Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes

In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both growth hormone deficiency (GHD) and GH excess have significan...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 20; no. 3; p. 772
Main Authors Bonfig, Walter, Holl, Reinhard W.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.02.2019
MDPI
Subjects
Children & youth
Conflicts of interest
Diabetes
Diabetic retinopathy
Growth hormones
Hemoglobin
Insulin
Insulin-like growth factors
Metabolism
Pediatrics
Physical growth
Proteins
Switzerland
Austria
Germany
growth hormone treatment
type 1 diabetes
growth hormone
GH–IGF-I axis
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms20030772

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Summary:In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both growth hormone deficiency (GHD) and GH excess have significant influence on carbohydrate metabolism. These complex interactions are challenging in diagnosing GHD in subjects with type 1 diabetes mellitus (T1DM) and in treating subjects with T1DM with GH. So far, there is only limited clinical experience in GH treatment in patients with T1DM, but recently first reports on metabolic safety and efficacy of GH treatment in subjects with T1DM have been published.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20030772