group was found to have higher TOS compared to the BD II group. This finding is compatible with the literature on BD I and may be associated with the more severe course of BD I.
Author	Kalenderoglu, Aysun Bulut, Mahmut Celik, Hakim Savas, Haluk A. Erel, Ozcan Yumru, Mehmet
Author_xml	– sequence: 1 givenname: Mehmet surname: Yumru fullname: Yumru, Mehmet organization: Psychiatry Department, Gaziantep University, Medical Faculty, Gaziantep, Turkey – sequence: 2 givenname: Haluk A. surname: Savas fullname: Savas, Haluk A. email: dr_haluksavas@yahoo.com.tr organization: Psychiatry Department, Gaziantep University, Medical Faculty, Gaziantep, Turkey – sequence: 3 givenname: Aysun surname: Kalenderoglu fullname: Kalenderoglu, Aysun organization: Psychiatry Department, Gaziantep University, Medical Faculty, Gaziantep, Turkey – sequence: 4 givenname: Mahmut surname: Bulut fullname: Bulut, Mahmut organization: Psychiatry Department, Gaziantep University, Medical Faculty, Gaziantep, Turkey – sequence: 5 givenname: Hakim surname: Celik fullname: Celik, Hakim organization: Biochemistry Department, Harran University, Medical Faculty, Sanliurfa, Turkey – sequence: 6 givenname: Ozcan surname: Erel fullname: Erel, Ozcan organization: Biochemistry Department, Harran University, Medical Faculty, Sanliurfa, Turkey
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Snippet	The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric disorders.... Objective - The oxidants are related with the membrane-associated pathologies in the central nervous system and may have an important role in neuropsychiatric...
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SubjectTerms	Adult Adult and adolescent clinical studies Antioxidants - metabolism Biological and medical sciences Bipolar disorder Bipolar Disorder - classification Bipolar Disorder - etiology Bipolar Disorder - metabolism Bipolar disorders Female Free Radicals - metabolism Humans Male Medical sciences Mood disorders Neuropharmacology Oxidants - metabolism Oxidative stress Oxidative Stress - physiology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Total antioxidant status Total oxidant status Young Adult
Title	Oxidative imbalance in bipolar disorder subtypes: A comparative study
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