Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses

p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we u...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 17; p. 9595
Main Authors Nordgaard, Cathrine, Tollenaere, Maxim A. X., Val, Ana Martinez Del, Bekker-Jensen, Dorte B., Blasius, Melanie, Olsen, Jesper V., Bekker-Jensen, Simon
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.09.2021
MDPI
Subjects
Carrier Proteins - metabolism
Cell cycle
Cell division
Cell Line, Tumor
Cyclin-dependent kinases
Cytokines
Golgi Apparatus - metabolism
Humans
Immune system
Inflammation
JNK Mitogen-Activated Protein Kinases - metabolism
Kinases
MAP Kinase Kinase 4 - metabolism
MAP Kinase Kinase 4 - physiology
MAP Kinase Signaling System - physiology
Mitogen-Activated Protein Kinase Kinases - metabolism
Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - physiology
Phosphorylation
Physiology
Principal components analysis
Proteins
Proto-Oncogene Proteins c-jun - metabolism
Signal Transduction
Stress, Physiological - physiology
GIGYF
translation and Golgi
p38
phosphorylation
JNK
stress signaling
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms22179595

Cover

Abstract p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics to identify several hundred substrates for both kinases. Our results indicate that the scale of signaling from p38 and JNK are of a similar magnitude. Among the many new targets, we highlight the regulation of the transcriptional regulators grb10-interacting GYF protein 1 and 2 (GIGYF1/2) by p38-dependent MAP kinase-activated protein kinase 2 (MK2) phosphorylation and 14–3–3 binding. We also show that the Golgi apparatus contains numerous substrates, and is a major target for regulation by p38 and JNK. When activated, these kinases mediate structural rearrangement of the Golgi apparatus, which positively affects protein flux through the secretory system. Our work expands on our knowledge about p38 and JNK signaling with important biological ramifications.
AbstractList p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics to identify several hundred substrates for both kinases. Our results indicate that the scale of signaling from p38 and JNK are of a similar magnitude. Among the many new targets, we highlight the regulation of the transcriptional regulators grb10-interacting GYF protein 1 and 2 (GIGYF1/2) by p38-dependent MAP kinase-activated protein kinase 2 (MK2) phosphorylation and 14–3–3 binding. We also show that the Golgi apparatus contains numerous substrates, and is a major target for regulation by p38 and JNK. When activated, these kinases mediate structural rearrangement of the Golgi apparatus, which positively affects protein flux through the secretory system. Our work expands on our knowledge about p38 and JNK signaling with important biological ramifications.
p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics to identify several hundred substrates for both kinases. Our results indicate that the scale of signaling from p38 and JNK are of a similar magnitude. Among the many new targets, we highlight the regulation of the transcriptional regulators grb10-interacting GYF protein 1 and 2 (GIGYF1/2) by p38-dependent MAP kinase-activated protein kinase 2 (MK2) phosphorylation and 14-3-3 binding. We also show that the Golgi apparatus contains numerous substrates, and is a major target for regulation by p38 and JNK. When activated, these kinases mediate structural rearrangement of the Golgi apparatus, which positively affects protein flux through the secretory system. Our work expands on our knowledge about p38 and JNK signaling with important biological ramifications.p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics to identify several hundred substrates for both kinases. Our results indicate that the scale of signaling from p38 and JNK are of a similar magnitude. Among the many new targets, we highlight the regulation of the transcriptional regulators grb10-interacting GYF protein 1 and 2 (GIGYF1/2) by p38-dependent MAP kinase-activated protein kinase 2 (MK2) phosphorylation and 14-3-3 binding. We also show that the Golgi apparatus contains numerous substrates, and is a major target for regulation by p38 and JNK. When activated, these kinases mediate structural rearrangement of the Golgi apparatus, which positively affects protein flux through the secretory system. Our work expands on our knowledge about p38 and JNK signaling with important biological ramifications.
Author Nordgaard, Cathrine
Olsen, Jesper V.
