Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner

The transcription factor Snail not only functions as a master regulator of epithelial-mesenchymal transition (EMT), but also mediates cell proliferation and survival. While previous studies have showed that Snail protects tumor cells from apoptosis through transcriptional repression of PTEN, the spe...

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Published inCell cycle (Georgetown, Tex.) Vol. 13; no. 11; pp. 1708 - 1716
Main Authors Lin, Yiwei, Kang, Tiebang, Zhou, Binhua P
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.06.2014
Landes Bioscience
Subjects
Blotting, Western
Cell Line, Tumor
Chromatin Immunoprecipitation
DNA Methylation - genetics
Doxorubicin - pharmacology
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
HEK293 Cells
Histone Demethylases - metabolism
Humans
LSD1
PARP1
Phthalazines
Piperazines
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases - metabolism
poly(ADP-ribosyl)ation
PTEN
PTEN Phosphohydrolase - antagonists & inhibitors
Real-Time Polymerase Chain Reaction
Snail
Snail Family Transcription Factors
Tetrazolium Salts
Thiazoles
Transcription Factors - metabolism
PTEN
PARP1
Snail
poly(ADP-ribosyl)ation
LSD1
Online AccessGet full text
ISSN1538-4101
1551-4005
1551-4005
DOI10.4161/cc.28619

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Abstract The transcription factor Snail not only functions as a master regulator of epithelial-mesenchymal transition (EMT), but also mediates cell proliferation and survival. While previous studies have showed that Snail protects tumor cells from apoptosis through transcriptional repression of PTEN, the specific mechanism remains unclear. In this study, we demonstrated that Snail cooperates with LSD1 to repress PTEN in a PARP1-dependent manner. Upon doxorubicin treatment, Snail becomes tightly associated with PARP1 through its pADPr-binding motif and is subject to poly(ADP-ribosyl)ation. This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression. Furthermore, treatment of tumor cells with PARP1 inhibitor AZD2281 can compromise doxorubicin-induced PTEN suppression and enhance the inhibitory effect of doxorubicin. Together, we proposed a tentative drug-resistant mechanism through which tumor cells defend themselves against DNA damage-induced apoptosis. PARP1 inhibitors in combination with DNA damaging reagents might represent a promising treatment strategy targeting tumors with over-activated Snail and LSD1.
AbstractList The transcription factor Snail not only functions as a master regulator of epithelial–mesenchymal transition (EMT), but also mediates cell proliferation and survival. While previous studies have showed that Snail protects tumor cells from apoptosis through transcriptional repression of PTEN, the specific mechanism remains unclear. In this study, we demonstrated that Snail cooperates with LSD1 to repress PTEN in a PARP1-dependent manner. Upon doxorubicin treatment, Snail becomes tightly associated with PARP1 through its pADPr-binding motif and is subject to poly(ADP-ribosyl)ation. This modification can enhance Snail–LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression. Furthermore, treatment of tumor cells with PARP1 inhibitor AZD2281 can compromise doxorubicin-induced PTEN suppression and enhance the inhibitory effect of doxorubicin. Together, we proposed a tentative drug-resistant mechanism through which tumor cells defend themselves against DNA damage-induced apoptosis. PARP1 inhibitors in combination with DNA damaging reagents might represent a promising treatment strategy targeting tumors with over-activated Snail and LSD1.
