GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study
Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin...
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| Published in | Pharmacological research Vol. 212; p. 107575 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.02.2025
Elsevier |
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| Online Access | Get full text |
| ISSN | 1043-6618 1096-1186 1096-1186 |
| DOI | 10.1016/j.phrs.2024.107575 |
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| Abstract | Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response.
CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 1000 Genomes imputed data, testing ∼10 million common genetic variants. GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. Secondary analyses included statin-by-placebo interaction analyses, and lookups in African ancestry cohorts.
Our GWAS identified two genome-wide significant (P < 5e-8) loci: APOE and HNF1A for CRP statin response corrected for baseline CRP. The missense lead variant rs429358 at APOE, contributing to the APOE-E4 haplotype, is a risk locus for dyslipidaemia, Alzheimer’s and coronary artery disease (CAD). The HNF1A locus is associated with diabetes, cholesterol levels, and CAD. Both loci are also associated with baseline CRP levels, and neither locus achieved a significant (P < 0.05) result from the statin v. placebo interaction meta-analysis using randomized clinical trial data. However, the interaction result (P-int=0.09) for APOE was suggestive and possibly underpowered.
The APOE-E4 signal may therefore be associated with both CRP and LDL-cholesterol statin response. Combined with suggestions in the literature that APOE also leads to differential statin benefit in Alzheimer’s, the APOE locus warrants further investigation for potential genetic effects on healthcare with statin treatment.
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| AbstractList | Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response.CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 1000 Genomes imputed data, testing ∼10 million common genetic variants. GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. Secondary analyses included statin-by-placebo interaction analyses, and lookups in African ancestry cohorts.Our GWAS identified two genome-wide significant (P < 5e-8) loci: APOE and HNF1A for CRP statin response corrected for baseline CRP. The missense lead variant rs429358 at APOE, contributing to the APOE-E4 haplotype, is a risk locus for dyslipidaemia, Alzheimer’s and coronary artery disease (CAD). The HNF1A locus is associated with diabetes, cholesterol levels, and CAD. Both loci are also associated with baseline CRP levels, and neither locus achieved a significant (P < 0.05) result from the statin v. placebo interaction meta-analysis using randomized clinical trial data. However, the interaction result (P-int=0.09) for APOE was suggestive and possibly underpowered.The APOE-E4 signal may therefore be associated with both CRP and LDL-cholesterol statin response. Combined with suggestions in the literature that APOE also leads to differential statin benefit in Alzheimer’s, the APOE locus warrants further investigation for potential genetic effects on healthcare with statin treatment. Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 1000 Genomes imputed data, testing ∼10 million common genetic variants. GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. Secondary analyses included statin-by-placebo interaction analyses, and lookups in African ancestry cohorts. Our GWAS identified two genome-wide significant (P < 5e-8) loci: APOE and HNF1A for CRP statin response corrected for baseline CRP. The missense lead variant rs429358 at APOE, contributing to the APOE-E4 haplotype, is a risk locus for dyslipidaemia, Alzheimer's and coronary artery disease (CAD). The HNF1A locus is associated with diabetes, cholesterol levels, and CAD. Both loci are also associated with baseline CRP levels, and neither locus achieved a significant (P < 0.05) result from the statin v. placebo interaction meta-analysis using randomized clinical trial data. However, the interaction result (P-int=0.09) for APOE was suggestive and possibly underpowered. The APOE-E4 signal may therefore be associated with both CRP and LDL-cholesterol statin response. Combined with suggestions in the literature that APOE also leads to differential statin benefit in Alzheimer's, the APOE locus warrants further investigation for potential genetic effects on healthcare with statin treatment.Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 1000 Genomes imputed data, testing ∼10 million common genetic variants. GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. Secondary analyses included statin-by-placebo interaction analyses, and lookups in African ancestry cohorts. Our GWAS identified two genome-wide significant (P < 5e-8) loci: APOE and HNF1A for CRP statin response corrected for baseline CRP. The missense lead variant rs429358 at APOE, contributing to the APOE-E4 haplotype, is a risk locus for dyslipidaemia, Alzheimer's and coronary artery disease (CAD). The HNF1A locus is associated with diabetes, cholesterol levels, and CAD. Both loci are also associated with baseline CRP levels, and neither locus achieved a significant (P < 0.05) result from the statin v. placebo interaction meta-analysis using randomized clinical trial data. However, the interaction result (P-int=0.09) for APOE was suggestive and possibly underpowered. The APOE-E4 signal may therefore be associated with both CRP and LDL-cholesterol statin response. Combined with suggestions in the literature that APOE also leads to differential statin benefit in Alzheimer's, the APOE locus warrants further investigation for potential genetic effects on healthcare with statin treatment. Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 1000 Genomes imputed data, testing ∼10 million common genetic variants. GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. Secondary analyses included statin-by-placebo interaction analyses, and lookups in African ancestry cohorts. Our GWAS identified two genome-wide significant (P < 5e-8) loci: APOE and HNF1A for CRP statin response corrected for baseline CRP. The missense lead variant rs429358 at APOE, contributing to the APOE-E4 haplotype, is a risk locus for dyslipidaemia, Alzheimer’s and coronary artery disease (CAD). The HNF1A locus is associated with diabetes, cholesterol levels, and CAD. Both loci are also associated with baseline CRP levels, and neither locus achieved a significant (P < 0.05) result from the statin v. placebo interaction meta-analysis using randomized clinical trial data. However, the interaction result (P-int=0.09) for APOE was suggestive and possibly underpowered. The APOE-E4 signal may therefore be associated with both CRP and LDL-cholesterol statin response. Combined with suggestions in the literature that APOE also leads to differential statin benefit in Alzheimer’s, the APOE locus warrants further investigation for potential genetic effects on healthcare with statin treatment. [Display omitted] |
| ArticleNumber | 107575 |
| Author | Vasan, Ramachandran S. Deshmukh, Harshal Tardif, Jean-Claude Asselin, Geraldine Taylor, Kent D. Noordam, Raymond Caulfield, Mark J. Post, Wendy S. Paul, Dirk S. Trompet, Stella Benjamin, Emelia J. Hitman, Graham A. Heard-Costa, Nancy L. Chen, Y.-D. Ida Theusch, Elizabeth Li, Xiaohui Chasman, Daniel I. Krauss, Ronald M. Dubé, Marie-Pierre Rotter, Jerome I. Magavern, Emma F. Munroe, Patricia B. Jukema, J.Wouter Ridker, Paul M. Warren, Helen R. Seeman, Teresa E. |