Tollenaere, Maxim A. X.
Val, Ana Martinez Del
Bekker-Jensen, Dorte B.
Blasius, Melanie
Bekker-Jensen, Simon
AuthorAffiliation 2 LEO Pharma A/S, Industriparken 55, 2750 Ballerup, Denmark
1 Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; nordgaard@sund.ku.dk (C.N.); EVXDK@leo-pharma.com (M.A.X.T.); blasius@sund.ku.dk (M.B.)
3 Mass Spectrometry for Quantitative Proteomics, Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; ana.mdval@cpr.ku.dk (A.M.D.V.); dorte.bekker-jensen@cpr.ku.dk (D.B.B.-J.); jesper.olsen@cpr.ku.dk (J.V.O.)
AuthorAffiliation_xml – name: 1 Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; nordgaard@sund.ku.dk (C.N.); EVXDK@leo-pharma.com (M.A.X.T.); blasius@sund.ku.dk (M.B.)
– name: 3 Mass Spectrometry for Quantitative Proteomics, Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; ana.mdval@cpr.ku.dk (A.M.D.V.); dorte.bekker-jensen@cpr.ku.dk (D.B.B.-J.); jesper.olsen@cpr.ku.dk (J.V.O.)
– name: 2 LEO Pharma A/S, Industriparken 55, 2750 Ballerup, Denmark
Author_xml – sequence: 1
  givenname: Cathrine
  orcidid: 0000-0002-9817-1961
  surname: Nordgaard
  fullname: Nordgaard, Cathrine
– sequence: 2
  givenname: Maxim A. X.
  surname: Tollenaere
  fullname: Tollenaere, Maxim A. X.
– sequence: 3
  givenname: Ana Martinez Del
  surname: Val
  fullname: Val, Ana Martinez Del
– sequence: 4
  givenname: Dorte B.
  surname: Bekker-Jensen
  fullname: Bekker-Jensen, Dorte B.
– sequence: 5
  givenname: Melanie
  orcidid: 0000-0001-5032-2209
  surname: Blasius
  fullname: Blasius, Melanie
– sequence: 6
  givenname: Jesper V.
  surname: Olsen
  fullname: Olsen, Jesper V.
– sequence: 7
  givenname: Simon
  surname: Bekker-Jensen
  fullname: Bekker-Jensen, Simon
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34502507$$D View this record in MEDLINE/PubMed
BookMark eNptkUlLJDEYhoMo7rc5DwEvc7A1W1UlF0Ga0XFBweXgKSSVpE1TndQkVQP--4krrXhKIM_38H55t8BqiMEC8AOjA0oFOvTzRSYEN6IS1QrYxIyQCUJ1s7p03wBbOc8RIpRUYh1sUFYhUqFmEzzc2NnYqcHHAKODw6OFp7GbeXjc9yqpYcxQP8GecqiCgedXF_DCB5VthmZMPszg1HZdESR4OySbM7yxuY-hADtgzaku2923cxvcn_y-m_6ZXF6fnk2PLyctw2SY4Ao77ZTQzmJOUMupbojWRLkGuVoIJ5BhRitu6tq0pNWOCsEYM8I0ldWcboOjV28_6oU1rQ1DUp3sk1-o9CSj8vLzS_CPchb_Sc4ornldBL_eBCn-HW0e5MLntqylgo1jlqRqsCCIo2d07ws6j2MKZb0XilDOGSrUz-VEH1Hef70A5BVoU8w5WSdbP7x0UAL6TmIkn6uVy9WWof0vQ-_eb_H_pRil0w
CitedBy_id crossref_primary_10_1016_j_cbi_2022_110106
crossref_primary_10_1093_jb_mvae080
crossref_primary_10_1038_s41413_024_00370_4
crossref_primary_10_1016_j_cell_2024_05_018
crossref_primary_10_1016_j_mcpro_2023_100527
crossref_primary_10_1126_sciadv_adl5638
crossref_primary_10_3390_ijms241512442
crossref_primary_10_1016_j_celrep_2022_111536
crossref_primary_10_1007_s13204_024_03076_5
crossref_primary_10_1111_febs_16275
Cites_doi 10.1038/nmeth1109-786
10.1016/j.molcel.2020.03.021
10.1038/nbt.1511
10.1016/j.cell.2016.11.034
10.1189/jlb.1208774
10.1101/gad.246272.114
10.1093/nar/gkz429
