Role of Glycosphingolipids in Formation and Function of Membrane Microdomains
Recent years have been characterized by a huge interest in the structure and function of mammalian cell membrane lipid domains. The interest in this subject grew further, when their participation in important membrane-associated events such as signal transmission, cell adhesion and lipid/protein sor...
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| Published in | Trends in Glycoscience and Glycotechnology Vol. 13; no. 71; pp. 239 - 250 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
FCCA(Forum: Carbohydrates Coming of Age)
2001
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-7352 1883-2113 1883-2113 |
| DOI | 10.4052/tigg.13.239 |
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| Abstract | Recent years have been characterized by a huge interest in the structure and function of mammalian cell membrane lipid domains. The interest in this subject grew further, when their participation in important membrane-associated events such as signal transmission, cell adhesion and lipid/protein sorting was postulated. A common feature of cell membrane domains is their peculiar lipid composition, being enriched in glycosphingolipids, sphingomyelin and cholesterol. A series of theoretical considerations and several experimental data suggest that glycosphingolipids play an important role in the formation and function of membrane domains. Within this review, the involvement of glycosphingolipids in the biogenesis, structure and function of domains is discussed in light of their strong amphiphilic nature and of their peculiar chemical features. These features differentiate glycosphingolipids from other lipids in the membrane, allowing either self-interaction or interaction with other membrane components and external ligands. Due to these interactions, glycosphingolipids undergo lateral phase, separation, segregation, and therefore form core domains within the membrane; glycosphingolipid domains constitute the nucleation point that allows co-segregation of other lipids and proteins in a complex domain; finally, glycosphingolipids confer dynamic properties on domains, that are essential to the modulation of cell functions. |
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| AbstractList | Recent years have been characterized by a huge interest in the structure and function of mammalian cell membrane lipid domains. The interest in this subject grew further, when their participation in important membrane-associated events such as signal transmission, cell adhesion and lipid/protein sorting was postulated. A common feature of cell membrane domains is their peculiar lipid composition, being enriched in glycosphingolipids, sphingomyelin and cholesterol. A series of theoretical considerations and several experimental data suggest that glycosphingolipids play an important role in the formation and function of membrane domains. Within this review, the involvement of glycosphingolipids in the biogenesis, structure and function of domains is discussed in light of their strong amphiphilic nature and of their peculiar chemical features. These features differentiate glycosphingolipids from other lipids in the membrane, allowing either self-interaction or interaction with other membrane components and external ligands. Due to these interactions, glycosphingolipids undergo lateral phase, separation, segregation, and therefore form core domains within the membrane; glycosphingolipid domains constitute the nucleation point that allows co-segregation of other lipids and proteins in a complex domain; finally, glycosphingolipids confer dynamic properties on domains, that are essential to the modulation of cell functions. |
| Author | Sonnino, Sandro Masserini, Massimo Ravasi, Daniela |
