The Memory Binding Test Detects Early Subtle Episodic Memory Decline in Preclinical Alzheimer's Disease: A Longitudinal Study

The asymptomatic at-risk phase might be the optimal time-window to establish clinically meaningful endpoints in Alzheimer's disease (AD). We investigated whether, compared with the Free and Cued Selective Reminding Test (FCSRT), the Memory Binding Test (MBT) can anticipate the diagnosis of emer...

Full description

Saved in:
Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 98; no. 2; p. 465
Main Authors Rapos Pereira, Filipa, George, Nathalie, Dalla Barba, Gianfranco, Dubois, Bruno, La Corte, Valentina
Format Journal Article
LanguageEnglish
Published United States 19.03.2024
Subjects
Online AccessGet full text
ISSN1387-2877
1875-8908
1875-8908
DOI10.3233/JAD-230921

Cover

Abstract The asymptomatic at-risk phase might be the optimal time-window to establish clinically meaningful endpoints in Alzheimer's disease (AD). We investigated whether, compared with the Free and Cued Selective Reminding Test (FCSRT), the Memory Binding Test (MBT) can anticipate the diagnosis of emergent subtle episodic memory (EM) deficits to an at-risk phase. Five-year longitudinal FCSRT and MBT scores from 45 individuals matched for age, education, and gender, were divided into 3 groups of 15 subjects: Aβ-/controls, Aβ+/stable, and Aβ+/progressors (preclinical-AD). The MBT adds an associative memory component (binding), particularly sensitive to subtle EM decline. In the MBT, EM decline started in the Aβ+/progressors (preclinical-AD) up to 4 years prior to diagnosis in delayed free recall (FR), followed by decline in binding-associated scores 1 year later. Conversely, in the FCSRT, EM-decline began later, up to 3 years prior to diagnosis, in the same group on both immediate and delayed versions of FR, while on total recall (TR) and intrusions decline started only 1 year prior to diagnosis. The MBT seems more sensitive than the FCSRT for early EM-decline detection, regarding the year of diagnosis and the number of scores showing AD-linked EM deficits (associated with the AD-characteristic amnesic hippocampal syndrome). Considering the MBT as a detection tool of early subtle EM-decline in an asymptomatic at-risk phase, and the FCSRT as a classification tool of stages of EM-decline from a preclinical phase, these tests ought to potentially become complementary diagnostic tools that can foster therapies to delay cognitive decline. Clinical trial registration title: Electrophysiological markers of the progression to clinical Alzheimer disease in asymptomatic at-risk individuals: a longitudinal event-related potential study of episodic memory in the INSIGHT pre-AD cohort (acronym: ePARAD).
AbstractList The asymptomatic at-risk phase might be the optimal time-window to establish clinically meaningful endpoints in Alzheimer's disease (AD). We investigated whether, compared with the Free and Cued Selective Reminding Test (FCSRT), the Memory Binding Test (MBT) can anticipate the diagnosis of emergent subtle episodic memory (EM) deficits to an at-risk phase. Five-year longitudinal FCSRT and MBT scores from 45 individuals matched for age, education, and gender, were divided into 3 groups of 15 subjects: Aβ-/controls, Aβ+/stable, and Aβ+/progressors (preclinical-AD). The MBT adds an associative memory component (binding), particularly sensitive to subtle EM decline. In the MBT, EM decline started in the Aβ+/progressors (preclinical-AD) up to 4 years prior to diagnosis in delayed free recall (FR), followed by decline in binding-associated scores 1 year later. Conversely, in the FCSRT, EM-decline began later, up to 3 years prior to diagnosis, in the same group on both immediate and delayed versions of FR, while