9G4+ Autoantibodies Are an Important Source of Apoptotic Cell Reactivity Associated With High Levels of Disease Activity in Systemic Lupus Erythematosus
Objective To determine the prevalence of anti–apoptotic cell (anti‐AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE). Methods Serum samples from 60 SLE patients and...
Saved in:
| Published in | Arthritis & rheumatology (Hoboken, N.J.) Vol. 65; no. 12; pp. 3165 - 3175 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.12.2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0004-3591 2326-5191 1529-0131 1529-0131 2326-5205 |
| DOI | 10.1002/art.38138 |
Cover
| Abstract | Objective
To determine the prevalence of anti–apoptotic cell (anti‐AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE).
Methods
Serum samples from 60 SLE patients and 40 healthy donors were incubated with apoptotic Jurkat cells and assayed by flow cytometry for the binding of 9G4+ antibodies. The samples were also tested for 9G4+ reactivity against naive B cells and total IgG and IgM anti‐AC antibody reactivity.
Results
The 9G4+ antibodies bound late ACs in sera from a majority of the SLE patients (60%) but in sera from only 2 healthy control subjects. Among samples with global IgM or IgG anti‐AC antibodies, those with 9G4+ anti‐AC antibodies predominated. Patients with high levels of 9G4+ anti‐AC antibodies were more likely to have active disease. This was the case even in patients with IgG anti‐AC antibodies or anti–double‐stranded DNA antibodies. Patients with lupus nephritis were also more likely to have 9G4+ anti‐AC antibodies. While 9G4+ reactivity to ACs often coincided with anti–B cell reactivity, some samples had distinct anti–AC or anti–B cell reactivity.
Conclusion
The 9G4+ antibody represents a major species of anti‐AC antibody in SLE serum, and this autoreactivity is associated with disease activity. The anti‐AC reactivity of 9G4+ antibodies can be separated from the germline VH4–34–encoded anti–B cell autoreactivity. Our results indicate that ACs are an important antigenic source in SLE that positively selects B cells with intrinsic autoreactivity against other self antigens. This selection of 9G4+ B cells by ACs may represent an important step in disease progression. |
|---|---|
| AbstractList | Objective
To determine the prevalence of anti–apoptotic cell (anti‐AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE).
Methods
Serum samples from 60 SLE patients and 40 healthy donors were incubated with apoptotic Jurkat cells and assayed by flow cytometry for the binding of 9G4+ antibodies. The samples were also tested for 9G4+ reactivity against naive B cells and total IgG and IgM anti‐AC antibody reactivity.
Results
The 9G4+ antibodies bound late ACs in sera from a majority of the SLE patients (60%) but in sera from only 2 healthy control subjects. Among samples with global IgM or IgG anti‐AC antibodies, those with 9G4+ anti‐AC antibodies predominated. Patients with high levels of 9G4+ anti‐AC antibodies were more likely to have active disease. This was the case even in patients with IgG anti‐AC antibodies or anti–double‐stranded DNA antibodies. Patients with lupus nephritis were also more likely to have 9G4+ anti‐AC antibodies. While 9G4+ reactivity to ACs often coincided with anti–B cell reactivity, some samples had distinct anti–AC or anti–B cell reactivity.
Conclusion
The 9G4+ antibody represents a major species of anti‐AC antibody in SLE serum, and this autoreactivity is associated with disease activity. The anti‐AC reactivity of 9G4+ antibodies can be separated from the germline VH4–34–encoded anti–B cell autoreactivity. Our results indicate that ACs are an important antigenic source in SLE that positively selects B cells with intrinsic autoreactivity against other self antigens. This selection of 9G4+ B cells by ACs may represent an important step in disease progression. To determine the prevalence of anti-apoptotic cell (anti-AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE).OBJECTIVETo determine the prevalence of anti-apoptotic cell (anti-AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE).Serum samples from 60 SLE patients and 40 healthy donors were incubated with apoptotic Jurkat cells and assayed by flow cytometry for the binding of 9G4+ antibodies. The samples were also tested for 9G4+ reactivity against naive B cells and total IgG and IgM anti-AC antibody reactivity.METHODSSerum samples from 60 SLE patients and 40 healthy donors were incubated with apoptotic Jurkat cells and assayed by flow cytometry for the binding of 9G4+ antibodies. The samples were also tested for 9G4+ reactivity against naive B cells and total IgG and IgM anti-AC antibody reactivity.The 9G4+ antibodies bound late ACs in sera from a majority of the SLE patients (60%) but in sera from only 2 healthy control subjects. Among samples with global IgM or IgG anti-AC antibodies, those with 9G4+ anti-AC antibodies predominated. Patients with high levels of 9G4+ anti-AC antibodies were more likely to have active disease. This was the case even in patients with IgG anti-AC antibodies or anti-double-stranded DNA antibodies. Patients with lupus nephritis were also more likely to have 9G4+ anti-AC antibodies. While 9G4+ reactivity to ACs often coincided with anti-B cell reactivity, some samples had distinct anti-AC or anti-B cell reactivity.RESULTSThe 9G4+ antibodies bound late ACs in sera from a majority of the SLE patients (60%) but in sera from only 2 healthy control subjects. Among samples with global IgM or IgG anti-AC antibodies, those with 9G4+ anti-AC antibodies predominated. Patients with high levels of 9G4+ anti-AC antibodies were more likely to have active disease. This was the case even in patients with IgG anti-AC antibodies or anti-double-stranded DNA antibodies. Patients with lupus nephritis were also more likely to have 9G4+ anti-AC antibodies. While 9G4+ reactivity to ACs often coincided with anti-B cell reactivity, some samples had distinct anti-AC or anti-B cell reactivity.The 9G4+ antibody represents a major species of anti-AC antibody in SLE serum, and this autoreactivity is associated with disease activity. The anti-AC reactivity of 9G4+ antibodies can be separated from the germline VH4-34-encoded anti-B cell autoreactivity. Our results indicate that ACs are an important antigenic source in SLE that positively selects B cells with intrinsic autoreactivity against other self antigens. This selection of 9G4+ B cells by ACs may represent an important step in disease progression.CONCLUSIONThe 9G4+ antibody represents a major species of anti-AC antibody in SLE serum, and this autoreactivity is associated with disease activity. The anti-AC reactivity of 9G4+ antibodies can be separated from the germline VH4-34-encoded anti-B cell autoreactivity. Our results indicate that ACs are an important antigenic source in SLE that positively selects B cells with intrinsic autoreactivity against other self antigens. This selection of 9G4+ B cells by ACs may represent an important step in disease progression. To determine the prevalence of anti-apoptotic cell (anti-AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE). Serum samples from 60 SLE patients and 40 healthy donors were incubated with apoptotic Jurkat cells and assayed by flow cytometry for the binding of 9G4+ antibodies. The samples were also tested for 9G4+ reactivity against naive B cells and total IgG and IgM anti-AC antibody reactivity. The 9G4+ antibodies bound late ACs in sera from a majority of the SLE patients (60%) but in sera from only 2 healthy control subjects. Among samples with global IgM or IgG anti-AC antibodies, those with 9G4+ anti-AC antibodies predominated. Patients with high levels of 9G4+ anti-AC antibodies were more likely to have active disease. This was the case even in patients with IgG anti-AC antibodies or anti-double-stranded DNA antibodies. Patients with lupus nephritis were also more likely to have 9G4+ anti-AC antibodies. While 9G4+ reactivity to ACs often coincided with anti-B cell reactivity, some samples had distinct anti-AC or anti-B cell reactivity. The 9G4+ antibody represents a major species of anti-AC antibody in SLE serum, and this autoreactivity is associated with disease activity. The anti-AC reactivity of 9G4+ antibodies can be separated from the germline VH4-34-encoded anti-B cell autoreactivity. Our results indicate that ACs are an important antigenic source in SLE that positively selects B cells with intrinsic autoreactivity against other self antigens. This selection of 9G4+ B cells by ACs may represent an important step in disease progression. Objective To determine the prevalence of anti-apoptotic cell (anti-AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+ specificities and disease activity in patients with systemic lupus erythematosus (SLE). Methods Serum samples from 60 SLE patients and 40 healthy donors were incubated with apoptotic Jurkat cells and assayed by flow cytometry for the binding of 9G4+ antibodies. The samples were also tested for 9G4+ reactivity against naive B cells and total IgG and IgM anti-AC antibody reactivity. Results