10.1038/s41467-018-03417-3
10.1016/j.celrep.2019.03.006
10.1038/s41580-019-0118-2
10.1038/jhg.2015.69
10.3389/fcell.2015.00079
10.1242/jcs.164871
10.1128/MCB.22.13.4929-4942.2002
10.1091/mbc.12.6.1811
10.1530/JME-15-0146
10.1002/bies.201700063
10.7554/eLife.58828
10.1128/MMBR.00043-14
10.1091/mbc.e17-02-0112
10.1128/MCB.17.6.3373
10.1093/nar/gkaa757
10.1101/gad.299420.117
10.1073/pnas.0812819106
10.1091/mbc.e07-11-1200
10.1038/nrm3546
10.1093/bioinformatics/btv133
10.1128/MMBR.00031-10
10.1007/s10072-015-2316-9
10.1016/S0092-8674(00)80487-0
10.1093/nar/gky198
10.1038/s41580-020-00322-w
10.1038/emboj.2013.223
10.1016/j.molcel.2020.06.010
10.1261/rna.054833.115
10.1038/s41574-018-0059-4
10.3390/cells7070065
10.1038/nrc2694
10.1016/j.celrep.2020.108262
10.1016/j.cell.2020.06.006
10.1038/ncomms2669
10.1128/MCB.01456-06
10.1038/nrm1834
10.1038/s41467-018-03309-6
10.1093/bioinformatics/btw580
10.1007/s00418-016-1527-3
10.1007/s10545-015-9851-7
10.1021/pr101065j
10.1083/jcb.200703166
10.1038/ncomms10075
10.1101/cshperspect.a005215
10.1016/j.molcel.2020.07.007
10.1038/s41467-020-18327-6
10.7554/eLife.60038
10.1128/MCB.16.3.1247
10.1007/s00418-013-1128-3
ContentType Journal Article
Copyright 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 by the authors. 2021
Copyright_xml – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2021 by the authors. 2021
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.3390/ijms22179595
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni)
Medical Database
Proquest Research Library
Research Library (Corporate)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database
MEDLINE
CrossRef
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID PMC8431686
34502507
10_3390_ijms22179595
Genre Journal Article
GroupedDBID ---
29J
2WC
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AFKRA
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
ESX
F5P
FRP
FYUFA
GNUQQ
GUQSH
GX1
HH5
HMCUK
HYE
IAO
IHR
ITC
KQ8
LK8
M1P
M2O
M48
MODMG
O5R
O5S
OK1
OVT
P2P
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RPM
TR2
TUS
UKHRP
~8M
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
3V.
7XB
8FK
K9.
MBDVC
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
ESTFP
PUEGO
5PM
ID FETCH-LOGICAL-c412t-151fbfa9bfe1820c83b72bb2af70f699f90d4dba8d66dc2cbf399444d9d75eb83
IEDL.DBID BENPR
ISSN 1422-0067
1661-6596
IngestDate Thu Aug 21 14:02:37 EDT 2025
Mon Sep 08 13:02:09 EDT 2025
Fri Jul 25 20:06:31 EDT 2025
Mon Jul 21 06:00:44 EDT 2025
Tue Jul 01 03:07:50 EDT 2025
Thu Apr 24 23:05:32 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 17
Keywords GIGYF
translation and Golgi
p38
phosphorylation
JNK
stress signaling
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c412t-151fbfa9bfe1820c83b72bb2af70f699f90d4dba8d66dc2cbf399444d9d75eb83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors contributed equally to this work.
