A dosing algorithm for metformin based on the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function - Duong, Janna K.; Kroonen, M. Y. A. M.; Kumar, S. S.; Heerspink, H. L.; Kirkpatrick, C. M.; Graham, G. G.; Williams, K. M.; Day, R. O. (European journal of clinical pharmacology, 2017)
Keywords: Adult; Aged; Aged, 80 and over; Algorithms; Antidiabetics; Biomedical and Life Sciences; Biomedicine; Creatinine; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Dose-Response Relationship, Drug; Drug dosages; Female; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - blood; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - urine; Kidney - metabolism; Kidney - physiopathology; Kidney Diseases - drug therapy; Kidney Diseases - metabolism; Kidney Diseases - physiopathology; Kidneys; Male; Metabolism; Metformin; Metformin - administration & dosage; Metformin - blood; Metformin - pharmacokinetics; Metformin - urine; Middle Aged; Models, Biological; Pharmacokinetics and Disposition; Pharmacology/Toxicology; Prescription drugs; Renal function; Therapeutic drug monitoring; Urine; Kidney disease; Population modelling; Metformin; Type 2 diabetes mellitus; Pharmacokinetics; Renal clearance