Effect of Familial Longevity on Frailty and Sarcopenia: A Case–Control Study

Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were rec...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of environmental research and public health Vol. 20; no. 2; p. 1534
Main Authors Belenguer-Varea, Angel, Avellana-Zaragoza, Juan Antonio, Inglés, Marta, Cunha-Pérez, Cristina, Cuesta-Peredo, David, Borrás, Consuelo, Viña, José, Tarazona-Santabalbina, Francisco José
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.01.2023
MDPI
Subjects
Online AccessGet full text
ISSN1660-4601
1661-7827
1660-4601
DOI10.3390/ijerph20021534

Cover

Abstract Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were recruited in this observational case–control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians’ offspring (case group) and 88 non-centenarians’ offspring (control group). The main variables were frailty and sarcopenia based on Fried’s phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) (p = 0.001), and lower levels of IL-6 (p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06–8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
AbstractList Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65-80 years were recruited in this observational case-control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians' offspring (case group) and 88 non-centenarians' offspring (control group). The main variables were frailty and sarcopenia based on Fried's phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) ( = 0.001), and lower levels of IL-6 ( = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06-8.47, = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were recruited in this observational case–control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians’ offspring (case group) and 88 non-centenarians’ offspring (control group). The main variables were frailty and sarcopenia based on Fried’s phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) (p = 0.001), and lower levels of IL-6 (p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06–8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65-80 years were recruited in this observational case-control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians' offspring (case group) and 88 non-centenarians' offspring (control group). The main variables were frailty and sarcopenia based on Fried's phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) (p = 0.001), and lower levels of IL-6 (p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06-8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65-80 years were recruited in this observational case-control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians' offspring (case group) and 88 non-centenarians' offspring (control group). The main variables were frailty and sarcopenia based on Fried's phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) (p = 0.001), and lower levels of IL-6 (p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06-8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were recruited in this observational case–control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians’ offspring (case group) and 88 non-centenarians’ offspring (control group). The main variables were frailty and sarcopenia based on Fried’s phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) ( p = 0.001), and lower levels of IL-6 ( p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06–8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Author Tarazona-Santabalbina, Francisco José
Cuesta-Peredo, David
Viña, José
Cunha-Pérez, Cristina
Belenguer-Varea, Angel
Avellana-Zaragoza, Juan Antonio
Inglés, Marta
Borrás, Consuelo
AuthorAffiliation 3 Freshage Research Group, Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain
4 Department of Quality Management, Hospital Universitario de la Ribera, 46600 Valencia, Spain
5 Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain
2 School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain
1 Division of Geriatrics, Hospital Universitario de la Ribera, 46600 Valencia, Spain
6 Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), 46010 Valencia, Spain
AuthorAffiliation_xml – name: 3 Freshage Research Group, Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain
– name: 1 Division of Geriatrics, Hospital Universitario de la Ribera, 46600 Valencia, Spain
– name: 2 School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain
– name: 4 Department of Quality Management, Hospital Universitario de la Ribera, 46600 Valencia, Spain
– name: 5 Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain
– name: 6 Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), 46010 Valencia, Spain
Author_xml – sequence: 1
  givenname: Angel
  surname: Belenguer-Varea
  fullname: Belenguer-Varea, Angel
– sequence: 2
  givenname: Juan Antonio
  surname: Avellana-Zaragoza
  fullname: Avellana-Zaragoza, Juan Antonio
– sequence: 3
  givenname: Marta
  orcidid: 0000-0002-5328-2692
  surname: Inglés
  fullname: Inglés, Marta
– sequence: 4
  givenname: Cristina
  surname: Cunha-Pérez
  fullname: Cunha-Pérez, Cristina
