PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis - Langsted, Anne; Nordestgaard, Børge G.; Benn, Marianne; Tybjærg-Hansen, Anne; Kamstrup, Pia R. (The journal of clinical endocrinology and metabolism, 2016)
Keywords: Adult; Aged; Aged, 80 and over; Aortic stenosis; Aortic valve; Aortic Valve Stenosis - genetics; Aortic Valve Stenosis - pathology; Aortic Valve Stenosis - prevention & control; Biomarkers - analysis; Cholesterol; Cholesterol, LDL - blood; Cohort analysis; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Genotypes; Heart attacks; Heart diseases; Heterozygote; Heterozygotes; Homozygotes; Humans; Ischemia; Kexin; Lipoprotein(a) - blood; Low density lipoprotein; Male; Middle Aged; Mutation; Mutation - genetics; Myocardial infarction; Myocardial Infarction - genetics; Myocardial Infarction - pathology; Myocardial Infarction - prevention & control; Population studies; Prognosis; Proprotein Convertase 9 - genetics; Proprotein convertases; Prospective Studies; Rheumatic heart disease; Risk Factors; Sex ratio; Stenosis; Subtilisin; Young Adult