Management of STEC Gastroenteritis: Is There a Role for Probiotics?

Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut micr...

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Published inInternational journal of environmental research and public health Vol. 16; no. 9; p. 1649
Main Authors Giordano, Mario, Baldassarre, Maria Elisabetta, Palmieri, Viviana, Torres, Diletta D., Carbone, Vincenza, Santangelo, Luisa, Gentile, Federico, Panza, Raffaella, Di Mauro, Federica, Capozza, Manuela, Di Mauro, Antonio, Laforgia, Nicola
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.05.2019
MDPI
Subjects
Anemia
Diarrhea
Disease
E coli
Escherichia coli Infections - drug therapy
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Food contamination & poisoning
Gastroenteritis - complications
Gastroenteritis - drug therapy
Gastroenteritis - epidemiology
Gastroenteritis - microbiology
Gastrointestinal Microbiome
Hemolytic-Uremic Syndrome - drug therapy
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - microbiology
Humans
Incidence
Infections
Inflammatory bowel disease
Kidneys
Large intestine
Medical Subject Headings-MeSH
Metabolism
Microbiota
Microorganisms
Mortality
Pathogens
Pediatrics
Prevention
Probiotics
Probiotics - therapeutic use
Review
Shiga-Toxigenic Escherichia coli - physiology
Italy
“Hemolytic-Uremic Syndrome” [Mesh]
“Microbiota” [Mesh]
“Probiotics” [Mesh]
“Shiga-Toxigenic Escherichia coli” [Mesh]
Online AccessGet full text
ISSN1660-4601
1661-7827
1660-4601
DOI10.3390/ijerph16091649

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Abstract Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.
AbstractList Shiga toxin-producing (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.
Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.
Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.
Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.
Author Torres, Diletta D.
Di Mauro, Antonio
Capozza, Manuela
Santangelo, Luisa
Giordano, Mario
Panza, Raffaella
Palmieri, Viviana
Di Mauro, Federica
Carbone, Vincenza
Laforgia, Nicola
Gentile, Federico
Baldassarre, Maria Elisabetta
AuthorAffiliation 2 Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy; mariaelisabetta.baldassarre@uniba.it (M.E.B.); viviana_palmieri@libero.it (V.P.); raffaella.panza@uniba.it (R.P.); manuelacapozza26@gmail.com (M.C.); nicola.laforgia@uniba.it (N.L.)
1 Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123 Italy; mariogiordanobari@fastwebnet.it (M.G.); dilettatorres@libero.it (D.D.T.); enzacarbone2009@alice.it (V.C.); luisa.santangelo@hotmail.it (L.S.); fede_genti@msn.com (F.G.)
3 Department of Public Health, University of Naples Federico II, Napoli 80138, Italy; dimauro.federica@libero.it
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– name: 2 Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy; mariaelisabetta.baldassarre@uniba.it (M.E.B.); viviana_palmieri@libero.it (V.P.); raffaella.panza@uniba.it (R.P.); manuelacapozza26@gmail.com (M.C.); nicola.laforgia@uniba.it (N.L.)
– name: 1 Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123 Italy; mariogiordanobari@fastwebnet.it (M.G.); dilettatorres@libero.it (D.D.T.); enzacarbone2009@alice.it (V.C.); luisa.santangelo@hotmail.it (L.S.); fede_genti@msn.com (F.G.)
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Cites_doi 10.1038/nrmicro.2017.58
10.3389/fcimb.2015.00024
10.1016/S0378-3782(13)70083-5
10.1160/TH08-05-0317
10.1182/blood.V98.6.1828
10.1056/NEJMoa1802598
10.1681/ASN.2004100861
10.1007/s00253-014-5837-x
10.1111/j.1365-2672.2000.tb05338.x
10.1046/j.1523-1755.2001.060003831.x
10.1097/MPG.0000000000000320
10.1016/j.jpeds.2016.09.013
10.1128/AEM.02130-10
10.1111/j.1863-2378.2007.01059.x
10.1001/jama.290.10.1360
10.1128/AEM.03303-12
10.2807/1560-7917.ES.2016.21.38.30343
10.1056/NEJMoa1802597
10.1097/01.mpg.0000441927.20931.d6
10.1016/j.anaerobe.2013.01.002
10.1039/C5FO01041A
10.4315/0362-028X-70.2.287
10.1038/cti.2017.2
10.1097/MCG.0b013e31826852b7
10.1586/14787210.5.4.653
10.1089/fpd.2013.1704
10.1021/jf103011z
10.1016/j.amjmed.2012.09.006
10.1007/s00253-015-6704-0
10.1007/s00467-018-4112-2
10.1186/1756-0500-7-331
10.1111/jam.13124
10.1007/s00467-012-2383-6
10.3390/ijerph110504745
10.1111/1750-3841.12079
10.1146/annurev.micro.55.1.201
10.1016/j.clinre.2014.10.008
10.1016/j.ijfoodmicro.2010.09.010
10.1016/j.tem.2015.07.002
10.1007/s00467-017-3850-x
10.1016/j.ijmm.2012.11.006
10.3389/fcimb.2018.00025
10.3390/nu10020195
10.1001/archpediatrics.2011.152
10.7326/L18-0561
10.1016/j.hoc.2017.08.010
10.1016/S1473-3099(11)70165-7
10.1186/1824-7288-39-15
10.3390/nu8110677
10.1111/zph.12112
10.1126/science.1110591
10.1542/peds.2015-2153
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Keywords “Hemolytic-Uremic Syndrome” [Mesh]
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These authors contributed equally to this work.