ORCID 0000-0002-9817-1961
0000-0001-5032-2209
OpenAccessLink https://www.proquest.com/docview/2571238840?pq-origsite=%requestingapplication%&accountid=15518
PMID 34502507
PQID 2571238840
PQPubID 2032341
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8431686
proquest_miscellaneous_2571920806
proquest_journals_2571238840
pubmed_primary_34502507
crossref_citationtrail_10_3390_ijms22179595
crossref_primary_10_3390_ijms22179595
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20210904
PublicationDateYYYYMMDD 2021-09-04
PublicationDate_xml – month: 9
  year: 2021
  text: 20210904
  day: 4
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle International journal of molecular sciences
PublicationTitleAlternate Int J Mol Sci
PublicationYear 2021
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Wagner (ref_1) 2009; 9
Borisova (ref_11) 2018; 9
Cargnello (ref_2) 2011; 75
Bossard (ref_29) 2007; 179
Wieczorek (ref_54) 2017; 33
Wu (ref_43) 2020; 182
Manieri (ref_6) 2015; 55
Peter (ref_30) 2017; 31
ref_56
Zhang (ref_41) 2015; 36
Villumsen (ref_7) 2013; 32
ref_16
Chu (ref_40) 2009; 106
Hickey (ref_33) 2020; 79
Canovas (ref_3) 2021; 22
Day (ref_13) 2013; 140
Bekier (ref_28) 2017; 28
Kranjc (ref_24) 2017; 147
Glick (ref_14) 2011; 3
Ruscica (ref_35) 2019; 47
Vind (ref_37) 2020; 48
Krebs (ref_42) 2015; 60
Vind (ref_44) 2020; 78
Blasius (ref_49) 2014; 28
Iordanov (ref_45) 1997; 17
Madeira (ref_18) 2015; 31
Shiloh (ref_10) 2013; 14
Hogrebe (ref_51) 2018; 9
Kirk (ref_17) 2010; 87
Tollenaere (ref_8) 2015; 6
Juszkiewicz (ref_34) 2020; 9
Cox (ref_53) 2011; 10
Fu (ref_20) 2016; 22
Yaffe (ref_19) 1997; 91
Tollenaere (ref_21) 2019; 26
Weber (ref_31) 2020; 33
Feinstein (ref_23) 2008; 19
Meydan (ref_46) 2020; 79
Hubbe (ref_36) 2018; 46
Xiang (ref_27) 2013; 4
Ronkina (ref_50) 2007; 27
Potelle (ref_15) 2015; 38
Swaffer (ref_9) 2016; 167
Colaert (ref_55) 2009; 6
Cervigni (ref_48) 2015; 128
Raingeaud (ref_26) 1996; 16
Valente (ref_47) 2015; 3
Gaestel (ref_4) 2006; 7
Sinha (ref_32) 2020; 9
Zeke (ref_12) 2016; 80
Joazeiro (ref_38) 2019; 20
Martin (ref_39) 2020; 11
Franceschi (ref_5) 2018; 14
Lei (ref_25) 2002; 22
Jesch (ref_22) 2001; 12
Cox (ref_52) 2008; 26
References_xml – volume: 6
  start-page: 786
  year: 2009
  ident: ref_55
  article-title: Improved visualization of protein consensus sequences by iceLogo
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1109-786
– volume: 78
  start-page: 700
  year: 2020
  ident: ref_44
  article-title: ZAKalpha Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2020.03.021
– volume: 26
  start-page: 1367
  year: 2008
  ident: ref_52
  article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1511
– volume: 167
  start-page: 1750
  year: 2016
  ident: ref_9
  article-title: CDK Substrate Phosphorylation and Ordering the Cell Cycle
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.034
– volume: 87
  start-page: 245
  year: 2010
  ident: ref_17
  article-title: Biogenesis of secretory organelles during B cell differentiation
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1208774
– volume: 28
  start-page: 1977
  year: 2014
  ident: ref_49
  article-title: A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response
  publication-title: Genes Dev.
