Prevalence of Chromosomal Abnormalities in Iranian Patients with Infertility

• Published in: Archives of Iranian medicine Vol. 26; no. 2; pp. 110 - 116
• Main Authors: Abbaspour, Saima, Isazadeh, Alireza, Heidari, Matin, Heidari, Masoud, Hajazimian, Saba, Soleyman-Nejad, Morteza, Taskhiri, Mohammad Hossein, Bolhassani, Manzar, Ebrahimi, Amir Hossein, Keshavarz, Parvaneh, Shiri, Zahra, Heidari, Mansour
• Format: Journal Article
• Language: English
• Published: Iran Academy of Medical Sciences of I.R. Iran 01.02.2023
• Subjects: Chromosome Aberrations; Chromosomes; Female; Genetics; Humans; Infertility; Infertility, Female - epidemiology; Infertility, Female - genetics; Infertility, Male - epidemiology; Infertility, Male - genetics; Iran - epidemiology; Karyotyping; Male; Mens health; Miscarriage; Original; Prevalence; Womens health; Iran; Cytogenetics; Chromosomal abnormalities; Infertility; Karyotyping
• ISSN: 1029-2977; 1735-3947; 1735-3947
• DOI: 10.34172/aim.2023.17

Background: The numerical and structural abnormalities of chromosomes are the most common cause of infertility. Here, we evaluated the prevalence and types of chromosomal abnormalities in Iranian infertile patients. Methods: We enrolled 1750 couples of reproductive age with infertility, who referred to infertility clinics in Tehran during 2014- 2019, in order to perform chromosomal analysis. Peripheral blood samples were obtained from all couples and chromosomal abnormalities were evaluated by G-banded metaphase karyotyping. In some cases, the detected abnormalities were confirmed using fluorescence in-situ hybridization (FISH). Results: We detected various chromosomal abnormalities in 114/3500 (3.257%) patients with infertility. The prevalence of chromosomal abnormalities was 44/114 (38.596%) among infertile females and 70/114 (61.403%) among infertile males. Structural chromosomal abnormalities were found in 27/1750 infertile females and 35/1750 infertile males. Numerical chromosomal abnormalities were found in 17/1750 of females and 35/1750 of males. The 45, XY, rob (13;14) (p10q10) translocation and Klinefelter syndrome (47, XXY) were the most common structural and numerical chromosomal abnormalities in the Iranian infertile patients, respectively. Conclusion: In general, we found a high prevalence of chromosomal abnormalities in Iranian patients with reproductive problems. Our study highlights the importance of cytogenetic studies in infertile patients before starting infertility treatments approaches.