Association of Co-Exposure of Antenatal Steroid and Prophylactic Indomethacin with Spontaneous Intestinal Perforation

To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight. We conducted a retrospective study of preterm infants admitt...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of pediatrics Vol. 235; pp. 34 - 41.e1
Main Authors Kandraju, Hemasree, Kanungo, Jaideep, Lee, Kyong-Soon, Daspal, Sibasis, Adie, Mohammad Amin, Dorling, Jon, Ye, Xiang Y., Lee, Shoo K., Shah, Prakesh S., Beltempo, Marc, Ting, Joseph, Cieslak, Zenon, Sherlock, Rebecca, Mehrem, Ayman Abou, Toye, Jennifer, Aziz, Khalid, Fajardo, Carlos, Bodani, Jaya, Strueby, Lannae, Seshia, Mary, Louis, Deepak, Alvaro, Ruben, Mukerji, Amit, Da Silva, Orlando, Ng, Eugene, Lemyre, Brigitte, Daboval, Thierry, Khurshid, Faiza, Pelausa, Ermelinda, Barrington, Keith, Lapoint, Anie, Ethier, Guillaume, Drolet, Christine, Piedboeuf, Bruno, Claveau, Martine, St-Hilaire, Marie, Bertelle, Valerie, Masse, Edith, Canning, Roderick, Makary, Hala, Ojah, Cecil, Monterrosa, Luis, Emberley, Julie, Afifi, Jehier, Kajetanowicz, Andrzej, Whittle, Wendy, Morais, Michelle, Dahlgren, Leanne, El-Chaar, Darine, Theriault, Katherine, Ouellet, Annie, Butt, Kimberly, Wood, Stephen, Metcalfe, Amy, O'Quinn, Candace, Pylypjuk, Christy, Boucoiran, Isabelle, Taillefer, Catherine, Crane, Joan, Abenhaim, Haim, Smith, Graeme, Wou, Karen, Chandra, Sue, Ubhi, Jagdeep, Carson, George, Helewa, Michael, Grigoriu, Ariadna, Gratton, Rob, Andrews, James, Melamed, Nir, Burrows, Jason, Taboun, Fatima, Wesson, Lara, MacLellan, Erin, Boss, Hayley, Allen, Vicky
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2021
Subjects
indomethacin
infant
intestinal perforation
preterm
steroid
CNN
intestinal perforation
preterm
NICU
IVH
SIP
infant
PDA
steroid
indomethacin
Online AccessGet full text
ISSN0022-3476
1097-6833
1097-6833
DOI10.1016/j.jpeds.2021.03.012

Cover

Abstract To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight. We conducted a retrospective study of preterm infants admitted to Canadian Neonatal Network units between 2010 and 2018. Infants were classified into 2 groups based on receipt of antenatal steroids; the latter subgrouped as recent (≤7 days before birth) or latent (>7 days before birth) exposures. The co-exposure was prophylactic indomethacin. The primary outcome was SIP. Multivariable logistic regression analysis was used to calculate aORs. Among 4720 eligible infants, 4121 (87%) received antenatal steroids and 1045 (22.1%) received prophylactic indomethacin. Among infants exposed to antenatal steroids, those who received prophylactic indomethacin had higher odds of SIP (aOR 1.61, 95% CI 1.14-2.28) compared with no prophylactic indomethacin. Subgroup analyses revealed recent antenatal steroids exposure with prophylactic indomethacin had higher odds of SIP (aOR 1.67, 95% CI 1.15-2.43), but latent antenatal steroids exposure with prophylactic indomethacin did not (aOR 1.24, 95% CI 0.48-3.21), compared with the respective groups with no prophylactic indomethacin. Among those not exposed to antenatal steroids, mortality was lower among those who received prophylactic indomethacin (aOR 0.45, 95% CI 0.28-0.73) compared with no prophylactic indomethacin. In preterm neonates of <26 weeks of gestation or birth weight <750 g, co-exposure of antenatal steroids and prophylactic indomethacin was associated with SIP, especially if antenatal steroids was received within 7 days before birth. Among those unexposed to antenatal steroids, prophylactic indomethacin was associated with lower odds of mortality.
AbstractList To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight. We conducted a retrospective study of preterm infants admitted to Canadian Neonatal Network units between 2010 and 2018. Infants were classified into 2 groups based on receipt of antenatal steroids; the latter subgrouped as recent (≤7 days before birth) or latent (>7 days before birth) exposures. The co-exposure was prophylactic indomethacin. The primary outcome was SIP. Multivariable logistic regression analysis was used to calculate aORs. Among 4720 eligible infants, 4121 (87%) received antenatal steroids and 1045 (22.1%) received prophylactic indomethacin. Among infants exposed to antenatal steroids, those who received prophylactic indomethacin had higher odds of SIP (aOR 1.61, 95% CI 1.14-2.28) compared with no prophylactic indomethacin. Subgroup analyses revealed recent antenatal steroids exposure with prophylactic indomethacin had higher odds of SIP (aOR 1.67, 95% CI 1.15-2.43), but latent antenatal steroids exposure with prophylactic indomethacin did not (aOR 1.24, 95% CI 0.48-3.21), compared with the respective groups with no prophylactic indomethacin. Among those not exposed to antenatal steroids, mortality was lower among those who received prophylactic indomethacin (aOR 0.45, 95% CI 0.28-0.73) compared with no prophylactic indomethacin. In preterm neonates of <26 weeks of gestation or birth weight <750 g, co-exposure of antenatal steroids and prophylactic indomethacin was associated with SIP, especially if antenatal steroids was received within 7 days before birth. Among those unexposed to antenatal steroids, prophylactic indomethacin was associated with lower odds of mortality.
To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight.OBJECTIVETo evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation (SIP) among neonates born at <26 weeks of gestation or <750 g birth weight.We conducted a retrospective study of preterm infants admitted to Canadian Neonatal Network units between 2010 and 2018. Infants were classified into 2 groups based on receipt of antenatal steroids; the latter subgrouped as recent (≤7 days before birth) or latent (>7 days before birth) exposures. The co-exposure was prophylactic indomethacin. The primary outcome was SIP. Multivariable logistic regression analysis was used to calculate aORs.STUDY DESIGNWe conducted a retrospective study of preterm infants admitted to Canadian Neonatal Network units between 2010 and 2018. Infants were classified into 2 groups based on receipt of antenatal steroids; the latter subgrouped as recent (≤7 days before birth) or latent (>7 days before birth) exposures. The co-exposure was prophylactic indomethacin. The primary outcome was SIP. Multivariable logistic regression analysis was used to calculate aORs.Among 4720 eligible infants, 4121 (87%) received antenatal steroids and 1045 (22.1%) received prophylactic indomethacin. Among infants exposed to antenatal steroids, those who received prophylactic indomethacin had higher odds of SIP (aOR 1.61, 95% CI 1.14-2.28) compared with no prophylactic indomethacin. Subgroup analyses revealed recent antenatal steroids exposure with prophylactic indomethacin had higher odds of SIP (aOR 1.67, 95% CI 1.15-2.43), but latent antenatal steroids exposure with prophylactic indomethacin did not (aOR 1.24, 95% CI 0.48-3.21), compared with the respective groups with no prophylactic indomethacin. Among those not exposed to antenatal steroids, mortality was lower among those who received prophylactic indomethacin (aOR 0.45, 95% CI 0.28-0.73) compared with no prophylactic indomethacin.RESULTSAmong 4720 eligible infants, 4121 (87%) received antenatal steroids and 1045 (22.1%) received prophylactic indomethacin. Among infants exposed to antenatal steroids, those who received prophylactic indomethacin had higher odds of SIP (aOR 1.61, 95% CI 1.14-2.28) compared with no prophylactic indomethacin. Subgroup analyses revealed recent antenatal steroids exposure with prophylactic indomethacin had higher odds of SIP (aOR 1.67, 95% CI 1.15-2.43), but latent antenatal steroids exposure with prophylactic indomethacin did not (aOR 1.24, 95% CI 0.48-3.21), compared with the respective groups with no prophylactic indomethacin. Among those not exposed to antenatal steroids, mortality was lower among those who received prophylactic indomethacin (aOR 0.45, 95% CI 0.28-0.73) compared with no prophylactic indomethacin.In preterm neonates of <26 weeks of gestation or birth weight <750 g, co-exposure of antenatal steroids and prophylactic indomethacin was associated with SIP, especially if antenatal steroids was received within 7 days before birth. Among those unexposed to antenatal steroids, prophylactic indomethacin was associated with lower odds of mortality.CONCLUSIONSIn preterm neonates of <26 weeks of gestation or birth weight <750 g, co-exposure of antenatal steroids and prophylactic indomethacin was associated with SIP, especially if antenatal steroids was received within 7 days before birth. Among those unexposed to antenatal steroids, prophylactic indomethacin was associated with lower odds of mortality.
