Identification and Synthesis of Impurities in Pinocembrin A New Drug for the Treatment of Ischemic Stroke

Four minor impurities in pinocembrin （1）--a new drug to treat ischemic stroke, were analysed and identified by means of HPLC-UV-MS analysis, spectroscopic evidences and chemical synthetic methods. Their chemical struc- tures were identified as 5,7-dihydroxy-2-phenyl-4H-l-benzopyran-4-one （2）, 3-phen...

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Published inChinese journal of chemistry Vol. 30; no. 6; pp. 1315 - 1319
Main Author 杨庆云 童元峰 陈锋 戚燕 李薇 吴松
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.06.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Multidisciplinary
impurity
ischemic stroke
Liquid chromatography
Patients
Physical Sciences
pinocembrin
Science & Technology
side product
Stroke
synthesis
中风
化学合成
杂质
缺血
羟基苯基
苯并吡喃
药物治疗
识别
synthesis
impurity
side product
pinocembrin
ischemic stroke
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ISSN1001-604X
1614-7065
DOI10.1002/cjoc.201200201

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Summary:Four minor impurities in pinocembrin （1）--a new drug to treat ischemic stroke, were analysed and identified by means of HPLC-UV-MS analysis, spectroscopic evidences and chemical synthetic methods. Their chemical struc- tures were identified as 5,7-dihydroxy-2-phenyl-4H-l-benzopyran-4-one （2）, 3-phenyl-l-（2,4,6-trihydroxyphenyl）- 1-propanone （3）, 5,%dihydroxy-2-cyclohexyl-4H-l-benzopyran-4-one （4）, and 2,3-dihydro-5,7-dihydroxy-2- cyclohexyl-4H-l-benzopyran-4-one （5）, respectively. All of the impurities were side products of excessive hydro- genation of the target product I or the starting material 2 in the course of synthesis, and 5 was a new compound.
Bibliography:31-1547/O6
Yang, Qingyun Tong, Yuanfeng Chen, Feng Qi, Yan Li, Wei Wu, Song
pinocembrin, impurity, ischemic stroke, side product, synthesis
Four minor impurities in pinocembrin （1）--a new drug to treat ischemic stroke, were analysed and identified by means of HPLC-UV-MS analysis, spectroscopic evidences and chemical synthetic methods. Their chemical struc- tures were identified as 5,7-dihydroxy-2-phenyl-4H-l-benzopyran-4-one （2）, 3-phenyl-l-（2,4,6-trihydroxyphenyl）- 1-propanone （3）, 5,%dihydroxy-2-cyclohexyl-4H-l-benzopyran-4-one （4）, and 2,3-dihydro-5,7-dihydroxy-2- cyclohexyl-4H-l-benzopyran-4-one （5）, respectively. All of the impurities were side products of excessive hydro- genation of the target product I or the starting material 2 in the course of synthesis, and 5 was a new compound.
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istex:8851941E782A320D0A7A3B8E72B04D59A4212E20
the Research Special Fund for Public Welfare Industry of Health - No. 200902008
ArticleID:CJOC201200201
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200201