– sequence: 5
  givenname: David
  orcidid: 0000-0002-8710-646X
  surname: Cuesta-Peredo
  fullname: Cuesta-Peredo, David
– sequence: 6
  givenname: Consuelo
  orcidid: 0000-0003-4606-1792
  surname: Borrás
  fullname: Borrás, Consuelo
– sequence: 7
  givenname: José
  orcidid: 0000-0001-9709-0089
  surname: Viña
  fullname: Viña, José
– sequence: 8
  givenname: Francisco José
  orcidid: 0000-0003-4531-1446
  surname: Tarazona-Santabalbina
  fullname: Tarazona-Santabalbina, Francisco José
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36674289$$D View this record in MEDLINE/PubMed
BookMark eNp1kc1qHDEQhEVwiH_ia45BkIsv6-h_NDkEzOJNAkt8cHwWPZoeW8ustJFmDHvLO-QN8ySZjR1jG3xSg74qqrsOyV5MEQl5x9mplDX7GFaYNzeCMcG1VK_IATeGzZRhfO_RvE8OS1kxJq0y9RuyL42plLD1Afl-3nXoB5o6uoB16AP0dJniNd6GYUtTpIsMoZ9GiC29hOzTBmOAT_SMzqHgn1-_5ykOOfX0chjb7VvyuoO-4PH9e0SuFuc_5l9ny4sv3-Zny5lX3A4zA7aR3mrUpjUdQmM97yrPvLYomprr1oiq9ZazloNXDeO16BQqBF9Lrbk8Ip_vfDdjs8bW45QBerfJYQ156xIE9_Qnhht3nW5dbY1WYmdwcm-Q088Ry-DWoXjse4iYxuJEZayQupLVhH54hq7SmOO03o6qhBD2n-H7x4keovw_9QSc3gE-p1Iydg8IZ27XpXva5SRQzwQ-DDCE3b2nTl6S_QUZbKTH
CitedBy_id crossref_primary_10_1111_acel_14429
crossref_primary_10_1186_s12865_024_00677_1
crossref_primary_10_3389_fnut_2024_1390517
Cites_doi 10.3389/fnagi.2014.00134
10.1007/s40520-019-01283-7
10.1093/ageing/afs194
10.1016/j.arr.2016.08.006
10.1038/sj.ki.5002650
10.1093/gerona/glr223
10.3390/ijerph17176146
10.1093/gerona/58.5.M425
10.1111/acel.13595
10.2147/CIA.S243211
10.1111/jgs.12876
10.1186/s12979-022-00320-w
10.1111/j.1532-5415.2008.01656.x
10.1002/jcsm.13055
10.1016/j.arr.2012.09.003
10.18632/aging.101078
10.1177/096228029400300404
10.1016/S0140-6736(18)31694-5
10.1007/s11357-014-9677-5
10.1371/annotation/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd
10.1111/j.1532-5415.2004.52561.x
10.1016/j.jamda.2016.09.010
10.1093/gerona/glx053
10.1016/j.exger.2019.110692
10.1001/jama.290.15.2030
10.1007/s00198-018-4429-5
10.1007/s11357-012-9472-0
10.1016/j.smrv.2021.101448
10.1093/oxfordjournals.aje.a116813
10.1007/s41999-022-00619-3
10.1016/j.smrv.2018.10.004
10.1371/journal.pmed.0040297
10.1111/j.1474-9726.2009.00474.x
10.1111/j.1532-5415.2009.02490.x
10.1016/j.smrv.2021.101437
10.2307/2530417
10.5551/jat.12.67
10.1016/j.freeradbiomed.2019.09.019
10.1371/journal.pone.0057962
10.1111/j.1532-5415.2009.02381.x
10.1093/gerona/gly141
10.1186/s12877-022-03439-z
10.1016/j.redox.2019.101127
10.1093/gerona/glq098
10.1016/j.exger.2013.02.004
10.1002/jcsm.12875
10.1111/j.1532-5415.2008.01949.x
10.1016/j.jamda.2017.04.019
10.1016/S0140-6736(19)31786-6
10.1016/B978-0-12-804753-8.00008-7
10.1016/j.amjcard.2017.08.040
10.1093/gerona/glx034
10.1016/j.arr.2017.01.006
10.1007/s11357-011-9257-x
10.1093/gerona/59.4.M385
10.1007/s11357-012-9463-1
10.1111/jgs.14190
10.1038/sj.ijo.0802714
10.1038/s41574-018-0059-4
10.3389/fmed.2017.00214
10.1007/s12603-016-0844-5
10.1371/journal.pone.0241993
10.18632/aging.100912
10.1111/1475-6773.11194
10.1016/j.maturitas.2018.06.001
10.1038/srep00961
10.1038/sj.ejhg.5201508
10.1111/j.1532-5415.2004.52068.x
10.1371/journal.pone.0111810
10.1016/j.jamda.2020.10.036
10.2147/CIA.S157089
10.1097/00005768-200009001-00009
10.1186/1745-6215-15-34
10.1093/ageing/afy125
10.1007/s11357-020-00227-8
ContentType Journal Article
Copyright 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 by the authors. 2023
Copyright_xml – notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 by the authors. 2023
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8C1
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.3390/ijerph20021534
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Public Health Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials Local Electronic Collection Information
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Public Health
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
Publicly Available Content Database
CrossRef
MEDLINE - Academic

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Public Health
EISSN 1660-4601
ExternalDocumentID PMC9865421
36674289
10_3390_ijerph20021534
Genre Journal Article
Observational Study
GeographicLocations Spain
GeographicLocations_xml – name: Spain
GrantInformation_xml – fundername: Instituto de Salud Carlos III
  grantid: Red temática de investigación cooperativa en envejecimiento y fragilidad: RD12/0043/0033. European Regional Development Funds
– fundername: Hospital de La Ribera
  grantid: Health Department grants for research (2012-2013, 2014-2015)
– fundername: Ministry for de Economy and Competitiveness, Carlos III Health Institute (Spain)
– fundername: Hospital Universitario de La Ribera in Alzira (Valencia, Spain)
– fundername: European Regional Development Funds
  grantid: RD12/0043/0033
GroupedDBID ---
29J
2WC
53G
5GY
5VS
7X7
7XC
88E
8C1
8FE
8FG
8FH
8FI
8FJ
8R4
8R5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABGAM
ABUWG
ACGFO
ACGOD
ACIWK
ADBBV
AENEX
AFKRA
AFRAH
AFZYC
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EBD
EBS
EJD
EMB
EMOBN
F5P
FYUFA
GX1
HH5
HMCUK
HYE
KQ8
L6V
M1P
M48
MODMG
O5R
O5S
OK1
OVT
P2P
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
Q2X
RNS
RPM
SV3
TR2
UKHRP
XSB
2XV
3V.