Author Wesson, Lara
Bodani, Jaya
Lee, Shoo K.
Smith, Graeme
Lemyre, Brigitte
Whittle, Wendy
Metcalfe, Amy
Melamed, Nir
Burrows, Jason
O'Quinn, Candace
Shah, Prakesh S.
Louis, Deepak
Taillefer, Catherine
Daspal, Sibasis
Makary, Hala
Pylypjuk, Christy
Ojah, Cecil
Kanungo, Jaideep
Drolet, Christine
Kajetanowicz, Andrzej
Morais, Michelle
MacLellan, Erin
Da Silva, Orlando
Butt, Kimberly
Allen, Vicky
Ye, Xiang Y.
Wood, Stephen
Pelausa, Ermelinda
Boss, Hayley
Adie, Mohammad Amin
Emberley, Julie
Sherlock, Rebecca
Canning, Roderick
Dahlgren, Leanne
Daboval, Thierry
Mukerji, Amit
El-Chaar, Darine
Lapoint, Anie
Taboun, Fatima
Boucoiran, Isabelle
Gratton, Rob
Ouellet, Annie
Beltempo, Marc
Masse, Edith
Lee, Kyong-Soon
Piedboeuf, Bruno
Dorling, Jon
Abenhaim, Haim
Barrington, Keith
Chandra, Sue
St-Hilaire, Marie
Ethier, Guillaume
Fajardo, Carlos
Wou, Karen
Grigoriu, Ariadna
Mehrem, Ayman Abou
Kandraju, Hemasree
Toye, Jennifer
Ubhi, Jagdeep
Monterrosa, Luis
Helewa, Michael
Claveau, Martine
Andrews, James
Crane, Joan
Ng, Eugene
Ting, Joseph
Aziz, Khalid
Afifi, Jehier
Strueby,
Author_xml – sequence: 1
  givenname: Hemasree
  orcidid: 0000-0002-9119-2700
  surname: Kandraju
  fullname: Kandraju, Hemasree
  organization: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
– sequence: 2
  givenname: Jaideep
  surname: Kanungo
  fullname: Kanungo, Jaideep
  organization: Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
– sequence: 3
  givenname: Kyong-Soon
  surname: Lee
  fullname: Lee, Kyong-Soon
  organization: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
– sequence: 4
  givenname: Sibasis
  surname: Daspal
  fullname: Daspal, Sibasis
  organization: Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
– sequence: 5
  givenname: Mohammad Amin
  surname: Adie
  fullname: Adie, Mohammad Amin
  organization: Division of Neonatology, Windsor Regional Hospital, Windsor, Ontario, Canada
– sequence: 6
  givenname: Jon
  surname: Dorling
  fullname: Dorling, Jon
  organization: Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
– sequence: 7
  givenname: Xiang Y.
  orcidid: 0000-0003-2583-6974
  surname: Ye
  fullname: Ye, Xiang Y.
  organization: Maternal-infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada
– sequence: 8
  givenname: Shoo K.
  surname: Lee
  fullname: Lee, Shoo K.
  organization: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
– sequence: 9
  givenname: Prakesh S.
  surname: Shah
  fullname: Shah, Prakesh S.
  email: Prakeshkumar.Shah@sinaihealth.ca
  organization: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
– sequence: 10
  givenname: Marc
  surname: Beltempo
  fullname: Beltempo, Marc
– sequence: 11
  givenname: Joseph
  surname: Ting
  fullname: Ting, Joseph
– sequence: 12
  givenname: Zenon
  surname: Cieslak
  fullname: Cieslak, Zenon
– sequence: 13
  givenname: Rebecca
  surname: Sherlock
  fullname: Sherlock, Rebecca
– sequence: 14
  givenname: Ayman Abou
  surname: Mehrem
  fullname: Mehrem, Ayman Abou
– sequence: 15
  givenname: Jennifer
  surname: Toye
  fullname: Toye, Jennifer
– sequence: 16
  givenname: Khalid
  surname: Aziz
  fullname: Aziz, Khalid
– sequence: 17
  givenname: Carlos
  surname: Fajardo
  fullname: Fajardo, Carlos
– sequence: 18
  givenname: Jaya
  surname: Bodani
  fullname: Bodani, Jaya
– sequence: 19
  givenname: Lannae
  surname: Strueby
  fullname: Strueby, Lannae
– sequence: 20
  givenname: Mary
  surname: Seshia
  fullname: Seshia, Mary
– sequence: 21
  givenname: Deepak
  surname: Louis
  fullname: Louis, Deepak
– sequence: 22
  givenname: Ruben
  surname: Alvaro
  fullname: Alvaro, Ruben
– sequence: 23
  givenname: Amit
  surname: Mukerji
  fullname: Mukerji, Amit
– sequence: 24
  givenname: Orlando
  surname: Da Silva
  fullname: Da Silva, Orlando
– sequence: 25
  givenname: Eugene
  surname: Ng
  fullname: Ng, Eugene
– sequence: 26
  givenname: Brigitte
  surname: Lemyre
  fullname: Lemyre, Brigitte
– sequence: 27
  givenname: Thierry
  surname: Daboval
  fullname: Daboval, Thierry
– sequence: 28
  givenname: Faiza
  surname: Khurshid
  fullname: Khurshid, Faiza
– sequence: 29
  givenname: Ermelinda
  surname: Pelausa
  fullname: Pelausa, Ermelinda
– sequence: 30
  givenname: Keith
  surname: Barrington
  fullname: Barrington, Keith
– sequence: 31
  givenname: Anie
  surname: Lapoint
  fullname: Lapoint, Anie
– sequence: 32
  givenname: Guillaume
  surname: Ethier
  fullname: Ethier, Guillaume
– sequence: 33
  givenname: Christine
  surname: Drolet
  fullname: Drolet, Christine
– sequence: 34
  givenname: Bruno
  surname: Piedboeuf
  fullname: Piedboeuf, Bruno
– sequence: 35
  givenname: Martine
  surname: Claveau
  fullname: Claveau, Martine
– sequence: 36
  givenname: Marie
  surname: St-Hilaire
  fullname: St-Hilaire, Marie
– sequence: 37
  givenname: Valerie
  surname: Bertelle
  fullname: Bertelle, Valerie
– sequence: 38
  givenname: Edith
  surname: Masse
  fullname: Masse, Edith
– sequence: 39
  givenname: Roderick
  surname: Canning
  fullname: Canning, Roderick
– sequence: 40
  givenname: Hala
  surname: Makary
  fullname: Makary, Hala
– sequence: 41
  givenname: Cecil
  surname: Ojah
  fullname: Ojah, Cecil
– sequence: 42
  givenname: Luis
  surname: Monterrosa
  fullname: Monterrosa, Luis
– sequence: 43
  givenname: Julie
  surname: Emberley
  fullname: Emberley, Julie
– sequence: 44
  givenname: Jehier
  surname: Afifi
  fullname: Afifi, Jehier
– sequence: 45
  givenname: Andrzej
  surname: Kajetanowicz
  fullname: Kajetanowicz, Andrzej
– sequence: 46
  givenname: Wendy
  surname: Whittle
  fullname: Whittle, Wendy
– sequence: 47
  givenname: Michelle
  surname: Morais
  fullname: Morais, Michelle
– sequence: 48
  givenname: Leanne
  surname: Dahlgren
  fullname: Dahlgren, Leanne
– sequence: 49
  givenname: Darine
  surname: El-Chaar
  fullname: El-Chaar, Darine
– sequence: 50
  givenname: Katherine
  surname: Theriault
  fullname: Theriault, Katherine
