Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix

• Published in: Anticancer research Vol. 38; no. 1; p. 457
• Main Authors: Okonogi, Noriyuki, Wakatsuki, Masaru, Kato, Shingo, Shiba, Shintaro, Kobayashi, Daijiro, Kiyohara, Hiroki, Karasawa, Kumiko, Ohno, Tatsuya, Nakano, Takashi, Kamada, Tadashi, Shozu, Makio
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.01.2018
• Subjects: Cancer therapies; Carbon; Cervical cancer; Cervical carcinoma; Cervix; Clinical trials; Disease; Gastrointestinal tract; Ion beams; Lymphatic system; Patients; Radiation therapy; Squamous cell carcinoma; Toxicity; Tumors; Uterus; Japan; radiotherapy; Carbon-ion radiotherapy; particle radiation therapy; uterine cervical cancer; squamous cell carcinoma
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.12244

To evaluate the long-term outcomes of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical squamous cell carcinoma (LAC-SqCC) in 2 prospective phase I/II studies. In the first study, 14 patients were treated with 68.8-72.8 Gy (RBE)/24 fractions. In a subsequent study, 22 patients were treated with 64.0-72.0 Gy (RBE)/20 fractions while limiting the dose to the gastro-intestinal (GI) <60 Gy (RBE). The 10-year local control rates were 92% and 61% for the patients administered a total dose of 72.0-72.8 Gy (RBE) and 64.0-68.8 Gy (RBE), respectively. Two patients in the first study developed grade 3/4 rectal or bladder complications; however, no grade 3 or higher complications occurred in the second study. C-ion RT with a higher dose was associated with excellent LC in LAC-SqCC. Long-term safety was confirmed based on the establishment of dose constraints for the GI tract.