ABJCF
ATCPS
AZQEC
BHPHI
CGR
CUY
CVF
ECM
EIF
GROUPED_DOAJ
HCIFZ
IAO
IEP
M2P
M7S
M~E
NPM
PATMY
PYCSY
7XB
8FK
DWQXO
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
ESTFP
PUEGO
5PM
ID FETCH-LOGICAL-c418t-6a8b3c85e56d6feab8c1f7c0c58e2b915d627dc810d1ac4b0192f4e4eac935513
IEDL.DBID M48
ISSN 1660-4601
1661-7827
IngestDate Thu Aug 21 18:39:01 EDT 2025
Mon Sep 08 04:08:07 EDT 2025
Fri Jul 25 09:33:57 EDT 2025
Wed Feb 19 02:25:24 EST 2025
Tue Jul 01 01:25:39 EDT 2025
Thu Apr 24 23:04:18 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords frailty
function
muscle
longevity
aging
heredity
interleukin-6
sarcopenia
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c418t-6a8b3c85e56d6feab8c1f7c0c58e2b915d627dc810d1ac4b0192f4e4eac935513
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
ORCID 0000-0001-9709-0089
0000-0002-5328-2692
0000-0003-4606-1792
0000-0003-4531-1446
0000-0002-8710-646X
OpenAccessLink https://www.proquest.com/docview/2767222821?pq-origsite=%requestingapplication%&accountid=15518
PMID 36674289
PQID 2767222821
PQPubID 54923
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9865421
proquest_miscellaneous_2768235737
proquest_journals_2767222821
pubmed_primary_36674289
crossref_primary_10_3390_ijerph20021534
crossref_citationtrail_10_3390_ijerph20021534
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20230114
PublicationDateYYYYMMDD 2023-01-14
PublicationDate_xml – month: 1
  year: 2023
  text: 20230114
  day: 14
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle International journal of environmental research and public health
PublicationTitleAlternate Int J Environ Res Public Health
PublicationYear 2023
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Vandenbroucke (ref_31) 2007; 4
Kim (ref_40) 2013; 35
Garatachea (ref_16) 2013; 12
Andersen (ref_17) 2012; 67
Arosio (ref_41) 2019; 31
Ensrud (ref_52) 2009; 57
Westendorp (ref_26) 2009; 57
You (ref_65) 2018; 114
Trevisan (ref_12) 2022; 13
Zhang (ref_4) 2018; 29
Soysal (ref_44) 2016; 31
ref_54
Liu (ref_11) 2018; 13
Shimada (ref_5) 2020; 22
Ainsworth (ref_78) 2000; 32
Dato (ref_14) 2012; 34
Pradas (ref_55) 2019; 21
Baeyens (ref_34) 2018; 39
Mazzotti (ref_46) 2014; 6
Terry (ref_23) 2004; 52
Maldonado (ref_37) 1993; 138
Gregory (ref_49) 2021; 58
Picca (ref_56) 2019; 126
Gueresi (ref_59) 2013; 48
ref_60
Serna (ref_74) 2022; 10
Landi (ref_9) 2014; 43
Davies (ref_13) 2022; 13
Shadyab (ref_30) 2018; 47
Schoenmaker (ref_24) 2006; 14
ref_67
Landi (ref_7) 2013; 42
Kulminski (ref_39) 2008; 56
Gambini (ref_68) 2014; 62
Hoogendijk (ref_77) 2019; 394
Inzitari (ref_38) 2017; 52
Kupper (ref_75) 1981; 37
Engberg (ref_18) 2009; 8
Andersen (ref_62) 2019; 74
Mazor (ref_81) 2002; 37
Kocevska (ref_48) 2021; 59
Tian (ref_53) 2020; 42
Bucci (ref_28) 2016; 8
Lee (ref_47) 2022; 13
Borras (ref_73) 2016; 8
Gubbi (ref_82) 2017; 120
Sanders (ref_42) 2016; 64
Gostynski (ref_63) 2004; 28
Xu (ref_79) 2020; 15
Serna (ref_20) 2012; 2
ref_36
Li (ref_57) 2022; 21
Terry (ref_71) 2004; 59
Wilson (ref_10) 2017; 36
Cournil (ref_15) 2010; 65A
Atzmon (ref_22) 2004; 52
Barral (ref_29) 2017; 72
Lovato (ref_50) 2019; 43
Stijntjes (ref_27) 2013; 8
Gentilini (ref_19) 2013; 35
Bayer (ref_33) 2014; 15
Ayers (ref_43) 2014; 36
Barzilai (ref_58) 2003; 290
Foreman (ref_2) 2018; 392
Fried (ref_32) 2001; 56
Hirano (ref_61) 2005; 12
ref_80
Angulo (ref_69) 2017; 18
Jager (ref_76) 2008; 73
Artaza (ref_66) 2017; 21
Spagnoli (ref_8) 2009; 64
(ref_72) 2020; 149
ref_1
Ayers (ref_64) 2017; 72
Terry (ref_21) 2003; 58
Klein (ref_51) 2017; 4
Rakib (ref_70) 2022; 19
Vermeiren (ref_3) 2016; 17
Franceschi (ref_45) 2018; 14
Tudor (ref_35) 1994; 3
ref_6
Adams (ref_25) 2008; 56
References_xml – volume: 6
  start-page: 134
  year: 2014
  ident: ref_46
  article-title: Human Longevity Is Associated with Regular Sleep Patterns, Maintenance of Slow Wave Sleep, and Favorable Lipid Profile
  publication-title: Front. Aging Neurosci.