  doi: 10.1101/gad.246272.114
– volume: 47
  start-page: 7035
  year: 2019
  ident: ref_35
  article-title: Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz429
– volume: 9
  start-page: 1017
  year: 2018
  ident: ref_11
  article-title: p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03417-3
– volume: 26
  start-page: 3511
  year: 2019
  ident: ref_21
  article-title: GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.03.006
– volume: 20
  start-page: 368
  year: 2019
  ident: ref_38
  article-title: Mechanisms and functions of ribosome-associated protein quality control
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-019-0118-2
– volume: 60
  start-page: 637
  year: 2015
  ident: ref_42
  article-title: GIGYF2 mutation in late-onset Parkinson’s disease with cognitive impairment
  publication-title: J. Hum. Genet.
  doi: 10.1038/jhg.2015.69
– volume: 3
  start-page: 79
  year: 2015
  ident: ref_47
  article-title: Mechanisms and Regulation of the Mitotic Inheritance of the Golgi Complex
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2015.00079
– volume: 128
  start-page: 2249
  year: 2015
  ident: ref_48
  article-title: JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.164871
– volume: 22
  start-page: 4929
  year: 2002
  ident: ref_25
  article-title: The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.22.13.4929-4942.2002
– volume: 12
  start-page: 1811
  year: 2001
  ident: ref_22
  article-title: Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.12.6.1811
– volume: 55
  start-page: R11
  year: 2015
  ident: ref_6
  article-title: Stress kinases in the modulation of metabolism and energy balance
  publication-title: J. Mol. Endocrinol.
  doi: 10.1530/JME-15-0146
– ident: ref_16
  doi: 10.1002/bies.201700063
– volume: 9
  start-page: e58828
  year: 2020
  ident: ref_32
  article-title: EDF1 coordinates cellular responses to ribosome collisions
  publication-title: Elife
  doi: 10.7554/eLife.58828
– volume: 80
  start-page: 793
  year: 2016
  ident: ref_12
  article-title: JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.00043-14
– volume: 28
  start-page: 2833
  year: 2017
  ident: ref_28
  article-title: Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e17-02-0112
– volume: 17
  start-page: 3373
  year: 1997
  ident: ref_45
  article-title: Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.17.6.3373
– volume: 48
  start-page: 10648
  year: 2020
  ident: ref_37
  article-title: Ribosomal stress-surveillance: Three pathways is a magic number
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa757
– volume: 31
  start-page: 1147
  year: 2017
  ident: ref_30
  article-title: GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression
  publication-title: Genes Dev.
  doi: 10.1101/gad.299420.117
– volume: 106
  start-page: 2097
  year: 2009
  ident: ref_40
  article-title: A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0812819106
– volume: 19
  start-page: 2696
  year: 2008
  ident: ref_23
  article-title: GRASP55 regulates Golgi ribbon formation
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e07-11-1200
– volume: 14
  start-page: 197
  year: 2013
  ident: ref_10
  article-title: The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3546
– volume: 31
  start-page: 2276
  year: 2015
  ident: ref_18
  article-title: 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv133
– volume: 75
  start-page: 50
  year: 2011
  ident: ref_2
  article-title: Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.00031-10
– volume: 36
  start-page: 2073
  year: 2015
  ident: ref_41
  article-title: The contribution of GIGYF2 to Parkinson’s disease: A meta-analysis
  publication-title: Neurol. Sci.
  doi: 10.1007/s10072-015-2316-9
– volume: 91
  start-page: 961
  year: 1997
  ident: ref_19
  article-title: The structural basis for 14-3-3:phosphopeptide binding specificity
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80487-0
– volume: 46
  start-page: 5792
  year: 2018
  ident: ref_36
  article-title: 4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky198
– volume: 22
  start-page: 346
  year: 2021
  ident: ref_3
  article-title: Diversity and versatility of p38 kinase signalling in health and disease
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-00322-w
– volume: 32
  start-page: 3029
  year: 2013
  ident: ref_7
  article-title: A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis
  publication-title: EMBO J.