The 9G4+ antibodies bound late ACs in sera from a majority of the SLE patients (60%) but in sera from only 2 healthy control subjects. Among samples with global IgM or IgG anti-AC antibodies, those with 9G4+ anti-AC antibodies predominated. Patients with high levels of 9G4+ anti-AC antibodies were more likely to have active disease. This was the case even in patients with IgG anti-AC antibodies or anti-double-stranded DNA antibodies. Patients with lupus nephritis were also more likely to have 9G4+ anti-AC antibodies. While 9G4+ reactivity to ACs often coincided with anti-B cell reactivity, some samples had distinct anti-AC or anti-B cell reactivity. Conclusion The 9G4+ antibody represents a major species of anti-AC antibody in SLE serum, and this autoreactivity is associated with disease activity. The anti-AC reactivity of 9G4+ antibodies can be separated from the germline VH4-34-encoded anti-B cell autoreactivity. Our results indicate that ACs are an important antigenic source in SLE that positively selects B cells with intrinsic autoreactivity against other self antigens. This selection of 9G4+ B cells by ACs may represent an important step in disease progression. [PUBLICATION ABSTRACT] |
| Author | Palmer, Elise M. Marin, Elides Y. Richardson, Christopher Hartson, Louise Chida, Asiya Seema Sanz, Ignacio Jenks, Scott A. |
| Author_xml | – sequence: 1 givenname: Scott A. surname: Jenks fullname: Jenks, Scott A. organization: University of Rochester School of Medicine – sequence: 2 givenname: Elise M. surname: Palmer fullname: Palmer, Elise M. organization: University of Rochester School of Medicine – sequence: 3 givenname: Elides Y. surname: Marin fullname: Marin, Elides Y. organization: University of Rochester School of Medicine – sequence: 4 givenname: Louise surname: Hartson fullname: Hartson, Louise organization: Emory University School of Medicine – sequence: 5 givenname: Asiya Seema surname: Chida fullname: Chida, Asiya Seema organization: University of Rochester School of Medicine – sequence: 6 givenname: Christopher surname: Richardson fullname: Richardson, Christopher organization: University of Rochester School of Medicine – sequence: 7 givenname: Ignacio surname: Sanz fullname: Sanz, Ignacio organization: University of Rochester School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23983101$$D View this record in MEDLINE/PubMed |
| BookMark | eNp90d9r1TAUB_AgE3c3ffAfkIAvinTLj6Y3fSzXuQ0uCNvEx3Kannoz2qYm6aT_iX-u2e7mw0BfEhI-50tyzhE5GN2IhLzl7IQzJk7BxxOpudQvyIorUWaMS35AVoyxPJOq5IfkKITbdBRSyVfkUMhSS874ivwuz_NPtJqjgzHaxrUWA608Uhjp5TA5H9M9vXazN0hdR6vJTdFFa-gG-55eIZho72xcaBWCMxYitvS7jTt6YX_s6BbvsA_3hZ9tQAhIqydvR3q9hIhDytrO0xzomV_iDgeILszhNXnZQR_wzeN-TL59ObvZXGTbr-eXm2qbmZznOpO6BWVaNKXkUGAjGlhrwZUB1elWtE2JUnUAje4aDeW6aBR23BQAqkAmQB6TD_vcybufM4ZYDzaY9DcY0c2h5nkh1kVaWaLvn9Hb1Jcxve5BMS5kLpJ696jmZsC2nrwdwC_1U88T-LgHxrsQPHZ_CWf1_TzrNM_6YZ7Jnj6zxkaI1o3Rg-3_V_HL9rj8O7qurm72FX8AxyKy5Q |
| CODEN | ARHEAW |
| CitedBy_id | crossref_primary_10_1136_annrheumdis_2021_220349 crossref_primary_10_1016_j_cell_2016_05_034 crossref_primary_10_1016_j_coi_2015_10_001 crossref_primary_10_4049_jimmunol_1900799 crossref_primary_10_1016_j_molmed_2017_05_006 crossref_primary_10_1002_art_41673 crossref_primary_10_1038_s41598_017_00664_0 crossref_primary_10_4049_jimmunol_1700601 crossref_primary_10_1038_s41598_020_78223_3 crossref_primary_10_1084_jem_20150585 crossref_primary_10_1186_s13075_015_0561_1 crossref_primary_10_1007_s00281_014_0430_z crossref_primary_10_1007_s10875_014_0025_4 crossref_primary_10_1111_imr_12820 crossref_primary_10_1084_jem_20230774 crossref_primary_10_4049_jimmunol_1202263 crossref_primary_10_1038_nri_2017_24 crossref_primary_10_1038_ni_3175 crossref_primary_10_1038_s41467_023_37083_x |
| Cites_doi | 10.1084/jem.20031763 10.4049/jimmunol.1102797 10.1006/bbrc.2000.3322 10.1007/s10495-008-0227-4 10.1074/jbc.M310805200 10.1172/JCI0211638 10.1084/jem.20081165 10.4049/jimmunol.172.7.4298 10.1016/j.jaut.2007.02.005 10.1038/sj.ki.5002133 10.1002/art.1780251101 10.1371/journal.pone.0017495 10.1006/jmbi.1996.0110 10.1046/j.1365-3083.2000.00654.x 10.4049/jimmunol.175.4.2692 10.1084/jem.179.4.1317 10.1002/art.20187 10.1172/JCI24179 10.1136/ard.2007.081828 10.1016/j.molimm.2006.09.027 10.1002/eji.200838624 10.1038/sj.cdd.4402184 10.1016/j.clim.2012.01.002 10.1002/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H 10.1126/science.1061663 10.1136/ard.57.9.566 10.1006/jaut.2001.0519 10.1016/j.biolcel.2004.04.013 10.1002/art.34380 10.1371/journal.pone.0035356 10.1080/08916930701356663 10.1093/rheumatology/32.10.876 10.1038/sj.cdd.4400460 10.4049/jimmunol.176.1.68 10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO;2-K 10.4049/jimmunol.168.5.2538 10.1002/art.22947 10.1002/art.24535 10.1111/j.1749-6632.2003.tb06035.x 10.1006/bcmd.1996.0020 10.1016/j.clim.2004.02.017 10.2119/2008-00102.Catera 10.1016/j.jim.2007.09.017 10.1007/s00281-004-0188-9 10.1002/art.1780350606 |