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References Tsai (ref_1) 2013; 126
Mogna (ref_42) 2012; 46
Giordano (ref_11) 2019; 34
Neu (ref_21) 2013; 39
ref_58
Hickey (ref_10) 2011; 165
Livrelli (ref_55) 2011; 77
Dini (ref_47) 2016; 121
Napolitano (ref_27) 2015; 6
Likotrafiti (ref_45) 2013; 20
Denis (ref_57) 2013; 79
Gigliucci (ref_32) 2018; 8
ref_51
Indrio (ref_20) 2013; 89
Bielaszewska (ref_13) 2011; 11
Freedman (ref_37) 2018; 379
ref_18
Fijan (ref_33) 2014; 11
Edberg (ref_28) 2000; 88
Noris (ref_15) 2005; 16
Germinario (ref_12) 2016; 21
Sargeant (ref_39) 2007; 54
Rosenbaum (ref_24) 2015; 26
Baldassarre (ref_59) 2019; 170
Garg (ref_17) 2003; 290
Rund (ref_43) 2013; 303
Szajewska (ref_36) 2014; 58
Schnadower (ref_41) 2018; 379
Goldwater (ref_54) 2007; 5
Kappler (ref_2) 2017; 31
Leclerc (ref_30) 2001; 55
Arena (ref_46) 2014; 98
Zoja (ref_14) 2019; 34
Indrio (ref_25) 2013; 57
Maier (ref_49) 2010; 144
Lei (ref_23) 2015; 39
Rahal (ref_53) 2015; 5
Ubeda (ref_22) 2017; 6
Sommer (ref_31) 2017; 15
ref_35
ref_34
Schweppe (ref_5) 2009; 101
Peterson (ref_52) 2007; 70
Iebba (ref_26) 2016; 39
Tan (ref_44) 2013; 78
(ref_6) 2014; 2
Freedman (ref_3) 2017; 180
Callaway (ref_40) 2009; 11
Tsai (ref_50) 2010; 58
Ardissino (ref_9) 2016; 137
Cordonnier (ref_56) 2015; 99
Ruggenenti (ref_8) 2001; 60
Wisener (ref_38) 2015; 62
Spinale (ref_16) 2013; 28
Bian (ref_48) 2016; 7
Tarr (ref_4) 2005; 365
Morigi (ref_7) 2001; 98
Eckburg (ref_29) 2005; 308
Majowicz (ref_19) 2014; 11
References_xml – volume: 15
  start-page: 630
  year: 2017
  ident: ref_31
  article-title: The resilience of the intestinal microbiota influences health and disease
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.58
– volume: 5
  start-page: 24
  year: 2015
  ident: ref_53
  article-title: Approaches to treatment of emerging Shiga toxin-producing Escherichia coli infections highlighting the O104:H4 serotype
  publication-title: Front. Cell. Infect. Microbiol.
  doi: 10.3389/fcimb.2015.00024
– volume: 2
  start-page: EHEC-0024-2013
  year: 2014
  ident: ref_6
  article-title: Shiga Toxin (Stx) Classification, Structure, and Function
  publication-title: Microbiol. Spectr.
