Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons - Huang, Hsien-Sung; Allen, John A.; Mabb, Angela M.; King, Ian F.; Miriyala, Jayalakshmi; Taylor-Blake, Bonnie; Sciaky, Noah; Dutton, J. Walter; Lee, Hyeong-Min; Chen, Xin; Jin, Jian; Bridges, Arlene S.; et al. (Nature (London), 2011)
Keywords: 631/154/309/436; 631/208/200; 631/378/2571/1696; 692/699/375/366; Alleles; Angelman Syndrome - drug therapy; Angelman Syndrome - genetics; Animals; Cells, Cultured; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Drug Evaluation, Preclinical; Fathers; Female; Gene Silencing - drug effects; Genomic Imprinting - drug effects; Genomic Imprinting - genetics; Humanities and Social Sciences; letter; Male; Mice; Mice, Inbred C57BL; Mothers; multidisciplinary; Neurons - drug effects; Neurons - metabolism; Science; Science (multidisciplinary); Small Molecule Libraries - administration & dosage; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Topoisomerase Inhibitors - administration & dosage; Topoisomerase Inhibitors - analysis; Topoisomerase Inhibitors - pharmacokinetics; Topoisomerase Inhibitors - pharmacology; Topotecan - administration & dosage; Topotecan - pharmacokinetics; Topotecan - pharmacology; Ubiquitin-Protein Ligases - deficiency; Ubiquitin-Protein Ligases - genetics