The transcription factor Snail not only functions as a master regulator of epithelial-mesenchymal transition (EMT), but also mediates cell proliferation and survival. While previous studies have showed that Snail protects tumor cells from apoptosis through transcriptional repression of PTEN, the specific mechanism remains unclear. In this study, we demonstrated that Snail cooperates with LSD1 to repress PTEN in a PARP1-dependent manner. Upon doxorubicin treatment, Snail becomes tightly associated with PARP1 through its pADPr-binding motif and is subject to poly(ADP-ribosyl)ation. This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression. Furthermore, treatment of tumor cells with PARP1 inhibitor AZD2281 can compromise doxorubicin-induced PTEN suppression and enhance the inhibitory effect of doxorubicin. Together, we proposed a tentative drug-resistant mechanism through which tumor cells defend themselves against DNA damage-induced apoptosis. PARP1 inhibitors in combination with DNA damaging reagents might represent a promising treatment strategy targeting tumors with over-activated Snail and LSD1.The transcription factor Snail not only functions as a master regulator of epithelial-mesenchymal transition (EMT), but also mediates cell proliferation and survival. While previous studies have showed that Snail protects tumor cells from apoptosis through transcriptional repression of PTEN, the specific mechanism remains unclear. In this study, we demonstrated that Snail cooperates with LSD1 to repress PTEN in a PARP1-dependent manner. Upon doxorubicin treatment, Snail becomes tightly associated with PARP1 through its pADPr-binding motif and is subject to poly(ADP-ribosyl)ation. This modification can enhance Snail-LSD1 interaction and promote the recruitment of LSD1 to PTEN promoter, where LSD1 removes methylation on histone H3 lysine 4 for transcription repression. Furthermore, treatment of tumor cells with PARP1 inhibitor AZD2281 can compromise doxorubicin-induced PTEN suppression and enhance the inhibitory effect of doxorubicin. Together, we proposed a tentative drug-resistant mechanism through which tumor cells defend themselves against DNA damage-induced apoptosis. PARP1 inhibitors in combination with DNA damaging reagents might represent a promising treatment strategy targeting tumors with over-activated Snail and LSD1.
Author Lin, Yiwei
Kang, Tiebang
Zhou, Binhua P
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Cites_doi 10.1016/j.cell.2004.11.002
10.1002/emmm.200900041
10.1038/sj.onc.1205416
10.1128/MCB.25.16.7158-7169.2005
10.1042/0264-6021:3420249
10.1096/fj.08-123265
10.1038/emboj.2010.63
10.1016/j.cell.2009.11.007
10.1126/science.1149250
10.1038/ncb1173
10.1038/onc.2011.153
10.1158/0008-5472.CAN-06-1570
10.1242/jcs.114.13.2375
10.1038/nature03445
10.1126/science.7545954
10.1038/35000034
10.1093/carcin/bgp324
10.1128/MCB.02061-07
10.4161/cam.4.2.10943
10.1038/nature03443
10.1186/bcr1259
10.1038/378789a0
10.1016/j.molcel.2010.06.017
10.1016/j.gde.2010.06.001
10.1128/MCB.01314-07
10.1182/blood-2010-01-265769
10.1242/dev.01907