– volume: 89
  start-page: S15
  year: 2013
  ident: ref_20
  article-title: Microbiota in healthy term infant
  publication-title: Early Hum. Dev.
  doi: 10.1016/S0378-3782(13)70083-5
– volume: 101
  start-page: 252
  year: 2009
  ident: ref_5
  article-title: Shiga toxins, glycosphingolipid diversity, and endothelial cell injury
  publication-title: Thromb. Haemost.
  doi: 10.1160/TH08-05-0317
– volume: 98
  start-page: 1828
  year: 2001
  ident: ref_7
  article-title: Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress
  publication-title: Blood
  doi: 10.1182/blood.V98.6.1828
– volume: 379
  start-page: 2002
  year: 2018
  ident: ref_41
  article-title: Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1802598
– volume: 16
  start-page: 1035
  year: 2005
  ident: ref_15
  article-title: Hemolytic uremic syndrome
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2004100861
– volume: 98
  start-page: 7569
  year: 2014
  ident: ref_46
  article-title: Probiotic abilities of riboflavin-overproducing Lactobacillus strains: A novel promising application of probiotics
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-014-5837-x
– volume: 88
  start-page: 106S
  year: 2000
  ident: ref_28
  article-title: Escherichia coli: The best biological drinking water indicator for public health protection
  publication-title: J. Appl. Microbiol.
  doi: 10.1111/j.1365-2672.2000.tb05338.x
– volume: 6
  start-page: 1050
  year: 2015
  ident: ref_27
  article-title: Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches
  publication-title: Front. Microbiol.
– volume: 60
  start-page: 831
  year: 2001
  ident: ref_8
  article-title: Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura
  publication-title: Kidney Int.
  doi: 10.1046/j.1523-1755.2001.060003831.x
– volume: 58
  start-page: 531
  year: 2014
  ident: ref_36
  article-title: European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Use of probiotics for management of acute gastroenteritis: A position paper by the ESPGHAN Working Group for Probiotics and Prebiotics
  publication-title: J. Pediatr. Gastroenterol. Nutr.
  doi: 10.1097/MPG.0000000000000320
– volume: 180
  start-page: 184
  year: 2017
  ident: ref_3
  article-title: Province-Wide Review of Pediatric Shiga Toxin-Producing Escherichia coli Case Management
  publication-title: J. Pediatr.
  doi: 10.1016/j.jpeds.2016.09.013
– ident: ref_58
– volume: 77
  start-page: 1127
  year: 2011
  ident: ref_55
  article-title: Effect of a new probiotic Saccharomyces cerevisiae strain on survival of Escherichia coli O157:H7 in a dynamic gastrointestinal model
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.02130-10
– volume: 54
  start-page: 260
  year: 2007
  ident: ref_39
  article-title: Pre-harvest interventions to reduce the shedding of E. coli O157 in the faeces of weaned domestic ruminants: A systematic review
  publication-title: Zoonoses Public Health
  doi: 10.1111/j.1863-2378.2007.01059.x
– volume: 290
  start-page: 1360
  year: 2003
  ident: ref_17
  article-title: Long-term Renal Prognosis of Diarrhoea-Associated Hemolytic Uremic Syndrome
  publication-title: JAMA
  doi: 10.1001/jama.290.10.1360
– volume: 79
  start-page: 1058
  year: 2013
  ident: ref_57
  article-title: Enterohemorrhagic Escherichia coli O157:H7 survival in an in vitro model of the human large intestine and interactions with probiotic yeasts and resident microbiota
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.03303-12
– volume: 21
  start-page: 30343
  year: 2016
  ident: ref_12
  article-title: Community-wide outbreak of haemolytic uraemic syndrome associated with Shiga toxin 2-producing Escherichia coli O26:H11 in southern Italy, summer 2013
  publication-title: Eurosurveillance
  doi: 10.2807/1560-7917.ES.2016.21.38.30343
– volume: 379
  start-page: 2015
  year: 2018
  ident: ref_37
  article-title: Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1802597
– volume: 57
  start-page: S11
  year: 2013
  ident: ref_25
  article-title: Microbiota involvement in the gut-brain axis
  publication-title: J. Pediatr. Gastroenterol. Nutr.
  doi: 10.1097/01.mpg.0000441927.20931.d6
– volume: 20
  start-page: 5
  year: 2013
  ident: ref_45
  article-title: Development of antimicrobial synbiotics using potentially-probiotic faecal isolates of Lactobacillus fermentum and Bifidobacterium longum
  publication-title: Anaerobe
  doi: 10.1016/j.anaerobe.2013.01.002
– volume: 7
  start-page: 789
  year: 2016
  ident: ref_48
  article-title: In vitro assessment of the antimicrobial potentials of Lactobacillus helveticus strains isolated from traditional cheese in Sinkiang China against food-borne pathogens
  publication-title: Food Funct.
  doi: 10.1039/C5FO01041A
– volume: 70
  start-page: 287
  year: 2007
  ident: ref_52
  article-title: Effect of Lactobacillus acidophilus strain NP51 on Escherichia coli O157: H7 fecal shedding and finishing performance in beef feedlot cattle
  publication-title: J. Food Prot.
