Genome instability, cancer and aging
DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of individual organisms. The cellular response to DNA damage can be roughly divided in two parts. First, when damage is severe, programmed cell dea...
Saved in:
| Published in | Biochimica et biophysica acta Vol. 1790; no. 10; pp. 963 - 969 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.10.2009
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/j.bbagen.2009.03.020 |
Cover
| Abstract | DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of individual organisms. The cellular response to DNA damage can be roughly divided in two parts. First, when damage is severe, programmed cell death may occur or, alternatively, temporary or permanent cell cycle arrest. This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage can be repaired through one or more of the many sophisticated genome maintenance pathways. However, erroneous DNA repair and incomplete restoration of chromatin after damage is resolved, produce mutations and epimutations, respectively, both of which have been shown to accumulate with age. An increased burden of mutations and/or epimutations in aged tissues increases cancer risk and adversely affects gene transcriptional regulation, leading to progressive decline in organ function. Cellular degeneration and uncontrolled cell proliferation are both major hallmarks of aging. Despite the fact that one seems to exclude the other, they both may be driven by a common mechanism. Here, we review age-related changes in the mammalian genome and their possible functional consequences, with special emphasis on genome instability in stem/progenitor cells. |
|---|---|
| AbstractList | DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of individual organisms. The cellular response to DNA damage can be roughly divided in two parts. First, when damage is severe, programmed cell death may occur or, alternatively, temporary or permanent cell cycle arrest. This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage can be repaired through one or more of the many sophisticated genome maintenance pathways. However, erroneous DNA repair and incomplete restoration of chromatin after damage is resolved, produce mutations and epimutations, respectively, both of which have been shown to accumulate with age. An increased burden of mutations and/or epimutations in aged tissues increases cancer risk and adversely affects gene transcriptional regulation, leading to progressive decline in organ function. Cellular degeneration and uncontrolled cell proliferation are both major hallmarks of aging. Despite the fact that one seems to exclude the other, they both may be driven by a common mechanism. Here, we review age-related changes in the mammalian genome and their possible functional consequences, with special emphasis on genome instability in stem/progenitor cells. DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of individual organisms. The cellular response to DNA damage can be roughly divided in two parts. First, when damage is severe, programmed cell death may occur or, alternatively, temporary or permanent cell cycle arrest. This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage can be repaired through one or more of the many sophisticated genome maintenance pathways. However, erroneous DNA repair and incomplete restoration of chromatin after damage is resolved, produce mutations and epimutations, respectively, both of which have been shown to accumulate with age. An increased burden of mutations and/or epimutations in aged tissues increases cancer risk and adversely affects gene transcriptional regulation, leading to progressive decline in organ function. Cellular degeneration and uncontrolled cell proliferation are both major hallmarks of aging. Despite the fact that one seems to exclude the other, they both may be driven by a common mechanism. Here, we review age-related changes in the mammalian genome and their possible functional consequences, with special emphasis on genome instability in stem/progenitor cells.DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of individual organisms. The cellular response to DNA damage can be roughly divided in two parts. First, when damage is severe, programmed cell death may occur or, alternatively, temporary or permanent cell cycle arrest. This protects against cancer but can have negative effects on the long term, e.g., by depleting stem cell reservoirs. Second, damage can be repaired through one or more of the many sophisticated genome maintenance pathways. However, erroneous DNA repair and incomplete restoration of chromatin after damage is resolved, produce mutations and epimutations, respectively, both of which have been shown to accumulate with age. An increased burden of mutations and/or epimutations in aged tissues increases cancer risk and adversely affects gene transcriptional regulation, leading to progressive decline in organ function. Cellular degeneration and uncontrolled cell proliferation are both major hallmarks of aging. Despite the fact that one seems to exclude the other, they both may be driven by a common mechanism. Here, we review age-related changes in the mammalian genome and their possible functional consequences, with special emphasis on genome instability in stem/progenitor cells. |
| Author | Maslov, Alexander Y. Vijg, Jan |
| Author_xml | – sequence: 1 givenname: Alexander Y. surname: Maslov fullname: Maslov, Alexander Y. email: amaslov@aecom.yu.edu – sequence: 2 givenname: Jan surname: Vijg fullname: Vijg, Jan email: jvijg@aecom.yu.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19344750$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkctKAzEUhoNUtF7eQKQLwY0znplkMh0XgohWoeBG1yHJnKkp06Qm00Lf3pTW60KzySL_5eR8B6RnnUVCTjJIM8j45TRVSk7QpjlAlQJNIYcd0s-GZZ4MAXiP9IECS1jGi31yEMIU4imqYo_sZxVlrCygT85GaN0MB8aGTirTmm51MdDSavQDaeuBnBg7OSK7jWwDHm_vQ_Jyf_d8-5CMn0aPtzfjRMeSLhnSpsllQRXLVV7zRmleMlVpzkDRYV5WlLNaNhIYk2VRcsp1zbMCACsApSk9JNeb3PlCzbDWaDsvWzH3Zib9SjhpxM8Xa17FxC0FowWrKMSA822Ad28LDJ2YmaCxbaVFtwiipCyWc1pF5en3qs-Oj81EAdsItHcheGy-JCDWAMRUbACINQABVEQA0Xb1y6ZNJzvj1gOb9j_z9v8Yl7w06EXQBiOL2njUnaid-TvgHXGtofE |
