Pathway-Based Mendelian Randomization for Pre-Infection IL-6 Levels Highlights Its Role in Coronavirus Disease - Kamali, Zoha; Esmaeil, Nafiseh; Thio, Chris H. L.; Vaez, Ahmad; Snieder, Harold (Genes, 2024)
Keywords: Antagonists; B cells; biomarkers; Biomarkers - blood; blood; Communicable diseases; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - genetics; COVID-19 - virology; COVID-19 infection; Datasets; Disease; disease course; disease severity; Genetics; Genome-Wide Association Study; Genomes; Health aspects; Hospitalization; hospitals; Humans; Infectious diseases; Interleukin 6; Interleukin 6 receptors; Interleukin-6 - blood; Interleukin-6 - genetics; Interleukins; Mendelian Randomization Analysis; Orthocoronavirinae; Polymorphism, Single Nucleotide; prognosis; Proteins; Receptors, Interleukin-6 - blood; Receptors, Interleukin-6 - genetics; risk; SARS-CoV-2; Sensitivity analysis; signal transduction; Signal Transduction - genetics; Statistical significance; Iran; interleukin 6; GWAS; mendelian randomization; severe COVID-19; causality