10.1016/j.lungcan.2008.02.007
10.1038/sj.onc.1210546
10.1056/NEJMoa0900212
10.1002/jcp.20515
10.1002/bies.1132
10.1016/j.brainresbull.2009.04.013
10.3390/ijms11124891
10.1016/j.molcel.2010.10.029
10.1093/neuonc/nor049
10.1038/nature06092
10.1016/j.molcel.2010.06.006
10.1371/journal.pone.0011700
10.1016/j.cell.2004.12.012
10.1158/0008-5472.CAN-08-1735
10.1038/35000025
10.1016/j.bbrc.2011.11.142
10.1016/j.ceb.2008.03.006
10.1038/nrc2812
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Keywords PTEN
PARP1
Snail
poly(ADP-ribosyl)ation
LSD1
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References Yamada KM (R16) 2001; 114
R41
Lin Y (R46) 2012
R40
R21
R43
R20
R42
R23
R45
R22
R44
R25
R24
R27
R26
R29
R28
R1
R2
R3
R4
R5
R6
R7
R8
R9
R30
R10
R32
R31
R12
R34
R11
R33
R14
R36
R13
R35
R38
R15
R37
R18
R17
R39
R19
15448698 - Nat Cell Biol. 2004 Oct;6(10):931-40
19410636 - Brain Res Bull. 2009 Aug 28;80(1-2):79-84
20603083 - Mol Cell. 2010 Jul 9;39(1):152-60
8524414 - Nature. 1995 Dec 21-28;378(6559):789-92
21614180 - Int J Mol Sci. 2010;11(12):4891-2
17805299 - Nature. 2007 Sep 6;449(7158):105-8
10455009 - Biochem J. 1999 Sep 1;342 ( Pt 2):249-68
18450439 - Curr Opin Cell Biol. 2008 Jun;20(3):294-302
20661477 - PLoS One. 2010;5(7):e11700
22166209 - Biochem Biophys Res Commun. 2012 Jan 13;417(2):679-85
19945376 - Cell. 2009 Nov 25;139(5):871-90
12082640 - Oncogene. 2002 May 9;21(20):3241-6
17785446 - Mol Cell Biol. 2007 Nov;27(21):7475-85
18258916 - Science. 2008 Feb 8;319(5864):819-21
20042638 - Carcinogenesis. 2010 Mar;31(3):512-20
19223552 - Cancer Res. 2009 Mar 1;69(5):2065-71
15829966 - Nature. 2005 Apr 14;434(7035):913-7
21577210 - Oncogene. 2011 Oct 20;30(42):4365-72
10655587 - Nat Cell Biol. 2000 Feb;2(2):84-9
11559746 - J Cell Sci. 2001 Jul;114(Pt 13):2375-82
20591646 - Curr Opin Genet Dev. 2010 Oct;20(5):512-8
21095583 - Mol Cell. 2010 Nov 24;40(4):521-32
24966873 - Front Biol (Beijing). 2013 Apr 1;8(2):228-233
18172008 - Mol Cell Biol. 2008 Mar;28(5):1528-40
19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34
15620353 - Cell. 2004 Dec 29;119(7):941-53
16250021 - J Cell Physiol. 2006 Jun;207(3):571-81
21653597 - Neuro Oncol. 2011 Aug;13(8):894-903
15607977 - Cell. 2004 Dec 17;119(6):803-14
15829967 - Nature. 2005 Apr 14;434(7035):917-21
15983400 - Development. 2005 Jul;132(14):3151-61
20389281 - EMBO J. 2010 Jun 2;29(11):1803-16
17563753 - Oncogene. 2007 Nov 22;26(53):7445-56
16055725 - Mol Cell Biol. 2005 Aug;25(16):7158-69
10655586 - Nat Cell Biol. 2000 Feb;2(2):76-83
20739657 - Blood. 2010 Nov 25;116(22):4578-87
17145880 - Cancer Res. 2006 Dec 1;66(23):11341-7
20049735 - EMBO Mol Med. 2009 Sep;1(6-7):315-22
20168078 - Cell Adh Migr. 2010 Apr-Jun;4(2):199-203
19001527 - FASEB J. 2009 Mar;23(3):672-8
20603072 - Mol Cell. 2010 Jul 9;39(1):8-24
18372076 - Lung Cancer. 2008 Oct;62(1):8-14
7545954 - Science. 1994 Oct 7;266(5182):66-71
11598958 - Bioessays. 2001 Oct;23(10):912-23
16168102 - Breast Cancer Res. 2005;7(5):R589-97
20200537 - Nat Rev Cancer. 2010 Apr;10(4):293-301
References_xml – ident: R35
  doi: 10.1016/j.cell.2004.11.002