| ContentType | Journal Article |
| Copyright | Copyright © 2013 by the American College of Rheumatology Copyright © 2013 by the American College of Rheumatology. |
| Copyright_xml | – notice: Copyright © 2013 by the American College of Rheumatology – notice: Copyright © 2013 by the American College of Rheumatology. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QL 7QP 7T5 7TM 7U7 C1K H94 K9. 7X8 |
| DOI | 10.1002/art.38138 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Toxicology Abstracts Bacteriology Abstracts (Microbiology B) Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Calcium & Calcified Tissue Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Toxicology Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1529-0131 2326-5205 |
| EndPage | 3175 |
| ExternalDocumentID | 3138908191 23983101 10_1002_art_38138 ART38138 |
| Genre | article Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIH Medical Scientist Training Program through a grant to the University of Rochester – fundername: NIH (National Institute of Allergy and Infectious Diseases [NIAID]) funderid: R37‐AI‐049660 – fundername: Autoimmunity Centers of Excellence grant from the NIAID funderid: U19‐AI‐56390; P01‐AI‐078907; R01‐AI‐84808 – fundername: NIAID NIH HHS grantid: P01-AI-078907 – fundername: NIDCR NIH HHS grantid: T90 DE021985 – fundername: NIAID NIH HHS grantid: U19 AI056390 – fundername: NIAID NIH HHS grantid: U19-AI-56390 – fundername: NIAID NIH HHS grantid: R37 AI049660 – fundername: NIAID NIH HHS grantid: R21 AI057431 – fundername: NIAID NIH HHS grantid: R37-AI-049660 – fundername: NIAID NIH HHS grantid: R01 AI049660 – fundername: NIAID NIH HHS grantid: R01-AI-84808 – fundername: NIDCR NIH HHS grantid: R01 DE017585 |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 10A 1CY 1KJ 1L6 1OB 1OC 1ZS 23N 31~ 3O- 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52W 52X 53G 5GY 5RE 66C 6J9 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEVG AAFWJ AAHQN AAIPD AAKAS AAMMB AAMNL AANHP AANLZ AAQQT AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABQWH ABXGK ACAHQ ACBWZ ACCZN ACFBH ACGFO ACMXC ACPOU ACRPL ACSCC ACXBN ACXQS ACYXJ ADBTR ADEOM ADIZJ ADMGS ADNMO ADOZA ADZCM AEFGJ AEIGN AEIMD AEUYR AFBPY AFFNX AFFPM AFGKR AFWVQ AFZJQ AGQPQ AGXDD AGYGG AHBTC AI. AIACR AIDQK AIDYY AITYG AIURR ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZFZN BDRZF BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM EBS EJD EMOBN EX3 F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J5H JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LSO LUTES LW6 LYRES M65 MEWTI MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NNB OIG OVD P2P P2W P2X P2Z P4B P4D Q11 QB0 QRW RIWAO RJQFR ROL RX1 RXW RYL SJN SUPJJ TAE TEORI TWZ UB1 V2E V8K V9Y VH1 W8V WH7 WIB WIH WIJ WIK WJL WOW WQJ WXI WXSBR X6Y X7M XG1 XPP XV2 YFH YOC ZGI ZXP ZZTAW ~IA ~WT AAHHS AAYXX ACCFJ ADZOD AEEZP AEQDE AIWBW AJBDE CITATION CGR CUY CVF ECM EIF NPM 0R~ 33P 3SF 52U 52V 5VS 7QL 7QP 7T5 7TM 7U7 AAESR AASGY ABLJU ABPVW ACGFS ACGOF ACIWK ACPRK ADBBV ADKYN ADXAS ADZMN AENEX AEYWJ AFRAH AHMBA ALAGY ALVPJ AZVAB BFHJK BHBCM BMXJE C1K DIK FUBAC H94 K9. KBYEO NF~ O66 O9- PQQKQ WBKPD WHWMO WOHZO WVDHM 7X8 |
| ID | FETCH-LOGICAL-c4148-38da5cdec931a6eb2ba78215ca5f8d2db9e35faab8fb8a976b5ef1c6aa56e02a3 |
| IEDL.DBID | DR2 |
| ISSN | 0004-3591 2326-5191 1529-0131 |
| IngestDate | Fri Sep 05 02:42:42 EDT 2025 Mon Jun 30 10:13:12 EDT 2025 Mon Jul 21 05:54:36 EDT 2025 Tue Jul 01 01:05:24 EDT 2025 Thu Apr 24 23:09:43 EDT 2025 Sun Sep 21 06:17:24 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor Copyright © 2013 by the American College of Rheumatology. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4148-38da5cdec931a6eb2ba78215ca5f8d2db9e35faab8fb8a976b5ef1c6aa56e02a3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3981458 |
| PMID | 23983101 |
| PQID | 1462012342 |
| PQPubID | 946334 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_1462761460 proquest_journals_1462012342 pubmed_primary_23983101 crossref_primary_10_1002_art_38138 crossref_citationtrail_10_1002_art_38138 wiley_primary_10_1002_art_38138_ART38138 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | December 2013 |
