Investigation of Possible Link Between Interferon-α and Lyme Disease

• Published in: Emerging infectious diseases Vol. 29; no. 11; p. 2409
• Main Authors: Alaedini, Armin, Crow, Mary K., Fallon, Brian A., Jacek, Elzbieta, Wormser, Gary P.
• Format: Journal Article
• Language: English
• Published: Atlanta Centers for Disease Control and Prevention 01.11.2023
• Subjects: bacteria; Borrelia burgdorferi; Health care networks; Interferon; Interferon-α; Investigation of Possible Link Between Interferon-α and Lyme Disease; Letter; Lyme disease; Post-treatment Lyme disease symptoms; Vector-borne diseases; New York; Lehigh Valley; United States > US; Pennsylvania
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2911.230839

In our study, we decided to evaluate the potential role of IFN-α in this particular group of patients with posttreatment Lyme disease symptoms (PTLDS), based on the extensive animal and human data that connect IFN-α with adverse cognitive, neuropsychiatric, and behavioral manifestations. Direct quantitation of IFN-α can be challenging, as highlighted by the fact that concentrations for some study participants in the Hernandez et al. article appeared to fall below the limit of quantitation, thus complicating the analysis and interpretation of the data. Columbia University, New York, New York, USA (A. Alaedini, B.A. Fallon); New York Medical College, Valhalla, New York, USA (A. Alaedini, G.P. Wormser); Hospital for Special Surgery, New York (M.K. Crow); The New York State Psychiatric Institute, New York (B.A. Fallon); Lehigh Valley Health Network, Allentown, Pennsylvania, USA (E. Jacek) Hernández SA, Ogrinc K, Korva M, Kastrin A, Bogovič P, Rojko T, et al. Google Scholar Armin Alaedini , Mary K. Crow, Brian A. Fallon, Elzbieta Jacek, and Gary P. Wormser Columbia University, New York, New York, USA (A. Alaedini, B.A. Fallon); New York Medical College, Valhalla, New York, USA (A. Alaedini, G.P. Wormser); Hospital for Special Surgery, New York (M.K. Crow); The New York State Psychiatric Institute, New York (B.A. Fallon); Lehigh Valley Health Network, Allentown, Pennsylvania, USA (E. Jacek)