– sequence: 51
  givenname: Annie
  surname: Ouellet
  fullname: Ouellet, Annie
– sequence: 52
  givenname: Kimberly
  surname: Butt
  fullname: Butt, Kimberly
– sequence: 53
  givenname: Stephen
  surname: Wood
  fullname: Wood, Stephen
– sequence: 54
  givenname: Amy
  surname: Metcalfe
  fullname: Metcalfe, Amy
– sequence: 55
  givenname: Candace
  surname: O'Quinn
  fullname: O'Quinn, Candace
– sequence: 56
  givenname: Christy
  surname: Pylypjuk
  fullname: Pylypjuk, Christy
– sequence: 57
  givenname: Isabelle
  surname: Boucoiran
  fullname: Boucoiran, Isabelle
– sequence: 58
  givenname: Catherine
  surname: Taillefer
  fullname: Taillefer, Catherine
– sequence: 59
  givenname: Joan
  surname: Crane
  fullname: Crane, Joan
– sequence: 60
  givenname: Haim
  surname: Abenhaim
  fullname: Abenhaim, Haim
– sequence: 61
  givenname: Graeme
  surname: Smith
  fullname: Smith, Graeme
– sequence: 62
  givenname: Karen
  surname: Wou
  fullname: Wou, Karen
– sequence: 63
  givenname: Sue
  surname: Chandra
  fullname: Chandra, Sue
– sequence: 64
  givenname: Jagdeep
  surname: Ubhi
  fullname: Ubhi, Jagdeep
– sequence: 65
  givenname: George
  surname: Carson
  fullname: Carson, George
– sequence: 66
  givenname: Michael
  surname: Helewa
  fullname: Helewa, Michael
– sequence: 67
  givenname: Ariadna
  surname: Grigoriu
  fullname: Grigoriu, Ariadna
– sequence: 68
  givenname: Rob
  surname: Gratton
  fullname: Gratton, Rob
– sequence: 69
  givenname: James
  surname: Andrews
  fullname: Andrews, James
– sequence: 70
  givenname: Nir
  surname: Melamed
  fullname: Melamed, Nir
– sequence: 71
  givenname: Jason
  surname: Burrows
  fullname: Burrows, Jason
– sequence: 72
  givenname: Fatima
  surname: Taboun
  fullname: Taboun, Fatima
– sequence: 73
  givenname: Lara
  surname: Wesson
  fullname: Wesson, Lara
– sequence: 74
  givenname: Erin
  surname: MacLellan
  fullname: MacLellan, Erin
– sequence: 75
  givenname: Hayley
  surname: Boss
  fullname: Boss, Hayley
– sequence: 76
  givenname: Vicky
  surname: Allen
  fullname: Allen, Vicky
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33741365$$D View this record in MEDLINE/PubMed
BookMark eNqFkc1u1DAURi1URKeFJ0BCWbJJuP6JkwixGI1KW6kSlQpry7VvNB4ydrCdwrw9mZnCoptZWZbPub76vgty5oNHQt5TqChQ-WlTbUa0qWLAaAW8AspekQWFrilly_kZWQAwVnLRyHNykdIGADoB8Iacc94IymW9INMypWCczi74IvTFKpRXf8aQpoj769Jn9DrroXjIGIOzhfa2uI9hXO8GbbIzxa23YYt5rY3zxW-X18XDGHzWHsOU5teMKTs_T7jH2Id4-Okted3rIeG75_OS_Ph69X11U959u75dLe9KIyjNpZVoJXDKOypkzR6NBtY2sreN0GgQZc-5QDS6s8KiYX1d88aIVraWStSUX5KPx7ljDL-meRG1dcngMBy3U6wGLkTbNmxGPzyj0-MWrRqj2-q4U_-imgF-BEwMKUXs_yMU1L4QtVGHQtS-EAVczYXMVvfCMi4fMshRu-GE--Xo4hzRk8OoknHoDVoX0WRlgzvhf37hm8F5Z_TwE3cn7b-wiL3K
CitedBy_id crossref_primary_10_1016_j_jpeds_2021_04_013
crossref_primary_10_3389_fimmu_2023_995558
crossref_primary_10_1038_s41372_024_01971_x
crossref_primary_10_1542_neo_24_2_e97
crossref_primary_10_1038_s41372_022_01547_7
crossref_primary_10_1186_s12887_021_02905_8
crossref_primary_10_1016_j_jpeds_2021_07_006
crossref_primary_10_1007_s40272_024_00626_w
crossref_primary_10_1038_s41372_023_01653_0
crossref_primary_10_3389_fped_2024_1450121
crossref_primary_10_3390_children12020142
crossref_primary_10_1016_j_jpeds_2023_113457
crossref_primary_10_1016_j_jpeds_2023_113568
crossref_primary_10_1055_a_1925_5173
crossref_primary_10_1016_j_jpedsurg_2024_06_017
crossref_primary_10_1038_s41372_023_01782_6
crossref_primary_10_1055_s_0042_1756678
Cites_doi 10.1038/jp.2013.128
10.1542/peds.2014-0183
10.1542/peds.108.2.e35
10.1211/002235703765344577
10.1038/jp.2016.196
10.1038/jp.2010.59
10.1136/archdischild-2011-300659
10.1016/j.jpeds.2020.12.057
10.1016/j.jpeds.2021.01.011
10.1038/jp.2015.41
10.1001/archpediatrics.2011.95
10.1038/s41390-020-01249-w
10.1007/s00431-016-2705-y
10.1055/s-0037-1603325
10.1210/jc.2004-0013
10.1542/peds.2006-2804
10.1203/00006450-200101000-00020
10.1006/mvre.1999.2162
10.1542/peds.2009-2959
10.1542/peds.93.4.543
10.1097/MPG.0b013e3181558591
10.1542/peds.2005-1273
10.1203/PDR.0b013e31818c7920
10.1016/j.jpeds.2017.02.003
10.1016/j.jpeds.2016.04.083
10.1038/sj.jp.7211429
10.1056/NEJM200406243502618
10.1038/sj.jp.7211589
10.1016/j.jpedsurg.2020.05.013
10.3171/2014.11.PEDS14363
10.1053/siny.2000.0036
10.1016/j.ajog.2008.01.026
10.1007/s10024001-0096-0
10.1056/NEJM200106283442602
ContentType Journal Article
Contributor Wesson, Lara
Bodani, Jaya
Smith, Graeme
Lemyre, Brigitte
Whittle, Wendy
Metcalfe, Amy
Melamed, Nir
Burrows, Jason
O'Quinn, Candace
Louis, Deepak
Taillefer, Catherine
Makary, Hala
Pylypjuk, Christy
Ojah, Cecil
Drolet, Christine
Kajetanowicz, Andrzej
Morais, Michelle
MacLellan, Erin
Da Silva, Orlando
Butt, Kimberly
Allen, Vicky
Wood, Stephen
Pelausa, Ermelinda
Boss, Hayley
Emberley, Julie
Sherlock, Rebecca
Canning, Roderick
Dahlgren, Leanne
Daboval, Thierry
Mukerji, Amit
El-Chaar, Darine
Lapoint, Anie
Taboun, Fatima
Boucoiran, Isabelle
Gratton, Rob
Ouellet, Annie
Beltempo, Marc
Masse, Edith
Piedboeuf, Bruno
Abenhaim, Haim
Barrington, Keith
Chandra, Sue
St-Hilaire, Marie
Ethier, Guillaume
Fajardo, Carlos
Wou, Karen
Grigoriu, Ariadna
Mehrem, Ayman Abou
Toye, Jennifer
Ubhi, Jagdeep
Monterrosa, Luis
Helewa, Michael
Claveau, Martine
Andrews, James
Crane, Joan
Ng, Eugene
Ting, Joseph
Aziz, Khalid
Afifi, Jehier
Strueby, Lannae
Cieslak, Zenon
Alvaro, Ruben
Khurshid, Faiza
Theriault, Katherine
Seshia, Mary
Bertelle, Valerie
Carson, George
Contributor_xml – sequence: 1
  givenname: Marc
  surname: Beltempo
  fullname: Beltempo, Marc
– sequence: 2
  givenname: Joseph
  surname: Ting
  fullname: Ting, Joseph
– sequence: 3
  givenname: Zenon
  surname: Cieslak
  fullname: Cieslak, Zenon
– sequence: 4
  givenname: Rebecca
  surname: Sherlock
  fullname: Sherlock, Rebecca
– sequence: 5
  givenname: Ayman Abou
  surname: Mehrem
  fullname: Mehrem, Ayman Abou
– sequence: 6
  givenname: Jennifer
  surname: Toye
  fullname: Toye, Jennifer
– sequence: 7