| CitedBy_id | crossref_primary_10_1016_j_molcel_2010_08_015 crossref_primary_10_1093_hmg_ddv612 crossref_primary_10_1016_j_arr_2016_05_005 crossref_primary_10_1111_acel_13084 crossref_primary_10_1016_j_dnarep_2022_103323 crossref_primary_10_31083_j_fbl2809230 crossref_primary_10_1111_j_1474_9726_2010_00577_x crossref_primary_10_1371_journal_pcbi_1003006 crossref_primary_10_1038_s41598_018_34580_8 crossref_primary_10_1186_s13039_020_00488_0 crossref_primary_10_1074_mcp_M115_052167 crossref_primary_10_1186_s12862_016_0743_8 crossref_primary_10_1177_0300060513487631 crossref_primary_10_1007_s10495_012_0711_8 crossref_primary_10_1007_s11357_012_9477_8 crossref_primary_10_1083_jcb_201010131 crossref_primary_10_1111_j_1349_7006_2012_02290_x crossref_primary_10_1002_mc_20791 crossref_primary_10_1007_s11538_014_0027_7 crossref_primary_10_3390_molecules22010105 crossref_primary_10_1093_nar_gks312 crossref_primary_10_1258_ebm_2012_011421 crossref_primary_10_14336_AD_2017_0103 crossref_primary_10_1002_cbin_11504 crossref_primary_10_3109_01480545_2012_737803 crossref_primary_10_1111_acel_12118 crossref_primary_10_1089_rej_2020_2388 crossref_primary_10_1016_j_mrfmmm_2015_03_014 crossref_primary_10_1523_JNEUROSCI_1634_10_2010 crossref_primary_10_1186_s13104_024_06927_0 crossref_primary_10_1210_er_2009_0039 crossref_primary_10_14336_AD_2024_0579 crossref_primary_10_3389_fnagi_2020_00136 crossref_primary_10_1016_j_febslet_2014_02_011 crossref_primary_10_1126_scisignal_296pe73 crossref_primary_10_3390_cells12081156 crossref_primary_10_1093_genetics_iyab028 crossref_primary_10_3724_abbs_2022054 crossref_primary_10_7554_eLife_34836 crossref_primary_10_1128_EC_00097_10 crossref_primary_10_1053_j_gastro_2020_08_018 crossref_primary_10_1016_j_mad_2011_01_004 crossref_primary_10_18632_oncotarget_5786 crossref_primary_10_1242_jcs_067306 crossref_primary_10_1089_dna_2011_1596 crossref_primary_10_4236_fns_2012_32026 crossref_primary_10_1039_c0ib00117a crossref_primary_10_1016_j_ceb_2012_10_004 crossref_primary_10_1016_j_mrfmmm_2015_03_006 crossref_primary_10_1016_j_mad_2012_11_001 crossref_primary_10_1080_24709360_2024_2443714 crossref_primary_10_3390_antiox8110528 crossref_primary_10_1016_j_arr_2019_100995 crossref_primary_10_1016_j_mad_2018_02_002 crossref_primary_10_1016_j_mehy_2012_02_004 crossref_primary_10_1089_scd_2009_0264 crossref_primary_10_18632_oncotarget_7958 crossref_primary_10_1038_s41467_022_32583_8 crossref_primary_10_1371_journal_pone_0085609 crossref_primary_10_1128_MCB_00453_10 crossref_primary_10_1126_sciadv_aax2659 crossref_primary_10_1371_journal_pone_0106471 crossref_primary_10_1007_s10522_023_10035_0 crossref_primary_10_1016_j_mad_2016_03_007 crossref_primary_10_1038_srep32566 crossref_primary_10_1074_jbc_M109_064444 crossref_primary_10_1186_s40659_016_0095_2 crossref_primary_10_3390_ijms13056492 crossref_primary_10_1074_jbc_M113_480459 crossref_primary_10_1534_g3_113_010108 crossref_primary_10_1038_leu_2012_241 crossref_primary_10_1089_scd_2016_0356 crossref_primary_10_1002_gepi_21618 crossref_primary_10_1371_journal_pone_0065731 crossref_primary_10_1111_php_12406 crossref_primary_10_1016_j_cell_2013_06_051 crossref_primary_10_1016_j_febslet_2010_11_016 crossref_primary_10_1007_s11357_011_9216_6 crossref_primary_10_1016_j_mrfmmm_2015_07_010 |
| Cites_doi | 10.1523/JNEUROSCI.4608-03.2004 10.1093/genetics/156.3.927 10.1111/j.1474-9728.2004.00082.x 10.1016/j.cell.2005.02.003 10.1016/S1521-6616(03)00203-1 10.1073/pnas.96.16.9230 10.1523/JNEUROSCI.4560-04.2005 10.1038/nature05862 10.1634/stemcells.2005-0345 10.1038/377657a0 10.1016/j.abb.2003.12.022 10.1016/j.gene.2003.08.025 10.1111/j.1474-9728.2004.00128.x 10.1046/j.1474-9728.2003.00048.x 10.1101/gad.14.4.397 10.1038/nrm2241 10.1371/journal.pbio.0020137 10.1073/pnas.162369899 10.1111/j.1749-6632.1992.tb27437.x 10.1038/415045a 10.1016/0165-1110(81)90011-7 10.1126/science.1079161 10.1038/nature03260 10.1016/0047-6374(79)90083-6 10.1126/science.1065521 10.1016/j.tig.2008.11.007 10.1038/nature04958 10.1038/nature05092 10.1016/0092-8674(82)90248-3 10.1038/270301a0 10.1038/nature05091 10.1016/S0047-6374(02)00028-3 10.1016/j.mad.2007.05.004 10.1371/journal.pcbi.0030170 10.1101/gr.125502 10.1038/ng0894-536 10.1196/annals.1297.094 10.4161/cc.4.3.1518 10.1016/j.stem.2007.03.002 10.1038/433581a 10.1093/hmg/5.2.215 10.1098/rspb.1962.0065 10.1016/S0960-9822(00)00447-4 10.1006/jtbi.2001.2430 10.1038/35092592 10.1073/pnas.0500398102 10.1038/35041682 10.1148/49.3.349 10.1073/pnas.45.1.30 10.1016/j.cell.2008.10.025 10.1371/journal.pbio.0050201 10.1038/nature05159 10.1038/nrm2450 10.1126/science.1087573 10.1038/sj.onc.1208615 10.1101/gad.1067403 10.1016/j.cell.2007.01.030 10.1385/CBB:40:1:1 10.1038/362709a0 10.1038/nrg1673 10.1152/ajpcell.1989.256.6.C1262 10.1038/356215a0 10.1111/j.1749-6632.1958.tb46828.x 10.1038/nrc1073 10.1158/0008-5472.CAN-07-1670 10.5194/bg-3-281-2006 10.1002/mus.880050213 10.1126/science.66.1699.84 10.1016/j.mrgentox.2003.09.010 10.1038/nature04844 |
| ContentType | Journal Article |
| Copyright | 2009 Elsevier B.V. 2009 Elsevier B.V. All rights reserved 2009 |
| Copyright_xml | – notice: 2009 Elsevier B.V. – notice: 2009 Elsevier B.V. All rights reserved 2009 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.bbagen.2009.03.020 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1872-8006 |
| EndPage | 969 |
| ExternalDocumentID | PMC4354930 19344750 10_1016_j_bbagen_2009_03_020 S0304416509000749 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: AG20438 – fundername: NIA NIH HHS grantid: R01 AG020438 – fundername: NIEHS NIH HHS grantid: ES11044 – fundername: NIEHS NIH HHS grantid: U01 ES011044 – fundername: NIA NIH HHS grantid: P01 AG017242 – fundername: NIA NIH HHS grantid: AG17242 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH -~X .55 .GJ AAYJJ ABJNI AFFNX AI. CGR CUY CVF ECM EIF F5P H~9 K-O MVM NPM RIG TWZ UHS VH1 X7M Y6R YYP ZE2 ZGI ~KM 7X8 5PM |
| ID | FETCH-LOGICAL-c416t-83ff2a53b42b2d6fbc674b9c640b38279364dafa044a757636cd61500e900bc33 |
| IEDL.DBID | AIKHN |
| ISSN | 0304-4165 0006-3002 |
| IngestDate | Thu Aug 21 18:21:38 EDT 2025 Fri Sep 05 04:11:31 EDT 2025 Thu Apr 03 07:03:15 EDT 2025 Tue Jul 01 00:21:55 EDT 2025 Thu Apr 24 23:12:45 EDT 2025 Fri Feb 23 02:32:39 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Senescence DNA damage Stem cell Aging Genome instability Epimutation Cancer Apoptosis |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c416t-83ff2a53b42b2d6fbc674b9c640b38279364dafa044a757636cd61500e900bc33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 19344750 |
| PQID | 734044639 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4354930 proquest_miscellaneous_734044639 pubmed_primary_19344750 crossref_primary_10_1016_j_bbagen_2009_03_020 crossref_citationtrail_10_1016_j_bbagen_2009_03_020 elsevier_sciencedirect_doi_10_1016_j_bbagen_2009_03_020 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-10-01 |
| PublicationDateYYYYMMDD | 2009-10-01 |
| PublicationDate_xml | – month: 10 year: 2009 text: 2009-10-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biochimica et biophysica acta |
| PublicationTitleAlternate | Biochim Biophys Acta |
| PublicationYear | 2009 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Charlesworth (bib3) 2000; 156 K.W. Kinzler, B. Vogelstein, Cancer-susceptibility genes. Gatekeepers and caretakers, Nature 386 (1997) 761, 763. Collins, Sedivy (bib57) 2003; 2 Molofsky, Slutsky, Joseph (bib59) 2006; 443 Bailey, Maslov, Pruitt (bib44) 2004; 3 Kirkwood (bib4) 1977; 270 Sharpless, Bardeesy, Lee (bib61) 2001; 413 Sheckley (bib75) 1978 Ruzankina, Pinzon-Guzman, Asare (bib67) 2007; 1 Maynard Smith (bib13) 1962; 157 de Klein, Muijtjens, van Os (bib71) 2000; 10 Vijg (bib5) 2007 Cairns (bib42) 2002; 99 Janzen, Forkert, Fleming (bib58) 2006; 443 Dollé, Vijg (bib20) 2002; 12 Kastan, Gowans, Lieberman (bib25) 1982; 30 Shao, Deng, Henegariu (bib45) 1999; 96 Khrapko, Vijg (bib6) 2009; 25 Failla (bib11) 1958; 71 Campisi (bib38) 2005; 120 Russell, Selby, von Halle, Sheridan, Valcovic (bib14) 1981; 86 Fraser, Hirsh, Giaever, Kumm, Eisen (bib31) 2004; 2 Collins, Cadet, Moller, Poulsen, Vina (bib8) 2004; 423 Harding, Pompei, Lee, Wilson (bib62) 2008; 68 Brown, Baltimore (bib72) 2000; 14 Gavrilov, Gavrilova (bib32) 2001; 213 Conboy, Rando (bib52) 2005; 4 de Duve (bib1) 