Zebrafish as a good vertebrate model for molecular imaging using fluorescent probes

Fluorescent probes have been used extensively to monitor biomolecules and biologically relevant species in vitro and in vivo. A new trend in this area that has been stimulated by the desire to obtain more detailed information about the biological effects of analytes is the change from live cell to w...

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Bibliographic Details
Published inChemical Society reviews Vol. 40; no. 5; pp. 2120 - 2130
Main Authors Ko, Sung-Kyun, Chen, Xiaoqiang, Yoon, Juyoung, Shin, Injae
Format Journal Article
LanguageEnglish
Published England 01.01.2011
Subjects
animal models
Animals
bioactive properties
chemical species
Danio rerio
fluorescence
fluorescent dyes
Fluorescent Dyes - chemistry
fluorescent proteins
Freshwater
image analysis
Luminescent Proteins - chemistry
Models, Animal
Molecular Imaging
Quantum Dots
vertebrates
Zebrafish
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ISSN0306-0012
1460-4744
1460-4744
DOI10.1039/c0cs00118j

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Summary:Fluorescent probes have been used extensively to monitor biomolecules and biologically relevant species in vitro and in vivo. A new trend in this area that has been stimulated by the desire to obtain more detailed information about the biological effects of analytes is the change from live cell to whole animal fluorescent imaging. Zebrafish has received great attention for live vertebrate imaging due to several noticeable advantages. In this tutorial review, recent advances in live zebrafish imaging using fluorescent probes, such as fluorescent proteins, synthetic fluorescent dyes and quantum dots, are highlighted.
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ISSN:0306-0012
1460-4744
1460-4744
DOI:10.1039/c0cs00118j