Usefulness of Fibrinogen/Fibrin Degradation Products Value in Differential Diagnosis Between Acute Ischemic Stroke and Acute Aortic Dissection

• Published in: Journal of UOEH Vol. 40; no. 2; pp. 139 - 145
• Main Authors: UCHIDA, Takayuki, HARAYAMA, Nobuya, ARAI, Hideaki, NIHEI, Shun-ichi, KANAZAWA, Ayako, OTSUJI, Ken, AIBARA, Keiji, KAMOCHI, Masayuki, ENDO, Takeru
• Format: Journal Article
• Language: English
• Published: Japan The University of Occupational and Environmental Health, Japan 01.06.2018
• Subjects: acute aortic dissection; acute ischemic stroke; Aged; Aged, 80 and over; Aneurysm, Dissecting - diagnosis; Aneurysm, Dissecting - drug therapy; Diagnosis, Differential; Female; Fibrin Fibrinogen Degradation Products - therapeutic use; fibrinogen/fibrin degradation products; Humans; Male; Middle Aged; Stroke - diagnosis; Stroke - drug therapy; fibrinogen/fibrin degradation products; acute aortic dissection; acute ischemic stroke
• ISSN: 0387-821X; 2187-2864; 2187-2864
• DOI: 10.7888/juoeh.40.139

A post-marketing surveillance study reported fatalities following tissue plasminogen activator administration in acute aortic dissection (AAD) with the symptoms of acute ischemic stroke (AIS) patients. Therefore, it is important to discriminate AAD from AIS. The present study aimed to investigate whether fibrinogen/fibrin degradation products (FDP) value can be useful in differential diagnosis between AAD and AIS. The study group comprised 20 AAD patients (10 men and 10 women; age 63.9 ± 13.6 years) and 159 AIS patients (91 men and 68 women; age 74.2 ± 10.6 years) who were transported to our hospital from 2007 to 2012. The AAD cases were further divided into patent-type AAD and thrombosed-type AAD. FDP values were significantly higher in the AAD group than in the AIS group (18.15 [5.2 - 249.9] μg/ml vs. 2.3 [1.5 - 4.45] μg/ml ; P < 0.001). In AAD groups, FDP values were significantly higher in the patent-type AAD group (n = 9) than in the thrombosed type AAD group (n = 11) (293.2 μg/ml [63.1 - 419.6 μg/ml ] vs. 5.6 μg/ml [3.8 - 7.9 μg/ml ]. FDP values were significantly higher in patients with AAD than in those with AIS, especially those with patent-type AAD compared with AIS patients. High FDP values may be a useful marker for differential diagnosis between patent-type AAD and AIS.