2005; 433 Finch, Kirkwood (bib30) 1999 Bahar, Hartmann, Rodriguez (bib29) 2006; 441 Carlson, Faulkner (bib53) 1989; 256 Bortoli, Renault, Eveno, Auffray, Butler-Browne, Pietu (bib56) 2003; 321 Gavrilov, Gavrilova (bib35) 2004; 1019 Kamminga, de Haan (bib48) 2006; 24 Vijg, Dolle (bib41) 2007; 128 Chambers, Shaw, Gatza, Fisk, Donehower, Goodell (bib49) 2007; 5 Maslov, Barone, Plunkett, Pruitt (bib43) 2004; 24 Kaya, Marcos, Yanikoglu, Creus (bib15) 2004; 557 Vijg, Dollé (bib19) 2002; 123 Sharpless, DePinho (bib73) 2007; 8 Fraga, Ballestar, Paz (bib21) 2005; 102 Issa (bib22) 2003; 109 Muller (bib9) 1927; 66 Donehower, Harvey, Slagle (bib66) 1992; 356 Szilard (bib12) 1959; 45 Bergman, Atzmon, Ye, MacCarthy, Barzilai (bib34) 2007; 3 Groth, Rocha, Verreault, Almouzni (bib26) 2007; 128 Zacks, Sheff (bib54) 1982; 5 Oberdoerffer, Michan, McVay (bib28) 2008; 135 Kirkwood, Austad (bib33) 2000; 408 Campisi (bib37) 2003; 3 Rando (bib50) 2006; 441 Friedberg, Walker, Siede, Wood, Schultz, Ellenberger (bib2) 2006 Henshaw, Riley, Stapleton (bib10) 1947; 49 Young, Duplaa, Romero-Ramos (bib36) 2004; 40 Boerrigter, Dolle, Martus, Gossen, Vijg (bib18) 1995; 377 Brown, Baltimore (bib69) 2003; 17 Chakalova, Debrand, Mitchell, Osborne, Fraser (bib27) 2005; 6 Cimprich, Cortez (bib68) 2008; 9 Krishnamurthy, Ramsey, Ligon (bib60) 2006; 443 Rehen, Yung, McCreight (bib16) 2005; 25 Hasty, Campisi, Hoeijmakers, van Steeg, Vijg (bib39) 2003; 299 Cortez, Guntuku, Qin, Elledge (bib70) 2001; 294 Slagboom, Vijg (bib23) 1992; 673 Tyner, Venkatachalam, Choi (bib63) 2002; 415 Zhuravlev, Avetisov (bib74) 2006 Harris, Levine (bib65) 2005; 24 Lindahl (bib7) 1993; 362 Rossi, Bryder, Seita, Nussenzweig, Hoeijmakers, Weissman (bib46) 2007; 447 Harrison (bib47) 1979; 9 Conboy, Conboy, Smythe, Rando (bib51) 2003; 302 Issa, Ottaviano, Celano, Hamilton, Davidson, Baylin (bib24) 1994; 7 Hasty, Vijg (bib40) 2004; 3 Martin, Ogburn, Colgin, Gown, Edland, Monnat (bib17) 1996; 5 Conboy, Conboy, Wagers, Girma, Weissman, Rando (bib55) 2005; 433 Bergman (10.1016/j.bbagen.2009.03.020_bib34) 2007; 3 Collins (10.1016/j.bbagen.2009.03.020_bib57) 2003; 2 de Duve (10.1016/j.bbagen.2009.03.020_bib1) 2005; 433 Friedberg (10.1016/j.bbagen.2009.03.020_bib2) 2006 Khrapko (10.1016/j.bbagen.2009.03.020_bib6) 2009; 25 Kastan (10.1016/j.bbagen.2009.03.020_bib25) 1982; 30 Campisi (10.1016/j.bbagen.2009.03.020_bib37) 2003; 3 Janzen (10.1016/j.bbagen.2009.03.020_bib58) 2006; 443 Rossi (10.1016/j.bbagen.2009.03.020_bib46) 2007; 447 Tyner (10.1016/j.bbagen.2009.03.020_bib63) 2002; 415 Maynard Smith (10.1016/j.bbagen.2009.03.020_bib13) 1962; 157 Chakalova (10.1016/j.bbagen.2009.03.020_bib27) 2005; 6 Conboy (10.1016/j.bbagen.2009.03.020_bib52) 2005; 4 Boerrigter (10.1016/j.bbagen.2009.03.020_bib18) 1995; 377 Groth (10.1016/j.bbagen.2009.03.020_bib26) 2007; 128 Szilard (10.1016/j.bbagen.2009.03.020_bib12) 1959; 45 Bortoli (10.1016/j.bbagen.2009.03.020_bib56) 2003; 321 Muller (10.1016/j.bbagen.2009.03.020_bib9) 1927; 66 Fraser (10.1016/j.bbagen.2009.03.020_bib31) 2004; 2 Vijg (10.1016/j.bbagen.2009.03.020_bib41) 2007; 128 Cimprich (10.1016/j.bbagen.2009.03.020_bib68) 2008; 9 Zhuravlev (10.1016/j.bbagen.2009.03.020_bib74) 2006 Rehen (10.1016/j.bbagen.2009.03.020_bib16) 2005; 25 Failla (10.1016/j.bbagen.2009.03.020_bib11) 1958; 71 Conboy (10.1016/j.bbagen.2009.03.020_bib55) 2005; 433 Harding (10.1016/j.bbagen.2009.03.020_bib62) 2008; 68 Hasty (10.1016/j.bbagen.2009.03.020_bib40) 2004; 3 Molofsky (10.1016/j.bbagen.2009.03.020_bib59) 2006; 443 Collins (10.1016/j.bbagen.2009.03.020_bib8) 2004; 423 Bailey (10.1016/j.bbagen.2009.03.020_bib44) 2004; 3 Brown (10.1016/j.bbagen.2009.03.020_bib72) 2000; 14 Bahar (10.1016/j.bbagen.2009.03.020_bib29) 2006; 441 de Klein (10.1016/j.bbagen.2009.03.020_bib71) 2000; 10 Oberdoerffer (10.1016/j.bbagen.2009.03.020_bib28) 2008; 135 Hasty (10.1016/j.bbagen.2009.03.020_bib39) 2003; 299 Vijg (10.1016/j.bbagen.2009.03.020_bib5) 2007 Sheckley (10.1016/j.bbagen.2009.03.020_bib75) 1978 Cairns (10.1016/j.bbagen.2009.03.020_bib42) 2002; 99 Maslov (10.1016/j.bbagen.2009.03.020_bib43) 2004; 24 Rando (10.1016/j.bbagen.2009.03.020_bib50) 2006; 441 Charlesworth (10.1016/j.bbagen.2009.03.020_bib3) 2000; 156 Henshaw (10.1016/j.bbagen.2009.03.020_bib10) 1947; 49 Chambers (10.1016/j.bbagen.2009.03.020_bib49) 2007; 5 Kirkwood (10.1016/j.bbagen.2009.03.020_bib4) 1977; 270 Russell (10.1016/j.bbagen.2009.03.020_bib14) 1981; 86 Dollé (10.1016/j.bbagen.2009.03.020_bib20) 2002; 12 Conboy (10.1016/j.bbagen.2009.03.020_bib51) 2003; 302 Kaya (10.1016/j.bbagen.2009.03.020_bib15) 2004; 557 Krishnamurthy (10.1016/j.bbagen.2009.03.020_bib60) 2006; 443 Issa (10.1016/j.bbagen.2009.03.020_bib22) 2003; 109 Martin (10.1016/j.bbagen.2009.03.020_bib17) 1996; 5 Lindahl (10.1016/j.bbagen.2009.03.020_bib7) 1993; 362 Carlson (10.1016/j.bbagen.2009.03.020_bib53) 1989; 256 Sharpless (10.1016/j.bbagen.2009.03.020_bib61) 2001; 413 Ruzankina (10.1016/j.bbagen.2009.03.020_bib67) 2007; 1 Vijg (10.1016/j.bbagen.2009.03.020_bib19) 2002; 123 Young (10.1016/j.bbagen.2009.03.020_bib36) 2004; 40 Campisi (10.1016/j.bbagen.2009.03.020_bib38) 2005; 120 Issa (10.1016/j.bbagen.2009.03.020_bib24) 1994; 7 Zacks (10.1016/j.bbagen.2009.03.020_bib54) 1982; 5 Brown (10.1016/j.bbagen.2009.03.020_bib69) 2003; 17 Fraga (10.1016/j.bbagen.2009.03.020_bib21) 2005; 102 Kirkwood (10.1016/j.bbagen.2009.03.020_bib33) 2000; 408 Kamminga (10.1016/j.bbagen.2009.03.020_bib48) 2006; 24 Donehower (10.1016/j.bbagen.2009.03.020_bib66) 1992; 356 Sharpless (10.1016/j.bbagen.2009.03.020_bib73) 2007; 8 Slagboom (10.1016/j.bbagen.2009.03.020_bib23) 1992; 673 Shao (10.1016/j.bbagen.2009.03.020_bib45) 1999; 96 Finch (10.1016/j.bbagen.2009.03.020_bib30) 1999 Harrison (10.1016/j.bbagen.2009.03.020_bib47) 1979; 9 Harris (10.1016/j.bbagen.2009.03.020_bib65) 2005; 24 Gavrilov (10.1016/j.bbagen.2009.03.020_bib32) 2001; 213 10.1016/j.bbagen.2009.03.020_bib64 Gavrilov (10.1016/j.bbagen.2009.03.020_bib35) 2004; 1019 Cortez (10.1016/j.bbagen.2009.03.020_bib70) 2001; 294 16456126 - Stem Cells. 2006 May;24(5):1143-9 7139710 - Cell. 1982 Sep;30(2):509-16 10691732 - Genes Dev. 2000 Feb 15;14(4):397-402 15247076 - Ann N Y Acad Sci. 2004 Jun;1019:509-12 15745943 - J Neurosci. 2005 Mar 2;25(9):2176-80 17784782 - PLoS Comput Biol. 2007 Aug;3(8):e170 17676974 - PLoS Biol. 2007 Aug;5(8):e201 11089980 - Nature. 2000 Nov 9;408(6809):233-8 12044939 - Mech Ageing Dev. 2002 Apr 30;123(8):907-15 12610296 - Science. 2003 Feb 28;299(5611):1355-9 12882406 - Aging Cell. 2003 Jun;2(3):145-50 12629044 - Genes Dev. 2003 Mar 1;17 (5):615-28 18371340 - Cell Stem Cell. 2007 Jun 7;1(1):113-26 17802387 - Science. 1927 Jul 22;66(1699):84-7 19110336 - Trends Genet. 2009 Feb;25(2):91-8 593350 - Nature. 1977 Nov 24;270(5635):301-4 7951326 - Nat Genet. 1994 Aug;7(4):536-40 9126728 - Nature. 1997 Apr 24;386(6627):761, 763 16094312 - Nat Rev Genet. 2005 Sep;6(9):669-77 16957737 - Nature. 2006 Sep 28;443(7110):453-7 7566182 - Nature. 1995 Oct 19;377(6550):657-9 20266009 - Radiology. 1947 Sep;49(3):349-60 19041753 - Cell. 2008 Nov 28;135(5):907-18 15124029 - PLoS Biol. 2004 Jun;2(6):e137 10801416 - Curr Biol. 2000 Apr 20;10(8):479-82 12149477 - Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10567-70 1552940 - Nature. 