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(1996) FEBS Lett. 389, 52-54 46. Pitto, M., Palestini, P., Ferraretto, A., Flati, S., Pavan, A., Ravasi, D., Masserini, M., and Bottiroli, G. (1999) Biochem. J. 343, 177-184 24. Sharom, F.J., and Grant, C.W., (1978) Biochem. Biophys. Acta 507, 280-293 45. Mutoh, T., Tokuda, A., Miyadai, T., Hamaguchi, M., and Fujiki, N. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 5087-5091 |
| References_xml | – reference: 46. Pitto, M., Palestini, P., Ferraretto, A., Flati, S., Pavan, A., Ravasi, D., Masserini, M., and Bottiroli, G. (1999) Biochem. J. 343, 177-184 – reference: 3. Anderson, R.G.W. (1993) Proc. Natl. Acad. Sci. USA 90, 10909-10913 – reference: 30. Riboni, L., Viani, P., Bassi, R., Prinetti, A., Tettamanti, G. (1997) Progress in Lipid Research 36, 153-195 – reference: 54. Benowitz, L.I., and Routtenberg, A. (1997) Trends Neurosci. 20, 84-91 – reference: 61. Sonnino, S., Acquotti, D., Cantù, L., Chigorno, V., Valsecchi, M., Casellato, R., Masserini, M., Corti, M., Allevi, P., and Tettamanti, G. (1994) Chem. Phys. Lipids 69, 95-104 – reference: 41. Terzaghi, A., Tettamanti, G., and Masserini, M. (1993) Biochemistry 32, 9722-9725 – reference: 53. Kasahara, K., Watanabe, K., Takeuchi, K., Kaneko, H., Oohira, A., Yamamoto, T., and Sanai, Y. (2000) J. Biol. Chem. 275, 34701-34709 – reference: 12. Cinek, T., and Horejsi, V. (1992) J. Immunol. 149, 2262-2270 – reference: 19. Prinetti, A., Chigorno, V., Tettamanti, G., and Sonnino, S. (2000) J. Biol. Chem. 275, 11658-11665 – reference: 59. Cantù, L., Corti, M., Casellato, R., Acquotti, D., and Sonnino, S. (1991) Chem. Phys. Lipids 60, 111-118 – reference: 6. Lisanti, M.P., Scherer, P.E., Tang, Z., and Sargiacomo, M. (1994) Trends Cell Biol. 4, 231-235 – reference: 56. Cantù, L., Corti, M., Sonnino, S., and Tettamanti, G. (1990) Chem. Phys. Lipids 55, 223-229 – reference: 26. Palestini, P., Pitto, M., Ferraretto, A., Tettamanti, G., and Masserini, M. (1998) Biochemistry 37, 3143-3148 – reference: 15. Moss, D.J., and White, C.A. (1992) Eur. J. Cell Biol. 57, 59-65 – reference: 52. Kasahara, K., Watanabe, Y., Yamamoto, T., and Sanai, Y. (1997) J. Biol. Chem. 272, 29947-29953 – reference: 39. Nyholm, P.G., and Pascher, I. (1993) Biochemistry 32, 1225-1234 – reference: 49. Yang, L., and Glaser, M., (1996) Biochemistry 35, 13966-13974 – reference: 29. Masserini, M., Giuliani, A., Palestini, P., Acquotti, D., Pitto, M., Chigorno, V., and Tettamanti, G. (1990) Biochemistry 29, 697-701 – reference: 42. Schroeder, E, Nemecz, G., Wood, W.G., Joiner, C., Morrot, G., Ayraut-Jarrier, M., and Devaux, PF. (1991) Biochim. Biophys. Acta 1066, 183-192 – reference: 18. Chigorno, V., Palestini, P., Sciannamblo, M. T., Dolo, V., Pavan, A., Tettamanti, G., and Sonnino, S. (2000) Eur. J. Biochem. 267, 4187-4197 – reference: 16. Ledesma, M.D., Simons, K., and Dotti, C.G. (1998) Proc. Natl. Acad. Sci. USA 95, 3966-3971 – reference: 22. Olive, S., Dubois, C., Schachner, M., and Rougon, G. (1995) J. Neurochem. 65, 2307-2317 – reference: 31. Wiegandt, H. (1985) in “New Comprehesive Biochemistry” (Wiegandt, H., ed.) Glycosphingolipids 10, 199-260 – reference: 37. Acquotti, D., Fronza, G., Ragg, E., and Sonnino, S. (1991) Chem. Phys. Lipids 59, 107-125 – reference: 27. Pitto, M., Mutoh, T., Kuriyama, M., Ferraretto, A., Palestini, P., and Masserini, M. (1998) FEBS Lett. 439, 93-96 – reference: 24. Sharom, F.J., and Grant, C.W., (1978) Biochem. Biophys. Acta 507, 280-293 – reference: 45. Mutoh, T., Tokuda, A., Miyadai, T., Hamaguchi, M., and Fujiki, N. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 5087-5091 – reference: 28. Goins, B., and Freire, E. (1985) Biochemistry 24, 1791-1797 – reference: 36. Acquotti, D., Cantù, L., Ragg, E., and Sonnino, S. (1994) Eur. J. Biochem. 