– ident: R44
  doi: 10.1002/emmm.200900041
– ident: R3
  doi: 10.1038/sj.onc.1205416
– ident: R29
  doi: 10.1128/MCB.25.16.7158-7169.2005
– ident: R27
  doi: 10.1042/0264-6021:3420249
– ident: R38
  doi: 10.1096/fj.08-123265
– ident: R18
  doi: 10.1038/emboj.2010.63
– ident: R8
  doi: 10.1016/j.cell.2009.11.007
– ident: R37
  doi: 10.1126/science.1149250
– ident: R7
  doi: 10.1038/ncb1173
– ident: R40
  doi: 10.1038/onc.2011.153
– ident: R21
  doi: 10.1158/0008-5472.CAN-06-1570
– volume: 114
  start-page: 2375
  year: 2001
  ident: R16
  publication-title: J Cell Sci
  doi: 10.1242/jcs.114.13.2375
– ident: R31
  doi: 10.1038/nature03445
– ident: R41
  doi: 10.1126/science.7545954
– ident: R4
  doi: 10.1038/35000034
– ident: R22
  doi: 10.1093/carcin/bgp324
– ident: R14
  doi: 10.1128/MCB.02061-07
– ident: R9
  doi: 10.4161/cam.4.2.10943
– ident: R30
  doi: 10.1038/nature03443
– ident: R15
  doi: 10.1186/bcr1259
– ident: R42
  doi: 10.1038/378789a0
– ident: R28
  doi: 10.1016/j.molcel.2010.06.017
– year: 2012
  ident: R46
  publication-title: Front Biol
– ident: R33
  doi: 10.1016/j.gde.2010.06.001
– ident: R36
  doi: 10.1128/MCB.01314-07
– ident: R43
  doi: 10.1182/blood-2010-01-265769
– ident: R2
  doi: 10.1242/dev.01907
– ident: R12
  doi: 10.1016/j.lungcan.2008.02.007
– ident: R17
  doi: 10.1038/sj.onc.1210546
– ident: R32
  doi: 10.1056/NEJMoa0900212
– ident: R1
  doi: 10.1002/jcp.20515
– ident: R6
  doi: 10.1002/bies.1132
– ident: R23
  doi: 10.1016/j.brainresbull.2009.04.013
– ident: R13
  doi: 10.3390/ijms11124891
– ident: R39
  doi: 10.1016/j.molcel.2010.10.029
– ident: R26
  doi: 10.1093/neuonc/nor049
– ident: R24
  doi: 10.1038/nature06092
– ident: R25
  doi: 10.1016/j.molcel.2010.06.006
– ident: R11
  doi: 10.1371/journal.pone.0011700
– ident: R19
  doi: 10.1016/j.cell.2004.12.012
– ident: R20
  doi: 10.1158/0008-5472.CAN-08-1735
– ident: R5
  doi: 10.1038/35000025
– ident: R10
  doi: 10.1016/j.bbrc.2011.11.142
– ident: R34
  doi: 10.1016/j.ceb.2008.03.006
– ident: R45
  doi: 10.1038/nrc2812
– reference: 11559746 - J Cell Sci. 2001 Jul;114(Pt 13):2375-82
– reference: 17805299 - Nature. 2007 Sep 6;449(7158):105-8
– reference: 18372076 - Lung Cancer. 2008 Oct;62(1):8-14
– reference: 15607977 - Cell. 2004 Dec 17;119(6):803-14
– reference: 20042638 - Carcinogenesis. 2010 Mar;31(3):512-20
– reference: 19945376 - Cell. 2009 Nov 25;139(5):871-90
– reference: 24966873 - Front Biol (Beijing). 2013 Apr 1;8(2):228-233
– reference: 15829967 - Nature. 2005 Apr 14;434(7035):917-21
– reference: 19001527 - FASEB J. 2009 Mar;23(3):672-8
– reference: 15448698 - Nat Cell Biol. 2004 Oct;6(10):931-40
– reference: 8524414 - Nature. 1995 Dec 21-28;378(6559):789-92
– reference: 16250021 - J Cell Physiol. 2006 Jun;207(3):571-81
– reference: 17563753 - Oncogene. 2007 Nov 22;26(53):7445-56
– reference: 20049735 - EMBO Mol Med. 2009 Sep;1(6-7):315-22
– reference: 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34
– reference: 18450439 - Curr Opin Cell Biol. 2008 Jun;20(3):294-302
– reference: 20168078 - Cell Adh Migr. 2010 Apr-Jun;4(2):199-203