on total recall (TR) and intrusions decline started only 1 year prior to diagnosis. The MBT seems more sensitive than the FCSRT for early EM-decline detection, regarding the year of diagnosis and the number of scores showing AD-linked EM deficits (associated with the AD-characteristic amnesic hippocampal syndrome). Considering the MBT as a detection tool of early subtle EM-decline in an asymptomatic at-risk phase, and the FCSRT as a classification tool of stages of EM-decline from a preclinical phase, these tests ought to potentially become complementary diagnostic tools that can foster therapies to delay cognitive decline. Clinical trial registration title: Electrophysiological markers of the progression to clinical Alzheimer disease in asymptomatic at-risk individuals: a longitudinal event-related potential study of episodic memory in the INSIGHT pre-AD cohort (acronym: ePARAD).
Author La Corte, Valentina
Rapos Pereira, Filipa
George, Nathalie
Dalla Barba, Gianfranco
Dubois, Bruno
Author_xml – sequence: 1
  givenname: Filipa
  surname: Rapos Pereira
  fullname: Rapos Pereira, Filipa
  organization: Department of Neurology, Institute of Memory and Alzheimer's Disease (IM2A), Pitié-Salpêtrière University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France
– sequence: 2
  givenname: Nathalie
  surname: George
  fullname: George, Nathalie
  organization: Institut du Cerveau - Paris Brain Institute - ICM, INSERM, U 1127, CNRS, UMR 7225' APHP, CENIR, Centre MEG-EEG, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France
– sequence: 3
  givenname: Gianfranco
  surname: Dalla Barba
  fullname: Dalla Barba, Gianfranco
  organization: Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste, Italy
– sequence: 4
  givenname: Bruno
  surname: Dubois
  fullname: Dubois, Bruno
  organization: Department of Neurology, Centre of Excellence of Neurodegenerative Disease (CoEN), ICM, CIC Neurosciences, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France
– sequence: 5
  givenname: Valentina
  surname: La Corte
  fullname: La Corte, Valentina
  organization: Institut Universitaire de France, Paris, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38393903$$D View this record in MEDLINE/PubMed
BookMark eNo9kMtOwzAQAC1URB9w4QOQbxxQII6T2uYWmvJSEUgt58ixN60rJ6niRChI_DuBUk47h9ldacZoUFYlIHRO_GsaUHrzHCdeQH0RkCM0IpxFHhc-H_RMOfMCztgQjZ3b-r7fW-wEDSmnggqfjtDXagP4BYqq7vCdKbUp13gFrsEJNKAah-eyth1etlljAc93xlXaqMNGAsqaErAp8Vv9y0ZJi2P7uQFTQH3pcGIcSAe3OMaLqlybpu1_9M6yh-4UHefSOjj7mxP0fj9fzR69xevD0yxeeCokrPEE5TCNWMQZZKBlpgmVKtPTnFDCA5bnQkAoIFA5cMUCBToUVGstNYtyJkI6QVf7u225k92HtDbd1aaQdZcSP_2JmG6lTvcRe_tib-_arAD9rx6q0W9hZHCt
CitedBy_id crossref_primary_10_1007_s00415_024_12834_y
crossref_primary_10_3389_fnagi_2024_1414419
ContentType Journal Article
CorporateAuthor INSIGHT-preAD study group
CorporateAuthor_xml – name: INSIGHT-preAD study group
DBID CGR
CUY
CVF
ECM
EIF
NPM
ADTOC
UNPAY
DOI 10.3233/JAD-230921
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Unpaywall for CDI: Periodical Content
Unpaywall
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
EISSN 1875-8908
ExternalDocumentID 10.3233/jad-230921
38393903
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
0VX
29J
36B
4.4
53G
5GY
AAEJI
AAFNC
AAFWJ
AAGLT
AAPII
AAQXI
AAWTL
ABDBF
ABIVO
ABJNI
ABJZC
ABUBZ
ABUJY
ACGFS
ACPQW
ACPRK
ACUHS
ADEBD
ADZMO
AEJQA
AELRD
AENEX
AFRAH
AFRHK
AFYTF
AGIAB
AHDMH
AIRSE
AJGYC
AJNRN
ALIRC
ALMA_UNASSIGNED_HOLDINGS
APPIZ
ARTOV
CAG
CGR
COF
CUY
CVF
DU5
EAD
EAP
EBS
ECM
EIF
EJD
EMB
EMK
EMOBN
ESX
F5P
H13
HZ~
IL9
IOS
J8X
MET
MIO
MV1
NGNOM
NPM
O9-
P2P
Q1R
SAUOL
SCNPE
SFC
SV3
TUS
VUG
ADTOC
UNPAY
ID FETCH-LOGICAL-c417t-938e657587ebedabd13acbd6f131827ff99e49e2cfe8c72ced493dddad75f7943
IEDL.DBID UNPAY
ISSN 1387-2877
1875-8908