225, 271-288 – reference: 25. Ferraretto, A., Pitto, M., Palestini, P., and Masserini, M. (1997) Biochemistry 36, 9232-9236 – reference: 32. Pascher, I. (1976) Biochim. Biophys. Acta 455, 433-451 – reference: 57. Cantù, L., Corti, M., Sonnino, S., and Tettamanti, G. (1986) Chem. Phys. Lipids 41, 315-328 – reference: 58. Sonnino, S., Acquotti, D., Fronza, G., Cantù, L., Chigorno, V., Pitto, M., Kirschner, G., and Tettamanti, G. (1988) Chem. Phys. Lipids 46, 181-191 – reference: 8. Schnitzer, J.E., Liu, J., and Oh, P. (1995) J. Biol. Chem. 270, 14399-14404 – reference: 23. Vey, M., Pilkuhn, S., Wille, H., Nixon, R., DeArmond, S.J., Smart, E.J., Anderson, R.G., Taraboulos, A., and Prusiner, S.B. (1996) Proc. Natl. Acad. Sci. USA 93, 14945-14949 – reference: 1. Thompson, T.E., and Tillack, T.W. (1985) Ann. Rev. Biophys. Chem. 14, 361-386 – reference: 47. Calappi, E., Masserini, M., Schiavo, G., Montecucco, C., and Tettamanti, G. (1992) FEBS Lett. 309, 107-110 – reference: 10. Kurzchalia, T.V., and Parton, R.G. (1996) FEBS Lett. 389, 52-54 – reference: 5. Oka, N., Yamamoto, M., Schwencke, C., Kawabe, J., Ebina, T., Ohno, S., Couet, J., Lisanti, M.P., and Ishikawa, Y. (1997) J. Biol. Chem. 272, 33416-33421 – reference: 40. Masserini, M., Palestini, P., and Freire, E. (1989) Biochemistry 28, 5029-5039 – reference: 7. Okamoto, T., Schelgel, A., Scherer, P.E., and Lisanti, M.P. (1998) J. Biol. Chem. 273, 5419-5422 – reference: 2. Simons, K., and Van Meer, G. (1988) Biochemistry 27, 6197-6202 – reference: 4. Masserini, M., Palestini, P., and Pitto, M. (1999) J. Neurochem. 73, 1-11 – reference: 17. Wu, C., Butz, S., Ying, Y., and Anderson, R.G. (1997) J. Biol. Chem. 272, 3554-3559 – reference: 9. Smart, E.J., Mineo, C., and Anderson, R.G.W. (1996) J. Cell Biol. 134, 1169-1177 – reference: 33. Brocca, P., Berthault, P., and Sonnino, S. (1998) Biophysical J. 74, 309-318 – reference: 48. Palestini, P., Masserini, M., Bottiroli, G., Brunner, J., Mutoh, T., Ferraretto, A., Ravasi, D., and Pitto, M. (1999) Biosci. Reports 19, 385-395 – reference: 11. Brown, D., and Rose, J.K. (1992) Cell 68, 533-544 – reference: 13. Rothberg, K.G., Heuser, J.E., Donzell, W.C., Ying, Y., Glenney, J.R., and Anderson, R.G.W. (1992) Cell 68, 673-682 – reference: 20. Parton, R.G. (1994) J. Histochem. Cytochem. 42, 155-166 – reference: 44. Cameron, P.L., Ruffin, J.W., Bollag, R., Rasmussen, H., and Cameron, R.S. (1997) J. Neurosci. 17, 9520-9535 – reference: 38. Pascher, I., and Sundel, S. (1977) Chem. Phys. Lipids 20, 175-191 – reference: 50. Palestini, P., Pitto, M., Tedeschi, G., Ferraretto, A., Parenti, M., Brunner, J., and Masserini, M. (2000) J. of Biol. Chem. 275, 9978-9986 – reference: 14. Sargiacomo, M., Sudol, M., Tang, Z., and Lisanti, M.P. (1993) J. Cell Biol. 122, 789-807 – reference: 34. Bach, D., Sela, B., and Miller, I.R. (1982) Chem. Phys. Lipids 31, 381-394 – reference: 51. Aderem, A. (1995) Biochemical Society Transactions 23, 587-591 – reference: 43. Pitto, M., Brunner, J. Ferraretto, A., Ravasi, D., Palestini, P., and Masserini M. (2000) Glycoconjugate J. 17, 215-222. – reference: 60. Sonnino, S., Cantù, L., Corti, M., Acquotti, D., Kirschner, G., and Tettamanti, G. (1990) Chem. Phys. Lipids 56, 49-57 – reference: 21. Fra, A.M., Masserini, M., Palestini, P., Sonnino, S., and Simons, K. (1995) FEBS Lett. 375, 11-14 – reference: 35. Acquotti, D., Poppe, L., Dabrowski, J., von der Lieth, G.W., Sonnino, S., and Tettamanti, G. (1990) J. Am. Chem. Soc. 112, 7772-7778 – reference: 55. Sonnino, S., Cantiù, L., Acquotti, D., Corti, M., and Tettamanti, G. (1990) Chem. Phys. Lipids 52, 231-241 |
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| Title | Role of Glycosphingolipids in Formation and Function of Membrane Microdomains |
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