| PublicationDateYYYYMMDD | 2013-12-01 |
| PublicationDate_xml | – month: 12 year: 2013 text: December 2013 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Atlanta |
| PublicationTitle | Arthritis & rheumatology (Hoboken, N.J.) |
| PublicationTitleAlternate | Arthritis Rheum |
| PublicationYear | 2013 |
| Publisher | Wiley Subscription Services, Inc |
| Publisher_xml | – name: Wiley Subscription Services, Inc |
| References | 2004; 200 1994; 179 2012; 142 2012; 188 2005; 175 2009; 60 2005; 115 1999; 26 2008; 38 2008; 329 2008; 14 2008; 15 2000; 51 2006; 176 2008; 13 2008; 205 2007; 71 1992; 35 2000; 275 1998; 41 2005; 26 2011; 6 1999; 6 2007; 56 2007; 28 2004; 112 1982; 25 2004; 96 2004; 50 2001; 293 2003; 987 2002; 29 2004; 279 2006; 24 2002; 168 2002; 46 1993; 32 2004; 172 2008; 67 2007; 40 2001; 17 2002; 109 2012; 7 2007; 44 1996; 256 2012; 64 1998; 57 1996; 22 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_17_1 e_1_2_7_15_1 Richardson C (e_1_2_7_27_1) e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 Vollenhoven RF (e_1_2_7_21_1) 1999; 26 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_23_1 Saisoong S (e_1_2_7_33_1) 2006; 24 e_1_2_7_35_1 e_1_2_7_37_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_51_1 e_1_2_7_30_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_34_1 e_1_2_7_20_1 e_1_2_7_36_1 Bhat NM (e_1_2_7_22_1) 2002; 29 e_1_2_7_38_1 Pugh‐Bernard A (e_1_2_7_29_1) 2002; 46 |
| References_xml | – volume: 17 start-page: 71 year: 2001 end-page: 80 article-title: Activation of natural interferon‐α producing cells by apoptotic U937 cells combined with lupus IgG and its regulation by cytokines publication-title: J Autoimmun – volume: 28 start-page: 114 year: 2007 end-page: 21 article-title: Clearance deficiency and systemic lupus erythematosus (SLE) publication-title: J Autoimmun – volume: 329 start-page: 112 year: 2008 end-page: 24 article-title: Efficient generation of monoclonal antibodies from single human B cells by single cell RT‐PCR and expression vector cloning publication-title: J Immunol Methods – volume: 25 start-page: 1271 year: 1982 end-page: 7 article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 115 start-page: 3205 year: 2005 end-page: 16 article-title: Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus publication-title: J Clin Invest – volume: 29 start-page: 2114 year: 2002 end-page: 21 article-title: VH4‐34 encoded antibody in systemic lupus erythematosus: effect of isotype publication-title: J Rheumatol – volume: 26 start-page: 433 year: 2005 end-page: 52 article-title: Human innate B cells: a link between host defense and autoimmunity? publication-title: Springer Semin Immunopathol – volume: 293 start-page: 306 year: 2001 end-page: 11 article-title: Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family publication-title: Science – volume: 142 start-page: 390 year: 2012 end-page: 8 article-title: IgM autoantibodies to distinct apoptosis‐associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE publication-title: Clin Immunol – volume: 50 start-page: 1549 year: 2004 end-page: 60 article-title: Requirement of dying cells and environmental adjuvants for the induction of autoimmunity publication-title: Arthritis Rheum – volume: 41 start-page: 1241 year: 1998 end-page: 50 article-title: Impaired phagocytosis of apoptotic cell material by monocyte‐derived macrophages from patients with systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 60 start-page: 1733 year: 2009 end-page: 42 article-title: Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 175 start-page: 2692 year: 2005 end-page: 701 article-title: Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity? publication-title: J Immunol – volume: 205 start-page: 3007 year: 2008 end-page: 18 article-title: Induction of inflammatory and immune responses by HMGB1‐nucleosome complexes: implications for the pathogenesis of SLE publication-title: J Exp Med – volume: 46 start-page: S126 issue: Suppl year: 2002 article-title: VH4‐34 anti‐I/i autoantibodies recognize apoptotic cells publication-title: Arthritis Rheum – volume: 35 start-page: 630 year: 1992 end-page: 40 article-title: Derivation of the SLEDAI: a disease activity index for lupus patients publication-title: Arthritis Rheum – volume: 44 start-page: 1914 year: 2007 end-page: 21 article-title: Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs publication-title: Mol Immunol – volume: 7 start-page: e35356 year: 2012 article-title: 9G4 autoreactivity is increased in HIV‐infected patients and correlates with HIV broadly neutralizing