1992 Mar 19;356(6366):215-21 1485735 - Ann N Y Acad Sci. 1992 Dec 26;673:58-69 14637002 - Gene. 2003 Dec 4;321:145-54 17717515 - Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13 14645852 - Science. 2003 Nov 28;302(5650):1575-7 16009939 - Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9 15038819 - Aging Cell. 2004 Apr;3(2):55-65 12724732 - Nat Rev Cancer. 2003 May;3(5):339-49 15725724 - Cell Cycle. 2005 Mar;4(3):407-10 16810243 - Nature. 2006 Jun 29;441(7097):1080-6 16957735 - Nature. 2006 Sep 28;443(7110):421-6 15734683 - Cell. 2005 Feb 25;120(4):513-22 15569356 - Aging Cell. 2004 Dec;3(6):391-7 7070396 - Muscle Nerve. 1982 Feb;5(2):152-61 14983110 - Cell Biochem Biophys. 2004;40(1):1-80 10430925 - Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9230-5 15838523 - Oncogene. 2005 Apr 18;24(17):2899-908 8824877 - Hum Mol Genet. 1996 Feb;5(2):215-21 18594563 - Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27 11780111 - Nature. 2002 Jan 3;415(6867):45-53 11544531 - Nature. 2001 Sep 6;413(6851):86-91 16791200 - Nature. 2006 Jun 22;441(7096):1011-4 37377 - Mech Ageing Dev. 1979 Mar;9(5-6):427-33 7029265 - Mutat Res. 1981 May;86(3):355-79 11063673 - Genetics. 2000 Nov;156(3):927-31 14585281 - Clin Immunol. 2003 Oct;109(1):103-8 16957738 - Nature. 2006 Sep 28;443(7110):448-52 17617443 - Mech Ageing Dev. 2007 Jul-Aug;128(7-8):466-8 14989265 - Arch Biochem Biophys. 2004 Mar 1;423(1):57-65 17320509 - Cell. 2007 Feb 23;128(4):721-33 8469282 - Nature. 1993 Apr 22;362(6422):709-15 18519710 - Cancer Res. 2008 Jun 1;68(11):4465-78 14973255 - J Neurosci. 2004 Feb 18;24(7):1726-33 11721054 - Science. 2001 Nov 23;294(5547):1713-6 11742523 - J Theor Biol. 2001 Dec 21;213(4):527-45 2735398 - Am J Physiol. 1989 Jun;256(6 Pt 1):C1262-6 15716955 - Nature. 2005 Feb 17;433(7027):760-4 13583876 - Ann N Y Acad Sci. 1958 Sep 30;71(6):1124-40 12421760 - Genome Res. 2002 Nov;12(11):1732-8 14706518 - Mutat Res. 2004 Jan 10;557(1):53-62 15703726 - Nature. 2005 Feb 10;433(7026):581-2 16590351 - Proc Natl Acad Sci U S A. 1959 Jan;45(1):30-45 17554309 - Nature. 2007 Jun 7;447(7145):725-9 |
| References_xml | – volume: 25 start-page: 91 year: 2009 end-page: 98 ident: bib6 article-title: Mitochondrial DNA mutations and aging: devils in the details? publication-title: Trends Genet. – volume: 270 start-page: 301 year: 1977 end-page: 304 ident: bib4 article-title: Evolution of ageing publication-title: Nature – volume: 443 start-page: 453 year: 2006 end-page: 457 ident: bib60 article-title: p16INK4a induces an age-dependent decline in islet regenerative potential publication-title: Nature – volume: 17 start-page: 615 year: 2003 end-page: 628 ident: bib69 article-title: Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance publication-title: Genes Dev. – volume: 10 start-page: 479 year: 2000 end-page: 482 ident: bib71 article-title: Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice publication-title: Curr. Biol. – volume: 25 start-page: 2176 year: 2005 end-page: 2180 ident: bib16 article-title: Constitutional aneuploidy in the normal human brain publication-title: J. Neurosci. – volume: 673 start-page: 58 year: 1992 end-page: 69 ident: bib23 article-title: The dynamics of genome organization and expression during the aging process publication-title: Ann. N.Y. Acad. Sci. – volume: 362 start-page: 709 year: 1993 end-page: 715 ident: bib7 article-title: Instability and decay of the primary structure of DNA publication-title: Nature – volume: 441 start-page: 1080 year: 2006 end-page: 1086 ident: bib50 article-title: Stem cells, ageing and the quest for immortality publication-title: Nature – volume: 3 start-page: e170 year: 2007 ident: bib34 article-title: Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging publication-title: PLoS Comput. Biol. – volume: 294 start-page: 1713 year: 2001 end-page: 1716 ident: bib70 article-title: ATR and ATRIP: partners in checkpoint signaling publication-title: Science – volume: 256 start-page: C1262 year: 1989 end-page: 1266 ident: bib53 article-title: Muscle transplantation between young and old rats: age of host determines recovery publication-title: Am. J. Physiol. – volume: 7 start-page: 536 year: 1994 end-page: 540 ident: bib24 article-title: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon publication-title: Nat. Genet. – volume: 408 start-page: 233 year: 2000 end-page: 238 ident: bib33 article-title: Why do we age? publication-title: Nature – volume: 96 start-page: 9230 year: 1999 end-page: 9235 ident: bib45 article-title: Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 30 start-page: 509 year: 1982 end-page: 516 ident: bib25 article-title: Methylation of deoxycytidine incorporated by excision–repair synthesis of DNA publication-title: Cell – year: 1978 ident: bib75 article-title: Pilgrimage to Earth – volume: 302 start-page: 1575 year: 2003 end-page: 1577 ident: bib51 article-title: Notch-mediated restoration of regenerative potential to aged muscle publication-title: Science – volume: 557 start-page: 53 year: 2004 end-page: 62 ident: bib15 article-title: Evaluation of the genotoxicity of four herbicides in the wing spot test of publication-title: Mutat. Res. – volume: 1019 start-page: 509 year: 2004 end-page: 512 ident: bib35 article-title: The reliability-engineering approach to the problem of biological aging publication-title: Ann. N.Y. Acad. Sci. – volume: 109 start-page: 103 year: 2003 end-page: 108 ident: bib22 article-title: Age-related epigenetic changes and the immune system publication-title: Clin. Immunol. – year: 1999 ident: bib30 article-title: Chance, Development, and Aging – volume: 377 start-page: 657 year: 1995 end-page: 659 ident: bib18 article-title: Plasmid-based transgenic mouse model for studying in vivo mutations publication-title: Nature – volume: 433 start-page: 581 year: 2005 end-page: 582 ident: bib1 article-title: The onset of selection publication-title: Nature – volume: 128 start-page: 721 year: 2007 end-page: 733 ident: bib26 article-title: Chromatin challenges during DNA replication and repair publication-title: Cell – volume: 66 start-page: 84 year: 1927 end-page: 87 ident: bib9 article-title: Artificial transmutation of the gene publication-title: Science – volume: 443 start-page: 448 year: 2006 end-page: 452 ident: bib59 article-title: Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing publication-title: Nature – volume: 3 start-page: 339 year: 2003 end-page: 349 ident: bib37 article-title: Cancer and ageing: rival demons? publication-title: Nat. Rev. Cancer – start-page: 281 year: 2006 end-page: 291 ident: bib74 article-title: The definition of life in the context of its origin publication-title: Biogeosciences – volume: 213 start-page: 527 year: 2001 end-page: 545 ident: bib32 article-title: The reliability theory of aging and longevity publication-title: J. Theor. Biol. – volume: 123 start-page: 907 year: 2002 end-page: 915 ident: bib19 article-title: Large genome rearrangements as a primary cause of aging publication-title: Mech. Ageing Dev. – volume: 9 start-page: 616 year: 2008 end-page: 627 ident: bib68 article-title: ATR: an essential regulator of genome integrity publication-title: Nat. Rev. Mol. Cell Biol. – volume: 99 start-page: 10567 