  givenname: Khalid
  surname: Aziz
  fullname: Aziz, Khalid
– sequence: 8
  givenname: Carlos
  surname: Fajardo
  fullname: Fajardo, Carlos
– sequence: 9
  givenname: Jaya
  surname: Bodani
  fullname: Bodani, Jaya
– sequence: 10
  givenname: Lannae
  surname: Strueby
  fullname: Strueby, Lannae
– sequence: 11
  givenname: Mary
  surname: Seshia
  fullname: Seshia, Mary
– sequence: 12
  givenname: Deepak
  surname: Louis
  fullname: Louis, Deepak
– sequence: 13
  givenname: Ruben
  surname: Alvaro
  fullname: Alvaro, Ruben
– sequence: 14
  givenname: Amit
  surname: Mukerji
  fullname: Mukerji, Amit
– sequence: 15
  givenname: Orlando
  surname: Da Silva
  fullname: Da Silva, Orlando
– sequence: 16
  givenname: Eugene
  surname: Ng
  fullname: Ng, Eugene
– sequence: 17
  givenname: Brigitte
  surname: Lemyre
  fullname: Lemyre, Brigitte
– sequence: 18
  givenname: Thierry
  surname: Daboval
  fullname: Daboval, Thierry
– sequence: 19
  givenname: Faiza
  surname: Khurshid
  fullname: Khurshid, Faiza
– sequence: 20
  givenname: Ermelinda
  surname: Pelausa
  fullname: Pelausa, Ermelinda
– sequence: 21
  givenname: Keith
  surname: Barrington
  fullname: Barrington, Keith
– sequence: 22
  givenname: Anie
  surname: Lapoint
  fullname: Lapoint, Anie
– sequence: 23
  givenname: Guillaume
  surname: Ethier
  fullname: Ethier, Guillaume
– sequence: 24
  givenname: Christine
  surname: Drolet
  fullname: Drolet, Christine
– sequence: 25
  givenname: Bruno
  surname: Piedboeuf
  fullname: Piedboeuf, Bruno
– sequence: 26
  givenname: Martine
  surname: Claveau
  fullname: Claveau, Martine
– sequence: 27
  givenname: Marie
  surname: St-Hilaire
  fullname: St-Hilaire, Marie
– sequence: 28
  givenname: Valerie
  surname: Bertelle
  fullname: Bertelle, Valerie
– sequence: 29
  givenname: Edith
  surname: Masse
  fullname: Masse, Edith
– sequence: 30
  givenname: Roderick
  surname: Canning
  fullname: Canning, Roderick
– sequence: 31
  givenname: Hala
  surname: Makary
  fullname: Makary, Hala
– sequence: 32
  givenname: Cecil
  surname: Ojah
  fullname: Ojah, Cecil
– sequence: 33
  givenname: Luis
  surname: Monterrosa
  fullname: Monterrosa, Luis
– sequence: 34
  givenname: Julie
  surname: Emberley
  fullname: Emberley, Julie
– sequence: 35
  givenname: Jehier
  surname: Afifi
  fullname: Afifi, Jehier
– sequence: 36
  givenname: Andrzej
  surname: Kajetanowicz
  fullname: Kajetanowicz, Andrzej
– sequence: 37
  givenname: Wendy
  surname: Whittle
  fullname: Whittle, Wendy
– sequence: 38
  givenname: Michelle
  surname: Morais
  fullname: Morais, Michelle
– sequence: 39
  givenname: Leanne
  surname: Dahlgren
  fullname: Dahlgren, Leanne
– sequence: 40
  givenname: Darine
  surname: El-Chaar
  fullname: El-Chaar, Darine
– sequence: 41
  givenname: Katherine
  surname: Theriault
  fullname: Theriault, Katherine
– sequence: 42
  givenname: Annie
  surname: Ouellet
  fullname: Ouellet, Annie
– sequence: 43
  givenname: Kimberly
  surname: Butt
  fullname: Butt, Kimberly
– sequence: 44
  givenname: Stephen
  surname: Wood
  fullname: Wood, Stephen
– sequence: 45
  givenname: Amy
  surname: Metcalfe
  fullname: Metcalfe, Amy
– sequence: 46
  givenname: Candace
  surname: O'Quinn
  fullname: O'Quinn, Candace
– sequence: 47
  givenname: Christy
  surname: Pylypjuk
  fullname: Pylypjuk, Christy
– sequence: 48
  givenname: Isabelle
  surname: Boucoiran
  fullname: Boucoiran, Isabelle
– sequence: 49
  givenname: Catherine
  surname: Taillefer
  fullname: Taillefer, Catherine
– sequence: 50
  givenname: Joan
  surname: Crane
  fullname: Crane, Joan
– sequence: 51
  givenname: Haim
  surname: Abenhaim
  fullname: Abenhaim, Haim
– sequence: 52
  givenname: Graeme
  surname: Smith
  fullname: Smith, Graeme
– sequence: 53
  givenname: Karen
  surname: Wou
  fullname: Wou, Karen
– sequence: 54
  givenname: Sue
  surname: Chandra
  fullname: Chandra, Sue
– sequence: 55
  givenname: Jagdeep
  surname: Ubhi
  fullname: Ubhi, Jagdeep
– sequence: 56
  givenname: George
  surname: Carson
  fullname: Carson, George
– sequence: 57
  givenname: Michael
  surname: Helewa
  fullname: Helewa, Michael
– sequence: 58
  givenname: Ariadna
  surname: Grigoriu
  fullname: Grigoriu, Ariadna
– sequence: 59
  givenname: Rob
  surname: Gratton
  fullname: Gratton, Rob
– sequence: 60
  givenname: James
  surname: Andrews
  fullname: Andrews, James
– sequence: 61
  givenname: Nir
  surname: Melamed
  fullname: Melamed, Nir
– sequence: 62
  givenname: Jason
  surname: Burrows
  fullname: Burrows, Jason
– sequence: 63
  givenname: Fatima
  surname: Taboun
  fullname: Taboun, Fatima
– sequence: 64
  givenname: Lara
  surname: Wesson
  fullname: Wesson, Lara
– sequence: 65
  givenname: Erin
  surname: MacLellan
  fullname: MacLellan, Erin
– sequence: 66
  givenname: Hayley
  surname: Boss
  fullname: Boss, Hayley
– sequence: 67
  givenname: Vicky
  surname: Allen
  fullname: Allen, Vicky
Copyright 2021 Elsevier Inc.
Copyright © 2021 Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2021 Elsevier Inc.
– notice: Copyright © 2021 Elsevier Inc. All rights reserved.
CorporateAuthor Canadian Preterm Birth Network (CPTBN) Investigators
Canadian Neonatal Network (CNN)
CorporateAuthor_xml – name: Canadian Neonatal Network (CNN)
– name: Canadian Preterm Birth Network (CPTBN) Investigators
DBID AAYXX
CITATION
NPM
7X8
DOI 10.1016/j.jpeds.2021.03.012
DatabaseName CrossRef
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList PubMed

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1097-6833
EndPage 41.e1
ExternalDocumentID 33741365
10_1016_j_jpeds_2021_03_012
S0022347621002262
Genre Journal Article
GrantInformation_xml – fundername: Canadian Institutes of Health Research
  funderid: https://doi.org/10.13039/501100000024
– fundername: CIHR
  funderid: https://doi.org/10.13039/501100000024
GroupedDBID ---
--K
--M
-ET
-RU
.1-
.55
.FO
.GJ
.XZ
.~1
0R~
123
1B1
1CY
1P~
1RT
1~.
