Comparison of Human Ventral Frontal Cortex Areas for Cognitive Control and Language with Areas in Monkey Frontal Cortex

Human ventrolateral frontal cortex (vlFC) is identified with cognitive processes such as language and cognitive flexibility. The relationship between it and the vlFC of other primates has therefore been the subject of particular speculation. We used a combination of structural and functional neuroim...

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Published inNeuron (Cambridge, Mass.) Vol. 81; no. 3; pp. 700 - 713
Main Authors Neubert, Franz-Xaver, Mars, Rogier B., Thomas, Adam G., Sallet, Jerome, Rushworth, Matthew F.S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 05.02.2014
Subjects
Adult
Animals
Automation
Brain
Brain Mapping
Cognition & reasoning
Cognition - physiology
Cognitive ability
Diffusion Magnetic Resonance Imaging
Female
Frontal Lobe - anatomy & histology
Frontal Lobe - blood supply
Frontal Lobe - physiology
Humans
Hypotheses
Image Processing, Computer-Assisted
Language
Macaca
Macaca mulatta
Magnetic Resonance Imaging
Male
Mars
Meta-Analysis as Topic
Middle Aged
Neural Pathways - blood supply
Neural Pathways - physiology
Neuropsychological Tests
Oxygen - blood
Photic Stimulation
Primates
Young Adult
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ISSN0896-6273
1097-4199
1097-4199
DOI10.1016/j.neuron.2013.11.012

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Summary:Human ventrolateral frontal cortex (vlFC) is identified with cognitive processes such as language and cognitive flexibility. The relationship between it and the vlFC of other primates has therefore been the subject of particular speculation. We used a combination of structural and functional neuroimaging methods to identify key components of human vlFC. We compared how vlFC areas interacted with other brain areas in 25 humans and 25 macaques using the same methods. We identified a core set of 11 vlFC components that interacted in similar ways with similar distributed circuits in both species and, in addition, one distinctively human component in ventrolateral frontal pole. Fundamental differences in interactions with posterior auditory association areas in the two species were also present-these were ubiquitous throughout posterior human vlFC but channeled to different frontal regions in monkeys. Finally, there were some differences in interregional interactions within vlFC in the two species.
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ISSN:0896-6273
1097-4199
1097-4199
DOI:10.1016/j.neuron.2013.11.012