year: 2002 end-page: 10570 ident: bib42 article-title: Somatic stem cells and the kinetics of mutagenesis and carcinogenesis publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 433 start-page: 760 year: 2005 end-page: 764 ident: bib55 article-title: Rejuvenation of aged progenitor cells by exposure to a young systemic environment publication-title: Nature – volume: 447 start-page: 725 year: 2007 end-page: 729 ident: bib46 article-title: Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age publication-title: Nature – volume: 24 start-page: 1726 year: 2004 end-page: 1733 ident: bib43 article-title: Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice publication-title: J. Neurosci. – volume: 128 start-page: 466 year: 2007 end-page: 468 ident: bib41 article-title: Genome instability: cancer or aging? publication-title: Mech. Ageing Dev. – volume: 157 start-page: 115 year: 1962 end-page: 127 ident: bib13 article-title: Review lectures on senescence. I. The causes of ageing publication-title: Proc. Roy. Soc. B. – volume: 49 start-page: 349 year: 1947 end-page: 364 ident: bib10 article-title: The biologic effects of pile radiations publication-title: Radiology – volume: 5 start-page: 152 year: 1982 end-page: 161 ident: bib54 article-title: Age-related impeded regeneration of mouse minced anterior tibial muscle publication-title: Muscle Nerve – volume: 356 start-page: 215 year: 1992 end-page: 221 ident: bib66 article-title: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours publication-title: Nature – volume: 120 start-page: 513 year: 2005 end-page: 522 ident: bib38 article-title: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors publication-title: Cell – volume: 2 start-page: 145 year: 2003 end-page: 150 ident: bib57 article-title: Involvement of the INK4a/Arf gene locus in senescence publication-title: Aging Cell – volume: 8 start-page: 703 year: 2007 end-page: 713 ident: bib73 article-title: How stem cells age and why this makes us grow old publication-title: Nat. Rev. Mol. Cell Biol. – year: 2006 ident: bib2 article-title: DNA Repair and Mutagenesis – volume: 5 start-page: e201 year: 2007 ident: bib49 article-title: Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation publication-title: PLoS Biol. – volume: 45 start-page: 30 year: 1959 end-page: 45 ident: bib12 article-title: On the nature of the aging process publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 423 start-page: 57 year: 2004 end-page: 65 ident: bib8 article-title: Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? publication-title: Arch. Biochem. Biophys. – volume: 68 start-page: 4465 year: 2008 end-page: 4478 ident: bib62 article-title: Cancer suppression at old age publication-title: Cancer Res. – volume: 299 start-page: 1355 year: 2003 end-page: 1359 ident: bib39 article-title: Aging and genome maintenance: lessons from the mouse? publication-title: Science – volume: 415 start-page: 45 year: 2002 end-page: 53 ident: bib63 article-title: p53 mutant mice that display early ageing-associated phenotypes publication-title: Nature – volume: 4 start-page: 407 year: 2005 end-page: 410 ident: bib52 article-title: Aging, stem cells and tissue regeneration: lessons from muscle publication-title: Cell Cycle – volume: 1 start-page: 113 year: 2007 end-page: 126 ident: bib67 article-title: Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss publication-title: Cell Stem Cell – volume: 156 start-page: 927 year: 2000 end-page: 931 ident: bib3 article-title: Fisher, Medawar, Hamilton and the evolution of aging publication-title: Genetics – volume: 413 start-page: 86 year: 2001 end-page: 91 ident: bib61 article-title: Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis publication-title: Nature – reference: K.W. Kinzler, B. Vogelstein, Cancer-susceptibility genes. Gatekeepers and caretakers, Nature 386 (1997) 761, 763. – volume: 441 start-page: 1011 year: 2006 end-page: 1014 ident: bib29 article-title: Increased cell-to-cell variation in gene expression in ageing mouse heart publication-title: Nature – volume: 5 start-page: 215 year: 1996 end-page: 221 ident: bib17 article-title: Somatic mutations are frequent and increase with age in human kidney epithelial cells publication-title: Hum. Mol. Genet. – volume: 9 start-page: 427 year: 1979 end-page: 433 ident: bib47 article-title: Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations publication-title: Mech. Ageing Dev. – volume: 24 start-page: 2899 year: 2005 end-page: 2908 ident: bib65 article-title: The p53 pathway: positive and negative feedback loops publication-title: Oncogene – volume: 40 start-page: 1 year: 2004 end-page: 80 ident: bib36 article-title: Adult reserve stem cells and their potential for tissue engineering publication-title: Cell Biochem. Biophys. – volume: 135 start-page: 907 year: 2008 end-page: 918 ident: bib28 article-title: SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging publication-title: Cell – volume: 443 start-page: 421 year: 2006 end-page: 426 ident: bib58 article-title: Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a publication-title: Nature – volume: 71 start-page: 1124 year: 1958 end-page: 1140 ident: bib11 article-title: The aging process and cancerogenesis publication-title: Ann. N.Y. Acad. Sci. – volume: 14 start-page: 397 year: 2000 end-page: 402 ident: bib72 article-title: ATR disruption leads to chromosomal fragmentation and early embryonic lethality publication-title: Genes Dev. – volume: 102 start-page: 10604 year: 2005 end-page: 10609 ident: bib21 article-title: Epigenetic differences arise during the lifetime of monozygotic twins publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 321 start-page: 145 year: 2003 end-page: 154 ident: bib56 article-title: Gene expression profiling of human satellite cells during muscular aging using cDNA arrays publication-title: Gene – volume: 86 start-page: 355 year: 1981 end-page: 379 ident: bib14 article-title: Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendations for future work publication-title: Mutat. Res. – volume: 2 start-page: e137 year: 2004 ident: bib31 article-title: Noise minimization in eukaryotic gene expression publication-title: PLoS Biol. – volume: 24 start-page: 1143 year: 2006 end-page: 1149 ident: bib48 article-title: Cellular memory and hematopoietic stem cell aging publication-title: Stem Cells – volume: 12 start-page: 1732 year: 2002 end-page: 1738 ident: bib20 article-title: Genome dynamics in aging mice publication-title: Genome Res. – year: 2007 ident: bib5 article-title: Aging of the Genome – volume: 6 start-page: 669 year: 2005 end-page: 677 ident: bib27 article-title: Replication and transcription: shaping the landscape of the genome publication-title: Nat. Rev. Genet. – volume: 3 start-page: 55 year: 2004 end-page: 65 ident: bib40 article-title: Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity publication-title: Aging Cell – volume: 3 start-page: 391 year: 2004 end-page: 397 ident: bib44 article-title: Accumulation of mutations and somatic selection in aging neural stem/progenitor cells publication-title: Aging Cell – volume: 24 start-page: 1726 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib43 article-title: Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4608-03.2004 – volume: 156 start-page: 927 year: 2000 ident: 10.1016/j.bbagen.2009.03.020_bib3 article-title: Fisher, Medawar, Hamilton and the evolution of aging publication-title: Genetics doi: 10.1093/genetics/156.3.927 – volume: 3 start-page: 55 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib40 article-title: Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity publication-title: Aging Cell doi: 10.1111/j.1474-9728.2004.00082.x – volume: 120 start-page: 513 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib38 article-title: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors publication-title: Cell doi: 10.1016/j.cell.2005.02.003 – volume: 109 start-page: 103 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib22 article-title: Age-related epigenetic changes and the immune system publication-title: Clin. Immunol. doi: 10.1016/S1521-6616(03)00203-1 – volume: 96 start-page: 9230 year: 1999 ident: 10.1016/j.bbagen.2009.03.020_bib45 article-title: Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.96.16.9230 – volume: 25 start-page: 2176 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib16 article-title: Constitutional aneuploidy in the normal human brain publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4560-04.2005 – volume: 447 start-page: 725 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib46 article-title: Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age publication-title: Nature doi: 10.1038/nature05862 – volume: 24 start-page: 1143 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib48 article-title: Cellular memory and hematopoietic stem cell aging publication-title: Stem Cells doi: 10.1634/stemcells.2005-0345 – volume: 377 start-page: 657 year: 1995 ident: 10.1016/j.bbagen.2009.03.020_bib18 article-title: Plasmid-based transgenic mouse model for studying in vivo mutations publication-title: Nature doi: 10.1038/377657a0 – volume: 423 start-page: 57 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib8 article-title: Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2003.12.022 – volume: 321 start-page: 145 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib56 article-title: Gene expression profiling of human satellite cells during muscular aging using cDNA arrays publication-title: Gene doi: 10.1016/j.gene.2003.08.025 – volume: 3 start-page: 391 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib44 article-title: Accumulation of mutations and somatic selection in aging neural stem/progenitor cells publication-title: Aging Cell doi: 10.1111/j.1474-9728.2004.00128.x – volume: 2 start-page: 145 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib57 article-title: Involvement of the INK4a/Arf gene locus in senescence publication-title: Aging Cell doi: 10.1046/j.1474-9728.2003.00048.x – volume: 14 start-page: 397 year: 2000 ident: 10.1016/j.bbagen.2009.03.020_bib72 article-title: ATR disruption leads to chromosomal fragmentation and early embryonic lethality publication-title: Genes Dev. doi: 10.1101/gad.14.4.397 – year: 1978 ident: 10.1016/j.bbagen.2009.03.020_bib75 – volume: 8 start-page: 703 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib73 article-title: How stem cells age and why this makes us grow old publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2241 – volume: 2 start-page: e137 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib31 article-title: Noise minimization in eukaryotic gene expression publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0020137 – volume: 99 start-page: 10567 year: 2002 ident: 10.1016/j.bbagen.2009.03.020_bib42 article-title: Somatic stem cells and the kinetics of mutagenesis and carcinogenesis publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.162369899 – volume: 673 start-page: 58 year: 1992 ident: 10.1016/j.bbagen.2009.03.020_bib23 article-title: The dynamics of genome organization and expression during the aging process publication-title: Ann. N.Y. Acad. Sci. doi: 10.1111/j.1749-6632.1992.tb27437.x – volume: 415 start-page: 45 year: 2002 ident: 10.1016/j.bbagen.2009.03.020_bib63 article-title: p53 mutant mice that display early ageing-associated phenotypes publication-title: Nature doi: 10.1038/415045a – volume: 86 start-page: 355 year: 1981 ident: 10.1016/j.bbagen.2009.03.020_bib14 article-title: Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendations for future work publication-title: Mutat. Res. doi: 10.1016/0165-1110(81)90011-7 – volume: 299 start-page: 1355 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib39 article-title: Aging and genome maintenance: lessons from the mouse? publication-title: Science doi: 10.1126/science.1079161 – volume: 433 start-page: 760 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib55 article-title: Rejuvenation of aged progenitor cells by exposure to a young systemic environment publication-title: Nature doi: 10.1038/nature03260 – volume: 9 start-page: 427 year: 1979 ident: 10.1016/j.bbagen.2009.03.020_bib47 article-title: Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations publication-title: Mech. Ageing Dev. doi: 10.1016/0047-6374(79)90083-6 – volume: 294 start-page: 1713 year: 2001 ident: 10.1016/j.bbagen.2009.03.020_bib70 article-title: ATR and ATRIP: partners in checkpoint signaling publication-title: Science doi: 10.1126/science.1065521 – volume: 25 start-page: 91 year: 2009 ident: 10.1016/j.bbagen.2009.03.020_bib6 article-title: Mitochondrial DNA mutations and aging: devils in the details? publication-title: Trends Genet. doi: 10.1016/j.tig.2008.11.007 – volume: 441 start-page: 1080 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib50 article-title: Stem cells, ageing and the quest for immortality publication-title: Nature doi: 10.1038/nature04958 – volume: 443 start-page: 453 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib60 article-title: p16INK4a induces an age-dependent decline in islet regenerative potential publication-title: Nature doi: 10.1038/nature05092 – volume: 30 start-page: 509 year: 1982 ident: 10.1016/j.bbagen.2009.03.020_bib25 article-title: Methylation of deoxycytidine incorporated by excision–repair synthesis of DNA publication-title: Cell doi: 10.1016/0092-8674(82)90248-3 – volume: 270 start-page: 301 year: 1977 ident: 10.1016/j.bbagen.2009.03.020_bib4 article-title: Evolution of ageing publication-title: Nature doi: 10.1038/270301a0 – volume: 443 start-page: 448 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib59 article-title: Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing publication-title: Nature doi: 10.1038/nature05091 – volume: 123 start-page: 907 year: 2002 ident: 10.1016/j.bbagen.2009.03.020_bib19 article-title: Large genome rearrangements as a primary cause of aging publication-title: Mech. Ageing Dev. doi: 10.1016/S0047-6374(02)00028-3 – volume: 128 start-page: 466 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib41 article-title: Genome instability: cancer or aging? publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2007.05.004 – volume: 3 start-page: e170 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib34 article-title: Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.0030170 – volume: 12 start-page: 1732 year: 2002 ident: 