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| Cites_doi | 10.1136/jmedgenet-2016-103966 10.1093/brain/awad188 10.1038/ng.3404 10.1093/bioinformatics/btq340 10.1007/s10753-011-9348-y 10.1038/s41591-024-02931-w 10.1016/S0140-6736(03)14571-0 10.1093/bioinformatics/btab186 10.1038/s41588-018-0084-1 10.1186/s13195-017-0237-y 10.1016/j.atherosclerosis.2005.12.012 10.1161/01.CIR.101.12.1366 10.1038/ng.2213 10.1016/j.ajhg.2008.03.015 10.1016/0021-9150(95)05571-D 10.1016/j.ajhg.2010.11.011 10.2337/dc11-0323 10.1056/NEJMoa0807646 10.1001/jama.1997.03550160069041 10.1016/j.ajhg.2018.09.009 10.1093/eurheartj/ehz455 10.1186/s12864-016-2712-4 10.1093/bioinformatics/btw373 10.1038/ncomms6068 10.1038/sj.gene.6364289 10.1186/1471-2350-12-123 10.1001/jama.286.1.64 10.1007/s00125-022-05806-2 10.1161/01.CIR.100.3.230 10.1093/ije/dyab050 10.1111/cge.13178 10.1016/j.ajhg.2008.03.017 10.1161/CIRCGENETICS.111.961847 10.1007/s40265-023-01858-9 10.1038/nprot.2014.071 10.1016/j.atherosclerosis.2021.05.007 |
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| Keywords | Pharmacogenetics Pharmacology GWAS C-Reactive Protein Treatment Response Statins |
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| References | Yang, Lee, Goddard, Visscher (bib17) 2011; 88 Mach, Baigent, Catapano (bib1) 2020; 41 Albert, Danielson, Rifai, Ridker (bib4) 2001; 286 Tennant, Arnold, Ellison, Gilthorpe (bib42) 2022; 51 Pazzucconi, Dorigotti, Gianfranceschi (bib5) 1995; 117 Yang, Ferreira, Morris (bib16) 2012; 44 Theusch ETSLLDHGJJRCDWH (bib29) 2023; 88 Boughton, Welch, Flickinger (bib13) 2021; 37 Lee, Hong, Kang (bib38) 2023; 18 Eiriksdottir, Aspelund, Bjarnadottir (bib33) 2006; 186 Ridker, Rifai, Pfeffer, Sacks, Braunwald (bib3) 1999; 100 Reiner, Barber, Guan (bib23) 2008; 82 Cummings (bib35) 2023; 83 Farrer (bib20) 1997; 278 Postmus, Warren, Trompet (bib9) 2016; 53 Smit, Noordam, le Cessie, Trompet, Jukema (bib18) 2018; 93 Middelberg, Ferreira, Henders (bib28) 2011; 12 Postmus, Trompet, Deshmukh (bib6) 2014; 5 Finucane, Bulik-Sullivan, Gusev (bib15) 2015; 47 Smit, Trompet, Leong (bib8) 2020; 20 Chu, Guilianini, Barratt, Nyberg, Chasman, Ridker (bib10) 2012; 5 Chasman, Kozlowski, Zee, Kwiatkowski, Ridker (bib25) 2006; 7 Pearson, Starkey, Powell, Gribble, Clark, Hattersley (bib39) 2003; 362 Gerdes, Gerdes, Kervinen (bib37) 2000; 101 Winkler, Day, Croteau-Chonka (bib11) 2014; 9 Ligthart, Vaez, Hsu (bib22) 2016; 17 Staley, Blackshaw, Kamat (bib14) 2016; 32 Trompet, Postmus, Warren (bib7) 2022 Corder, Saunders, Strittmatter (bib30) 1993; 261 Ridker, Danielson, Fonseca (bib2) 2008; 359 Wu, McDade, Kuzawa (bib27) 2012; 35 Khalil, Rabès, Boileau, Varret (bib19) 2021; 328 Stalbow, Preuss, Smit (bib41) 2023; 66 Geifman, Brinton, Kennedy, Schneider, Butte (bib31) 2017; 9 Royall, Palmer (bib32) 2023 Hampel, Elhage, Cho, Apostolova, Nicoll, Atri (bib34) 2023; 146 McDonald, Shields, Lawry (bib40) 2011; 34 Mahajan, Wessel, Willems (bib24) 2018; 50 Fortea, Pegueroles, Alcolea (bib36) 2024; 30 Willer, Li, Abecasis (bib12) 2010; 26 Ligthart, Vaez, Võsa (bib26) 2018; 103 Ridker, Pare, Parker (bib21) 2008; 82 Albert (10.1016/j.phrs.2024.107575_bib4) 2001; 286 McDonald (10.1016/j.phrs.2024.107575_bib40) 2011; 34 Winkler (10.1016/j.phrs.2024.107575_bib11) 2014; 9 Fortea (10.1016/j.phrs.2024.107575_bib36) 2024; 30 Cummings (10.1016/j.phrs.2024.107575_bib35) 2023; 83 Mach (10.1016/j.phrs.2024.107575_bib1) 2020; 41 Postmus (10.1016/j.phrs.2024.107575_bib9) 2016; 53 Wu (10.1016/j.phrs.2024.107575_bib27) 2012; 35 Corder (10.1016/j.phrs.2024.107575_bib30) 1993; 261 Tennant (10.1016/j.phrs.2024.107575_bib42) 2022; 51 Geifman (10.1016/j.phrs.2024.107575_bib31) 2017; 9 Boughton (10.1016/j.phrs.2024.107575_bib13) 2021; 37 Royall (10.1016/j.phrs.2024.107575_bib32) 2023 Yang (10.1016/j.phrs.2024.107575_bib16) 2012; 44 Mahajan (10.1016/j.phrs.2024.107575_bib24) 2018; 50 Trompet (10.1016/j.phrs.2024.107575_bib7) 