  doi: 10.3389/fnagi.2014.00134
– volume: 31
  start-page: 1685
  year: 2019
  ident: ref_41
  article-title: The Frailty Index in Centenarians and Their Offspring
  publication-title: Aging Clin. Exp. Res.
  doi: 10.1007/s40520-019-01283-7
– volume: 42
  start-page: 203
  year: 2013
  ident: ref_7
  article-title: Sarcopenia and Mortality Risk in Frail Older Persons Aged 80 Years and Older: Results from IlSIRENTE Study
  publication-title: Age Ageing
  doi: 10.1093/ageing/afs194
– volume: 31
  start-page: 1
  year: 2016
  ident: ref_44
  article-title: Inflammation and Frailty in the Elderly: A Systematic Review and Meta-Analysis
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2016.08.006
– volume: 73
  start-page: 256
  year: 2008
  ident: ref_76
  article-title: Confounding: What It Is and How to Deal with It
  publication-title: Kidney Int.
  doi: 10.1038/sj.ki.5002650
– volume: 67
  start-page: 395
  year: 2012
  ident: ref_17
  article-title: Health Span Approximates Life Span among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glr223
– ident: ref_80
  doi: 10.3390/ijerph17176146
– volume: 58
  start-page: M425
  year: 2003
  ident: ref_21
  article-title: Cardiovascular Advantages Among the Offspring of Centenarians
  publication-title: J. Gerontol. Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/58.5.M425
– volume: 21
  start-page: e13595
  year: 2022
  ident: ref_57
  article-title: System-Level Metabolic Modeling Facilitates Unveiling Metabolic Signature in Exceptional Longevity
  publication-title: Aging Cell
  doi: 10.1111/acel.13595
– volume: 15
  start-page: 313
  year: 2020
  ident: ref_79
  article-title: Association between Body Composition and Frailty in Elder Inpatients
  publication-title: Clin. Interv. Aging
  doi: 10.2147/CIA.S243211
– volume: 62
  start-page: 1324
  year: 2014
  ident: ref_68
  article-title: Oxidative Stress Is Related to Frailty, Not to Age or Sex, in a Geriatric Population: Lipid and Protein Oxidation as Biomarkers of Frailty
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/jgs.12876
– volume: 19
  start-page: 64
  year: 2022
  ident: ref_70
  article-title: MicroRNAs: A Crossroad That Connects Obesity to Immunity and Aging
  publication-title: Immun. Ageing
  doi: 10.1186/s12979-022-00320-w
– volume: 56
  start-page: 898
  year: 2008
  ident: ref_39
  article-title: Cumulative Deficits Better Characterize Susceptibility to Death in Elderly People than Phenotypic Frailty: Lessons from the Cardiovascular Health Study
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2008.01656.x
– ident: ref_1
– volume: 13
  start-page: 2352
  year: 2022
  ident: ref_13
  article-title: Role of Sarcopenia in the Frailty Transitions in Older Adults: A Population-Based Cohort Study
  publication-title: J. Cachexia. Sarcopenia Muscle
  doi: 10.1002/jcsm.13055
– volume: 12
  start-page: 90
  year: 2013
  ident: ref_16
  article-title: Genes, Physical Fitness and Ageing
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2012.09.003
– volume: 8
  start-page: 3185
  year: 2016
  ident: ref_73
  article-title: Human Exceptional Longevity: Transcriptome from Centenarians Is Distinct from Septuagenarians and Reveals a Role of Bcl-XL in Successful Aging
  publication-title: Aging
  doi: 10.18632/aging.101078
– volume: 10
  start-page: 1931
  year: 2022
  ident: ref_74
  article-title: Functional Transcriptomic Analysis of Centenarians’ Offspring Reveals a Specific Genetic Footprint That May Explain That They Are Less Frail than Age-Matched Non-Centenarians’ Offspring
  publication-title: J. Gerontol. Ser. A
– volume: 3
  start-page: 345
  year: 1994
  ident: ref_35
  article-title: Review of Nonparametric Methods for the Analysis of Crossover Studies
  publication-title: Stat. Methods Med. Res.
  doi: 10.1177/096228029400300404
– volume: 392
  start-page: 2052
  year: 2018
  ident: ref_2
  article-title: Forecasting Life Expectancy, Years of Life Lost, and All-Cause and Cause-Specific Mortality for 250 Causes of Death: Reference and Alternative Scenarios for 2016–40 for 195 Countries and Territories
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)31694-5
– volume: 36
  start-page: 9677
  year: 2014
  ident: ref_43
  article-title: Association of Exceptional Parental Longevity and Physical Function in Aging
  publication-title: Age
  doi: 10.1007/s11357-014-9677-5
– ident: ref_54
  doi: 10.1371/annotation/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd
– volume: 52
  start-page: 2074
  year: 2004
  ident: ref_23
  article-title: Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2004.52561.x
– volume: 17
  start-page: 1163.e1
  year: 2016
  ident: ref_3
  article-title: Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis
  publication-title: J. Am. Med. Dir. Assoc.