10.1016/j.bbagen.2009.03.020_bib20 article-title: Genome dynamics in aging mice publication-title: Genome Res. doi: 10.1101/gr.125502 – volume: 7 start-page: 536 year: 1994 ident: 10.1016/j.bbagen.2009.03.020_bib24 article-title: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon publication-title: Nat. Genet. doi: 10.1038/ng0894-536 – volume: 1019 start-page: 509 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib35 article-title: The reliability-engineering approach to the problem of biological aging publication-title: Ann. N.Y. Acad. Sci. doi: 10.1196/annals.1297.094 – volume: 4 start-page: 407 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib52 article-title: Aging, stem cells and tissue regeneration: lessons from muscle publication-title: Cell Cycle doi: 10.4161/cc.4.3.1518 – volume: 1 start-page: 113 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib67 article-title: Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.03.002 – volume: 433 start-page: 581 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib1 article-title: The onset of selection publication-title: Nature doi: 10.1038/433581a – volume: 5 start-page: 215 year: 1996 ident: 10.1016/j.bbagen.2009.03.020_bib17 article-title: Somatic mutations are frequent and increase with age in human kidney epithelial cells publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/5.2.215 – volume: 157 start-page: 115 year: 1962 ident: 10.1016/j.bbagen.2009.03.020_bib13 article-title: Review lectures on senescence. I. The causes of ageing publication-title: Proc. Roy. Soc. B. doi: 10.1098/rspb.1962.0065 – volume: 10 start-page: 479 year: 2000 ident: 10.1016/j.bbagen.2009.03.020_bib71 article-title: Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice publication-title: Curr. Biol. doi: 10.1016/S0960-9822(00)00447-4 – volume: 213 start-page: 527 year: 2001 ident: 10.1016/j.bbagen.2009.03.020_bib32 article-title: The reliability theory of aging and longevity publication-title: J. Theor. Biol. doi: 10.1006/jtbi.2001.2430 – volume: 413 start-page: 86 year: 2001 ident: 10.1016/j.bbagen.2009.03.020_bib61 article-title: Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis publication-title: Nature doi: 10.1038/35092592 – volume: 102 start-page: 10604 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib21 article-title: Epigenetic differences arise during the lifetime of monozygotic twins publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0500398102 – volume: 408 start-page: 233 year: 2000 ident: 10.1016/j.bbagen.2009.03.020_bib33 article-title: Why do we age? publication-title: Nature doi: 10.1038/35041682 – volume: 49 start-page: 349 year: 1947 ident: 10.1016/j.bbagen.2009.03.020_bib10 article-title: The biologic effects of pile radiations publication-title: Radiology doi: 10.1148/49.3.349 – volume: 45 start-page: 30 year: 1959 ident: 10.1016/j.bbagen.2009.03.020_bib12 article-title: On the nature of the aging process publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.45.1.30 – volume: 135 start-page: 907 year: 2008 ident: 10.1016/j.bbagen.2009.03.020_bib28 article-title: SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging publication-title: Cell doi: 10.1016/j.cell.2008.10.025 – volume: 5 start-page: e201 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib49 article-title: Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0050201 – volume: 443 start-page: 421 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib58 article-title: Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a publication-title: Nature doi: 10.1038/nature05159 – volume: 9 start-page: 616 year: 2008 ident: 10.1016/j.bbagen.2009.03.020_bib68 article-title: ATR: an essential regulator of genome integrity publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2450 – volume: 302 start-page: 1575 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib51 article-title: Notch-mediated restoration of regenerative potential to aged muscle publication-title: Science doi: 10.1126/science.1087573 – year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib5 – volume: 24 start-page: 2899 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib65 article-title: The p53 pathway: positive and negative feedback loops publication-title: Oncogene doi: 10.1038/sj.onc.1208615 – volume: 17 start-page: 615 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib69 article-title: Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance publication-title: Genes Dev. doi: 10.1101/gad.1067403 – volume: 128 start-page: 721 year: 2007 ident: 10.1016/j.bbagen.2009.03.020_bib26 article-title: Chromatin challenges during DNA replication and repair publication-title: Cell doi: 10.1016/j.cell.2007.01.030 – year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib2 – volume: 40 start-page: 1 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib36 article-title: Adult reserve stem cells and their potential for tissue engineering publication-title: Cell Biochem. Biophys. doi: 10.1385/CBB:40:1:1 – volume: 362 start-page: 709 year: 1993 ident: 10.1016/j.bbagen.2009.03.020_bib7 article-title: Instability and decay of the primary structure of DNA publication-title: Nature doi: 10.1038/362709a0 – volume: 6 start-page: 669 year: 2005 ident: 10.1016/j.bbagen.2009.03.020_bib27 article-title: Replication and transcription: shaping the landscape of the genome publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1673 – volume: 256 start-page: C1262 year: 1989 ident: 10.1016/j.bbagen.2009.03.020_bib53 article-title: Muscle transplantation between young and old rats: age of host determines recovery publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1989.256.6.C1262 – volume: 356 start-page: 215 year: 1992 ident: 10.1016/j.bbagen.2009.03.020_bib66 article-title: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours publication-title: Nature doi: 10.1038/356215a0 – volume: 71 start-page: 1124 year: 1958 ident: 10.1016/j.bbagen.2009.03.020_bib11 article-title: The aging process and cancerogenesis publication-title: Ann. N.Y. Acad. Sci. doi: 10.1111/j.1749-6632.1958.tb46828.x – volume: 3 start-page: 339 year: 2003 ident: 10.1016/j.bbagen.2009.03.020_bib37 article-title: Cancer and ageing: rival demons? publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1073 – volume: 68 start-page: 4465 year: 2008 ident: 10.1016/j.bbagen.2009.03.020_bib62 article-title: Cancer suppression at old age publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-1670 – ident: 10.1016/j.bbagen.2009.03.020_bib64 – start-page: 281 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib74 article-title: The definition of life in the context of its origin publication-title: Biogeosciences doi: 10.5194/bg-3-281-2006 – year: 1999 ident: 10.1016/j.bbagen.2009.03.020_bib30 – volume: 5 start-page: 152 year: 1982 ident: 10.1016/j.bbagen.2009.03.020_bib54 article-title: Age-related impeded regeneration of mouse minced anterior tibial muscle publication-title: Muscle Nerve doi: 10.1002/mus.880050213 – volume: 66 start-page: 84 year: 1927 ident: 10.1016/j.bbagen.2009.03.020_bib9 article-title: Artificial transmutation of the gene publication-title: Science doi: 10.1126/science.66.1699.84 – volume: 557 start-page: 53 year: 2004 ident: 10.1016/j.bbagen.2009.03.020_bib15 article-title: Evaluation of the genotoxicity of four herbicides in the wing spot test of Drosophila melanogaster using two different strains publication-title: Mutat. Res. doi: 10.1016/j.mrgentox.2003.09.010 – volume: 441 start-page: 1011 year: 2006 ident: 10.1016/j.bbagen.2009.03.020_bib29 article-title: Increased cell-to-cell variation in gene expression in ageing mouse heart publication-title: Nature doi: 10.1038/nature04844 – reference: 14989265 - Arch Biochem Biophys. 