serum activity publication-title: PLoS One – volume: 38 start-page: 3561 year: 2008 end-page: 74 article-title: Endogenous humoral autoreactive immune responses to apoptotic cells: effects on phagocytic uptake, chemotactic migration and antigenic spread publication-title: Eur J Immunol – volume: 112 start-page: 175 year: 2004 end-page: 82 article-title: Apoptosis, subcellular particles, and autoimmunity publication-title: Clin Immunol – volume: 26 start-page: 1727 year: 1999 end-page: 33 article-title: VH4‐34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics publication-title: J Rheumatol – volume: 51 start-page: 134 year: 2000 end-page: 40 article-title: Recognition of auto‐ and exoantigens by V4‐34 gene encoded antibodies publication-title: Scand J Immunol – volume: 168 start-page: 2538 year: 2002 end-page: 43 article-title: C1q deficiency and autoimmunity: the effects of genetic background on disease expression publication-title: J Immunol – volume: 14 start-page: 665 year: 2008 end-page: 74 article-title: Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation publication-title: Mol Med – volume: 6 start-page: 6 year: 1999 end-page: 12 article-title: Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease publication-title: Cell Death Differ – volume: 179 start-page: 1317 year: 1994 end-page: 30 article-title: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes publication-title: J Exp Med – article-title: Molecular determinants of 9G4 B cells autoreactivity and selection in human SLE publication-title: J Immunol – volume: 176 start-page: 68 year: 2006 end-page: 74 article-title: Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases publication-title: J Immunol – volume: 24 start-page: 51 year: 2006 end-page: 8 article-title: Correlations between antinucleosome antibodies and anti‐double‐stranded DNA antibodies, C3, C4, and clinical activity in lupus patients publication-title: Clin Exp Rheumatol – volume: 67 start-page: 1626 year: 2008 end-page: 32 article-title: IgG autoantibodies bound to surfaces of necrotic cells and complement C4 comprise the phagocytosis promoting activity for necrotic cells of systemic lupus erythaematosus sera publication-title: Ann Rheum Dis – volume: 275 start-page: 412 year: 2000 end-page: 7 article-title: Naturally occurring anti‐band 3 antibody binds to apoptotic human T‐lymphoid cell line Jurkat through sialylated poly‐N‐acetyllactosaminyl saccharide chains on the cell surface publication-title: Biochem Biophys Res Commun – volume: 64 start-page: 2319 year: 2012 end-page: 27 article-title: Prevalence and sociodemographic correlates of antinuclear antibodies in the United States publication-title: Arthritis Rheum – volume: 256 start-page: 577 year: 1996 end-page: 89 article-title: The I binding specificity of human VH 4‐34 (VH 4‐21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3 publication-title: J Mol Biol – volume: 6 start-page: e17495 year: 2011 article-title: Abnormal production of pro‐ and anti‐inflammatory cytokines by lupus monocytes in response to apoptotic cells publication-title: PLoS One – volume: 56 start-page: 3399 year: 2007 end-page: 411 article-title: Opsonization of late apoptotic cells by systemic lupus erythematosus autoantibodies inhibits their uptake via an Fcγ receptor–dependent mechanism publication-title: Arthritis Rheum – volume: 71 start-page: 664 year: 2007 end-page: 72 article-title: Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis publication-title: Kidney Int – volume: 57 start-page: 566 year: 1998 end-page: 70 article-title: Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus publication-title: Ann Rheum Dis – volume: 96 start-page: 603 year: 2004 end-page: 15 article-title: Rearrangement of nuclear ribonucleoprotein (RNP)‐containing structures during apoptosis and transcriptional arrest publication-title: Biol Cell – volume: 32 start-page: 876 year: 1993 end-page: 82 article-title: Identification of the 9G4 idiotope in systemic lupus erythematosus publication-title: Br J Rheumatol – volume: 22 start-page: 126 year: 1996 end-page: 38 article-title: The V4‐34 encoded anti‐i autoantibodies recognize a large subset of human and mouse B‐cells publication-title: Blood Cells Mol Dis – volume: 13 start-page: 1054 year: 2008 end-page: 63 article-title: Quantitative image based apoptotic index measurement using multispectral imaging flow cytometry: a comparison with standard photometric methods publication-title: Apoptosis – volume: 172 start-page: 4298 year: 2004 end-page: 307 article-title: Lupus IgG VH4.34 