  doi: 10.1016/j.jamda.2016.09.010
– volume: 72
  start-page: 1649
  year: 2017
  ident: ref_64
  article-title: Association of Family History of Exceptional Longevity with Decline in Physical Function in Aging
  publication-title: J. Gerontol. Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glx053
– volume: 126
  start-page: 110692
  year: 2019
  ident: ref_56
  article-title: The Metabolomics Side of Frailty: Toward Personalized Medicine for the Aged
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2019.110692
– volume: 290
  start-page: 2030
  year: 2003
  ident: ref_58
  article-title: Unique Lipoprotein Phenotype and Genotype Associated with Exceptional Longevity
  publication-title: J. Am. Med. Assoc.
  doi: 10.1001/jama.290.15.2030
– volume: 29
  start-page: 1253
  year: 2018
  ident: ref_4
  article-title: Association of Sarcopenia and Fractures in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis of Cohort Studies
  publication-title: Osteoporos. Int.
  doi: 10.1007/s00198-018-4429-5
– volume: 35
  start-page: 1975
  year: 2013
  ident: ref_40
  article-title: Association of Healthy Aging with Parental Longevity
  publication-title: Age
  doi: 10.1007/s11357-012-9472-0
– volume: 59
  start-page: 101448
  year: 2021
  ident: ref_48
  article-title: Heritability of Sleep Duration and Quality: A Systematic Review and Meta-Analysis
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2021.101448
– volume: 138
  start-page: 923
  year: 1993
  ident: ref_37
  article-title: Simulation Study of Confounder-Selection Strategies
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/oxfordjournals.aje.a116813
– volume: 56
  start-page: M146
  year: 2001
  ident: ref_32
  article-title: Frailty in Older Adults: Evidence for a Phenotype
  publication-title: J. Gerontol. Ser. Biological Sci. Med. Sci.
– volume: 13
  start-page: 967
  year: 2022
  ident: ref_47
  article-title: Functional Disabilities and Changes in Sleep Quality and Duration among Older Adults: Results from a Longitudinal Study in China, 2005–2014
  publication-title: Eur. Geriatr. Med.
  doi: 10.1007/s41999-022-00619-3
– volume: 43
  start-page: 71
  year: 2019
  ident: ref_50
  article-title: Insomnia and Mortality: A Meta-Analysis
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2018.10.004
– volume: 4
  start-page: 1628
  year: 2007
  ident: ref_31
  article-title: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.0040297
– volume: 8
  start-page: 270
  year: 2009
  ident: ref_18
  article-title: Centenarians—A Useful Model for Healthy Aging? A 29-Year Follow-up of Hospitalizations among 40000 Danes Born in 1905
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2009.00474.x
– volume: 57
  start-page: 2085
  year: 2009
  ident: ref_52
  article-title: Sleep Disturbances and Frailty Status in Older Community-Dwelling Men
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2009.02490.x
– volume: 39
  start-page: 1
  year: 2018
  ident: ref_34
  article-title: Sarcopenia: European Consensus on Definition and Diagnosis
  publication-title: Age Ageing
– volume: 58
  start-page: 101437
  year: 2021
  ident: ref_49
  article-title: The Heritability of Insomnia: Systematic Review and Meta-Analysis of Twin Studies
  publication-title: Sleep Med. Rev.
  doi: 10.1016/j.smrv.2021.101437
– volume: 37
  start-page: 271
  year: 1981
  ident: ref_75
  article-title: Matching in Epidemiologic Studies: Validity and Efficiency Considerations
  publication-title: Biometrics
  doi: 10.2307/2530417
– volume: 12
  start-page: 67
  year: 2005
  ident: ref_61
  article-title: Measurement of Small Dense Low-Density Lipoprotein Particles
  publication-title: J. Atheroscler. Thromb.
  doi: 10.5551/jat.12.67
– volume: 149
  start-page: 51
  year: 2020
  ident: ref_72
  article-title: Oxidative Stress and Exceptional Human Longevity: Systematic Review
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2019.09.019
– volume: 8
  start-page: 1
  year: 2013
  ident: ref_27
  article-title: Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0057962
– volume: 57
  start-page: 1634
  year: 2009
  ident: ref_26
  article-title: Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2009.02381.x
– volume: 74
  start-page: 108
  year: 2019
  ident: ref_62
  article-title: Reduced Prevalence and Incidence of Cognitive Impairment among Centenarian Offspring
  publication-title: J. Gerontol. Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/gly141
– ident: ref_6
  doi: 10.1186/s12877-022-03439-z
– volume: 21
  start-page: 101127
  year: 2019
  ident: ref_55
  article-title: Exceptional Human Longevity Is Associated with a Specific Plasma Phenotype of Ether Lipids
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2019.101127
– volume: 52
  start-page: 159
  year: 2017
  ident: ref_38
  article-title: The Challenge of Clinical Complexity in the 21st Century: Could Frailty Indexes Be the Answer?
  publication-title: Rev. Esp. Geriatr. Gerontol.