2022 Ligthart (10.1016/j.phrs.2024.107575_bib22) 2016; 17 Khalil (10.1016/j.phrs.2024.107575_bib19) 2021; 328 Ligthart (10.1016/j.phrs.2024.107575_bib26) 2018; 103 Gerdes (10.1016/j.phrs.2024.107575_bib37) 2000; 101 Stalbow (10.1016/j.phrs.2024.107575_bib41) 2023; 66 Ridker (10.1016/j.phrs.2024.107575_bib2) 2008; 359 Ridker (10.1016/j.phrs.2024.107575_bib21) 2008; 82 Postmus (10.1016/j.phrs.2024.107575_bib6) 2014; 5 Middelberg (10.1016/j.phrs.2024.107575_bib28) 2011; 12 Willer (10.1016/j.phrs.2024.107575_bib12) 2010; 26 Theusch ETSLLDHGJJRCDWH (10.1016/j.phrs.2024.107575_bib29) 2023; 88 Finucane (10.1016/j.phrs.2024.107575_bib15) 2015; 47 Eiriksdottir (10.1016/j.phrs.2024.107575_bib33) 2006; 186 Chu (10.1016/j.phrs.2024.107575_bib10) 2012; 5 Chasman (10.1016/j.phrs.2024.107575_bib25) 2006; 7 Pazzucconi (10.1016/j.phrs.2024.107575_bib5) 1995; 117 Smit (10.1016/j.phrs.2024.107575_bib8) 2020; 20 Hampel (10.1016/j.phrs.2024.107575_bib34) 2023; 146 Lee (10.1016/j.phrs.2024.107575_bib38) 2023; 18 Staley (10.1016/j.phrs.2024.107575_bib14) 2016; 32 Farrer (10.1016/j.phrs.2024.107575_bib20) 1997; 278 Yang (10.1016/j.phrs.2024.107575_bib17) 2011; 88 Reiner (10.1016/j.phrs.2024.107575_bib23) 2008; 82 Pearson (10.1016/j.phrs.2024.107575_bib39) 2003; 362 Smit (10.1016/j.phrs.2024.107575_bib18) 2018; 93 Ridker (10.1016/j.phrs.2024.107575_bib3) 1999; 100 |
| References_xml | – year: 2023 ident: bib32 article-title: Statin use moderates publication-title: Alzheimer’S. Dement. – volume: 9 start-page: 1192 year: 2014 end-page: 1212 ident: bib11 article-title: Quality control and conduct of genome-wide association meta-analyses publication-title: Nat. Protoc. – volume: 7 start-page: 211 year: 2006 end-page: 219 ident: bib25 article-title: Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein publication-title: Genes Immun. – volume: 328 start-page: 11 year: 2021 end-page: 22 ident: bib19 article-title: APOE gene variants in primary dyslipidemia publication-title: Atherosclerosis – volume: 12 start-page: 123 year: 2011 ident: bib28 article-title: Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits publication-title: BMC Med Genet – volume: 186 start-page: 222 year: 2006 end-page: 224 ident: bib33 article-title: Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study publication-title: Atherosclerosis – volume: 82 start-page: 1193 year: 2008 end-page: 1201 ident: bib23 article-title: Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein publication-title: Am. J. Hum. Genet. – volume: 53 start-page: 835 year: 2016 end-page: 845 ident: bib9 article-title: Meta-analysis of genome-wide association studies of HDL cholesterol response to statins publication-title: J. Med Genet – volume: 5 start-page: 5068 year: 2014 ident: bib6 article-title: Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins publication-title: Nat. Commun. – volume: 51 start-page: 1604 year: 2022 end-page: 1615 ident: bib42 article-title: Analyses of ‘change scores’ do not estimate causal effects in observational data publication-title: Int J. Epidemiol. – volume: 359 start-page: 2195 year: 2008 end-page: 2207 ident: bib2 article-title: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein publication-title: New Engl. J. Med. – volume: 146 start-page: 4414 year: 2023 end-page: 4424 ident: bib34 article-title: Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics publication-title: Brain – volume: 5 start-page: 58 year: 2012 end-page: 65 ident: bib10 article-title: Pharmacogenetic determinants of statin-induced reductions in C-reactive protein publication-title: Circ. Cardiovasc Genet – volume: 50 start-page: 559 year: 2018 end-page: 571 ident: bib24 article-title: Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes publication-title: Nat. Genet – volume: 88 start-page: 1 year: 2023 end-page: 72 ident: bib29 article-title: 