antibodies bind to a 220‐kDa glycoform of CD45/B220 on the surface of human B lymphocytes publication-title: J Immunol – volume: 40 start-page: 337 year: 2007 end-page: 9 article-title: Opsonization by anti‐dsDNA antibodies of apoptotic cells in systemic lupus erythematosus publication-title: Autoimmunity – volume: 987 start-page: 79 year: 2003 end-page: 90 article-title: Major peptide autoepitopes for nucleosome‐centered T and B cell interaction in human and murine lupus publication-title: Ann N Y Acad Sci – volume: 15 start-page: 243 year: 2008 end-page: 50 article-title: Clearance of apoptotic cells by phagocytes publication-title: Cell Death Differ – volume: 46 start-page: 191 year: 2002 end-page: 201 article-title: Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus publication-title: Arthritis Rheum – volume: 188 start-page: 902 year: 2012 end-page: 15 article-title: Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes publication-title: J Immunol – volume: 279 start-page: 5967 year: 2004 end-page: 74 article-title: Carbohydrate‐mediated phagocytic recognition of early apoptotic cells undergoing transient capping of CD43 glycoprotein publication-title: J Biol Chem – volume: 109 start-page: 41 year: 2002 end-page: 50 article-title: Phosphatidylserine‐dependent ingestion of apoptotic cells promotes TGF‐β1 secretion and the resolution of inflammation publication-title: J Clin Invest – volume: 200 start-page: 1359 year: 2004 end-page: 70 article-title: Apoptotic cells with oxidation‐specific epitopes are immunogenic and proinflammatory publication-title: J Exp Med – ident: e_1_2_7_34_1 doi: 10.1084/jem.20031763 – ident: e_1_2_7_14_1 doi: 10.4049/jimmunol.1102797 – ident: e_1_2_7_41_1 doi: 10.1006/bbrc.2000.3322 – ident: e_1_2_7_25_1 doi: 10.1007/s10495-008-0227-4 – ident: e_1_2_7_42_1 doi: 10.1074/jbc.M310805200 – ident: e_1_2_7_43_1 doi: 10.1172/JCI0211638 – ident: e_1_2_7_40_1 doi: 10.1084/jem.20081165 – ident: e_1_2_7_17_1 doi: 10.4049/jimmunol.172.7.4298 – ident: e_1_2_7_3_1 doi: 10.1016/j.jaut.2007.02.005 – ident: e_1_2_7_9_1 doi: 10.1038/sj.ki.5002133 – ident: e_1_2_7_23_1 doi: 10.1002/art.1780251101 – volume: 46 start-page: S126 year: 2002 ident: e_1_2_7_29_1 article-title: VH4‐34 anti‐I/i autoantibodies recognize apoptotic cells publication-title: Arthritis Rheum – volume: 29 start-page: 2114 year: 2002 ident: e_1_2_7_22_1 article-title: VH4‐34 encoded antibody in systemic lupus erythematosus: effect of isotype publication-title: J Rheumatol – ident: e_1_2_7_44_1 doi: 10.1371/journal.pone.0017495 – ident: e_1_2_7_50_1 doi: 10.1006/jmbi.1996.0110 – ident: e_1_2_7_46_1 doi: 10.1046/j.1365-3083.2000.00654.x – ident: e_1_2_7_45_1 doi: 10.4049/jimmunol.175.4.2692 – ident: e_1_2_7_37_1 doi: 10.1084/jem.179.4.1317 – ident: e_1_2_7_8_1 doi: 10.1002/art.20187 – ident: e_1_2_7_18_1 doi: 10.1172/JCI24179 – ident: e_1_2_7_11_1 doi: 10.1136/ard.2007.081828 – ident: e_1_2_7_38_1 doi: 10.1016/j.molimm.2006.09.027 – ident: e_1_2_7_39_1 doi: 10.1002/eji.200838624 – ident: e_1_2_7_2_1 doi: 10.1038/sj.cdd.4402184 – ident: e_1_2_7_16_1 doi: 10.1016/j.clim.2012.01.002 – ident: e_1_2_7_4_1 doi: 10.1002/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H – ident: e_1_2_7_7_1 doi: 10.1126/science.1061663 – ident: e_1_2_7_20_1 doi: 10.1136/ard.57.9.566 – ident: e_1_2_7_12_1 doi: 10.1006/jaut.2001.0519 – ident: e_1_2_7_49_1 doi: 10.1016/j.biolcel.2004.04.013 – ident: e_1_2_7_32_1 doi: 10.1002/art.34380 – ident: e_1_2_7_51_1 doi: 10.1371/journal.pone.0035356 – ident: e_1_2_7_10_1 doi: 10.1080/08916930701356663 – ident: e_1_2_7_19_1 doi: 10.1093/rheumatology/32.10.876 – ident: e_1_2_7_48_1 doi: 10.1038/sj.cdd.4400460 – ident: e_1_2_7_35_1 doi: 10.4049/jimmunol.176.1.68 – ident: e_1_2_7_5_1 doi: 10.1002/1529-0131(200201)46:1<191::AID-ART10027>3.0.CO;2-K – ident: e_1_2_7_6_1 doi: 10.4049/jimmunol.168.5.2538 – ident: e_1_2_7_15_1 doi: 10.1002/art.22947 – ident: e_1_2_7_13_1 doi: 10.1002/art.24535 – ident: e_1_2_7_47_1 doi: 10.1111/j.1749-6632.2003.tb06035.x – ident: e_1_2_7_31_1 doi: 10.1006/bcmd.1996.0020 – ident: e_1_2_7_27_1 article-title: Molecular determinants of 9G4 B cells autoreactivity and selection in human SLE publication-title: J Immunol – ident: e_1_2_7_36_1 doi: 10.1016/j.clim.2004.02.017 – ident: e_1_2_7_30_1 doi: 10.2119/2008-00102.Catera – volume: 26 start-page: 1727 year: 1999 ident: e_1_2_7_21_1 article-title: VH4‐34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics publication-title: J Rheumatol – ident: e_1_2_7_26_1 doi: 10.1016/j.jim.2007.09.017 – ident: e_1_2_7_28_1 doi: 10.1007/s00281-004-0188-9 – volume: 24 start-page: 51 year: 2006 ident: e_1_2_7_33_1 article-title: Correlations between antinucleosome antibodies and anti‐double‐stranded DNA antibodies, C3, C4, and clinical activity in lupus patients publication-title: Clin Exp Rheumatol – ident: e_1_2_7_24_1 doi: 10.1002/art.1780350606 |