– volume: 64
  start-page: 675
  year: 2009
  ident: ref_8
  article-title: Prevalence of Frailty in Middle-Aged and Older Community-Dwelling Europeans Living in 10 Countries
  publication-title: J. Gerontol. Ser. A Biol. Sci. Med. Sci.
– volume: 65A
  start-page: 1101
  year: 2010
  ident: ref_15
  article-title: Handgrip Strength: Indications of Paternal Inheritance in Three European Regions
  publication-title: J. Gerontol. Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glq098
– volume: 48
  start-page: 395
  year: 2013
  ident: ref_59
  article-title: Does the Longevity of One or Both Parents Influence the Health Status of Their Offspring?
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2013.02.004
– volume: 13
  start-page: 254
  year: 2022
  ident: ref_12
  article-title: Twelve-Year Sarcopenia Trajectories in Older Adults: Results from a Population-Based Study
  publication-title: J. Cachexia. Sarcopenia Muscle
  doi: 10.1002/jcsm.12875
– volume: 56
  start-page: 2089
  year: 2008
  ident: ref_25
  article-title: Centenarian Offspring: Start Healthier and Stay Healthier
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2008.01949.x
– volume: 18
  start-page: 734.e1
  year: 2017
  ident: ref_69
  article-title: Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging
  publication-title: J. Am. Med. Dir. Assoc.
  doi: 10.1016/j.jamda.2017.04.019
– volume: 394
  start-page: 1365
  year: 2019
  ident: ref_77
  article-title: Frailty: Implications for Clinical Practice and Public Health
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)31786-6
– ident: ref_36
  doi: 10.1016/B978-0-12-804753-8.00008-7
– volume: 120
  start-page: 2170
  year: 2017
  ident: ref_82
  article-title: Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring
  publication-title: Am. J. Cardiol.
  doi: 10.1016/j.amjcard.2017.08.040
– volume: 43
  start-page: 48
  year: 2014
  ident: ref_9
  article-title: Prevalence of and Interventions for Sarcopenia in Ageing Adults: A Systematic Review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)
  publication-title: Age Ageing
– volume: 72
  start-page: 1683
  year: 2017
  ident: ref_29
  article-title: Age-Related Biomarkers in LLFS Families with Exceptional Cognitive Abilities
  publication-title: J. Gerontol.—Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glx034
– volume: 36
  start-page: 1
  year: 2017
  ident: ref_10
  article-title: Frailty and Sarcopenia: The Potential Role of an Aged Immune System
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2017.01.006
– volume: 34
  start-page: 571
  year: 2012
  ident: ref_14
  article-title: Frailty Phenotypes in the Elderly Based on Cluster Analysis: A Longitudinal Study of Two Danish Cohorts. Evidence for a Genetic Influence on Frailty
  publication-title: Age
  doi: 10.1007/s11357-011-9257-x
– volume: 59
  start-page: 385
  year: 2004
  ident: ref_71
  article-title: Cardiovascular Disease Delay in Centenarian Offspring
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/59.4.M385
– volume: 35
  start-page: 1961
  year: 2013
  ident: ref_19
  article-title: Role of Epigenetics in Human Aging and Longevity: Genome-Wide DNA Methylation Profile in Centenarians and Centenarians’ Offspring
  publication-title: Age
  doi: 10.1007/s11357-012-9463-1
– volume: 64
  start-page: 1679
  year: 2016
  ident: ref_42
  article-title: Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/jgs.14190
– volume: 28
  start-page: 1082
  year: 2004
  ident: ref_63
  article-title: Analysis of the Relationship between Total Cholesterol, Age, Body Mass Index among Males and Females in the WHO MONICA Project
  publication-title: Int. J. Obes.
  doi: 10.1038/sj.ijo.0802714
– volume: 14
  start-page: 576
  year: 2018
  ident: ref_45
  article-title: Inflammaging: A New Immune–Metabolic Viewpoint for Age-Related Diseases
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/s41574-018-0059-4
– volume: 4
  start-page: 214
  year: 2017
  ident: ref_51
  article-title: Association between Sleep Patterns and Health in Families with Exceptional Longevity
  publication-title: Front. Med.
  doi: 10.3389/fmed.2017.00214
– volume: 21
  start-page: 825
  year: 2017
  ident: ref_66
  article-title: Cut-off Points for Muscle Mass—Not Grip Strength or Gait Speed—Determine Variations in Sarcopenia Prevalence
  publication-title: J. Nutr. Health Aging
  doi: 10.1007/s12603-016-0844-5
– ident: ref_60
  doi: 10.1371/journal.pone.0241993
– volume: 8
  start-page: 510
  year: 2016
  ident: ref_28
  article-title: Centenarians’ Offspring as a Model of Healthy Aging: A Reappraisal of the Data on Italian Subjects and a Comprehensive Overview
  publication-title: Aging
  doi: 10.18632/aging.100912
– volume: 37
  start-page: 1403
  year: 2002
  ident: ref_81
  article-title: A Demonstration of the Impact of Response Bias on the Results of Patient Satisfaction Surveys
  publication-title: Health Serv. Res.