1~5
354
3O-
4.4
41~
457
4G.
53G
5RE
5VS
7-5
85S
8P~
9JM
AAEDT
AAEDW
AAEJM
AAIKC
AAIKJ
AAKOC
AALRI
AAMNW
AAOAW
AAQFI
AAQQT
AAQXK
AATTM
AAWTL
AAXKI
AAXUO
AAYJJ
AAYWO
ABBQC
ABDPE
ABFNM
ABFRF
ABIVO
ABJNI
ABLJU
ABMAC
ABMZM
ABOCM
ABPPZ
ABWVN
ABXDB
ACDAQ
ACGFO
ACGFS
ACIEU
ACNCT
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
AEBSH
AEFWE
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFFNX
AFJKZ
AFPUW
AFRHN
AFTJW
AFXIZ
AGCQF
AGHFR
AGNAY
AGQPQ
AGUBO
AGYEJ
AHHHB
AI.
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJJEV
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
C45
C5W
CAG
COF
CS3
DU5
EBS
EFJIC
EFKBS
EJD
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HEF
HMK
HMO
HVGLF
HZ~
IHE
J1W
K-O
KOM
L7B
M27
M32
M41
MO0
N4W
N9A
NEJ
NQ-
O-L
O9-
OAUVE
OB2
OBH
OH-
OHH
OHT
OT-
OVD
P-8
P-9
P2P
PC.
PQQKQ
Q38
R2-
ROL
RPZ
SAE
SDF
SEL
SES
SEW
SJN
SPCBC
SSH
SSZ
T5K
TEORI
TWZ
UGJ
UHB
UHS
UKR
UV1
VH1
VVN
WH7
WOW
WUQ
X7M
XCE
XFW
XOL
YFH
YOC
YOJ
YQJ
YZZ
Z5R
ZGI
ZQV
ZXP
ZY1
~G-
~KM
AACTN
AAIAV
ACRZS
AFCTW
AFKWA
AJOXV
AMFUW
G8K
RIG
YCJ
AAYXX
ACLOT
CITATION
EFLBG
~HD
NPM
7X8
ID FETCH-LOGICAL-c411t-d6ed60313914652bca02876fd74aecee6f334eeca9d4dec2f5537c4868d16ea13
IEDL.DBID AIKHN
ISSN 0022-3476
1097-6833
IngestDate Sat Sep 27 19:52:15 EDT 2025
Wed Feb 19 02:28:09 EST 2025
Thu Sep 25 00:51:07 EDT 2025
Thu Apr 24 23:07:20 EDT 2025
Tue Jul 16 04:31:22 EDT 2024
Tue Aug 26 16:40:00 EDT 2025
IsPeerReviewed true
IsScholarly true
Keywords CNN
intestinal perforation
preterm
NICU
IVH
SIP
infant
PDA
steroid
indomethacin
Language English
License Copyright © 2021 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c411t-d6ed60313914652bca02876fd74aecee6f334eeca9d4dec2f5537c4868d16ea13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ORCID 0000-0003-2583-6974
0000-0002-9119-2700
PMID 33741365
PQID 2503448872
PQPubID 23479
ParticipantIDs proquest_miscellaneous_2503448872
pubmed_primary_33741365
crossref_primary_10_1016_j_jpeds_2021_03_012
crossref_citationtrail_10_1016_j_jpeds_2021_03_012
elsevier_sciencedirect_doi_10_1016_j_jpeds_2021_03_012
elsevier_clinicalkey_doi_10_1016_j_jpeds_2021_03_012
PublicationCentury 2000
PublicationDate 2021-08-01
PublicationDateYYYYMMDD 2021-08-01
PublicationDate_xml – month: 08
  year: 2021
  text: 2021-08-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The Journal of pediatrics
PublicationTitleAlternate J Pediatr
PublicationYear 2021
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Stavel, Wong, Cieslak, Sherlock, Claveau, Shah (bib11) 2017; 37
Attridge, Clark, Gordon (bib23) 2006; 26
Fowlie, Davis, McGuire (bib2) 2010; 7
Arnautovic, Longo, Trail-Burns, Tucker, Keszler, Laptook (bib24) 2021; 232
Kelleher, Salas, Bhat, Ambalavanan, Saha, Stoll (bib8) 2014; 134
Rainsford, Stetsko, Sirko, Debski (bib5) 2003; 55
Schmidt, Seshia, Shankaran, Mildenhall, Tyson, Lui (bib29) 2011; 165
Zozaya, Shah, Pierro, Zani, Synnes, Lee (bib14) 2021; 56
Blakely, Tyson, Lally, McDonald, Stoll, Stevenson (bib15) 2006; 117
Shah, Singhal, da Silva, Rouvinez-Bouali, Seshia, Lee (bib25) 2015; 35
Gordon, Price, Stiles (bib19) 2001; 49
Knight (bib36) 2001; 6
Gordon (bib30) 2009; 65
Schmidt, Davis, Moddemann, Ohlsson, Roberts, Saigal (bib4) 2001; 344
bib27
Jobe, Kemp, Schmidt, Takahashi, Newnham, Milad (bib33) 2021; 89
Ragouilliaux, Keeney, Hawkins, Rowen (bib38) 2007; 120
Wadhawan, Oh, Vohr, Saha, Das, Bell (bib10) 2013; 98
Shah, Lui, Sjors, Mirea, Reichman, Adams (bib17) 2016; 177
Sharma, Hudak, Tepas, Wludyka, Teng, Hastings (bib9) 2010; 30
Kramer, Platt, Wen, Joseph, Allen, Abrahamowicz (bib26) 2001; 108
Gordon, Herman, Marcinkiewicz, Gaston, Laubach, Aschner (bib31) 2007; 45
Jensen, Dysart, Gantz, Carper, Higgins, Keszler (bib35) 2017; 186
Slaughter, Reagan, Bapat, Newman, Klebanoff (bib12) 2016; 175
Ruh, Schmidt, Vogel, Klar (bib6) 1999; 58
Roberts, Brown, Medley, Dalziel (bib1) 2017; 3
Kajantie, Raivio, Janne, Hovi, Dunkel, Andersson (bib34) 2004; 89
Stoll, Hansen, Bell, Shankaran, Laptook, Walsh (bib18) 2010; 126
Renolleau, Toumazi, Bourmaud, Benoist, Chevenne, Mohamed (bib21) 2021; 234
Gordon (bib22) 2004; 350
Gordon, Swanson, Clark (bib32) 2008; 198
Attridge, Clark, Walker, Gordon (bib7) 2006; 26
Gordon, Price, Stiles, Rutledge (bib20) 2001; 4
Shah, Seidlitz, Chan, Yeh, Musrap, Lee (bib28) 2017; 34
Wadhawan, Oh, Hintz, Blakely, Das, Bell (bib13) 2014; 34
Roberts, Dalziel (bib37) 2006; 3
Ment, Oh, Ehrenkranz, Philip, Vohr, Allan (bib3) 1994; 93
Radic, Vincer, McNeely (bib16) 2015; 15
Schmidt (10.1016/j.jpeds.2021.03.012_bib4) 2001; 344
Radic (10.1016/j.jpeds.2021.03.012_bib16) 2015; 15
Gordon (10.1016/j.jpeds.2021.03.012_bib22) 2004; 350
Slaughter (10.1016/j.jpeds.2021.03.012_bib12) 2016; 175
Gordon (10.1016/j.jpeds.2021.03.012_bib19) 2001; 49
Gordon (10.1016/j.jpeds.2021.03.012_bib30) 2009; 65
Shah (10.1016/j.jpeds.2021.03.012_bib25) 2015; 35
Rainsford (10.1016/j.jpeds.2021.03.012_bib5) 2003; 55
Attridge (10.1016/j.jpeds.2021.03.012_bib7) 2006; 26
Stoll (10.1016/j.jpeds.2021.03.012_bib18) 2010; 126
Ment (10.1016/j.jpeds.2021.03.012_bib3) 1994; 93
Kelleher (10.1016/j.jpeds.2021.03.012_bib8) 2014; 134
Shah (10.1016/j.jpeds.2021.03.012_bib28) 2017; 34
Ragouilliaux (10.1016/j.jpeds.2021.03.012_bib38) 2007; 120
Shah (10.1016/j.jpeds.2021.03.012_bib17) 2016; 177
Zozaya (10.1016/j.jpeds.2021.03.012_bib14) 2021; 56
Schmidt (10.1016/j.jpeds.2021.03.012_bib29) 2011; 165
Stavel (10.1016/j.jpeds.2021.03.012_bib11) 2017; 37
Ruh (10.1016/j.jpeds.2021.03.012_bib6) 1999; 58
Gordon (10.1016/j.jpeds.2021.03.012_bib20) 2001; 4
Jensen (10.1016/j.jpeds.2021.03.012_bib35) 2017; 186
Fowlie (10.1016/j.jpeds.2021.03.012_bib2) 2010; 7
Sharma (10.1016/j.jpeds.2021.03.012_bib9) 2010; 30
Wadhawan (10.1016/j.jpeds.2021.03.012_bib10) 2013; 98
Roberts (10.1016/j.jpeds.2021.03.012_bib1) 2017; 3
Blakely (10.1016/j.jpeds.2021.03.012_bib15) 2006; 117
Wadhawan (10.1016/j.jpeds.2021.03.012_bib13) 2014; 34
Arnautovic (10.1016/j.jpeds.2021.03.012_bib24) 2021; 232
Knight (10.1016/j.jpeds.2021.03.012_bib36) 2001; 6
Gordon (10.1016/j.jpeds.2021.03.012_bib32) 2008; 198
Roberts (10.1016/j.jpeds.2021.03.012_bib37) 2006; 3
Jobe (10.1016/j.jpeds.2021.03.012_bib33) 2021; 89
Attridge (10.1016/j.jpeds.2021.03.012_bib23) 2006; 26
Gordon (10.1016/j.jpeds.2021.03.012_bib31) 2007; 45
Renolleau (10.1016/j.jpeds.2021.03.012_bib21) 2021; 234
Kajantie (10.1016/j.jpeds.2021.03.012_bib34) 2004; 89
Kramer (10.1016/j.jpeds.2021.03.012_bib26) 2001; 108
References_xml – volume: 108
  start-page: E35
  year: 2001
  ident: bib26
  article-title: A new and improved population-based Canadian reference for birth weight for gestational age
  publication-title: Pediatrics
– volume: 117
  start-page: e680
  year: 2006
  end-page: e687
  ident: bib15