51st European Mathematical Genetics Meeting (EMGM) 2023.P22 publication-title: Hum. Hered. – volume: 26 start-page: 2190 year: 2010 end-page: 2191 ident: bib12 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics – start-page: 12 year: 2022 ident: bib7 article-title: The pharmacogenetics of statin therapy on clinical events: no evidence that genetic variation affects statin response on myocardial infarction publication-title: Front Pharm. – volume: 82 start-page: 1185 year: 2008 end-page: 1192 ident: bib21 article-title: Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women’s Genome Health Study publication-title: Am. J. Hum. Genet. – volume: 35 start-page: 574 year: 2012 end-page: 583 ident: bib27 article-title: Genome-wide Association with C-Reactive Protein Levels in CLHNS: Evidence for the CRP and HNF1A Loci and their Interaction with Exposure to a Pathogenic Environment publication-title: Inflammation – volume: 17 start-page: 443 year: 2016 ident: bib22 article-title: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation publication-title: BMC Genom. – volume: 66 start-page: 116 year: 2023 end-page: 126 ident: bib41 article-title: The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations publication-title: Diabetologia – volume: 101 start-page: 1366 year: 2000 end-page: 1371 ident: bib37 article-title: The apolipoprotein ε4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction publication-title: Circulation – volume: 37 start-page: 3017 year: 2021 end-page: 3018 ident: bib13 article-title: LocusZoom.js: interactive and embeddable visualization of genetic association study results publication-title: Bioinformatics – volume: 103 start-page: 691 year: 2018 end-page: 706 ident: bib26 article-title: Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders publication-title: Am. J. Hum. Genet. – volume: 83 start-page: 569 year: 2023 end-page: 576 ident: bib35 article-title: Anti-amyloid monoclonal antibodies are transformative treatments that redefine Alzheimer’s disease therapeutics publication-title: Drugs – volume: 44 start-page: 369 year: 2012 end-page: 375 ident: bib16 article-title: Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits publication-title: Nat. Genet – volume: 9 start-page: 10 year: 2017 ident: bib31 article-title: Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease publication-title: Alzheimers Res Ther. – volume: 20 start-page: 462 year: 2020 end-page: 470 ident: bib8 article-title: Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study publication-title: Pharm. J. – volume: 34 start-page: 1860 year: 2011 end-page: 1862 ident: bib40 article-title: High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes publication-title: Diabetes Care – volume: 93 start-page: 498 year: 2018 end-page: 507 ident: bib18 article-title: A critical appraisal of pharmacogenetic inference publication-title: Clin. Genet – volume: 362 start-page: 1275 year: 2003 end-page: 1281 ident: bib39 article-title: Genetic cause of hyperglycaemia and response to treatment in diabetes publication-title: Lancet – volume: 41 start-page: 111 year: 2020 end-page: 188 ident: bib1 article-title: 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk publication-title: Eur. Heart J. – volume: 100 start-page: 230 year: 1999 end-page: 235 ident: bib3 article-title: Long-term effects of pravastatin on plasma concentration of C-reactive protein publication-title: Circulation – volume: 47 start-page: 1228 year: 2015 end-page: 1235 ident: bib15 article-title: Partitioning heritability by functional annotation using genome-wide association summary statistics publication-title: Nat. Genet – volume: 18 year: 2023 ident: bib38 article-title: Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial publication-title: . Publ. Online Oct. – volume: 286 start-page: 64 year: 2001 ident: bib4 