Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease - Huang, Biao; Zeng, Zipeng; Kim, Sunghyun; Fausto, Connor C.; Koppitch, Kari; Li, Hui; Li, Zexu; Chen, Xi; Guo, Jinjin; Zhang, Chennan C.; Ma, Tianyi; Medina, Pedro; et al. (Cell stem cell, 2024)
Keywords: Animals; CAKUT; Cell Differentiation; cellular plasticity; congenital anomalies of the kidney and urinary tract; CRISPR screen; Gene Editing; hPSC; human pluripotent stem cell; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Kidney - pathology; kidney organoid; Mice; Models, Biological; nephron progenitor cell; Nephrons - cytology; NPC; Organoids - cytology; Organoids - metabolism; PKD; podocyte; Podocytes - cytology; Podocytes - metabolism; polycystic kidney disease; Polycystic Kidney, Autosomal Dominant - genetics; Polycystic Kidney, Autosomal Dominant - metabolism; Polycystic Kidney, Autosomal Dominant - pathology; Wilms tumor; NPC; nephron progenitor cell; CAKUT; congenital anomalies of the kidney and urinary tract; hPSC; PKD; polycystic kidney disease; human pluripotent stem cell; podocyte; Wilms tumor; cellular plasticity; CRISPR screen; kidney organoid