  article-title: Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age
  publication-title: Pediatrics
– volume: 186
  start-page: 34
  year: 2017
  end-page: 40.e2
  ident: bib35
  article-title: Association between use of prophylactic indomethacin and the risk for bronchopulmonary dysplasia in extremely preterm infants
  publication-title: J Pediatr
– volume: 15
  start-page: 573
  year: 2015
  end-page: 579
  ident: bib16
  article-title: Temporal trends of intraventricular hemorrhage of prematurity in Nova Scotia from 1993 to 2012
  publication-title: J Neurosurg Pediatr
– volume: 232
  start-page: 59
  year: 2021
  end-page: 64.e1
  ident: bib24
  article-title: Antenatal risk factors associated with spontaneous intestinal perforation in preterm infants receiving postnatal indomethacin
  publication-title: J Pediatr
– volume: 350
  start-page: 2715
  year: 2004
  end-page: 2718
  ident: bib22
  article-title: Postnatal dexamethasone for lung disease of prematurity
  publication-title: N Engl J Med
– volume: 56
  start-page: 309
  year: 2021
  end-page: 316
  ident: bib14
  article-title: Neurodevelopmental and growth outcomes of extremely preterm infants with necrotizing enterocolitis or spontaneous intestinal perforation
  publication-title: J Pediatr Surg
– volume: 6
  start-page: 63
  year: 2001
  end-page: 73
  ident: bib36
  article-title: The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials
  publication-title: Semin Neonatol
– volume: 198
  start-page: 725
  year: 2008
  ident: bib32
  article-title: Antenatal indomethacin is more likely associated with spontaneous intestinal perforation rather than NEC
  publication-title: Am J Obstet Gynecol
– volume: 89
  start-page: 318
  year: 2021
  end-page: 325
  ident: bib33
  article-title: Antenatal corticosteroids: a reappraisal of the drug formulation and dose
  publication-title: Pediatr Res
– volume: 175
  start-page: 775
  year: 2016
  end-page: 783
  ident: bib12
  article-title: Nonsteroidal anti-inflammatory administration and patent ductus arteriosus ligation, a survey of practice preferences at US children's hospitals
  publication-title: Eur J Pediatr
– volume: 120
  start-page: e1458
  year: 2007
  end-page: e1464
  ident: bib38
  article-title: Maternal factors in extremely low birth weight infants who develop spontaneous intestinal perforation
  publication-title: Pediatrics
– volume: 93
  start-page: 543
  year: 1994
  end-page: 550
  ident: bib3
  article-title: Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial
  publication-title: Pediatrics
– ident: bib27
  article-title: Canadian Neonatal Network Abstractor's Manual v.3.4.1 (released July 10, 2019). Toronto: CNN
– volume: 3
  start-page: CD004454
  year: 2006
  ident: bib37
  article-title: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
  publication-title: Cochrane Database Syst Rev
– volume: 55
  start-page: 661
  year: 2003
  end-page: 668
  ident: bib5
  article-title: Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease
  publication-title: J Pharm Pharmacol
– volume: 58
  start-page: 137
  year: 1999
  end-page: 143
  ident: bib6
  article-title: Indomethacin-induced disturbances in villous microcirculation in the rat ileum
  publication-title: Microvasc Res
– volume: 4
  start-page: 532
  year: 2001
  end-page: 537
  ident: bib20
  article-title: Early postnatal dexamethasone diminishes transforming growth factor alpha localization within the ileal muscularis propria of newborn mice and extremely low-birth-weight infants
  publication-title: Pediatr Dev Pathol
– volume: 26
  start-page: 667
  year: 2006
  end-page: 670
  ident: bib23
  article-title: New insights into spontaneous intestinal perforation using a national data set (3): antenatal steroids have no adverse association with spontaneous intestinal perforation
  publication-title: J Perinatol
– volume: 126
  start-page: 443
  year: 2010
  end-page: 456
  ident: bib18
  article-title: Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network
  publication-title: Pediatrics
– volume: 177
  start-page: 144
  year: 2016
  end-page: 152.e6
  ident: bib17
  article-title: Neonatal outcomes of very low birth weight and very preterm neonates: an international comparison
  publication-title: J Pediatr
– volume: 45
  start-page: 509
  year: 2007
  end-page: 519
  ident: bib31
  article-title: A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin
  publication-title: J Pediatr Gastroenterol Nutr
– volume: 89
  start-page: 3999
  year: 2004
  end-page: 4003
  ident: bib34
  article-title: Circulating glucocorticoid bioactivity in the preterm newborn after antenatal betamethasone treatment
  publication-title: J Clin Endocrinol Metab
– volume: 34
  start-page: 64
  year: 2014
  end-page: 70
  ident: bib13
  article-title: Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis
  publication-title: J Perinatol
– volume: 26
  start-page: 93
  year: 2006
  end-page: 99
  ident: bib7
  article-title: New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure
  publication-title: J Perinatol
– volume: 37
  start-page: 188
  year: 2017
  end-page: 193
  ident: bib11
  article-title: Effect of prophylactic indomethacin administration and early feeding on spontaneous intestinal perforation in extremely low-birth-weight infants
  publication-title: J Perinatol
– volume: 35
  start-page: 595
  year: 2015
  end-page: 600
  ident: bib25
  article-title: Intestinal perforation in very preterm neonates: risk factors and outcomes
  publication-title: J Perinatol
– volume: 30
  start-page: 786
  year: 2010
  end-page: 793
  ident: bib9
  article-title: Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis
  publication-title: J Perinatol
– volume: 49
  start-page: 93
  year: 2001
  end-page: 100
  ident: bib19
  article-title: Dexamethasone administration to newborn mice alters mucosal and muscular morphology in the ileum and modulates IGF-I localization
  publication-title: Pediatr Res
– volume: 34
  start-page: 1241
  year: 2017
  end-page: 1249
  ident: bib28
  article-title: Internal audit of the Canadian Neonatal Network data collection system
  publication-title: Am J Perinatol
– volume: 3
  start-page: CD004454
  year: 2017
  ident: bib1
  article-title: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
  publication-title: Cochrane Database Syst Rev
– volume: 234
  start-page: 65
  year: 2021
  end-page: 70.e3
  ident: bib21
  article-title: Association between baseline cortisol serum concentrations and the effect of prophylactic hydrocortisone in extremely preterm infants
  publication-title: J Pediatr
– volume: 98
  start-page: F127
  year: 2013
  end-page: F132
  ident: bib10
  article-title: Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age
