Serological and molecular study of hepatitis E virus among illegal blood donors

To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s. A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the...

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Published inWorld journal of gastroenterology : WJG Vol. 18; no. 9; pp. 986 - 990
Main Author Cheng, Xian-Feng
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 07.03.2012
Subjects
Adult
Aged
Blood Banks - legislation & jurisprudence
Blood Donors
Brief
China - epidemiology
Female
Hepatitis Antibodies - blood
Hepatitis E - epidemiology
Hepatitis E - transmission
Hepatitis E - virology
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - immunology
HEV
Humans
Male
Middle Aged
Phylogeny
RNA, Viral - blood
Seroepidemiologic Studies
Surveys and Questionnaires
分子特征
分子生物学
戊型肝炎病毒
献血者
血清学
血清流行病学
China
Commercial blood donors
Hepatitis E
Molecular
Hepatitis E virus
Sero-epidemiology
Online AccessGet full text
ISSN1007-9327
2219-2840
2219-2840
DOI10.3748/wjg.v18.i9.986

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Abstract To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s. A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, sex, and periods of blood or plasma donation. Anhui Province and tested for the anti-HEV antibodies. The seropositive samples were subjected to nested reverse transcription-polymerase chain reaction and sequencing to analyze HEV partial genome. The prevalence of IgG and IgM HEV antibody in IBDs was 22.7% and 1.8%, and genotype 4 was the dominant circulating HEV type in IBDs. The prevalence of anti-HEV IgG was significantly related to sex (OR = 4.905, P = 0.004) and increased with age (OR = 2.78, P = 0.022), which ranged from 13.0% in those < 40 years old to 30.6% among older persons aged > 60 years. Moreover, frequency of blood donation was significantly associated with HEV seropositivity (OR = 2.06, P = 0.006). HEV partial sequences of ORF2 and obtained 3 sequences in serum samples of 10 IBDs which developed HEV specific IgM. This study helps define one of the possible routes of transmission of sporadic HEV infection and provides guidance to screen HEV in the blood donors so as to guarantee safe blood banks in China.
AbstractList To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s.AIMTo investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s.A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, sex, and periods of blood or plasma donation. Anhui Province and tested for the anti-HEV antibodies. The seropositive samples were subjected to nested reverse transcription-polymerase chain reaction and sequencing to analyze HEV partial genome.METHODSA total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, sex, and periods of blood or plasma donation. Anhui Province and tested for the anti-HEV antibodies. The seropositive samples were subjected to nested reverse transcription-polymerase chain reaction and sequencing to analyze HEV partial genome.The prevalence of IgG and IgM HEV antibody in IBDs was 22.7% and 1.8%, and genotype 4 was the dominant circulating HEV type in IBDs. The prevalence of anti-HEV IgG was significantly related to sex (OR = 4.905, P = 0.004) and increased with age (OR = 2.78, P = 0.022), which ranged from 13.0% in those < 40 years old to 30.6% among older persons aged > 60 years. Moreover, frequency of blood donation was significantly associated with HEV seropositivity (OR = 2.06, P = 0.006). HEV partial sequences of ORF2 and obtained 3 sequences in serum samples of 10 IBDs which developed HEV specific IgM.RESULTSThe prevalence of IgG and IgM HEV antibody in IBDs was 22.7% and 1.8%, and genotype 4 was the dominant circulating HEV type in IBDs. The prevalence of anti-HEV IgG was significantly related to sex (OR = 4.905, P = 0.004) and increased with age (OR = 2.78, P = 0.022), which ranged from 13.0% in those < 40 years old to 30.6% among older persons aged > 60 years. Moreover, frequency of blood donation was significantly associated with HEV seropositivity (OR = 2.06, P = 0.006). HEV partial sequences of ORF2 and obtained 3 sequences in serum samples of 10 IBDs which developed HEV specific IgM.This study helps define one of the possible routes of transmission of sporadic HEV infection and provides guidance to screen HEV in the blood donors so as to guarantee safe blood banks in China.CONCLUSIONThis study helps define one of the possible routes of transmission of sporadic HEV infection and provides guidance to screen HEV in the blood donors so as to guarantee safe blood banks in China.
AIM： To investigate the seroprevalence and molecular characteristics of hepatitis E virus （HEV） in the illegal blood donors （IBDs） of central China in the early 1990s.