  doi: 10.1038/emboj.2013.223
– volume: 79
  start-page: 588
  year: 2020
  ident: ref_46
  article-title: Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2020.06.010
– volume: 22
  start-page: 373
  year: 2016
  ident: ref_20
  article-title: Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements
  publication-title: RNA
  doi: 10.1261/rna.054833.115
– volume: 14
  start-page: 576
  year: 2018
  ident: ref_5
  article-title: Inflammaging: A new immune-metabolic viewpoint for age-related diseases
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/s41574-018-0059-4
– ident: ref_56
  doi: 10.3390/cells7070065
– volume: 9
  start-page: 537
  year: 2009
  ident: ref_1
  article-title: Signal integration by JNK and p38 MAPK pathways in cancer development
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2694
– volume: 33
  start-page: 108262
  year: 2020
  ident: ref_31
  article-title: 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108262
– volume: 182
  start-page: 404
  year: 2020
  ident: ref_43
  article-title: Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
  publication-title: Cell
  doi: 10.1016/j.cell.2020.06.006
– volume: 4
  start-page: 1659
  year: 2013
  ident: ref_27
  article-title: Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2669
– volume: 27
  start-page: 170
  year: 2007
  ident: ref_50
  article-title: The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.01456-06
– volume: 7
  start-page: 120
  year: 2006
  ident: ref_4
  article-title: MAPKAP kinases—MKs—Two’s company, three’s a crowd
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1834
– volume: 9
  start-page: 1045
  year: 2018
  ident: ref_51
  article-title: Benchmarking common quantification strategies for large-scale phosphoproteomics
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03309-6
– volume: 33
  start-page: 135
  year: 2017
  ident: ref_54
  article-title: DAPAR & ProStaR: Software to perform statistical analyses in quantitative discovery proteomics
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw580
– volume: 147
  start-page: 439
  year: 2017
  ident: ref_24
  article-title: Functional characterisation of the YIPF protein family in mammalian cells
  publication-title: Histochem. Cell Biol.
  doi: 10.1007/s00418-016-1527-3
– volume: 38
  start-page: 741
  year: 2015
  ident: ref_15
  article-title: Golgi post-translational modifications and associated diseases
  publication-title: J. Inherit. Metab. Dis.
  doi: 10.1007/s10545-015-9851-7
– volume: 10
  start-page: 1794
  year: 2011
  ident: ref_53
  article-title: Andromeda: A peptide search engine integrated into the MaxQuant environment
  publication-title: J. Proteome Res.
  doi: 10.1021/pr101065j
– volume: 179
  start-page: 1123
  year: 2007
  ident: ref_29
  article-title: Dimeric PKD regulates membrane fission to form transport carriers at the TGN
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200703166
– volume: 6
  start-page: 10075
  year: 2015
  ident: ref_8
  article-title: p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms10075
– volume: 3
  start-page: a005215
  year: 2011
  ident: ref_14
  article-title: Models for Golgi traffic: A critical assessment
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a005215
– volume: 79
  start-page: 950
  year: 2020
  ident: ref_33
  article-title: GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2020.07.007
– volume: 11
  start-page: 4625
  year: 2020
  ident: ref_39
  article-title: NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-18327-6
– volume: 9
  start-page: e60038
  year: 2020
  ident: ref_34
  article-title: Ribosome collisions trigger cis-acting feedback inhibition of translation initiation
  publication-title: Elife
  doi: 10.7554/eLife.60038
– volume: 16
  start-page: 1247
  year: 1996
  ident: ref_26
  article-title: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.16.3.1247
– volume: 140
  start-page: 239
  year: 2013
  ident: ref_13
  article-title: A three-stage model of Golgi structure and function
  publication-title: Histochem. Cell Biol.