– reference: 20389281 - EMBO J. 2010 Jun 2;29(11):1803-16
– reference: 17785446 - Mol Cell Biol. 2007 Nov;27(21):7475-85
– reference: 19223552 - Cancer Res. 2009 Mar 1;69(5):2065-71
– reference: 15983400 - Development. 2005 Jul;132(14):3151-61
– reference: 21653597 - Neuro Oncol. 2011 Aug;13(8):894-903
– reference: 10655587 - Nat Cell Biol. 2000 Feb;2(2):84-9
– reference: 20739657 - Blood. 2010 Nov 25;116(22):4578-87
– reference: 19410636 - Brain Res Bull. 2009 Aug 28;80(1-2):79-84
– reference: 20661477 - PLoS One. 2010;5(7):e11700
– reference: 18258916 - Science. 2008 Feb 8;319(5864):819-21
– reference: 16168102 - Breast Cancer Res. 2005;7(5):R589-97
– reference: 17145880 - Cancer Res. 2006 Dec 1;66(23):11341-7
– reference: 20200537 - Nat Rev Cancer. 2010 Apr;10(4):293-301
– reference: 22166209 - Biochem Biophys Res Commun. 2012 Jan 13;417(2):679-85
– reference: 15829966 - Nature. 2005 Apr 14;434(7035):913-7
– reference: 7545954 - Science. 1994 Oct 7;266(5182):66-71
– reference: 21614180 - Int J Mol Sci. 2010;11(12):4891-2
– reference: 20603083 - Mol Cell. 2010 Jul 9;39(1):152-60
– reference: 21095583 - Mol Cell. 2010 Nov 24;40(4):521-32
– reference: 15620353 - Cell. 2004 Dec 29;119(7):941-53
– reference: 20603072 - Mol Cell. 2010 Jul 9;39(1):8-24
– reference: 21577210 - Oncogene. 2011 Oct 20;30(42):4365-72
– reference: 10455009 - Biochem J. 1999 Sep 1;342 ( Pt 2):249-68
– reference: 12082640 - Oncogene. 2002 May 9;21(20):3241-6
– reference: 11598958 - Bioessays. 2001 Oct;23(10):912-23
– reference: 20591646 - Curr Opin Genet Dev. 2010 Oct;20(5):512-8
– reference: 10655586 - Nat Cell Biol. 2000 Feb;2(2):76-83
– reference: 18172008 - Mol Cell Biol. 2008 Mar;28(5):1528-40
– reference: 16055725 - Mol Cell Biol. 2005 Aug;25(16):7158-69
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Snippet The transcription factor Snail not only functions as a master regulator of epithelial-mesenchymal transition (EMT), but also mediates cell proliferation and...
The transcription factor Snail not only functions as a master regulator of epithelial–mesenchymal transition (EMT), but also mediates cell proliferation and...
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SubjectTerms Blotting, Western
Cell Line, Tumor
Chromatin Immunoprecipitation
DNA Methylation - genetics
Doxorubicin - pharmacology
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
HEK293 Cells
Histone Demethylases - metabolism
Humans
LSD1
PARP1
Phthalazines
Piperazines
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases - metabolism
poly(ADP-ribosyl)ation
PTEN
PTEN Phosphohydrolase - antagonists & inhibitors
Real-Time Polymerase Chain Reaction
Snail
Snail Family Transcription Factors
Tetrazolium Salts
Thiazoles
Transcription Factors - metabolism
Title Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner
URI https://www.tandfonline.com/doi/abs/10.4161/cc.28619
https://www.ncbi.nlm.nih.gov/pubmed/24675890
https://www.proquest.com/docview/1531956782
https://pubmed.ncbi.nlm.nih.gov/PMC4111717
Volume 13
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