  doi: 10.1111/1475-6773.11194
– volume: 114
  start-page: 67
  year: 2018
  ident: ref_65
  article-title: Heritability of Muscle Mass in Korean Parent–Offspring Pairs in the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V)
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2018.06.001
– volume: 2
  start-page: 961
  year: 2012
  ident: ref_20
  article-title: Centenarians, but Not Octogenarians, up-Regulate the Expression of MicroRNAs
  publication-title: Sci. Rep.
  doi: 10.1038/srep00961
– volume: 14
  start-page: 79
  year: 2006
  ident: ref_24
  article-title: Evidence of Genetic Enrichment for Exceptional Survival Using a Family Approach: The Leiden Longevity Study
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/sj.ejhg.5201508
– volume: 52
  start-page: 274
  year: 2004
  ident: ref_22
  article-title: Clinical Phenotype of Families with Longevity
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2004.52068.x
– ident: ref_67
  doi: 10.1371/journal.pone.0111810
– volume: 22
  start-page: 846
  year: 2020
  ident: ref_5
  article-title: Effect of Sarcopenia Status on Disability Incidence Among Japanese Older Adults
  publication-title: J. Am. Med. Dir. Assoc.
  doi: 10.1016/j.jamda.2020.10.036
– volume: 13
  start-page: 947
  year: 2018
  ident: ref_11
  article-title: Frailty Transitions and Types of Death in Chinese Older Adults: A Population-Based Cohort Study
  publication-title: Clin. Interv. Aging
  doi: 10.2147/CIA.S157089
– volume: 32
  start-page: S498
  year: 2000
  ident: ref_78
  article-title: Compendium of Physical Activities: An Update of Activity Codes and MET Intensities
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1097/00005768-200009001-00009
– volume: 15
  start-page: 34
  year: 2014
  ident: ref_33
  article-title: An Evaluation of the Effectiveness of a Multi-Modal Intervention in Frail and Pre-Frail Older People with Type 2 Diabetes—the MID-Frail Study: Study Protocol for a Randomised Controlled Trial
  publication-title: Trials
  doi: 10.1186/1745-6215-15-34
– volume: 47
  start-page: 853
  year: 2018
  ident: ref_30
  article-title: Parental Longevity Predicts Healthy Ageing among Women
  publication-title: Age Ageing
  doi: 10.1093/ageing/afy125
– volume: 42
  start-page: 1377
  year: 2020
  ident: ref_53
  article-title: The Relationship of Parental Longevity with the Aging Brain—Results from UK Biobank
  publication-title: GeroScience
  doi: 10.1007/s11357-020-00227-8
SSID ssj0038469
Score 2.3581407
Snippet Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1534
SubjectTerms Age
Aged
Aging
Caregivers
Case-Control Studies
Cognitive ability
Frail Elderly
Frailty
Frailty - epidemiology
Gait
Gender
Geriatric Assessment - methods
Geriatrics
Humans
Informed consent
Life expectancy
Longevity
Population
Questionnaires
Sarcopenia
Sarcopenia - epidemiology
Sarcopenia - genetics
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1daxQxFL3U7YsgYq3atVUiCD6FTmYySaYgUpeWIrqIWujbkK9pV8pMW7cPfet_8B_6S7x3PrZdS30bSGBmcm_uPUluzgF4qyoRMWsJbpRJuEyD50UWceGK2FQ5r7Qs6KLwl6k6OJSfjvKjFZgOd2GorHKIiW2gDo2nPfLtVCtNuxWp-HB2zkk1ik5XBwkN20srhPctxdgDWMWQnCcjWP24N_36bYjNGWZbAsQCsxLH3Kg7GscMF_7bs58R_6ytWcgzuZym7mDPf0sob-Wk_SfwuAeTbLez_hqsxPopPOp24lh3wWgdph1BMWsq1qpcoMOxz019HEk1gjU1Q-w6O8VHWwf2Hf2eBLVmdoftsgmmuD_XvyddOTujmsOrZ3C4v_djcsB7FQXupTBzrqxxmTd5zFVQVbTOeFFpn_jcxNQVIg8q1cEbkQRhvXSE-SoZJUZk4l4X2XMY1U0dN4Dp1MkQbG4dwpZooyuSJMQQnEo94kQ9Bj4MWul7inFSujgtcalBg1wuD_IY3i36n3XkGvf23BpsUPaT7Fd54xJjeLNoxulBZx62js1l28cQo0-GH_eiM9niVZlCV8QF5xj0kjEXHYh6e7mlnp20FNyFIaEv8fL_n7UJD0mdnnZshNyC0fziMr5CDDN3r3vH_AvWOfLJ