  publication-title: Arch Dis Child Fetal Neonatal Ed
– volume: 7
  start-page: CD000174
  year: 2010
  ident: bib2
  article-title: Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants
  publication-title: Cochrane Database Syst Rev
– volume: 165
  start-page: 642
  year: 2011
  end-page: 646
  ident: bib29
  article-title: Effects of prophylactic indomethacin in extremely low-birth-weight infants with and without adequate exposure to antenatal corticosteroids
  publication-title: Arch Pediatr Adolesc Med
– volume: 65
  start-page: 138
  year: 2009
  end-page: 144
  ident: bib30
  article-title: Understanding intestinal vulnerability to perforation in the extremely low birth weight infant
  publication-title: Pediatr Res
– volume: 344
  start-page: 1966
  year: 2001
  end-page: 1972
  ident: bib4
  article-title: Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants
  publication-title: N Engl J Med
– volume: 134
  start-page: e1369
  year: 2014
  end-page: e1377
  ident: bib8
  article-title: Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants
  publication-title: Pediatrics
– volume: 34
  start-page: 64
  year: 2014
  ident: 10.1016/j.jpeds.2021.03.012_bib13
  article-title: Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis
  publication-title: J Perinatol
  doi: 10.1038/jp.2013.128
– volume: 134
  start-page: e1369
  year: 2014
  ident: 10.1016/j.jpeds.2021.03.012_bib8
  article-title: Prophylactic indomethacin and intestinal perforation in extremely low birth weight infants
  publication-title: Pediatrics
  doi: 10.1542/peds.2014-0183
– volume: 108
  start-page: E35
  year: 2001
  ident: 10.1016/j.jpeds.2021.03.012_bib26
  article-title: A new and improved population-based Canadian reference for birth weight for gestational age
  publication-title: Pediatrics
  doi: 10.1542/peds.108.2.e35
– volume: 55
  start-page: 661
  year: 2003
  ident: 10.1016/j.jpeds.2021.03.012_bib5
  article-title: Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease
  publication-title: J Pharm Pharmacol
  doi: 10.1211/002235703765344577
– volume: 37
  start-page: 188
  year: 2017
  ident: 10.1016/j.jpeds.2021.03.012_bib11
  article-title: Effect of prophylactic indomethacin administration and early feeding on spontaneous intestinal perforation in extremely low-birth-weight infants
  publication-title: J Perinatol
  doi: 10.1038/jp.2016.196
– volume: 30
  start-page: 786
  year: 2010
  ident: 10.1016/j.jpeds.2021.03.012_bib9
  article-title: Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis
  publication-title: J Perinatol
  doi: 10.1038/jp.2010.59
– volume: 98
  start-page: F127
  year: 2013
  ident: 10.1016/j.jpeds.2021.03.012_bib10
  article-title: Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age
  publication-title: Arch Dis Child Fetal Neonatal Ed
  doi: 10.1136/archdischild-2011-300659
– volume: 234
  start-page: 65
  year: 2021
  ident: 10.1016/j.jpeds.2021.03.012_bib21
  article-title: Association between baseline cortisol serum concentrations and the effect of prophylactic hydrocortisone in extremely preterm infants
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2020.12.057
– volume: 232
  start-page: 59
  year: 2021
  ident: 10.1016/j.jpeds.2021.03.012_bib24
  article-title: Antenatal risk factors associated with spontaneous intestinal perforation in preterm infants receiving postnatal indomethacin
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2021.01.011
– volume: 35
  start-page: 595
  year: 2015
  ident: 10.1016/j.jpeds.2021.03.012_bib25
  article-title: Intestinal perforation in very preterm neonates: risk factors and outcomes
  publication-title: J Perinatol
  doi: 10.1038/jp.2015.41
– volume: 165
  start-page: 642
  year: 2011
  ident: 10.1016/j.jpeds.2021.03.012_bib29
  article-title: Effects of prophylactic indomethacin in extremely low-birth-weight infants with and without adequate exposure to antenatal corticosteroids
  publication-title: Arch Pediatr Adolesc Med
  doi: 10.1001/archpediatrics.2011.95
– volume: 89
  start-page: 318
  year: 2021
  ident: 10.1016/j.jpeds.2021.03.012_bib33
  article-title: Antenatal corticosteroids: a reappraisal of the drug formulation and dose
  publication-title: Pediatr Res
  doi: 10.1038/s41390-020-01249-w
– volume: 3
  start-page: CD004454
  year: 2017
  ident: 10.1016/j.jpeds.2021.03.012_bib1
  article-title: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
  publication-title: Cochrane Database Syst Rev
– volume: 175
  start-page: 775
  year: 2016
  ident: 10.1016/j.jpeds.2021.03.012_bib12
  article-title: Nonsteroidal anti-inflammatory administration and patent ductus arteriosus ligation, a survey of practice preferences at US children's hospitals
  publication-title: Eur J Pediatr
  doi: 10.1007/s00431-016-2705-y
– volume: 3
  start-page: CD004454
  year: 2006
  ident: 10.1016/j.jpeds.2021.03.012_bib37
  article-title: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth
  publication-title: Cochrane Database Syst Rev
– volume: 34
  start-page: 1241
  year: 2017
  ident: 10.1016/j.jpeds.2021.03.012_bib28
  article-title: Internal audit of the Canadian Neonatal Network data collection system
  publication-title: Am J Perinatol
  doi: 10.1055/s-0037-1603325
– volume: 89
  start-page: 3999
  year: 2004
  ident: 10.1016/j.jpeds.2021.03.012_bib34
  article-title: Circulating glucocorticoid bioactivity in the preterm newborn after antenatal betamethasone treatment
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2004-0013
– volume: 120
  start-page: e1458
  year: 2007
  ident: 10.1016/j.jpeds.2021.03.012_bib38
  article-title: Maternal factors in extremely low birth weight infants who develop spontaneous intestinal perforation
  publication-title: Pediatrics
  doi: 10.1542/peds.2006-2804
– volume: 49
  start-page: 93
  year: 2001
  ident: 10.1016/j.jpeds.2021.03.012_bib19
  article-title: Dexamethasone administration to newborn mice alters mucosal and muscular morphology in the ileum and modulates IGF-I localization
  publication-title: Pediatr Res
  doi: 10.1203/00006450-200101000-00020
– volume: 58
  start-page: 137
  year: 1999
  ident: 10.1016/j.jpeds.2021.03.012_bib6
  article-title: Indomethacin-induced disturbances in villous microcirculation in the rat ileum
  publication-title: Microvasc Res
  doi: 10.1006/mvre.1999.2162
– volume: 7
  start-page: CD000174
  year: 2010
  ident: 10.1016/j.jpeds.2021.03.012_bib2
  article-title: Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants
  publication-title: Cochrane Database Syst Rev
– volume: 126
  start-page: 443
  year: 2010
  ident: 10.1016/j.jpeds.2021.03.012_bib18
  article-title: Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network
  publication-title: Pediatrics