article-title: for the PRINCE Investigators. Effect of Statin Therapy on C-Reactive Protein Levels publication-title: JAMA – volume: 32 start-page: 3207 year: 2016 end-page: 3209 ident: bib14 article-title: PhenoScanner: a database of human genotype–phenotype associations publication-title: Bioinformatics – volume: 30 start-page: 1284 year: 2024 end-page: 1291 ident: bib36 article-title: APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease publication-title: Nat. Med – volume: 117 start-page: 189 year: 1995 end-page: 198 ident: bib5 article-title: Therapy with HMG CoA reductase inhibitors: characteristics of the long-term permanence of hypocholesterolemic activity publication-title: Atherosclerosis – volume: 88 start-page: 76 year: 2011 end-page: 82 ident: bib17 article-title: GCTA: a tool for genome-wide complex trait analysis publication-title: Am. J. Hum. Genet – volume: 261 start-page: 921 year: 1993 end-page: 923 ident: bib30 article-title: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families publication-title: Science (1979) – volume: 278 start-page: 1349 year: 1997 ident: bib20 article-title: Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease publication-title: JAMA – volume: 53 start-page: 835 issue: 12 year: 2016 ident: 10.1016/j.phrs.2024.107575_bib9 article-title: Meta-analysis of genome-wide association studies of HDL cholesterol response to statins publication-title: J. Med Genet doi: 10.1136/jmedgenet-2016-103966 – volume: 146 start-page: 4414 issue: 11 year: 2023 ident: 10.1016/j.phrs.2024.107575_bib34 article-title: Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics publication-title: Brain doi: 10.1093/brain/awad188 – volume: 47 start-page: 1228 issue: 11 year: 2015 ident: 10.1016/j.phrs.2024.107575_bib15 article-title: Partitioning heritability by functional annotation using genome-wide association summary statistics publication-title: Nat. Genet doi: 10.1038/ng.3404 – volume: 26 start-page: 2190 issue: 17 year: 2010 ident: 10.1016/j.phrs.2024.107575_bib12 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 20 start-page: 462 issue: 3 year: 2020 ident: 10.1016/j.phrs.2024.107575_bib8 article-title: Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study publication-title: Pharm. J. – volume: 35 start-page: 574 issue: 2 year: 2012 ident: 10.1016/j.phrs.2024.107575_bib27 article-title: Genome-wide Association with C-Reactive Protein Levels in CLHNS: Evidence for the CRP and HNF1A Loci and their Interaction with Exposure to a Pathogenic Environment publication-title: Inflammation doi: 10.1007/s10753-011-9348-y – volume: 30 start-page: 1284 issue: 5 year: 2024 ident: 10.1016/j.phrs.2024.107575_bib36 article-title: APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease publication-title: Nat. Med doi: 10.1038/s41591-024-02931-w – volume: 362 start-page: 1275 issue: 9392 year: 2003 ident: 10.1016/j.phrs.2024.107575_bib39 article-title: Genetic cause of hyperglycaemia and response to treatment in diabetes publication-title: Lancet doi: 10.1016/S0140-6736(03)14571-0 – volume: 18 year: 2023 ident: 10.1016/j.phrs.2024.107575_bib38 article-title: Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial publication-title: BMJ. Publ. Online Oct. – volume: 37 start-page: 3017 issue: 18 year: 2021 ident: 10.1016/j.phrs.2024.107575_bib13 article-title: LocusZoom.js: interactive and embeddable visualization of genetic association study results publication-title: Bioinformatics doi: 10.1093/bioinformatics/btab186 – volume: 50 start-page: 559 issue: 4 year: 2018 ident: 10.1016/j.phrs.2024.107575_bib24 article-title: Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes publication-title: Nat. Genet doi: 10.1038/s41588-018-0084-1 – volume: 9 start-page: 10 issue: 1 year: 2017 ident: 10.1016/j.phrs.2024.107575_bib31 article-title: Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease publication-title: Alzheimers Res Ther. doi: 10.1186/s13195-017-0237-y – start-page: 12 year: 2022 ident: 10.1016/j.phrs.2024.107575_bib7 article-title: The pharmacogenetics of statin therapy on clinical events: no evidence that genetic variation affects statin response on myocardial infarction publication-title: Front Pharm. – volume: 186 start-page: 222 issue: 1 year: 2006 ident: 10.1016/j.phrs.2024.107575_bib33 article-title: Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.12.012 – volume: 101 start-page: 1366 issue: 12 year: 2000 ident: 10.1016/j.phrs.2024.107575_bib37 article-title: The apolipoprotein ε4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction publication-title: Circulation doi: 10.1161/01.CIR.101.12.1366 – volume: 44 start-page: 369 issue: 4 year: 2012 ident: 10.1016/j.phrs.2024.107575_bib16 article-title: Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits publication-title: Nat. Genet doi: 10.1038/ng.2213 – year: 2023 ident: 10.1016/j.phrs.2024.107575_bib32 article-title: Statin use moderates APOE’s and CRP’s associations with dementia and is associated with lesser dementia severity in ε4 carriers publication-title: Alzheimer’S. Dement. – volume: 82 start-page: 1185 issue: 5 year: 2008 ident: 10.1016/j.phrs.2024.107575_bib21 article-title: Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women’s Genome Health Study publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.03.015 – volume: 117 start-page: 189 issue: 2 year: 1995 ident: 10.1016/j.phrs.2024.107575_bib5 article-title: Therapy with HMG CoA reductase inhibitors: characteristics of the long-term permanence of hypocholesterolemic activity publication-title: Atherosclerosis doi: 10.1016/0021-9150(95)05571-D – volume: 88 start-page: 76 issue: 1 year: 2011 ident: 10.1016/j.phrs.2024.107575_bib17 article-title: GCTA: a tool for genome-wide complex trait analysis publication-title: Am. J. Hum. Genet doi: 10.1016/j.ajhg.2010.11.011 – volume: 34 start-page: 1860 issue: 8 year: 2011 ident: 10.1016/j.phrs.2024.107575_bib40 article-title: High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes publication-title: Diabetes Care doi: 10.2337/dc11-0323 – volume: 261 start-page: 921 issue: 5123 year: 1993 ident: 10.1016/j.phrs.2024.107575_bib30 article-title: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families publication-title: Science (1979) – volume: 359 start-page: 2195 issue: 21 year: 2008 ident: 10.1016/j.phrs.2024.107575_bib2 article-title: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein publication-title: New Engl. J. Med. doi: 10.1056/NEJMoa0807646 – volume: 278 start-page: 1349 issue: 16 year: 1997 ident: 10.1016/j.phrs.2024.107575_bib20 article-title: Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease publication-title: JAMA doi: 10.1001/jama.1997.03550160069041 – volume: 103 start-page: 691 issue: 5 year: 2018 ident: 10.1016/j.phrs.2024.107575_bib26 article-title: Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2018.09.009 – volume: 41 start-page: 111 issue: 1 year: 2020 ident: 10.1016/j.phrs.2024.107575_bib1 article-title: 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehz455 – volume: 17 start-page: 443 issue: 1 year: 2016 ident: 10.1016/j.phrs.2024.107575_bib22 article-title: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation publication-title: BMC Genom. doi: 10.1186/s12864-016-2712-4 – volume: 32 start-page: 3207 issue: 20 year: 2016 ident: 10.1016/j.phrs.2024.107575_bib14 article-title: PhenoScanner: a database of human genotype–phenotype associations publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw373 – volume: 5 start-page: 5068 issue: 1 year: 2014 ident: 10.1016/j.phrs.2024.107575_bib6 article-title: Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins publication-title: Nat. Commun. doi: 10.1038/ncomms6068 – volume: 7 