S100B in cardiac surgery brain monitoring: friend or foe?

Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat tren...

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Published inClinical chemistry and laboratory medicine Vol. 60; no. 3; pp. 317 - 331
Main Authors Lapergola, Giuseppe, Graziosi, Alessandro, D’Adamo, Ebe, Brindisino, Patrizia, Ferrari, Mariangela, Romanelli, Anna, Strozzi, Mariachiara, Libener, Roberta, Gavilanes, Danilo A. W., Maconi, Antonio, Satriano, Angela, Varrica, Alessandro, Gazzolo, Diego
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 23.02.2022
Walter De Gruyter & Company
Subjects
Adult
Biomarkers
Biomarkers - metabolism
Brain - metabolism
Brain damage
Brain injury
cardiac surgery
Cardiac Surgical Procedures
cardiopulmonary bypass
Cardiopulmonary Bypass - methods
Cardiovascular diseases
Child
Coronary artery disease
Heart Defects, Congenital - etiology
Heart Defects, Congenital - metabolism
Heart Defects, Congenital - surgery
Heart diseases
Heart surgery
Humans
Hypoxia
Ischemia
Monitoring
Morbidity
neurobiomarker
neuromonitoring
Patients
Pediatrics
Proteins
Reperfusion
S100 Calcium Binding Protein beta Subunit - metabolism
S100B
S100b protein
Surgery
neuromonitoring
cardiopulmonary bypass
cardiac surgery
brain injury
neurobiomarker
S100B
Online AccessGet full text
ISSN1434-6621
1437-4331
1437-4331
DOI10.1515/cclm-2021-1012

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Abstract Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B and in the peri-operative monitoring of adult and pediatric patients.
AbstractList Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B pros and cons in the peri-operative monitoring of adult and pediatric patients.
Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B pros and cons in the peri-operative monitoring of adult and pediatric patients.
Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B pros and cons in the peri-operative monitoring of adult and pediatric patients.Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B pros and cons in the peri-operative monitoring of adult and pediatric patients.
Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B and in the peri-operative monitoring of adult and pediatric patients.
Author Ferrari, Mariangela
Brindisino, Patrizia
Graziosi, Alessandro
Gavilanes, Danilo A. W.
Satriano, Angela
D’Adamo, Ebe
Maconi, Antonio
Lapergola, Giuseppe
Romanelli, Anna
Gazzolo, Diego
Strozzi, Mariachiara
Varrica, Alessandro
Libener, Roberta
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  fullname: Libener, Roberta
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  email: dgazzolo@hotmail.com
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CitedBy_id crossref_primary_10_1016_j_athoracsur_2023_09_026
crossref_primary_10_1186_s13019_023_02151_2
crossref_primary_10_4103_aca_aca_147_22
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Issue 3
Keywords neuromonitoring
cardiopulmonary bypass
cardiac surgery
brain injury
neurobiomarker
S100B
Language English
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Snippet Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac...
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StartPage 317
SubjectTerms Adult
Biomarkers
Biomarkers - metabolism
Brain - metabolism
Brain damage
Brain injury
cardiac surgery
Cardiac Surgical Procedures
cardiopulmonary bypass
Cardiopulmonary Bypass - methods
Cardiovascular diseases
Child
Coronary artery disease
Heart Defects, Congenital - etiology
Heart Defects, Congenital - metabolism
Heart Defects, Congenital - surgery
Heart diseases
Heart surgery
Humans
Hypoxia
Ischemia
Monitoring
Morbidity
neurobiomarker
neuromonitoring
Patients
Pediatrics
Proteins
Reperfusion
S100 Calcium Binding Protein beta Subunit - metabolism
S100B
S100b protein
Surgery
Title S100B in cardiac surgery brain monitoring: friend or foe?
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