Protective Effects of Peanut Sprouts from a Smart Farming System on the Barrier Function of Human Epithelial Cells
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day...
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| Published in | Preventive nutrition and food science Vol. 29; no. 4; pp. 474 - 484 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
한국식품영양과학회
31.12.2024
The Korean Society of Food Science and Nutrition |
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| Online Access | Get full text |
| ISSN | 2287-1098 2287-8602 |
| DOI | 10.3746/pnf.2024.29.4.474 |
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| Abstract | Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-induced epithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1 to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, the PSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly, it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation and dissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstrate that PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction. |
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| AbstractList | Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-induced epithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1 to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, the PSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly, it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation and dissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstrate that PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction.Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-induced epithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1 to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, the PSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly, it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation and dissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstrate that PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction. Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, poses an emerging threat as itcan lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effectsof peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-inducedepithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, thePSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly,it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation anddissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstratethat PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction. KCI Citation Count: 0 Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-induced epithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1 to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, the PSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly, it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation and dissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstrate that PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction. |
| Author | Hyun-Dong Cho Sae-Byuk Lee Eun-Jin Choi Hoon Kim Dong Yoon Kim Soo-Sung Kim Seong-Min Hong Dong Hyeon Kim |
| AuthorAffiliation | 3 College of Pharmacy, Gachon University, Incheon 21936, Korea 4 School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea 1 Department of Food and Nutrition, Sunchon National University, Suncheon 57922, Korea 2 NANUMBIO Co., Ltd., Suncheon 57922, Korea 6 Glocal University Project Team, Sunchon National University, Suncheon 57922, Korea 5 Institute of Fermentation Biotechnology, Kyungpook National University, Daegu 41566, Korea |
| AuthorAffiliation_xml | – name: 4 School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea – name: 3 College of Pharmacy, Gachon University, Incheon 21936, Korea – name: 1 Department of Food and Nutrition, Sunchon National University, Suncheon 57922, Korea – name: 5 Institute of Fermentation Biotechnology, Kyungpook National University, Daegu 41566, Korea – name: 2 NANUMBIO Co., Ltd., Suncheon 57922, Korea – name: 6 Glocal University Project Team, Sunchon National University, Suncheon 57922, Korea |
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| Keywords | inflammatory bowel diseases antioxidants intestinal barrier function Arachis |
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| Title | Protective Effects of Peanut Sprouts from a Smart Farming System on the Barrier Function of Human Epithelial Cells |
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