start-page: 211 issue: 3 year: 2006 ident: 10.1016/j.phrs.2024.107575_bib25 article-title: Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein publication-title: Genes Immun. doi: 10.1038/sj.gene.6364289 – volume: 12 start-page: 123 issue: 1 year: 2011 ident: 10.1016/j.phrs.2024.107575_bib28 article-title: Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits publication-title: BMC Med Genet doi: 10.1186/1471-2350-12-123 – volume: 286 start-page: 64 issue: 1 year: 2001 ident: 10.1016/j.phrs.2024.107575_bib4 article-title: for the PRINCE Investigators. Effect of Statin Therapy on C-Reactive Protein Levels publication-title: JAMA doi: 10.1001/jama.286.1.64 – volume: 66 start-page: 116 issue: 1 year: 2023 ident: 10.1016/j.phrs.2024.107575_bib41 article-title: The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations publication-title: Diabetologia doi: 10.1007/s00125-022-05806-2 – volume: 100 start-page: 230 issue: 3 year: 1999 ident: 10.1016/j.phrs.2024.107575_bib3 article-title: Long-term effects of pravastatin on plasma concentration of C-reactive protein publication-title: Circulation doi: 10.1161/01.CIR.100.3.230 – volume: 51 start-page: 1604 issue: 5 year: 2022 ident: 10.1016/j.phrs.2024.107575_bib42 article-title: Analyses of ‘change scores’ do not estimate causal effects in observational data publication-title: Int J. Epidemiol. doi: 10.1093/ije/dyab050 – volume: 93 start-page: 498 issue: 3 year: 2018 ident: 10.1016/j.phrs.2024.107575_bib18 article-title: A critical appraisal of pharmacogenetic inference publication-title: Clin. Genet doi: 10.1111/cge.13178 – volume: 82 start-page: 1193 issue: 5 year: 2008 ident: 10.1016/j.phrs.2024.107575_bib23 article-title: Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.03.017 – volume: 5 start-page: 58 issue: 1 year: 2012 ident: 10.1016/j.phrs.2024.107575_bib10 article-title: Pharmacogenetic determinants of statin-induced reductions in C-reactive protein publication-title: Circ. Cardiovasc Genet doi: 10.1161/CIRCGENETICS.111.961847 – volume: 83 start-page: 569 issue: 7 year: 2023 ident: 10.1016/j.phrs.2024.107575_bib35 article-title: Anti-amyloid monoclonal antibodies are transformative treatments that redefine Alzheimer’s disease therapeutics publication-title: Drugs doi: 10.1007/s40265-023-01858-9 – volume: 88 start-page: 1 issue: . 1 year: 2023 ident: 10.1016/j.phrs.2024.107575_bib29 article-title: 51st European Mathematical Genetics Meeting (EMGM) 2023.P22 publication-title: Hum. Hered. – volume: 9 start-page: 1192 issue: 5 year: 2014 ident: 10.1016/j.phrs.2024.107575_bib11 article-title: Quality control and conduct of genome-wide association meta-analyses publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.071 – volume: 328 start-page: 11 year: 2021 ident: 10.1016/j.phrs.2024.107575_bib19 article-title: APOE gene variants in primary dyslipidemia publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2021.05.007 |
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| Snippet | Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of... |
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| SubjectTerms | Aged Apolipoproteins E - genetics C-Reactive Protein C-Reactive Protein - metabolism Female Genome-Wide Association Study GWAS Hepatocyte Nuclear Factor 1-alpha - genetics Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Middle Aged Pharmacogenetics Pharmacology Polymorphism, Single Nucleotide Statins Treatment Response White People - genetics |
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| Title | GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study |
| URI | https://dx.doi.org/10.1016/j.phrs.2024.107575 https://www.ncbi.nlm.nih.gov/pubmed/39798939 https://www.proquest.com/docview/3154886608 https://doaj.org/article/2f1a2fa11fa44e9e8688f44ae10f03e9 |
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