IngestDate Sun Sep 07 11:20:40 EDT 2025
Mon Jul 21 05:43:49 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords episodic memory
Alzheimer’s disease
at-risk
free and cued selective reminding test
amyloid-β
memory binding test
preclinical Alzheimer’s disease
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c417t-938e657587ebedabd13acbd6f131827ff99e49e2cfe8c72ced493dddad75f7943
OpenAccessLink https://proxy.k.utb.cz/login?url=https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad230921?id=journal-of-alzheimers-disease%2Fjad230921
PMID 38393903
ParticipantIDs unpaywall_primary_10_3233_jad_230921
pubmed_primary_38393903
PublicationCentury 2000
PublicationDate 2024-03-19
PublicationDateYYYYMMDD 2024-03-19
PublicationDate_xml – month: 03
  year: 2024
  text: 2024-03-19
  day: 19
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Journal of Alzheimer's disease
PublicationTitleAlternate J Alzheimers Dis
PublicationYear 2024
SSID ssj0003097
Score 2.4305406
Snippet The asymptomatic at-risk phase might be the optimal time-window to establish clinically meaningful endpoints in Alzheimer's disease (AD). We investigated...
SourceID unpaywall
pubmed
SourceType Open Access Repository
Index Database
StartPage 465
SubjectTerms Alzheimer Disease - metabolism
Cognitive Dysfunction - diagnosis
Humans
Longitudinal Studies
Memory Disorders - diagnosis
Memory Disorders - etiology
Memory, Episodic
Mental Recall - physiology
Neuropsychological Tests
Title The Memory Binding Test Detects Early Subtle Episodic Memory Decline in Preclinical Alzheimer's Disease: A Longitudinal Study
URI https://www.ncbi.nlm.nih.gov/pubmed/38393903
https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad230921?id=journal-of-alzheimers-disease%2Fjad230921
UnpaywallVersion publishedVersion
Volume 98
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwxV07b9swECYSZ2iXPtBX2iTgkJW2RFIUmc2tEwRFbXiIgXQyKPKEKjUkI7ZROEOTv9Gp_62_pDw9gqBD0a2zjhB5PN1Dd_cdIcepBWWyJGFJpIBJAM00955xlXGjnXIaMFAcT9T5TH68TC53yPeuFwYLtIO27RfVqi4ERb6fSCkGHrHjK-sHLY9ZlTO7uPkCBf7fZW06Y3BlfXCqDY8xwfpX0hqfviXeJXsKE1Q9sjebTIef6ygtfH0hnKinswSnnmkT6QbfVHAh8EWsWfzAdj3alEu7_WYXiwdG6uwp-dkdr6lN-drfrLO-u_kD-fH_nf8ZedL6v3TYCOxzsgPlC3IbhJWOseZ3S98XdZ8NvQjmio4AcxwrWsMw06DkgmTT02WxqnzhuhUjwPZOoEVJp9fQtXrSYbeXX3c_VnTUbOeEDumnCmc0bTzOA6NYR7l9SWZnpxcfzlk7GYI5GadrZoQGzBjpNMigt5mPhXWZV3kcVBRP89wYkAa4y0G7lDvw0gjvvfVpkiMk3ivSK6sS3hBqTWzjjION8lTmaWK5VYpLzW0kbAb5Pnnd3O582cB_zENMb4SJxD45vr_u-4chpkLxmAfWzhvevv03snfkMQ_-Epa3xeaA9NbXGzgM_s46OyK7k-n4qBXN3wN7CZI
linkProvider Unpaywall
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwxV07b9swECZSZ2iXPtBX2qTgkJW2RFIUmc2tEwRBE2SIgXQyKPKIKjUkI7ZROEPbv9Gp_62_pDw9gqBDka2zjhB5PN1Dd_cdIfu5BWWKLGNZooBJAM00955xVXCjnXIaMFA8PVPHU3lymV1ukW99LwwWaEdtOyzrZVMIinw_kFKMPGLH19aPOh6zOjA7v_kMJf7fZV06Y3RlfXSqDU8xwfpP0gafviN-QLYVJqgGZHt6dj7-1ERp8euL4UQznSU69UybRLf4poILgS9i7eI7tuvhulrYzVc7n98xUkdPyK_-eG1typfhelUM3c1fyI__7_xPyePO_6XjVmCfkS2onpPvUVjpKdb8buj7sumzoRfRXNEJYI5jSRsYZhqVXJRsergol7UvXb9iAtjeCbSs6Pk19K2edNzv5fePn0s6abdzQMf0Y40zmtYe54FRrKPcvCDTo8OLD8esmwzBnEzzFTNCA2aMdB5l0NvCp8K6wquQRhXF8xCMAWmAuwDa5dyBl0Z4763Ps4CQeC_JoKoreE2oNalNCw42CbkMeWa5VYpLzW0ibAFhh7xqb3e2aOE_ZjGmN8IkYofs31737cMYU6F4zCJrZy1v39yP7C15xKO_hOVtqdklg9X1Gvaiv7Mq3nVC-QfPcQiG
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Memory+Binding+Test+Detects+Early+Subtle+Episodic+Memory+Decline+in+Preclinical+Alzheimer%E2%80%99s+Disease%3A+A+Longitudinal+Study&rft.jtitle=Journal+of+Alzheimer%27s+disease&rft.date=2024-03-19&rft.issn=1387-2877&rft_id=info:doi/10.3233%2Fjad-230921&rft.externalDocID=10.3233%2Fjad-230921
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1387-2877&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1387-2877&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1387-2877&client=summon