Dexmedetomidine for delirium prevention after cardiac surgery: An updated systematic review and meta-analysis with trial sequential analysis - Caetano da Silva, Lucas; Tapioca, Vanessa; Viana, Patricia; Pereira, Eduardo Maia; Gibicoski, Tathiane; Amaral, Sara (Anaesthesia critical care & pain medicine, 2025)
Keywords: Anesthesia; Cardiac surgery; Cardiac Surgical Procedures - adverse effects; Delirium; Delirium - prevention & control; Dexmedetomidine; Dexmedetomidine - therapeutic use; Emergence Delirium - prevention & control; Humans; Hypnotics and Sedatives - therapeutic use; Intensive care; Length of Stay; Meta-analysis; Postoperative Complications - prevention & control; Randomized Controlled Trials as Topic; RR; Delirium; CAM-ICU; Intensive care; TSA; MeSH; PRISMA; RASS; Cardiac surgery; CIs; Meta-analysis; LOS; RCTs; MD; Dexmedetomidine; GRADE; ICU; PROSPERO; RIS; Richmond Agitation-Sedation Scale; Randomized controlled trials; Confidence intervals; Intensive Care Unit; Risk-ratio; Mean differences; Length of stay; International prospective register of systematic reviews; Confusion Assessment Method for the Intensive Care Unit; Preferred reporting items for systematic review and meta-analyses; Required information size; Grading of recommendations assessment, development, and evaluation; Trial sequential analysis; Medical subject headings