AIM: To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s. METHODS: A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, sex, and periods of blood or plasma donation. Anhui Province and tested for the anti-HEV antibodies. The seropositive samples were subjected to nested reverse transcription-polymerase chain reaction and sequencing to analyze HEV partial genome. RESULTS: The prevalence of IgG and IgM HEV antibody in IBDs was 22.7% and 1.8%, and genotype 4 was the dominant circulating HEV type in IBDs. The prevalence of anti-HEV IgG was significantly related to sex (OR = 4.905, P = 0.004) and increased with age (OR = 2.78, P = 0.022), which ranged from 13.0% in those < 40 years old to 30.6% among older persons aged > 60 years. Moreover, frequency of blood donation was significantly associated with HEV seropositivity (OR = 2.06, P = 0.006). HEV partial sequences of ORF2 and obtained 3 sequences in serum samples of 10 IBDs which developed HEV specific IgM. CONCLUSION: This study helps define one of the possible routes of transmission of sporadic HEV infection and provides guidance to screen HEV in the blood donors so as to guarantee safe blood banks in China.
To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early 1990s. A total of 546 blood samples were collected from the IBDs in Maanshan city, a questionnaire was completed by each subject, detailing the age, sex, and periods of blood or plasma donation. Anhui Province and tested for the anti-HEV antibodies. The seropositive samples were subjected to nested reverse transcription-polymerase chain reaction and sequencing to analyze HEV partial genome. The prevalence of IgG and IgM HEV antibody in IBDs was 22.7% and 1.8%, and genotype 4 was the dominant circulating HEV type in IBDs. The prevalence of anti-HEV IgG was significantly related to sex (OR = 4.905, P = 0.004) and increased with age (OR = 2.78, P = 0.022), which ranged from 13.0% in those < 40 years old to 30.6% among older persons aged > 60 years. Moreover, frequency of blood donation was significantly associated with HEV seropositivity (OR = 2.06, P = 0.006). HEV partial sequences of ORF2 and obtained 3 sequences in serum samples of 10 IBDs which developed HEV specific IgM. This study helps define one of the possible routes of transmission of sporadic HEV infection and provides guidance to screen HEV in the blood donors so as to guarantee safe blood banks in China.
Author Xian-Feng Cheng Yu-Feng Wen Ming Zhu Sheng-Wei Zhan Chen Dong Ke-Xia Xiang Xiao-Bing Xia Gang Wang Ling-Fei Han
AuthorAffiliation Ma AnshanCenter for Disease Control and Prevention, Maanshan 243000,Anhui Province, China Department of Preventive Medi-cine, Wannan Medical College, Wuhu 241320, Anhui Province,China Department of Microbiology and Immunology,School of Medicine, Southeast University, Nanjing 210096, Ji-angsu Province, China Department of Clinical Laboratory, the Forth Peo-ple＇s Hospital of Maanshan, Maanshan 243000, Anhui Province,China
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Copyright 2012 Baishideng Publishing Group Co., Limited. All rights reserved. 2012
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Keywords Commercial blood donors
Hepatitis E
Molecular
Hepatitis E virus
Sero-epidemiology
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AIM： To investigate the seroprevalence and molecular characteristics of hepatitis E virus （HEV） in the illegal blood donors （IBDs） of central China in the early 1990s.
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Telephone: +86-553-3932061 Fax: +86-553-3932059
Correspondence to: Dr. Yu-Feng Wen, Associate Professor, Department of Preventive Medicine, Wannan Medical College, Wuhu 241320, Anhui Province, China. wyf@wnmc.edu.cn
Author contributions: Cheng XF, Zhu M, Xiang KX, Xia XB and Han LF performed the majority of experiments; Cheng XF and Wen YF provided vital reagents and analytical tools and revised the manuscript; Dong C and Wang G collected all the human materials; Wen YF designed the study and wrote the manuscript; all author contribute to this paper.
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To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the early...
AIM: To investigate the seroprevalence and molecular characteristics of hepatitis E virus (HEV) in the illegal blood donors (IBDs) of central China in the...
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SubjectTerms Adult
Aged
Blood Banks - legislation & jurisprudence
Blood Donors
Brief
China - epidemiology
Female
Hepatitis Antibodies - blood
Hepatitis E - epidemiology
Hepatitis E - transmission
Hepatitis E - virology
Hepatitis E virus - classification
Hepatitis E virus - genetics
Hepatitis E virus - immunology
HEV
Humans
Male
Middle Aged
Phylogeny
RNA, Viral - blood
Seroepidemiologic Studies
Surveys and Questionnaires
分子特征
分子生物学
戊型肝炎病毒
献血者
血清学
血清流行病学
Title Serological and molecular study of hepatitis E virus among illegal blood donors
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