  priority: 102
  providerName: ProQuest
Title Effect of Familial Longevity on Frailty and Sarcopenia: A Case–Control Study
URI https://www.ncbi.nlm.nih.gov/pubmed/36674289
https://www.proquest.com/docview/2767222821
https://www.proquest.com/docview/2768235737
https://pubmed.ncbi.nlm.nih.gov/PMC9865421
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fa9RAEB9s-yKItFbt2fZYoeBTNJtsdjeClHr0LKKHqAf3FvZf2pMj0XoF-9bv0G_oJ-lMchc9reDLEtgJ2Z2Zzfxmd3YG4ECWPKDV4pGWOo5E4l2UpwEdV8Sm0jqpRE4Xhd-P5MlYvJ1kk1_xTwsGfr_VtaN6UuPz2fMf3y4PccG_Io8TXfYX0y8Bx9REG2SpWION5qyIwvhEd6KQop0lKMylxCGhF9ImcLzl_VUD9Rfq_DN48jdrNNyE-wsYyY5auW_BnVA9gHvtHhxrrxZtw6hNTczqkjX1LVDV2Lu6Og1UL4LVFUPUOp3ho6k8-4QaT1OfmpfsiA3QuP28uh60geyMog0vH8J4ePx5cBIt6idETnA9j6TRNnU6C5n0sgzGasdL5WKX6ZDYnGdeJso7zWPPjROW0F4pgsB_MWVd5-kjWK_qKuwAU4kV3pvMWAQswQSbx7EP3luZOESIqgfRkmmFWyQXpxoXswKdDGJyscrkHjzr6L-2aTX-Sbm3lEGx1I4iUVLR1lXCe_C068aFQacdpgr1RUOjKZdPioN73Iqs-1QqUQnR1eyBWhFmR0BJt1d7qulZk3w711Tiiz_57wnswl0qUU_bNlzswfr8_CLsI5CZ2z6sqYnCVg84tcM3fdh4fTz68LHf6O4NSRr3UQ
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3bbtQwEB2V7QNICHFnoYCRQDxFjR3HcZAqVJZWW7pdIWilvgXfAouqpNCtUN_4B_6Hj-FLmMllYUHw1rdItpJoPPYcj8fnADxWJQ8YtXiklY4jKbyL8iTgxhWxqbJOZTKni8J7UzU-kK8O08MV-N7fhaGyyn5NbBZqXzvKka-LTGWUrRD8-fGniFSj6HS1l9AwnbSC32goxrqLHbvh7Atu4U42dl7ieD8RYntrfzSOOpWByEmu55Ey2iZOpyFVXpXBWO14mbnYpToIm_PUK5F5p3nsuXHSEiYqZZC4YhE3OU_wvRdgVVICZQCrL7amr9_0sSDB6E4AnGMUjDAWZy1tZJLk8frsY0BLNjUSaSKXw-JfWPfPks3fYuD2VbjSgVe22XrbNVgJ1XW43Gb-WHuh6QZMW0JkVpesUdVAB2eTunofSKWC1RVDrDw7wkdTefYWDUgCXjPzjG2yEYbUH1-_jdryeUY1jmc34eBc7HkLBlVdhTvAMmGl9yY1FmFSMMHmceyD91YJh7g0G0LUG61wHaU5KWscFbi1ISMXy0YewtNF_-OWzOOfPdf6MSi6SX1S_HLBITxaNON0pDMWU4X6tOmjiUEowZ-73Q7Z4lOJQtfHDe4QsqXBXHQgqu_llmr2oaH8zjUJi_G7__-th3BxvL83KSY70917cEkgHqNsEZdrMJh_Pg33ET_N7YPOSRm8O-958RMUEjCh
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3bahRBEG1iBBGCeHc1aguKT81OX6a7RxAJG5fExEXQwL6N05fRDWEmmg2SN__Bv_Fz_BKr5qar6FveBrqYGaqru05VV9ch5LEueQSvxZnVNmFKBM8yGSFwBWyqnddGZXhR-PVM7xyoV_N0vka-93dhsKyy3xObjTrUHnPkY2G0wWyF4OOyK4t4sz19cfyJIYMUnrT2dBqtiezFsy8Qvp08392GuX4ixPTlu8kO6xgGmFfcLpkurJPepjHVQZexcNbz0vjEpzYKl_E0aGGCtzwJvPDKIR4qVVSwW2Ffci7hvRfIRSOVQtoIMx-CPQl-HaE3B__HwAubtmGklFkyXhxG0GFTHZFKteoQ_0K5fxZr_ub9plfJlQ620q3Wzq6RtVhdJxttzo-2V5lukFnbCpnWJW34NMC06X5dfYjIT0HrigJKXhzBY1EF-hbUh9Rdi-IZ3aITcKY_vn6btIXzFKsbz26Sg3PR5i2yXtVVvEOoEU6FUKSFA4AUi-iyJAkxBKeFB0RqRoT1Sst918wcOTWOcghqUMn5qpJH5Okgf9y28fin5GY_B3m3nE_yX8Y3Io-GYViIeLpSVLE-bWQs9g6S8HO32ykbPiU1GD2EtiNiViZzEMAm36sj1eJj0-w7s0gpxu_-_7cekkuwGvL93dnePXJZABDDNBFXm2R9-fk03gfgtHQPGgul5P15L4mf1U8uPQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Familial+Longevity+on+Frailty+and+Sarcopenia%3A+A+Case%E2%80%93Control+Study&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.au=Belenguer-Varea%2C+Angel&rft.au=Avellana-Zaragoza%2C+Juan+Antonio&rft.au=Ingl%C3%A9s%2C+Marta&rft.au=Cunha-P%C3%A9rez%2C+Cristina&rft.date=2023-01-14&rft.issn=1660-4601&rft.eissn=1660-4601&rft.volume=20&rft.issue=2&rft.spage=1534&rft_id=info:doi/10.3390%2Fijerph20021534&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_ijerph20021534
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1660-4601&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1660-4601&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1660-4601&client=summon