| SSID | ssj0002353 ssj0000970605 |
| Score | 2.2347145 |
| Snippet | Objective
To determine the prevalence of anti–apoptotic cell (anti‐AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other... To determine the prevalence of anti-apoptotic cell (anti-AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other known 9G4+... Objective To determine the prevalence of anti-apoptotic cell (anti-AC) antibodies with the 9G4 idiotype (9G4+) and the relationship between this and other... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 3165 |
| SubjectTerms | Adolescent Adult Aged Aged, 80 and over Antibodies, Anti-Idiotypic - blood Apoptosis - immunology Autoantibodies - blood Autoimmune diseases Female Flow Cytometry Humans Immune system Immunoglobulin G - immunology Immunoglobulin M - immunology Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - immunology Male Middle Aged Severity of Illness Index |
| Title | 9G4+ Autoantibodies Are an Important Source of Apoptotic Cell Reactivity Associated With High Levels of Disease Activity in Systemic Lupus Erythematosus |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fart.38138 https://www.ncbi.nlm.nih.gov/pubmed/23983101 https://www.proquest.com/docview/1462012342 https://www.proquest.com/docview/1462761460 |
| Volume | 65 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqHhAX3o-FUhnEAQllu7FjryNOqz5ooeVQqOgBKfIrYsWSrJrkAL-En8uMnaQqDwlxi5TxI86M_dme-YaQ507ZElnJk1RZnmQul4kWTCW-NE45Ps-9w2jkk3fy8Cx7cy7ON8irIRYm8kOMB25oGWG-RgPXptm5JA2FkZ3CcsMx0DflEnnz904vqaMY7xko8eRf5OnAKjRjO2PJq2vRbwDzKl4NC87BTfJp6Gr0M_ky7Voztd9_YXH8z2-5RW70QJQuoubcJhu-ukOunfRX7XfJj_x19pIuuraGsV-aGr0NQdpTXdGjrwG1Vy19H87-aV3SxbpetzVURnf9akVPPUZMYGIKOmiAd_Tjsv1M0bWEHqOzUoMF9-IVEV0M8suKRh51qOu4W3cN3b_4Fsll66Zr7pGzg_0Pu4dJn8YhsRkeV3LltLDO25ynWsJO3miAJamwWpTKMWdyz0WptVGlURrgkRG-TK3UWkg_Y5rfJ5tVXfmHhBpR5lrkTMOskjErjeQunSNnv8ysV7MJeTH80ML2HOeYamNVRHZmVsBIF2GkJ-TZKLqOxB5_EtoatKLobbvBzRJDJJqxCXk6vgarxKsWXfm6izJzQD4SuvQgatPYCjIuAqhOobNBJ_7efAF7mvDw6N9FH5PrDDN2BI-bLbLZXnT-CeCm1myDgRy93Q5m8hPQqRai |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkaCX8i5bChjEAQllu7FjryNxWZWWLez2UFrRC4r8irrqkqya5AC_hJ-Lx05SlYeEuEXK-JHJjP15PP6M0CsjdA6s5FEsNI0Sk_JIMiIimysjDB2n1sBp5PkRn54mH87Y2Rp6252FCfwQfcANPMOP1-DgEJDevWINdaoduvmGihvopt-fA0h0fEUeRWjLQQmxf5bGHa_QiOz2Ra_PRr9BzOuI1U85B3fQl66zIdPkYtjUaqi__8Lj-L9fcxdttlgUT4Lx3ENrtriPbs3b3fYH6Ef6PnmDJ01dOvUvVAkJh07aYlngw68euBc1_uTD_7jM8WRVrurSVYb37HKJjy0cmoC7KXBnBNbgz4v6HEN2CZ5BvlIFBd-FXSI86eQXBQ5U6q6uWbNqKrx_-S3wy5ZVUz1Epwf7J3vTqL3JIdIJRCypMJJpY3VKY8ndYl5Jh0xipiXLhSFGpZayXEolciWkQ0iK2TzWXErG7YhI-gitF2VhHyOsWJ5KlhLpBpaEaK44NfEYaPt5oq0YDdDr7o9muqU5h9s2llkgaCaZ03TmNT1AL3vRVeD2-JPQTmcWWeveFayXCIDRhAzQi_61c0zYbZGFLZsgM3bgh7subQVz6lsB0kWHq2PXWW8Uf28-c8sa_7D976LP0e3pyXyWzQ6PPj5BGwQu8PAJODtovb5s7FMHo2r1zHvLT5WRGcc |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkSouvB8LBQzigISy3Tix1xGnVdulhW2FChU9VIr8ilh1m0RNcoBfws9lJk5SlYeEuEXK-BFnxvPZHn9DyCsrTYas5EEoTRTENhGB4kwGLtNW2miaOIu3kQ8Oxd5x_P6En6yRt_1dGM8PMWy4oWW08zUaeGmzrUvSUBjZMbibSF4j12MBbhIR0dEldxSLOgpK3PrnSdjTCk3Y1lD0qjP6DWFeBaytx5nfIqd9X32gydm4qfXYfP-FxvE_P-Y2udkhUTrzqnOHrLn8Ltk46M7a75Efybv4DZ01dQGDv9QFhhuCtKMqp_vnLWzPa_qp3fynRUZnZVHWBVRGt91qRY8cXpnAzBS0VwFn6Zdl_ZVibAldYLRShQV3_BkRnfXyy5x6InWoa9GUTUV3L755dtmiaqr75Hi--3l7L-jyOAQmxv3KSFrFjXUmiUIlYCmvFeCSkBvFM2mZ1YmLeKaUlpmWCvCR5i4LjVCKCzdhKnpA1vMid48I1TxLFE-YgmklZkZoEdlwiqT9IjZOTkbkdf9DU9ORnGOujVXq6ZlZCiOdtiM9Ii8H0dIze_xJaLPXirQz7gpXSwyhaMxG5MXwGswSz1pU7orGy0wB-gjo0kOvTUMrSLkIqDqEzrY68ffmU1jUtA-P_130Odn4uDNPF_uHH56QGwyzd7TRN5tkvb5o3FPAULV-1trKTzzPGHY |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=9G4%2B+autoantibodies+are+an+important+source+of+apoptotic+cell+reactivity+associated+with+high+levels+of+disease+activity+in+systemic+lupus+erythematosus&rft.jtitle=Arthritis+and+rheumatism&rft.au=Jenks%2C+Scott+A&rft.au=Palmer%2C+Elise+M&rft.au=Marin%2C+Elides+Y&rft.au=Hartson%2C+Louise&rft.date=2013-12-01&rft.eissn=1529-0131&rft.volume=65&rft.issue=12&rft.spage=3165&rft_id=info:doi/10.1002%2Fart.38138&rft_id=info%3Apmid%2F23983101&rft.externalDocID=23983101 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0004-3591&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0004-3591&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0004-3591&client=summon |