T-bet+ Cells Polarization in Patients Infected with Helicobacter pylori Increase the Risk of Peptic Ulcer Development

Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to det...

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Published in	Archives of medical research Vol. 50; no. 3; pp. 113 - 121
Main Authors	Bagheri, Nader, Shirzad, Hedayatollah, Mirzaei, Yousef, Nahid-Samiei, Mahboobeh, Sanaei, Mohammadjavad, Rahimian, Ghorbanali, Shafigh, Mohammadhadi, Zandi, Farid, Tahmasbi, Kamran, Razavi, Alireza
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.04.2019
Subjects	Adult Female Gastric Mucosa - immunology Gastric Mucosa - microbiology Gastric Mucosa - physiology Gastritis Gastritis - immunology Gastritis - pathology Helicobacter Infections - metabolism Helicobacter pylori Helicobacter pylori - immunology Humans Immunohistochemistry Interferon-gamma - biosynthesis Male Middle Aged Peptic Ulcer - epidemiology Peptic Ulcer - microbiology Peptic ulcer disease T-bet+ cells T-Lymphocytes, Regulatory - immunology Th1 cells Th17 Cells - immunology T-bet+ cells Peptic ulcer disease Th1 cells Helicobacter pylori Gastritis T-bet(+) cells
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ISSN	0188-4409 1873-5487 1873-5487
DOI	10.1016/j.arcmed.2019.07.005

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Abstract	Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet+ cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection. A total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet+ cells were determined by immunohistochemistry. The numbers of T-bet+ cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet+ cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet+ cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet+ cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD. Abnormal hyper-activation of T-bet+ cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions.
AbstractList	Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet+ cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection. A total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet+ cells were determined by immunohistochemistry. The numbers of T-bet+ cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet+ cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet+ cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet+ cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD. Abnormal hyper-activation of T-bet+ cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions. Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4 helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection. A total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet cells were determined by immunohistochemistry. The numbers of T-bet cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD. Abnormal hyper-activation of T-bet cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions. Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet+ cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection.BACKGROUNDPeptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet+ cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection.A total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet+ cells were determined by immunohistochemistry.METHODSA total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet+ cells were determined by immunohistochemistry.The numbers of T-bet+ cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet+ cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet+ cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet+ cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD.RESULTSThe numbers of T-bet+ cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet+ cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet+ cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet+ cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD.Abnormal hyper-activation of T-bet+ cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions.CONCLUSIONAbnormal hyper-activation of T-bet+ cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions.
Author	Shafigh, Mohammadhadi Mirzaei, Yousef Bagheri, Nader Zandi, Farid Tahmasbi, Kamran Nahid-Samiei, Mahboobeh Sanaei, Mohammadjavad Razavi, Alireza Rahimian, Ghorbanali Shirzad, Hedayatollah
Author_xml	– sequence: 1 givenname: Nader surname: Bagheri fullname: Bagheri, Nader organization: Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 2 givenname: Hedayatollah surname: Shirzad fullname: Shirzad, Hedayatollah email: shirzad1951@yahoo.com organization: Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 3 givenname: Yousef surname: Mirzaei fullname: Mirzaei, Yousef organization: Department of Biology, Faculty of Sciences, Soran University, Soran, Kurdistan Region, Iraq – sequence: 4 givenname: Mahboobeh surname: Nahid-Samiei fullname: Nahid-Samiei, Mahboobeh organization: Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 5 givenname: Mohammadjavad surname: Sanaei fullname: Sanaei, Mohammadjavad organization: Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 6 givenname: Ghorbanali surname: Rahimian fullname: Rahimian, Ghorbanali organization: Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 7 givenname: Mohammadhadi surname: Shafigh fullname: Shafigh, Mohammadhadi organization: Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 8 givenname: Farid surname: Zandi fullname: Zandi, Farid organization: Department of Medical Bacteriology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran – sequence: 9 givenname: Kamran surname: Tahmasbi fullname: Tahmasbi, Kamran organization: Department of Pathology, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 10 givenname: Alireza surname: Razavi fullname: Razavi, Alireza organization: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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Keywords	T-bet+ cells Peptic ulcer disease Th1 cells Helicobacter pylori Gastritis T-bet(+) cells
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Snippet	Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in... Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4 helper cells in...
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SubjectTerms	Adult Female Gastric Mucosa - immunology Gastric Mucosa - microbiology Gastric Mucosa - physiology Gastritis Gastritis - immunology Gastritis - pathology Helicobacter Infections - metabolism Helicobacter pylori Helicobacter pylori - immunology Humans Immunohistochemistry Interferon-gamma - biosynthesis Male Middle Aged Peptic Ulcer - epidemiology Peptic Ulcer - microbiology Peptic ulcer disease T-bet+ cells T-Lymphocytes, Regulatory - immunology Th1 cells Th17 Cells - immunology
Title	T-bet+ Cells Polarization in Patients Infected with Helicobacter pylori Increase the Risk of Peptic Ulcer Development
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