  doi: 10.1542/peds.2009-2959
– volume: 93
  start-page: 543
  year: 1994
  ident: 10.1016/j.jpeds.2021.03.012_bib3
  article-title: Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial
  publication-title: Pediatrics
  doi: 10.1542/peds.93.4.543
– volume: 45
  start-page: 509
  year: 2007
  ident: 10.1016/j.jpeds.2021.03.012_bib31
  article-title: A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin
  publication-title: J Pediatr Gastroenterol Nutr
  doi: 10.1097/MPG.0b013e3181558591
– volume: 117
  start-page: e680
  year: 2006
  ident: 10.1016/j.jpeds.2021.03.012_bib15
  article-title: Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age
  publication-title: Pediatrics
  doi: 10.1542/peds.2005-1273
– volume: 65
  start-page: 138
  year: 2009
  ident: 10.1016/j.jpeds.2021.03.012_bib30
  article-title: Understanding intestinal vulnerability to perforation in the extremely low birth weight infant
  publication-title: Pediatr Res
  doi: 10.1203/PDR.0b013e31818c7920
– volume: 186
  start-page: 34
  year: 2017
  ident: 10.1016/j.jpeds.2021.03.012_bib35
  article-title: Association between use of prophylactic indomethacin and the risk for bronchopulmonary dysplasia in extremely preterm infants
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2017.02.003
– volume: 177
  start-page: 144
  year: 2016
  ident: 10.1016/j.jpeds.2021.03.012_bib17
  article-title: Neonatal outcomes of very low birth weight and very preterm neonates: an international comparison
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2016.04.083
– volume: 26
  start-page: 93
  year: 2006
  ident: 10.1016/j.jpeds.2021.03.012_bib7
  article-title: New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure
  publication-title: J Perinatol
  doi: 10.1038/sj.jp.7211429
– volume: 350
  start-page: 2715
  year: 2004
  ident: 10.1016/j.jpeds.2021.03.012_bib22
  article-title: Postnatal dexamethasone for lung disease of prematurity
  publication-title: N Engl J Med
  doi: 10.1056/NEJM200406243502618
– volume: 26
  start-page: 667
  year: 2006
  ident: 10.1016/j.jpeds.2021.03.012_bib23
  article-title: New insights into spontaneous intestinal perforation using a national data set (3): antenatal steroids have no adverse association with spontaneous intestinal perforation
  publication-title: J Perinatol
  doi: 10.1038/sj.jp.7211589
– volume: 56
  start-page: 309
  year: 2021
  ident: 10.1016/j.jpeds.2021.03.012_bib14
  article-title: Neurodevelopmental and growth outcomes of extremely preterm infants with necrotizing enterocolitis or spontaneous intestinal perforation
  publication-title: J Pediatr Surg
  doi: 10.1016/j.jpedsurg.2020.05.013
– volume: 15
  start-page: 573
  year: 2015
  ident: 10.1016/j.jpeds.2021.03.012_bib16
  article-title: Temporal trends of intraventricular hemorrhage of prematurity in Nova Scotia from 1993 to 2012
  publication-title: J Neurosurg Pediatr
  doi: 10.3171/2014.11.PEDS14363
– volume: 6
  start-page: 63
  year: 2001
  ident: 10.1016/j.jpeds.2021.03.012_bib36
  article-title: The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials
  publication-title: Semin Neonatol
  doi: 10.1053/siny.2000.0036
– volume: 198
  start-page: 725
  year: 2008
  ident: 10.1016/j.jpeds.2021.03.012_bib32
  article-title: Antenatal indomethacin is more likely associated with spontaneous intestinal perforation rather than NEC
  publication-title: Am J Obstet Gynecol
  doi: 10.1016/j.ajog.2008.01.026
– volume: 4
  start-page: 532
  year: 2001
  ident: 10.1016/j.jpeds.2021.03.012_bib20
  article-title: Early postnatal dexamethasone diminishes transforming growth factor alpha localization within the ileal muscularis propria of newborn mice and extremely low-birth-weight infants
  publication-title: Pediatr Dev Pathol
  doi: 10.1007/s10024001-0096-0
– volume: 344
  start-page: 1966
  year: 2001
  ident: 10.1016/j.jpeds.2021.03.012_bib4
  article-title: Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants
  publication-title: N Engl J Med
  doi: 10.1056/NEJM200106283442602
SSID ssj0009400
Score 2.4707062
Snippet To evaluate the association of a combined exposure to antenatal steroids and prophylactic indomethacin with the outcome of spontaneous intestinal perforation...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 34
SubjectTerms indomethacin
infant
intestinal perforation
preterm
steroid
Title Association of Co-Exposure of Antenatal Steroid and Prophylactic Indomethacin with Spontaneous Intestinal Perforation
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0022347621002262
https://dx.doi.org/10.1016/j.jpeds.2021.03.012
https://www.ncbi.nlm.nih.gov/pubmed/33741365
https://www.proquest.com/docview/2503448872
Volume 235
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1dS-QwMOgK4ovc6d3pfUgEH69qPts-Louy3qEIKvgW0iSFFWmK7oJP_nZn2nS9e9CDe0zpNOnMZGYymQ9CDliuy7LyVVb6ysEBJbisYlZnyjqpRF4rqTEb-fxCT2_kr1t1u0ImQy4MhlUm2d_L9E5apydHCZtH7WyGOb6g2iRsZqwiylEOr3HQ9sWIrI3Pfk8vXmvvypSJgoHrADAUH-rCvO7a4LFsN2ddsVPG31JQbxmgnSI6_UA2kwVJx_0iP5KV0GyR9fN0R75NFn9gnMaaTmJ28tRG9ATicIwx6-izoVeA0jjz1DaeXj5EwPd9lzFFzxofsbO0hQ9SdNTSqzY2YEWGuHik6EMEuYBruOxi47uZPpGb05PryTRLzRUyJxmbZ14Hjx2mRQmyUvHKWbA0cl37XNoAmlPXQsgQnC299MHxWgHpnCx04ZkOlonPZNTEJuwQquraYc8SIbmVpSuLY-srzoNyShfa17uEDxg1LlUexwYY92YIMbszHRkMksEcCwNk2CU_l0BtX3jj_dflQCoz5JSCFDSgGN4H00uwv9ju34D7Az8Y2JB4y9JTwYBNKeDMW-TwzpeeUZY_IAQYcEKrr_877TeygaM-AvE7Gc0fFuEHWEXzao-sHj6zvcT7LxTlDWw
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1dS-QwMMgK572IenrneZ45uEeLNl9tH5dF2VV3EVTwLaRJCivSFG8X_Pk306br-aDCPbbNNMlMMjOZzAchv9NMFUXpyqRwpYUDirdJmRqVSGOF5FklhcJo5OlMje_Exb28XyOjPhYG3Soj7-94esut45uTiM2TZj7HGF8QbQI2M2YRZciH1wUWtR6Q9eHkcjx7yb0rYiQKOq4DQJ98qHXzemi8w7TdLG2TnabsLQH1lgLaCqLzLbIZNUg67Aa5TdZ8vUM-TeMd-Rey_AfjNFR0FJKz5yagJRAfh-izjjYbegMoDXNHTe3o9VMAfD-2EVN0UruAlaUN_JCioZbeNKEGLdKH5R-KNkTgCziG69Y3vu1pl9ydn92OxkksrpBYkaaLxCnvsMI0L4BXSlZaA5pGpiqXCeNBcqqKc-G9NYUTzltWSSCdFbnKXaq8SfkeGdSh9t8IlVVlsWYJF8yIwhb5qXElY15aqXLlqn3CeoxqGzOPYwGMR927mD3olgwayaBPuQYy7JPjFVDTJd54v7noSaX7mFLgghoEw_tgagX2atl9DPirXw8aNiTesnRU0KBTcjjz5hm0-dotlNUEOAcFjiv5_X-7PSIb49vplb6azC4PyGf80nkj_iCDxdPSH4KGtCh_xh3wF2wZD1I
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+Co-Exposure+of+Antenatal+Steroid+and+Prophylactic+Indomethacin+with+Spontaneous+Intestinal+Perforation&rft.jtitle=The+Journal+of+pediatrics&rft.au=Kandraju%2C+Hemasree&rft.au=Kanungo%2C+Jaideep&rft.au=Lee%2C+Kyong-Soon&rft.au=Daspal%2C+Sibasis&rft.date=2021-08-01&rft.issn=1097-6833&rft.eissn=1097-6833&rft.volume=235&rft.spage=34&rft_id=info:doi/10.1016%2Fj.jpeds.2021.03.012&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3476&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3476&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3476&client=summon