2004 Mar 1;423(1):57-65 – reference: 12629044 - Genes Dev. 2003 Mar 1;17 (5):615-28 – reference: 10801416 - Curr Biol. 2000 Apr 20;10(8):479-82 – reference: 16957738 - Nature. 2006 Sep 28;443(7110):448-52 – reference: 15716955 - Nature. 2005 Feb 17;433(7027):760-4 – reference: 16590351 - Proc Natl Acad Sci U S A. 1959 Jan;45(1):30-45 – reference: 16456126 - Stem Cells. 2006 May;24(5):1143-9 – reference: 11742523 - J Theor Biol. 2001 Dec 21;213(4):527-45 – reference: 16791200 - Nature. 2006 Jun 22;441(7096):1011-4 – reference: 12610296 - Science. 2003 Feb 28;299(5611):1355-9 – reference: 18371340 - Cell Stem Cell. 2007 Jun 7;1(1):113-26 – reference: 17676974 - PLoS Biol. 2007 Aug;5(8):e201 – reference: 14706518 - Mutat Res. 2004 Jan 10;557(1):53-62 – reference: 14637002 - Gene. 2003 Dec 4;321:145-54 – reference: 14973255 - J Neurosci. 2004 Feb 18;24(7):1726-33 – reference: 14983110 - Cell Biochem Biophys. 2004;40(1):1-80 – reference: 19110336 - Trends Genet. 2009 Feb;25(2):91-8 – reference: 15124029 - PLoS Biol. 2004 Jun;2(6):e137 – reference: 7951326 - Nat Genet. 1994 Aug;7(4):536-40 – reference: 593350 - Nature. 1977 Nov 24;270(5635):301-4 – reference: 14585281 - Clin Immunol. 2003 Oct;109(1):103-8 – reference: 11780111 - Nature. 2002 Jan 3;415(6867):45-53 – reference: 8469282 - Nature. 1993 Apr 22;362(6422):709-15 – reference: 8824877 - Hum Mol Genet. 1996 Feb;5(2):215-21 – reference: 37377 - Mech Ageing Dev. 1979 Mar;9(5-6):427-33 – reference: 7139710 - Cell. 1982 Sep;30(2):509-16 – reference: 7070396 - Muscle Nerve. 1982 Feb;5(2):152-61 – reference: 1552940 - Nature. 1992 Mar 19;356(6366):215-21 – reference: 12149477 - Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10567-70 – reference: 10691732 - Genes Dev. 2000 Feb 15;14(4):397-402 – reference: 15703726 - Nature. 2005 Feb 10;433(7026):581-2 – reference: 16810243 - Nature. 2006 Jun 29;441(7097):1080-6 – reference: 20266009 - Radiology. 1947 Sep;49(3):349-60 – reference: 17320509 - Cell. 2007 Feb 23;128(4):721-33 – reference: 11721054 - Science. 2001 Nov 23;294(5547):1713-6 – reference: 16957735 - Nature. 2006 Sep 28;443(7110):421-6 – reference: 15569356 - Aging Cell. 2004 Dec;3(6):391-7 – reference: 11544531 - Nature. 2001 Sep 6;413(6851):86-91 – reference: 11063673 - Genetics. 2000 Nov;156(3):927-31 – reference: 17784782 - PLoS Comput Biol. 2007 Aug;3(8):e170 – reference: 10430925 - Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9230-5 – reference: 18594563 - Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27 – reference: 9126728 - Nature. 1997 Apr 24;386(6627):761, 763 – reference: 12882406 - Aging Cell. 2003 Jun;2(3):145-50 – reference: 2735398 - Am J Physiol. 1989 Jun;256(6 Pt 1):C1262-6 – reference: 15725724 - Cell Cycle. 2005 Mar;4(3):407-10 – reference: 18519710 - Cancer Res. 2008 Jun 1;68(11):4465-78 – reference: 16957737 - Nature. 2006 Sep 28;443(7110):453-7 – reference: 15038819 - Aging Cell. 2004 Apr;3(2):55-65 – reference: 17554309 - Nature. 2007 Jun 7;447(7145):725-9 – reference: 17717515 - Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13 – reference: 1485735 - Ann N Y Acad Sci. 1992 Dec 26;673:58-69 – reference: 19041753 - Cell. 2008 Nov 28;135(5):907-18 – reference: 7566182 - Nature. 1995 Oct 19;377(6550):657-9 – reference: 15745943 - J Neurosci. 2005 Mar 2;25(9):2176-80 – reference: 15838523 - Oncogene. 2005 Apr 18;24(17):2899-908 – reference: 12044939 - Mech Ageing Dev. 2002 Apr 30;123(8):907-15 – reference: 12421760 - Genome Res. 2002 Nov;12(11):1732-8 – reference: 17802387 - Science. 1927 Jul 22;66(1699):84-7 – reference: 16094312 - Nat Rev Genet. 2005 Sep;6(9):669-77 – reference: 15734683 - Cell. 2005 Feb 25;120(4):513-22 – reference: 16009939 - Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9 – reference: 15247076 - Ann N Y Acad Sci. 2004 Jun;1019:509-12 – reference: 14645852 - Science. 2003 Nov 28;302(5650):1575-7 – reference: 17617443 - Mech Ageing Dev. 2007 Jul-Aug;128(7-8):466-8 – reference: 12724732 - Nat Rev Cancer. 2003 May;3(5):339-49 – reference: 7029265 - Mutat Res. 1981 May;86(3):355-79 – reference: 13583876 - Ann N Y Acad Sci. 1958 Sep 30;71(6):1124-40 – reference: 11089980 - Nature. 2000 Nov 9;408(6809):233-8 |
| SSID | ssj0000595 ssj0025309 |
| Score | 2.3067913 |
| SecondaryResourceType | review_article |
| Snippet | DNA damage-driven genome instability underlies the diversity of life forms generated by the evolutionary process but is detrimental to the somatic cells of... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 963 |
| SubjectTerms | Aging Aging - genetics Animals Apoptosis Apoptosis - genetics Cancer DNA Damage Epimutation Genome instability Genomic Instability Humans Models, Biological Mutation Neoplasms - genetics Senescence Stem cell Stem Cells - metabolism |
| Title | Genome instability, cancer and aging |
| URI | https://dx.doi.org/10.1016/j.bbagen.2009.03.020 https://www.ncbi.nlm.nih.gov/pubmed/19344750 https://www.proquest.com/docview/734044639 https://pubmed.ncbi.nlm.nih.gov/PMC4354930 |
| Volume | 1790 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT-MwEB1BEVouiK-F8qUcOGLqxq5jH1EFFCpxYBfBzYodW3S1pAjKgQu_nbGTAAUkJE6REltxnu2ZF814HsBeiP5IkStCpcsI97xLcuUska4raeEFVTZmW5yLwSU_u-5dz0C_OQsT0ipr21_Z9Git6zudGs3O3WjU-ROCekgn0ONFR6hmYS5Fby9bMHd4OhycvxnkXhRfCe1J6NCcoItpXsbgvi3rwpXsgAbh76891GcG-jGR8p1nOl6CxZpSJofVqJdhxpUrMF-JTD6twK9-o-m2CnsnrhzfumQUSGFMi33aT2yY-PskL4skShatweXx0d_-gNQ6CcTi50yIZN6neY8Znpq0EN5YkXGjrODUMJniDhS8yH2OcOUZ_l8wYYtQB546RM5Yxn5DqxyXbgOSruXGFMYjbZBcZc4oLxz1SAKkQNdetIE12GhbFxEPWhb_dZMt9k9XiAZ9S6Up04hoG8hrr7uqiMY37bMGdj21GDTa-W96Js0saYQ2BD_y0o0fH3TGeIhdM9WG9WrS3oaiYtnD8Nqp6XxtEEpwTz8pRzexFDeSTa4Y3fzxgLdgIcanYnrgNrQm949uB2nOxOzC7MFzd7dezOE6vLgavgAHF_vS |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT8IwFH5BiNGL8bf4cwePVgot3XokRAVBLmrCrVm7NmJ0EMUD_71tt4moCYnXrc2673Xvfct7fR_Aucv-RCzmCEc6RNTQOoq5VijS9QgnhmGufLXFgHUe6e2wOSxBuzgL48oqc9-f-XTvrfMrtRzN2mQ0qt27pJ6lEzbi-UDIV6BCnah1GSqtbq8zmDvkphdfceORm1CcoPNlXlLa7zbNG1eSS-yEv_-OUL8Z6M9Cym-R6XoTNnJKGbSyVW9BSafbsJqJTM62Ya1daLrtwPmNTsevOhg5UujLYmcXgXKGfwviNAm8ZNEuPF5fPbQ7KNdJQMq-zhRFxJhG3CSSNmQjYUYqFlLJFaNYkqhhv0BGk9jEFq44tP8XhKnE9YHH2iInFSF7UE7HqT6AoK6olIk0ljZElIdacsM0NpYERMyG9qQKpMBGqLyJuNOyeBFFtdizyBB1-pZcYCIsolVAX7MmWRONJePDAnaxsBmE9fNLZgaFlYSF1iU_4lSPP95FSKjLXRNehf3MaPOlcN_20D12wZxfA1wL7sU76ejJt-K2ZJNygg__veAzWOs83PVFvzvoHcG6z1X5UsFjKE_fPvSJpTxTeZpv6U8U__wV |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome+instability%2C+cancer+and+aging&rft.jtitle=Biochimica+et+biophysica+acta&rft.au=Maslov%2C+Alexander+Y&rft.au=Vijg%2C+Jan&rft.date=2009-10-01&rft.issn=0006-3002&rft.volume=1790&rft.issue=10&rft.spage=963&rft_id=info:doi/10.1016%2Fj.bbagen.2009.03.020&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon |