A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects - Li, Rui; Niosi, Mark; Johnson, Nathaniel; Tess, David A.; Kimoto, Emi; Lin, Jian; Yang, Xin; Riccardi, Keith A.; Ryu, Sangwoo; El-Kattan, Ayman F.; Maurer, Tristan S.; Tremaine, Larry M.; et al. (Drug metabolism and disposition, 2018)
Keywords: ATP-Binding Cassette Transporters - metabolism; Bile; Biopsy; Bosentan; Confidence intervals; Drug interaction; Drug interactions; Drug Interactions - physiology; Exposure; Healthy Volunteers; Hepatocytes - metabolism; Humans; Liver; Liver - metabolism; Mathematical models; Membrane Transport Proteins - metabolism; Modelling; MRP protein; Multidrug resistance; Multidrug Resistance-Associated Proteins - metabolism; Organic Anion Transporters - metabolism; Organic Anion Transporters, Sodium-Dependent - metabolism; Pharmacodynamics; Pharmacokinetics; Pharmacology; Predictions; Proteins; Sensitivity analysis; Sodium; Substrates; Sulfonamides - blood; Sulfonamides - pharmacokinetics; Symporters - metabolism; Toxicity; DILI; BSEP; CI; DDI; MCMC; PBPK; MRP; OATP; ET; RBC; NTCP; P450; PK; PET