Super-resolution microscopy: Insights into mitochondria–lysosome crosstalk in health and disease

Live super-resolution microscopy has allowed for new insights into recently identified mitochondria–lysosome contact sites, which mediate crosstalk between mitochondria and lysosomes, including co-regulation of Rab7 GTP hydrolysis and Drp1 GTP hydrolysis. Here, we highlight recent findings and futur...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 222; no. 12; p. 1
Main Authors Leisten, Eric D., Woods, Abby C., Wong, Yvette C.
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 04.12.2023
Subjects
Disease
Dynamins
Guanosine Triphosphate
Hydrolysis
Lysosomes
Microscopy
Mitochondria
Mitochondrial Membranes
Neuroscience
Organelles
rab7 GTP-Binding Proteins
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ISSN0021-9525
1540-8140
1540-8140
DOI10.1083/jcb.202305032

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Summary:Live super-resolution microscopy has allowed for new insights into recently identified mitochondria–lysosome contact sites, which mediate crosstalk between mitochondria and lysosomes, including co-regulation of Rab7 GTP hydrolysis and Drp1 GTP hydrolysis. Here, we highlight recent findings and future perspectives on this dynamic pathway and its roles in health and disease.
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ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202305032