  doi: 10.4315/0362-028X-70.2.287
– volume: 6
  start-page: e128
  year: 2017
  ident: ref_22
  article-title: Roles of the intestinal microbiota in pathogen protection
  publication-title: Clin. Transl. Immunol.
  doi: 10.1038/cti.2017.2
– volume: 46
  start-page: S29
  year: 2012
  ident: ref_42
  article-title: Assessment of the In Vitro Inhibitory Activity of Specific Probiotic Bacteria Against Different Escherichia coli Strains
  publication-title: J. Clin. Gastroenterol.
  doi: 10.1097/MCG.0b013e31826852b7
– volume: 5
  start-page: 653
  year: 2007
  ident: ref_54
  article-title: Treatment and prevention of enterohemorrhagic Escherichia coli infection and hemolytic uremic syndrome
  publication-title: Expert Rev. Anti-Infect. Ther.
  doi: 10.1586/14787210.5.4.653
– volume: 11
  start-page: 447
  year: 2014
  ident: ref_19
  article-title: Global Incidence of Human Shiga Toxin–Producing Escherichia coli Infections and Deaths: A Systematic Review and Knowledge Synthesis
  publication-title: Foodborne Pathog. Dis.
  doi: 10.1089/fpd.2013.1704
– volume: 58
  start-page: 11265
  year: 2010
  ident: ref_50
  article-title: Immunomodulating activity of Lactobacillus paracasei subsp. paracasei NTU 101 in enterohemorrhagic Escherichia coli O157H7-infected mice
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf103011z
– volume: 126
  start-page: 200
  year: 2013
  ident: ref_1
  article-title: Untying the Knot of Thrombotic Thrombocytopenic Purpura and Atypical Hemolytic Uremic Syndrome
  publication-title: Am. J. Med.
  doi: 10.1016/j.amjmed.2012.09.006
– volume: 99
  start-page: 9097
  year: 2015
  ident: ref_56
  article-title: Enterohemorrhagic Escherichia coli infection has donor-dependent effect on human gut microbiota and may be antagonized by probiotic yeast during interaction with Peyer’s patches
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-015-6704-0
– volume: 34
  start-page: 517
  year: 2019
  ident: ref_11
  article-title: A pediatric neurologic assessment score may drive the eculizumab-based treatment of Escherichia coli-related hemolytic uremic syndrome with neurological involvement
  publication-title: Pediatr. Nephrol.
  doi: 10.1007/s00467-018-4112-2
– volume: 11
  start-page: 67
  year: 2009
  ident: ref_40
  article-title: Diet, Escherichia coli O157: H7, and cattle: A review after 10 years
  publication-title: Curr. Issues Mol. Biol.
– ident: ref_51
  doi: 10.1186/1756-0500-7-331
– volume: 121
  start-page: 78
  year: 2016
  ident: ref_47
  article-title: Treatment of in vitro enterohemorrhagic Escherichia coli infection using phage and probiotics
  publication-title: J. Appl. Microbiol.
  doi: 10.1111/jam.13124
– volume: 28
  start-page: 2097
  year: 2013
  ident: ref_16
  article-title: Long-term outcomes of Shiga toxin hemolytic uremic syndrome
  publication-title: Pediatr. Nephrol.
  doi: 10.1007/s00467-012-2383-6
– volume: 11
  start-page: 4745
  year: 2014
  ident: ref_33
  article-title: Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph110504745
– volume: 78
  start-page: M587
  year: 2013
  ident: ref_44
  article-title: Safety assessment and probiotic evaluation of Enterococcus faecium YF5 isolated from sourdough
  publication-title: Food Sci.
  doi: 10.1111/1750-3841.12079
– ident: ref_18
– volume: 55
  start-page: 201
  year: 2001
  ident: ref_30
  article-title: Advances in the Bacteriology of the Coliform Group: Their Suitability as Markers of Microbial Water Safety
  publication-title: Annu. Rev. Microbiol.
  doi: 10.1146/annurev.micro.55.1.201
– volume: 39
  start-page: 9
  year: 2015
  ident: ref_23
  article-title: The interplay between the intestinal microbiota and the immune system
  publication-title: Clin. Res. Hepatol. Gastroenterol.
  doi: 10.1016/j.clinre.2014.10.008
– volume: 144
  start-page: 133
  year: 2010
  ident: ref_49
  article-title: Protective effects of Lactobacilli, Bifidobacteria and Staphylococci on the infection of cultured HT29 cells with different enterohemorrhagic Escherichia coli serotypes are strain-specific
  publication-title: Int. J. Food Microbiol.
  doi: 10.1016/j.ijfoodmicro.2010.09.010
– volume: 26
  start-page: 493
  year: 2015
  ident: ref_24
  article-title: The gut microbiota in human energy homeostasis and obesity
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2015.07.002
– volume: 34
  start-page: 379
  year: 2019
  ident: ref_14
  article-title: Shiga toxin triggers endothelial and podocyte injury: The role of complement activation
  publication-title: Pediatr. Nephrol.
  doi: 10.1007/s00467-017-3850-x
– volume: 303
  start-page: 1
  year: 2013
  ident: ref_43
  article-title: Antagonistic effects of probiotic Escherichia coli Nissle 1917 on EHEC strains of serotype O104:H4 and O157:H7
  publication-title: Int. J. Med. Microbiol.
  doi: 10.1016/j.ijmm.2012.11.006
– volume: 8
  start-page: 25
  year: 2018
  ident: ref_32
  article-title: Metagenomic Characterization of the Human Intestinal Microbiota in Fecal Samples from STEC-Infected Patients
  publication-title: Front. Cell. Infect. Microbiol.
  doi: 10.3389/fcimb.2018.00025
– ident: ref_35
  doi: 10.3390/nu10020195
– volume: 165
  start-page: 884
  year: 2011
  ident: ref_10
  article-title: Early Volume Expansion During Diarrhoea and Relative Nephroprotection During Subsequent Hemolytic Uremic Syndrome
  publication-title: Arch. Pediatr. Adolesc. Med.
  doi: 10.1001/archpediatrics.2011.152
– volume: 170
  start-page: 143
  year: 2019
  ident: ref_59
  article-title: Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota
  publication-title: Ann. Intern. Med.
  doi: 10.7326/L18-0561
– volume: 31
  start-page: 1081
  year: 2017
  ident: ref_2
  article-title: Thrombotic Microangiopathies (TTP, HUS, HELLP)
  publication-title: Hematol. Oncol. Clin. N. Am.
  doi: 10.1016/j.hoc.2017.08.010
– volume: 11
  start-page: 671
  year: 2011
  ident: ref_13
  article-title: Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: A microbiological study
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(11)70165-7
– volume: 39
  start-page: 15
  year: 2013
  ident: ref_21
  article-title: Gastrointestinal function development and microbiota
  publication-title: Ital. J. Pediatr.
  doi: 10.1186/1824-7288-39-15
– ident: ref_34
  doi: 10.3390/nu8110677
– volume: 39
  start-page: 1
  year: 2016
  ident: ref_26
  article-title: Eubiosis and dysbiosis: The two sides of the microbiota
  publication-title: New Microbiol.
– volume: 62
  start-page: 75
  year: 2015
  ident: ref_38
  article-title: The use of direct-fed microbials to reduce shedding of Escherichia coli O157 in beef cattle: A systematic review and meta-analysis
  publication-title: Zoonoses Public Health
  doi: 10.1111/zph.12112
– volume: 308
  start-page: 1635
  year: 2005
  ident: ref_29
  article-title: Diversity of the Human Intestinal Microbial Flora
  publication-title: Science
  doi: 10.1126/science.1110591
– volume: 365
  start-page: 1073
  year: 2005
  ident: ref_4
  article-title: Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
  publication-title: Lancet
– volume: 137
  start-page: e20152153
  year: 2016
  ident: ref_9
  article-title: Early Volume Expansion and Outcomes of Hemolytic Uremic Syndrome
  publication-title: Pediatrics
  doi: 10.1542/peds.2015-2153
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Snippet Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic...
Shiga toxin-producing (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS)....
Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic...
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StartPage 1649
SubjectTerms Anemia
Diarrhea
Disease
E coli
Escherichia coli Infections - drug therapy
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Food contamination & poisoning
Gastroenteritis - complications
Gastroenteritis - drug therapy
Gastroenteritis - epidemiology
Gastroenteritis - microbiology
Gastrointestinal Microbiome
Hemolytic-Uremic Syndrome - drug therapy
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - microbiology
Humans
Incidence
Infections
Inflammatory bowel disease
Kidneys
Large intestine
Medical Subject Headings-MeSH
Metabolism
Microbiota
Microorganisms
Mortality
Pathogens
Pediatrics
Prevention
Probiotics
Probiotics - therapeutic use
Review
Shiga-Toxigenic Escherichia coli - physiology
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Title Management of STEC Gastroenteritis: Is There a Role for Probiotics?
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Volume 16
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