  doi: 10.1007/s00418-013-1128-3
SSID ssj0023259
Score 2.3837485
Snippet p38 and c-Jun N-terninal kinase (JNK) are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates,...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 9595
SubjectTerms Carrier Proteins - metabolism
Cell cycle
Cell division
Cell Line, Tumor
Cyclin-dependent kinases
Cytokines
Golgi Apparatus - metabolism
Humans
Immune system
Inflammation
JNK Mitogen-Activated Protein Kinases - metabolism
Kinases
MAP Kinase Kinase 4 - metabolism
MAP Kinase Kinase 4 - physiology
MAP Kinase Signaling System - physiology
Mitogen-Activated Protein Kinase Kinases - metabolism
Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - physiology
Phosphorylation
Physiology
Principal components analysis
Proteins
Proto-Oncogene Proteins c-jun - metabolism
Signal Transduction
Stress, Physiological - physiology
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEB58IHgR39YXEfQkVbdt0uQgIuIDRQ_qgp5Kkya6Urur3QX33ztpdovr69wpLTNJ5htm8n0A2zI2CNMj4ythrIRZyPyUS-5jEUdpKmioK3b-6xt20YwuH-jDGAzVRgcOLH8t7ayeVPM93_t46x_hhj-0FSeW7Putl9cyQGgtqKDjMFl1iuwQX1T3ExA2VLJpDcxGPqOCuRH4H2-PJqcfiPP74OSXTHQ2CzMDCEmOXcznYEwX8zDlRCX7C_B46-Tl0eGkbQgCPHLezp9aBAGn5fnulUT2SSfkJC0ycnlzRa5aBeaykrgri-RE57kdTiV31T0ScuvGaHW5CM2z0_uTC38goOCrqBF0fczmRppUSKMtT7vioYwDKYPUxAeGCYzOQRZlMuUZY5kKlDQIVzBymchiqiUPl2CiaBd6BQiNlIgUHobGxGjBEagFDR1SzZWlg5Ee7A49l6gBu7gVucgTrDKsn5OvfvZgp7buOFaNP-zWh0FIhksjwUMG0y3HytSDrfox7grb6kgL3e45GxEgGmYeLLuY1R8KI2qBX-xBPBLN2sAybo8-KVrPFfM2t8QBnK3-_1trMB3YyZeq7bQOE933nt5A6NKVm9Wq_ASO1-3Z
  priority: 102
  providerName: Scholars Portal
Title Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses
URI https://www.ncbi.nlm.nih.gov/pubmed/34502507
https://www.proquest.com/docview/2571238840
https://www.proquest.com/docview/2571920806
https://pubmed.ncbi.nlm.nih.gov/PMC8431686
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEB61qZC4IN6YlmiR4ISsJmvven1AFVRNq1aNUKBSOFneFwQFO9TJof--M36RguDiy45ka2d35hvv7PcBvNGJR5ge-9CkniTMIhnmSqsQizgh8lRErmbnv5zKs6v4fC7mOzDt7sJQW2UXE-tAbUtD_8gPcWlhkFVYjxytfoWkGkWnq52ERt5KK9j3NcXYLuxhSBajAex9PJl-mvUlWMRr-bQxZqVQilQ2rfARFv6Hix8_K44APRWkNbGdpP5Cnn82UG5lpMlDeNBCSfah8f0j2HHFY7jXiEvePIGvs0ZmHieelZ4h0GOn5fLbgiHwJL7vTcX0DVtFiuWFZefTC3axKDCnVay5usiO3XJJTarsc32fhM2adlpXPYWrycmX47OwFVIITTzm6xCzutc-T7V3xNduVKQTrjXPfTLyMkUvjWxsda6slNZwoz3CFvSgTW0inFbRMxgUZeFeABOxSWODQdH7BC0UAjY-dpFwyhAtjA7gXTdzmWlZxknsYplhtUHznG3PcwBve-tVw67xD7uDzglZu8eq7PeKCOB1P4y7g4488sKVm8Ym5YiKZQDPG5_1L4piQQAwCSC5483egJi3744Ui-81A7ciAgElX_7_s_bhPqcOmPr46QAG6-uNe4UQZq2HsJvME3yqyemwXaNDSioCn5exugV8kvU-
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFD4anRC8IO4EBhiJPaForR0n9sOEYGx061ahsknjKcQ3KCpJIa1Q_xy_jePc6EDwtuccJbGP7fMd-_j7AJ6rxCFMj1yopfMSZiwOM6FEiEkc55nkzFbs_CfjeHgWHZ3z8w342d6F8WWV7ZpYLdSm0H6PfAeHFi6yAvORl_NvoVeN8qerrYRG1kgrmN2KYqy52DGyqx-YwpW7h2_Q39uUHuyf7g3DRmUg1NGALkIMeU65TCpnPZm5FkwlVCmauaTvYolN6JvIqEyYODaaauUwpmPzjDQJt0owfO8V2Iz8BkoPNl_vj99NupSP0UqubYBRMIy5jOvSe8Zkf2f65WtJMSGQ3GtbrAfFv5DunwWbaxHw4CbcaKAreVWPtVuwYfPbcLUWs1zdgQ-TWtYeHU0KRxBYkrfF7NOUIND1_OLLkqgVmTNBstyQo_GIjKY5xtCS1FclyZ6dzXxRLHlf3V8hk7p815Z34exSuvQe9PIitw-A8EjLSOMi7FyCFgIBIh1Yxq3QnoZGBfCi7blUN6zmXlxjlmJ24_s5Xe_nALY763nN5vEPu63WCWkzp8v09wgM4Fn3GGejP2LJclssaxtJEYXHAdyvfdZ9iEXcA84kgOSCNzsDz_R98Uk-_VwxfgtPWCDih___radwbXh6cpweH45Hj-A69dU31dHXFvQW35f2McKnhXrSjFECHy97WvwC-UgwbQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwED6NIRAviN8EBhiJPaGorR079gNCaKNsK1RoMKk8ZbFjQ1FJCmmF-q_x13GOk64Dwduec8oP39n3XXz-PoBnOnUI0xMXG-W8hBkTcS61jLGI4zxXnNmGnf_dWBycJEcTPtmCX91ZGN9W2a2JzUJdVMb_I-9haOEiK7Ee6bm2LeL9_vDl_HvsFaT8TmsnpxFCZGRXP7F8q18c7qOvdykdvv64dxC3CgOxSQZ0EWO6c9rlSjvricyNZDqlWtPcpX0nFL5-v0gKnctCiMJQox3mc_y0QhUpt1oyvO8luJyyJPGyEenkrNhjtBFqG2D-iwVXIjTdM6b6venXbzXFUkBxr2qxmQ7_wrh_tmpu5L7hDbjeglbyKkTZTdiy5S24EmQsV7fh03EQtEcXk8oRhJTkTTX7PCUIcT2z-LImekXmTJK8LMjReERG0xKzZ03CIUmyZ2cz3w5LPjQnV8hxaNy19R04uZABvQvbZVXa-0B4YlRicPl1LkULidCQDizjVhpPQKMjeN6NXGZaPnMvqzHLsK7x45xtjnMEu2vreeDx-IfdTueErJ3NdXYWexE8XV_Geeg3V_LSVstgoyjibxHBveCz9YNYwj3UTCNIz3lzbeA5vs9fKadfGq5v6akKpHjw_9d6AldxMmRvD8ejh3CN-rabZs9rB7YXP5b2EeKmhX7cBCiB04ueEb8BuZwuCQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+the+Golgi+Apparatus+by+p38+and+JNK+Kinases+during+Cellular+Stress+Responses&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Nordgaard%2C+Cathrine&rft.au=Tollenaere%2C+Maxim+A+X&rft.au=Martinez+Del+Val%2C+Ana&rft.au=Bekker-Jensen%2C+Dorte+B&rft.date=2021-09-04&rft.pub=MDPI+AG&rft.issn=1661-6596&rft.eissn=1422-0067&rft.volume=22&rft.issue=17&rft.spage=9595&rft_id=info:doi/10.3390%2Fijms22179595&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon